Reaction

Cardiac Valve Disease reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,674 reports · 241 co-occurring drugs

As of the last recalculation, Cardiac Valve Disease appears in 5,674 FAERS reports alongside 241 co-occurring drug terms. The strongest observed disproportionality signal is OCTREOTIDE ACETATE (PRR 10.9).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Octreotide Acetate	90	10.9	11.0
Digoxin	205	10.8	10.9
Apixaban	184	10.4	10.4
Amiodarone Hydrochloride	28	9.2	9.2
Captopril	22	8.4	8.4
Agalsidase Beta	21	8.4	8.4
Warfarin Sodium	102	8.2	8.2
Methylphenidate	64	8.2	8.2
Bumetanide	53	7.4	7.4
Nitroglycerin	98	6.8	6.8
Enalapril Maleate	45	6.7	6.7
Isosorbide Dinitrate	34	6.4	6.4
Glyburide	42	6.4	6.4
Diltiazem Hydrochloride	59	6.3	6.3
Tolterodine Tartrate	15	6.1	6.2
Warfarin	203	6.0	6.1
Ezetimibe And Simvastatin	24	5.8	5.8
Cephalexin	33	5.6	5.6
Dofetilide	16	5.6	5.6
Metolazone	17	5.6	5.6
Amlodipine Besylate And Benazepril Hydrochloride	13	5.2	5.2
Quinine	12	5.1	5.1
Meclizine Hcl 12.5Mg	19	5.1	5.1
Meclizine Hcl 25Mg	19	5.1	5.1
Meclizine Hcl 12.5 Mg	19	5.1	5.1
Meclizine Hcl 25 Mg	19	5.1	5.1
Methylphenidate Hydrochloride	81	5.1	5.1
Human Insulin	17	5.0	5.0
Furosemide	499	4.9	4.9
Ampicillin	11	4.9	4.9
Ampicillin Sodium	11	4.9	4.9
Potassium Chloride, Dextrose Monohydrate	118	4.8	4.8
Potassium Chloride Oral	118	4.8	4.8
Potassium Chloride Extended-Release	118	4.7	4.8
Spironolactone	177	4.7	4.7
Potassium Chloride	144	4.7	4.7
Carvedilol	170	4.7	4.7
Quinapril Hydrochloride	10	4.7	4.7
Sacubitril And Valsartan	143	4.6	4.6
Valsartan And Hydrochlorothiazide	17	4.6	4.6
Meclizine	20	4.5	4.5
Metoprolol Tartrate	318	4.5	4.5
Desloratadine	13	4.5	4.5
Metoroprolol Tartrate	79	4.4	4.4
Chlorhexidine Gluconate	11	4.4	4.4
Torsemide	38	4.2	4.2
Lanreotide Acetate	9	4.2	4.2
Sotalol Hydrochloride	19	4.2	4.2
Cimetidine	11	4.2	4.2
Metoprolol	279	4.2	4.2
Meclizine Hydrochloride	22	4.1	4.1
Romosozumab-Aqqg	15	4.1	4.1
Metoprolol Tartrate Injection	201	4.0	4.0
Atropine	9	4.0	4.0
Atorvastatin Calcium	259	4.0	4.0
Gentamicin	14	3.9	3.9
Estrogens, Conjugated	63	3.9	3.9
Celecoxib	137	3.9	3.9
Sucralfate Oral	15	3.9	3.9
Ranolazine	11	3.9	3.9
Conjugated Estrogens	61	3.9	3.9
Sucralfate Oral Suspension	15	3.9	3.9
Rabeprazole	23	3.8	3.8
Temazepam	39	3.8	3.8
Losartan Potassium And Hydrochlorothiazide	12	3.8	3.8
Promethazine Hydrochloride	19	3.8	3.8
Diphenoxylate Hydrochloride And Atropine Sulfate	14	3.8	3.8
Nifedipine	48	3.8	3.8
Gentamicin Sulfate	16	3.7	3.7
Dorzolamide Hydrochloride And Timolol Maleate	8	3.7	3.7
