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Which drugs are most reported with Atrial septal defect?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 8,292 reports · 241 co-occurring drugs

As of the last recalculation, Atrial Septal Defect appears in 8,292 FAERS reports alongside 241 co-occurring drug terms. The strongest observed disproportionality signal is PAROXETINE HYDROCHLORIDE (PRR 42.3).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Paroxetine Hydrochloride	1,299	42.3	42.9
Zidovudine	151	28.9	29.2
Ampicillin	83	25.4	25.6
Ampicillin Sodium	83	25.4	25.6
Misoprostol	70	18.2	18.3
Lamotirigine	487	18.1	18.2
Lamotrigine Extended-Release	487	18.1	18.2
Lamotrigine Chewable Dispersible	487	18.1	18.2
Progesterone	142	15.8	15.9
Nevirapine	45	12.6	12.6
Sertraline Hydrochloride	526	11.8	11.9
Lamotrigine	580	11.8	11.9
Venlafaxine	324	11.8	11.8
Dolutegravir Sodium	42	11.7	11.8
Tenofovir Disoproxil Fumarate Tablets	39	11.4	11.4
Promethazine Hydrochloride	77	10.5	10.5
Lamivudine Oral	102	10.2	10.3
Lamivudine	120	9.9	9.9
Lopinavir And Ritonavir	52	9.7	9.7
Levetiracetam In Sodium Chloride	257	8.6	8.6
Levetiracetam Oral	257	8.6	8.6
Levetiracetam Injection	257	8.6	8.6
Valproic Acid	106	8.5	8.6
Fluoxetine Hydrochloride	412	8.5	8.5
Sertraline	376	8.4	8.4
Venlafaxine Hydrochloride	419	8.3	8.3
Dimenhydrinate	35	8.3	8.3
Darunavir	48	8.0	8.0
Valproate Sodium	64	7.8	7.8
Cefuroxime	34	7.5	7.5
Ritonavir 100 Mg	44	7.4	7.4
Paroxetine Hydrochloride Hemihydrate	97	7.4	7.4
Citalopram Hydrobromide	304	7.4	7.4
Paroxetine	97	7.2	7.3
Ritonavir	82	7.1	7.1
Insulin	155	7.1	7.1
Lacosamide	100	6.8	6.8
Citalopram	343	6.5	6.5
Escitslopram	145	6.4	6.4
Oseltamivir	20	6.3	6.3
Magnesium Sulfate In Water For	31	6.1	6.1
Levetiracetam	310	6.0	6.0
Magnesium Sulfate Heptahydrate	31	6.0	6.0
Magnesium Sulfate	31	6.0	6.0
Clobazam	56	5.8	5.8
Escitalopram Oxalate	157	5.5	5.5
Butalbital, Acetaminophen, And Caffeine	23	5.4	5.4
Cephalexin	46	5.4	5.4
Raltegravir	35	5.3	5.3
Atazanavir	30	5.3	5.3
Lithium	52	5.2	5.2
Lithium Bromatum	52	5.2	5.2
Lithium Carbonate	35	5.2	5.2
Folic Acid	483	5.1	5.1
Nifedipine	93	5.0	5.0
Quetiapine	362	4.9	4.9
Azithromycin Dihydrate	112	4.8	4.9
Escitalopram	260	4.8	4.8
Phytonadione	16	4.7	4.7
Ondansetron Hydrochloride	223	4.7	4.7
Miconazole Nitrate	16	4.6	4.6
Zonisamide	27	4.6	4.6
Topiramate	167	4.6	4.6
Levothyroxine Sodium Anhydrous	178	4.5	4.5
Amoxicillin	136	4.5	4.5
Terbinafine Hydrochloride	16	4.5	4.5
Sumatriptan Succinate	45	4.5	4.5
Dalteparin Sodium	18	4.3	4.3
Ondansetron	178	4.2	4.2
Ondansetron Tablets	178	4.2	4.2
