Reaction

Protein Total Decreased reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,716 reports · 221 co-occurring drugs

As of the last recalculation, Protein Total Decreased appears in 3,716 FAERS reports alongside 221 co-occurring drug terms. The strongest observed disproportionality signal is DEXAMETHASONE SODIUM PHOSPHATE (PRR 14.4).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Dexamethasone Sodium Phosphate	26	14.4	14.5
Deferasirox	53	11.3	11.4
Hydrocortisone Sodium Succinate	18	10.8	10.8
Fosaprepitant Dimeglumine	25	10.2	10.3
Fondaparinux Sodium	14	9.7	9.7
Exemestane	34	9.0	9.0
Magnesium Sulfate In Water For	20	8.8	8.8
Magnesium Sulfate Heptahydrate	20	8.6	8.7
Magnesium Sulfate	20	8.6	8.6
Crizotinib	19	8.4	8.4
Dalteparin Sodium	15	8.0	8.0
Magnesium Hydroxide	19	7.9	7.9
Alemtuzumab	27	7.9	7.9
Dextrose	18	7.7	7.7
Dextrose Monohydrate	18	7.6	7.6
Standardized Senna Concentrate	16	7.1	7.2
Granisetron Hydrochloride	13	7.0	7.0
Diphenoxylate Hydrochloride And Atropine Sulfate	17	7.0	7.0
Polatuzumab Vedotin	12	6.9	6.9
Atropine Sulfate	13	6.8	6.8
Basiliximab	14	6.7	6.7
Eplerenone	15	6.6	6.6
Meropenem	37	6.5	6.5
Voclosporin	10	6.5	6.5
Ascorbic Acid	26	6.3	6.3
Valproate Sodium	23	6.3	6.3
Sunitinib Malate	43	6.2	6.2
Atropine	9	6.1	6.1
Aprepitant	20	6.1	6.1
Bisacodyl	15	6.0	6.0
Phytonadione	9	6.0	6.0
Dicyclomine Hydrochloride	15	5.9	5.9
Sennosides 8.6 Mg Tablets	22	5.9	5.9
Senna	22	5.9	5.9
Goserelin	14	5.9	5.9
Senna Leaf	24	5.9	5.9
Magnesium Oxide	43	5.8	5.8
Gentamicin Sulfate	16	5.7	5.7
Sennosides	30	5.7	5.7
Imatinib Mesylate	28	5.7	5.7
Temozolomide	21	5.6	5.6
Asfotase Alfa	10	5.6	5.6
Gentamicin	13	5.6	5.6
Dronabinol	8	5.6	5.6
Sodium Bicarbonate	23	5.6	5.6
Sodium Bicarbonate Injection,	23	5.6	5.6
Ciprofloxacin Hydrochloride And Hydrocortisone	20	5.4	5.4
Metoclopramide Hydrochloride	73	5.4	5.4
Lubiprostone	9	5.3	5.3
Digoxin	67	5.3	5.3
Torsemide	31	5.3	5.3
Potassium Chloride, Dextrose Monohydrate	85	5.2	5.2
Potassium Chloride Oral	85	5.2	5.2
Potassium Chloride Extended-Release	85	5.2	5.2
Enoxaparin Sodium	53	5.2	5.2
Bisacodyl Suppositories	12	5.2	5.2
Daspone	9	5.2	5.2
Dapsone Gel, 5%	9	5.2	5.2
Biscodyl	12	5.2	5.2
Diphenhydramine Hcl	10	5.0	5.0
Tolvaptan	13	5.0	5.0
Carisoprodol	17	5.0	5.0
Lactulose	34	5.0	5.0
Nystatin	24	4.9	4.9
Sucralfate	21	4.9	4.9
Potassium Chloride	98	4.9	4.9
Granisetron	9	4.8	4.8
Clozapine	105	4.8	4.8
Everolimus	43	4.8	4.8
Fulvestrant	28	4.8	4.8
Epoetin Alfa	10	4.7	4.7
Dapsone	9	4.7	4.7
Calcium Carbonate	56	4.7	4.7
Fluconazole	58	4.7	4.7
Furosemide	312	4.7	4.7
Micafungin Sodium	7	4.6	4.6
Posaconazole Delayed-Release	9	4.6	4.6
Pegaspargase	10	4.6	4.6
Sirolimus	11	4.6	4.6
Tobramycin Sulfate	10	4.5	4.5
Metoclopramide	44	4.5	4.5
Zoledronic Acid	32	4.5	4.5
Metolazone	9	4.5	4.5
Heparin Sodium	11	4.5	4.5
Sodium Chloride	62	4.5	4.5
Voriconazole	24	4.4	4.5
Trametinib	19	4.4	4.4
Tranexamic Acid	7	4.4	4.4
Brentuximab Vedotin	8	4.4	4.4
Haloperidol Lactate	19	4.3	4.3
Acyclovir	86	4.3	4.3
Loperamide Hydrochloride	34	4.3	4.3
Prochlorperazine	21	4.3	4.3
Amlodipine Besylate And Benazepril Hydrochloride	7	4.3	4.3
Pancrelipase	29	4.2	4.2
Famotidine	87	4.2	4.2
Loperamide Hydrochloride And Dimethicone	24	4.2	4.2
Tobramycin Solution	9	4.2	4.2
Filgrastim	28	4.2	4.2
Avapritinib	9	4.2	4.2
Haloperidol	18	4.2	4.2
Teduglutide	10	4.2	4.2
Ferrous Sulfate	37	4.2	4.2
Tretinoin	6	4.1	4.1