Cyclobenzaprine Hydrochloride	9	3.7	3.7
Colchicine	26	3.6	3.6
Dronedarone	10	3.6	3.6
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	30	3.6	3.6
Ezetimibe	72	3.6	3.6
Docusate Sodium 100Mg	23	3.5	3.5
Docusate Sodium	54	3.5	3.5
Butalbital, Acetaminophen, And Caffeine	10	3.4	3.4
Docusate Sodium - Sennosides	30	3.4	3.4
Aspirin 325 Mg	449	3.4	3.4
Aspirin 81 Mg	449	3.4	3.4
Atropine Sulfate	10	3.4	3.4
Ferrous Sulfate	46	3.4	3.4
Aspirin	466	3.4	3.4
Rabeprazole Sodium	25	3.4	3.4
Clopidogrel	178	3.4	3.4
Valsartan	95	3.4	3.4
Erythromycin	17	3.3	3.3
Losartan Potassium	71	3.3	3.3
Amlodipine Besylate And Valsartan	10	3.3	3.3
Metoprolol Succinate Er Tablets	56	3.3	3.3
Labetalol	12	3.3	3.3
Terazosin Hydrochloride	8	3.3	3.3
Calcitriol Capsules 0.25 Mcg	18	3.3	3.3
Calcitriol Capsules 0.5 Mcg	18	3.3	3.3
0Xygen	44	3.3	3.3
Oxygen	44	3.3	3.3
Metoprolol Succinate	77	3.3	3.3
Darbepoetin Alfa	48	3.3	3.3
Carisoprodol	17	3.3	3.3
Rifampin	13	3.3	3.3
Bosutinib	8	3.3	3.3
Atenolol	117	3.3	3.3
Calcitriol	18	3.3	3.3
Enalapril	49	3.3	3.3
Sucralfate	21	3.2	3.2
Isosorbide Mononitrate	18	3.2	3.2
Meperidine Hydrochloride	8	3.2	3.2
Piperacillin Sodium And Tazobactam Sodium	17	3.2	3.2
Gemfibrozil	13	3.1	3.1
Cyanocobalamin	28	3.1	3.1
Amlodipine Besylate	123	3.1	3.1
Paricalcitol	12	3.1	3.1
Tafamidis	10	3.1	3.1
Amoxicillin And Clavulanate Potassium	23	3.1	3.1
Epoetin Alfa	10	3.1	3.1
Bosentan	42	3.1	3.1
Insulin Human	33	3.1	3.1
Imatinib Mesylate	23	3.0	3.0
Acalabrutinib	10	3.0	3.0
Paroxetine Hydrochloride	74	3.0	3.0
Lovastatin	21	3.0	3.0
Sodium Bicarbonate	19	3.0	3.0
Sodium Bicarbonate Injection,	19	3.0	3.0
Hydrochlorothiazide	117	3.0	3.0
Amoxicillin	61	3.0	3.0
Candesartan Cilexetil	21	2.9	2.9
Azithromycin Dihydrate	46	2.9	2.9
Iron	52	2.9	2.9
Drs. Clotrimazole	9	2.9	2.9
Family Wellness Clotrimazole	9	2.9	2.9
Clotrimazole Topical	9	2.9	2.9
Alprazolam	156	2.8	2.8
Norepinephrine Bitartrate	11	2.8	2.8
Metformin Hcl	42	2.8	2.8
Dabigatran Etexilate Mesylate	55	2.8	2.8
Simvastatin	186	2.8	2.8
Lisinopril	226	2.8	2.8
Dalteparin Sodium	8	2.8	2.8
Guaifenesin	23	2.8	2.8
Doxazosin	21	2.8	2.8
Doxazosin Mesylate	27	2.8	2.8
Irbesartan	33	2.7	2.7
Desoximetasone	14	2.7	2.7
Clotrimazole	9	2.7	2.7
Enoxaparin Sodium	42	2.7	2.7
Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride And Dextrose	6	2.7	2.7
Atorvastatin Calcium, Film Coated	51	2.7	2.7
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	15	2.7	2.7
Naproxen Sodium, Pseudoephedrine Hydrochloride	15	2.7	2.7
Amphetamine	6	2.7	2.7
Dabigatran Etexilate	56	2.7	2.7