Oxcarbazepine	53	4.1	4.1
Fluoxetine	102	3.9	3.9
Gentamicin Sulfate	24	3.8	3.8
Diclofenac	127	3.7	3.7
Ramipril	181	3.7	3.7
Carbamazepine	97	3.7	3.7
Labetalol	19	3.6	3.6
Desloratadine	15	3.5	3.5
Sumatriptan	53	3.5	3.5
Metoclopramide Hydrochloride	105	3.4	3.4
Valsartan Oral	74	3.4	3.4
Ferrous Sulfate	68	3.4	3.4
Selexipag	35	3.4	3.4
Diazepam Oral Solution (Concentrate)	119	3.4	3.4
Diazepam Oral	119	3.4	3.4
Metoprolol Tartrate Injection	250	3.4	3.4
Nitrofurantoin	22	3.4	3.4
Emtricitabine And Tenofovir Disoproxil Fumarate	60	3.3	3.3
Nitrofurantoin (Monohydrate/Macrocrystals)	22	3.3	3.3
Phenobarbital	19	3.3	3.3
Tenofovir Disoproxil Fumarate	43	3.3	3.3
Ibuprofen And Diphenhydramine Citrate	30	3.2	3.2
Ursosiol	25	3.2	3.2
Metoclopramide	70	3.2	3.2
Divalproex Sodium	59	3.2	3.2
Aripiprazole Oral	51	3.1	3.1
Aripiprazole Orally Disintegrating	51	3.1	3.1
Gentamicin	16	3.1	3.1
Ibuprofen Capsule	239	3.1	3.1
Ibuprofen Tablet, Film Coated	239	3.1	3.1
Ibupfrofen	239	3.1	3.1
Ibuprofen Tablets Usp, 200Mg	239	3.1	3.1
Ibuprofen Oral	239	3.1	3.1
Ibuprofen Capsules 200 Mg	239	3.1	3.1
Ibuprofen 200 Mg	239	3.1	3.1
Ibuprofen 200Mg	239	3.1	3.1
Oseltamivir Phosphate	29	3.0	3.0
Palivizumab	18	2.9	2.9
Iron	77	2.9	2.9
Ursodiol	25	2.9	2.9
Albuterol	136	2.9	2.9
Indomethacin	15	2.8	2.8
Metoprolol	280	2.8	2.8
Nystatin Ointment	29	2.8	2.8
Nystatin Cream	29	2.8	2.8
Diazepam	133	2.8	2.8
Bupropion Hydrochloride	108	2.8	2.8
Ibuprofen	290	2.7	2.7
Meperidine Hydrochloride	10	2.7	2.7
Azathioprine	95	2.7	2.7
Azithromycin	43	2.7	2.7
Duloxetine	74	2.7	2.7
Cetiirizine	45	2.7	2.7
Nystatin	29	2.7	2.7
Metoprolol Tartrate	284	2.7	2.7
Emtricitabine And Tenofovir Alafenamide	12	2.7	2.7
Salmeterol Xinafoate	9	2.6	2.6
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	165	2.6	2.6
Meclizine	17	2.6	2.6
Azithromycin Monohydrate	43	2.6	2.6
Meclizine Hcl 12.5Mg	14	2.6	2.6
Meclizine Hcl 25Mg	14	2.6	2.6
Meclizine Hcl 12.5 Mg	14	2.6	2.6
Meclizine Hcl 25 Mg	14	2.6	2.6
Erythromycin	19	2.5	2.5
Epoetin Alfa	12	2.5	2.5
Insulin Human	40	2.5	2.5
Ivacaftor	8	2.5	2.5
Clindamycin Phosphate	33	2.5	2.5
Levothyroxine Sodium	288	2.3	2.3
Canakinumab	10	2.3	2.3
Meclizine Hydrochloride	18	2.3	2.3
Etonogestrel And Ethinyl Estradiol	20	2.3	2.3
Diclofenac Sodium	133	2.2	2.2
Amoxicillin And Clavulanate Potassium	24	2.2	2.2
Clindamycin	25	2.2	2.2
Bisoprolol Fumarate	118	2.2	2.2
Cetirizine Hcl	8	2.2	2.2
Bleomycin Sulfate	9	2.2	2.2
Nicotine Polacrilex Mini	13	2.2	2.2
Nicotine Polarilex	13	2.2	2.2
Zolpidem Tartrate	116	2.2	2.2
Drospirenone And Ethinyl Estradiol	38	2.2	2.2
Olanzapine	92	2.2	2.2
Riociguat	28	2.2	2.2