Cisplatin	57	4.1	4.1
Memantine	10	4.1	4.1
Memantine Hydrochloride	10	4.1	4.1
Sodium Chloride Tablet	53	4.1	4.1
Sodium Chloride Tablets	53	4.1	4.1
Ibrutinib	58	4.1	4.1
Letrozole	44	4.0	4.0
Erlotinib Hydrochloride	9	4.0	4.0
Extended Phenytoin Sodium	12	4.0	4.0
Dabrafenib	15	4.0	4.0
Mesna	6	4.0	4.0
Bortezomib	63	4.0	4.0
Bendamustine Hcl	11	4.0	4.0
Irinotecan Hydrochloride	9	3.9	3.9
Loratadine Oral	34	3.9	3.9
Cabozantinib	33	3.9	3.9
Ondansetron	74	3.8	3.9
Ondansetron Tablets	74	3.8	3.9
Insulin Human	27	3.8	3.8
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	14	3.8	3.8
Naproxen Sodium, Pseudoephedrine Hydrochloride	14	3.8	3.8
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	21	3.8	3.8
Posaconazole	11	3.8	3.8
Trastuzumab	46	3.8	3.8
Capecitabine	61	3.8	3.8
Ondansetron Hydrochloride	81	3.8	3.8
Letrozole Tablets	32	3.7	3.8
Levofloxacin	40	3.7	3.7
Levofloxacin In 5% Dextrose	40	3.7	3.7
Fingolimod Hcl	57	3.7	3.7
Anakinra	11	3.7	3.7
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	33	3.7	3.7
Ganciclovir Sodium	7	3.7	3.7
Cetirizine Hcl	6	3.7	3.7
Prochlorperazine Maleate	6	3.7	3.7
Fesoterodine Fumarate	7	3.6	3.6
Bumetanide	17	3.6	3.6
Leucovorin Calcium	12	3.5	3.5
Cefepime	9	3.5	3.5
Pertuzumab	17	3.5	3.5
Loperamide Hcl	8	3.5	3.5
Valacyclovir Hydrochloride	43	3.4	3.4
Pegvaliase-Pqpz	5	3.4	3.4
Dapagliflozin	19	3.4	3.4
Mesna Injection	5	3.4	3.4
Regorafenib	7	3.4	3.4
Iohexol	5	3.4	3.4
Cytarabine	36	3.4	3.4
Multivitamin	30	3.4	3.4
Paclitaxel	59	3.4	3.4
Thalidomide	22	3.4	3.4
Paclitaxel (Aibumin-Bound)	49	3.4	3.4
Alteplase	9	3.4	3.4
Entecavir	7	3.4	3.4
Fam-Trastuzumab Deruxtecan-Nxki	6	3.3	3.3
Ado-Trastuzumab Emtansine	5	3.3	3.3
Tobramycin	14	3.3	3.3
Dexamethasone 1.5 Mg	165	3.3	3.3
Acalabrutinib	7	3.2	3.2
Blinatumomab	6	3.2	3.2
Donepezil Hydrochloride	21	3.2	3.2
Dexamethasone	165	3.2	3.2
Linezolid	17	3.2	3.2
Rucaparib	5	3.2	3.2
Eculizumab	30	3.1	3.1
Fluorouracil Cream, 0.5%	42	3.1	3.1
Pemetrexed Disodium	21	3.1	3.1
Linagliptin	10	3.1	3.1
Polyethylene Glycol 3350	52	3.1	3.1
Vincristine Sulfate	16	3.1	3.1
Fluorouracil	42	3.1	3.1
Atezolizumab	21	3.0	3.0
Pembrolizumab	54	2.9	2.9
Erlotinib	5	2.9	2.9
Romosozumab-Aqqg	7	2.9	2.9
Panitumumab	8	2.9	2.9
Gemcitabine Hydrochloride	27	2.9	2.9
Tafamidis	6	2.9	2.9
Venetoclax	30	2.7	2.7
Lenvatinib	16	2.7	2.7
Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride And Dextrose	4	2.7	2.7
Rotigotine	7	2.7	2.7
Dofetilide	5	2.7	2.7
Armodafinil	10	2.7	2.7
Paliperidone	11	2.6	2.6
Axitinib	9	2.6	2.6
Lenalidomide	189	2.6	2.6
Gemcitabine	18	2.6	2.6
Methoxy Polyethylene Glycol-Epoetin Beta	5	2.5	2.5
Desvenlafaxine Succinate	12	2.5	2.5
Pazopanib Hydrochloride	12	2.5	2.5
Gefitinib	4	2.5	2.5
Rocuronium Bromide	5	2.4	2.4
Pemetrexed	9	2.4	2.4
Palbociclib	39	2.3	2.3
Dornase Alfa	8	2.3	2.3
Niraparib	9	2.3	2.3
Encorafenib	4	2.3	2.3
Prasugrel Hydrochloride	4	2.2	2.2
Cinacalcet Hydrochloride	18	2.2	2.2
Ixazomib	11	2.1	2.1
Pomalidomide	39	2.1	2.1
Daratumumab	15	2.1	2.1
Inclisiran	3	2.1	2.1
Carfilzomib	10	2.0	2.0
Lumacaftor And Ivacaftor	3	2.0	2.0
Belimumab	11	1.9	1.9
Selinexor	3	1.9	1.9
Ribavirin	22	1.9	1.9
Lutetium Lu 177 Vipivotide Tetraxetan	4	1.7	1.7
Remdesivir	4	1.7	1.7
Sacubitril And Valsartan	26	1.3	1.3
Patiromer	3	1.2	1.2
Relugolix	5	1.2	1.2
Pegfilgrastim	19	1.1	1.1
Tirzepatide	23	0.8	0.8
Nirmatrelvir And Ritonavir	6	0.6	0.6

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.