Sildenafil Citrate	91	2.6	2.6
Vancomycin	41	2.6	2.6
Trazodone Hydrochloride	11	2.6	2.6
Vancomycin Hydrochloride	46	2.6	2.6
Sildenafil	40	2.5	2.5
Niacin	8	2.5	2.5
Minocycline	8	2.5	2.5
Lisinopril And Hydrochlorothiazide	7	2.5	2.5
Ambrisentan	84	2.5	2.5
Glipizide	41	2.5	2.5
Sildenafil Powder,	24	2.5	2.5
Testosterone Cypionate	6	2.5	2.5
Losartan	114	2.4	2.4
Macitentan	45	2.4	2.4
Teriparatide	72	2.4	2.4
Carboxymethylcellulose Sodium	6	2.3	2.3
Conjugated Estrogens And Medroxyprogesterone Acetate	15	2.3	2.3
Baricitinib	6	2.3	2.3
Clopidogrel Bisulfate	63	2.3	2.3
Insulin Aspart	40	2.2	2.2
Erythropoietin	12	2.1	2.1
Riociguat	19	2.1	2.1
Selexipag	15	2.1	2.1
Budesonide And Formoterol Fumarate Dihydrate	56	2.1	2.1
Insulin Lispro	79	2.1	2.1
Interferon Beta-1A	107	2.1	2.1
Latanoprost	28	2.0	2.0
Daptomycin	5	2.0	2.0
Epoprostenol	7	2.0	2.0
Ranibizumab	14	1.9	1.9
Insulin Degludec	12	1.9	1.9
Carbidopa And Levodopa	24	1.9	1.9
Tiotropium Bromide	69	1.9	1.9
Insulin Glargine	123	1.8	1.8
Niraparib	11	1.8	1.8
Prasugrel Hydrochloride	5	1.8	1.8
Cortisone Acetate	6	1.8	1.8
Bleomycin Sulfate	5	1.8	1.8
Hydrocodone Bitartrate	21	1.8	1.8
Tadalafil	48	1.8	1.8
Eculizumab	26	1.8	1.8
Trifluridine And Tipiracil	5	1.7	1.7
Ibrutinib	37	1.7	1.7
Peginterferon Beta-1A	6	1.7	1.7
Fluticasone Propionate And Salmeterol	19	1.7	1.7
Brimonidine Tartrate	8	1.6	1.6
Pomalidomide	46	1.6	1.6
Ruxolitinib	32	1.6	1.6
Nintedanib	14	1.6	1.6
Ticagrelor	14	1.6	1.6
Trastuzumab	30	1.6	1.6
Sevelamer Carbonate	5	1.6	1.6
Patiromer	6	1.6	1.6
Exenatide	22	1.5	1.5
Rotigotine	6	1.5	1.5
Treprostinil	51	1.5	1.5
Dasatinib	15	1.5	1.5
Lenalidomide	168	1.5	1.5
Loratadine And Pseudoephedrine Sulfate	3	1.4	1.4
Vibegron	3	1.4	1.4
Ravulizumab	5	1.4	1.4
Fesoterodine Fumarate	4	1.4	1.4
Cenobamate	3	1.3	1.3
Umeclidinium Bromide And Vilanterol Trifenatate	6	1.3	1.3
Naproxen Sodium Tablet	19	1.3	1.3
Benralizumab	7	1.3	1.3
Tolvaptan	5	1.3	1.3
Diroximel Fumarate	4	1.2	1.2
Rifaximin	7	1.2	1.2
Palivizumab	5	1.2	1.2
Hydrocodone Bitartrate And Acetaminophen	18	1.2	1.2
Alirocumab	8	1.2	1.2
Carfilzomib	9	1.2	1.2
Risankizumab-Rzaa	26	1.2	1.2
Bimatoprost	9	1.1	1.1
Obinutuzumab	5	1.1	1.1
Leuprolide Acetate	22	1.0	1.0
Cinacalcet Hydrochloride	13	1.0	1.0
Pirfenidone	11	1.0	1.0
Cannabidiol	6	0.9	0.9
Enzalutamide	14	0.9	0.9
Osimertinib	7	0.8	0.8
Etonogestrel	10	0.8	0.8
Tapentadol Hydrochloride	7	0.8	0.8
Ixazomib	6	0.8	0.8
Abaloparatide	6	0.7	0.7
Apremilast	28	0.7	0.7
Relugolix	4	0.6	0.6
Evolocumab	21	0.5	0.5

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.