Valsartan	88	2.1	2.1
Epoprostenol	11	2.1	2.1
Oxazepam	18	2.1	2.1
Enoxaparin Sodium	47	2.1	2.1
Mometasone	15	2.1	2.1
Quetiapine Fumarate	24	2.0	2.0
Amlodipine Besylate And Valsartan	9	2.0	2.0
Metolazone	9	2.0	2.0
Metronidazole Topical	38	2.0	2.0
Acetaminophen	346	2.0	2.0
Metronidazole	50	2.0	2.0
Digoxin	56	2.0	2.0
Mometasone Furoate	32	1.9	1.9
Bupropion	34	1.9	1.9
Cetirizine	59	1.9	1.9
Olanzapine Pamoate	31	1.9	1.9
Loratadine And Pseudoephedrine Sulfate	6	1.9	1.9
Norepinephrine	8	1.9	1.9
Mirtazapine	68	1.9	1.9
Levodopa	9	1.9	1.9
Aripiprazole	90	1.9	1.9
Macitentan	50	1.8	1.8
Efavirenz	8	1.8	1.8
Piperacillin And Tazobactam	9	1.8	1.8
Glyburide	17	1.8	1.8
Metformin Hydrochloride	41	1.7	1.7
Erythropoietin	14	1.7	1.7
Oxycodone And Acetaminophen Tablets	8	1.7	1.7
Brivaracetam	6	1.7	1.7
Metformin Hydrochloride Tablets	38	1.7	1.7
Metformin Hydrochloride Extended-Release Tablets	38	1.7	1.7
Metformin Hydrochloride Tablet	38	1.7	1.7
Ibuprofen Tablets, Coated	28	1.7	1.7
Ibuprofen Sodium	28	1.6	1.6
Diclofenac Sodium 1%	23	1.6	1.6
Diclofenac Sodium Topical	23	1.6	1.6
Diclofenac Sodium Topical Gel, 1%	23	1.6	1.6
Loratadine Tablet	34	1.6	1.6
Norepinephrine Bitartrate	9	1.6	1.6
Guaifenesin	19	1.6	1.6
Phenytoin	13	1.6	1.6
Tadalafil	62	1.6	1.6
Fondaparinux Sodium	5	1.6	1.6
Abacavir Sulfate	6	1.5	1.5
Prochlorperazine	17	1.5	1.5
Duloxetine Hydrochloride	113	1.5	1.5
Risperidone	80	1.5	1.5
Insulin Glargine-Yfgn	13	1.5	1.5
Methadone	25	1.5	1.5
Oxycodone And Acetaminophen	13	1.4	1.4
Sildenafil	32	1.4	1.4
Sildenafil Powder,	19	1.3	1.3
Imatinib	9	1.3	1.3
Clozapine	63	1.3	1.3
Insulin Glulisine	5	1.2	1.2
Armodafinil	10	1.2	1.2
Acetaminophen, Aspirin (Nsaid) And Caffeine	8	1.2	1.2
Icosapent Ethyl	4	1.2	1.2
Ifosfamide	10	1.2	1.2
Treprostinil	56	1.1	1.1
Fluticasone Furoate And Vilanterol Trifenatate	16	1.1	1.1
Ethyl Alcohol	12	1.1	1.1
Bosentan	21	1.0	1.0
Isopropyl Alcohol	14	1.0	1.0
Vortioxetine	7	1.0	1.0
Ambrisentan	48	1.0	1.0
Isotretinoin	19	1.0	1.0
Methylphenidate	11	1.0	1.0
Acetaminophen, Aspirin, And Caffeine	8	1.0	1.0
Belimumab	12	1.0	1.0
Fesoterodine Fumarate	4	0.9	0.9
Sevoflurane	3	0.9	0.9
Alcohol	14	0.9	0.9
Insulin Lispro	48	0.9	0.9
Fingolimod Hcl	29	0.8	0.8
Docetaxel Anhydrous	22	0.8	0.8
Docetaxel	22	0.8	0.8
Sofosbuvir	6	0.8	0.8
Glatiramer Acetate	17	0.7	0.7
Peginterferon Alfa-2A	15	0.7	0.7
Peginterferon Beta-1A	3	0.6	0.6
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	4	0.6	0.6
Buprenorphine	20	0.5	0.5
Natalizumab	39	0.5	0.5
Levonorgestrel	24	0.3	0.3
Adapalene	3	0.0	0.0

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.