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Which drugs are most reported with Congenital anomaly?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 7,696 reports · 242 co-occurring drugs

As of the last recalculation, Congenital Anomaly appears in 7,696 FAERS reports alongside 242 co-occurring drug terms. The strongest observed disproportionality signal is CORTISONE ACETATE (PRR 72.9).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Cortisone Acetate	319	72.9	74.8
Diclofenac Potassium, Film Coated	216	71.4	73.3
Diclofenac Potassium Tablets	216	71.3	73.2
Pseudoephedrine Hydrochloride	246	66.9	68.5
Pseudoephedrine Hcl	247	62.6	64.0
Chlorhexidine Gluconate	192	58.3	59.5
Desoximetasone	389	58.1	59.3
Diclofenac Potassium	216	55.6	56.7
Botulinum Toxin Type A	226	50.7	51.6
Minocycline	201	47.9	48.7
Naproxen Sodium Tablet, Coated	207	42.5	43.1
Naproxen Sodium, Coated Tablets	207	42.5	43.1
Naproxen Sodium 220Mg	207	42.4	43.0
Paroxetine Hydrochloride	1,198	42.0	42.5
Acetaminophen And Codeine	176	40.0	40.5
Tofacitinib Citrate	148	31.1	31.5
Cetirizine Hydrochloride Allergy	296	27.5	27.7
Cetirizine Hydrochloride Tablets	296	27.4	27.7
Diclofenac Sodium 1%	340	26.9	27.1
Diclofenac Sodium Topical	340	26.9	27.1
Diclofenac Sodium Topical Gel, 1%	340	26.8	27.1
Zidovudine	123	25.3	25.5
Progesterone	174	21.0	21.2
Divalproex Sodium	324	19.6	19.7
Hydrocodone Bitartrate And Acetaminophen	389	19.6	19.7
Tenofovir Disoproxil Fumarate Tablets	61	19.3	19.4
Adalimumab-Adaz	338	18.1	18.2
Candesartan	221	17.2	17.3
Adalimumab-Fkjp	281	17.0	17.1
Cetirizine	457	16.9	17.0
Adalimumab-Aaty	281	16.6	16.7
Lopinavir And Ritonavir	82	16.5	16.6
Sulfasalazine	423	15.4	15.5
Atomoxetine Hydrochloride	131	15.1	15.2
Mirabegron	210	15.1	15.1
Cetiirizine	225	14.8	14.8
Mepolizumab	253	14.2	14.3
Zinc Gluconate	134	14.1	14.2
Leflunomide	507	14.0	14.0
Darunavir	77	13.9	14.0
Golimumab	414	13.7	13.8
Isopropyl Alcohol	168	13.7	13.8
Methylprednisolone Sodium Succinate	227	13.6	13.7
Zinc	122	13.6	13.6
Zinc Chloride	122	13.5	13.5
Calcium Gluconate	59	13.3	13.4
Diclofenac	403	13.3	13.4
Levetiracetam In Sodium Chloride	363	13.2	13.3
Levetiracetam Oral	363	13.2	13.3
Levetiracetam Injection	363	13.2	13.3
Methylprednisolone Acetate	39	13.2	13.3
Hydroxychloroquine	346	13.1	13.1
Tramadol Hydrochloride	178	13.1	13.1
Valproate Sodium	98	13.0	13.0
Sarilumab	124	12.9	12.9
Nevirapine	42	12.7	12.7
Ritonavir	133	12.5	12.6
Naproxen	343	12.3	12.4
Anti-Itch	289	12.1	12.1
Anti-Pruritic	289	12.1	12.1
Antipruritic (Anti-Itch)	289	12.1	12.1
Cool Relief Gel With Aloe	289	12.1	12.1
Drs. Hydrocortisone	289	12.1	12.1
Hydrocortisone Continuous Spray	289	12.1	12.1
Hydrocortisone Spray	289	12.1	12.1
Anti-Itch Cream	289	12.1	12.1
Hydrocortisone Lotion	289	12.1	12.1
Hydrocortisone Cream 1%	289	12.1	12.1
Hydrocortisone Cream 1/2%	289	12.1	12.1
Hydrocortisone 1%	289	12.1	12.1
Hydrocortisone Cream	290	12.1	12.1
Alendronate Sodium	426	12.0	12.1
Alcohol	168	11.9	12.0
Diphenhydramine Hydrochloride Capsule, Liquid Filled	92	11.8	11.8
Hydrocortisone Acetate	299	11.5	11.6
Erenumab-Aooe	227	11.5	11.5
Tocilizumab	455	11.4	11.4
Sertraline Hydrochloride	470	11.4	11.4
Methadone Hydrochloride	43	10.8	10.8
Topiramate	356	10.8	10.8
Buprenorphine	347	10.6	10.6
Certolizumab Pegol	429	10.4	10.5
Lamotrigine	472	10.3	10.3
Azathioprine	319	10.2	10.2
Hydroxychloroquine Sulfate	321	9.9	9.9
Hydrocortisone	302	9.5	9.5
Lamotirigine	240	9.3	9.3
Lamotrigine Extended-Release	240	9.3	9.3
Lamotrigine Chewable Dispersible	240	9.3	9.3
Ritonavir 100 Mg	48	8.7	8.8
Levetiracetam	407	8.6	8.7
Hydromorphone Hydrochloride	283	8.6	8.6
Abatacept	408	8.4	8.4
Cetirizine Hydrochloride	476	8.3	8.3
Oxycodone And Acetaminophen Tablets	35	8.0	8.0
Diclofenac Sodium	414	7.8	7.8
Atazanavir	41	7.8	7.8
Quetiapine Fumarate	83	7.7	7.7
Antacid	131	7.6	7.6
Naproxen Sodium	379	7.5	7.5
Oxycodone Hydrochloride	547	7.3	7.3
Ustekinumab	259	7.0	7.1
Raltegravir	42	6.9	6.9
Triamcinolone Acetonide Ointment Usp, 0.05%	59	6.9	6.9
Calcium Carbonate	164	6.7	6.7
Tenofovir Disoproxil Fumarate	80	6.6	6.6
Methylprednisolone	322	6.5	6.5
Ramipril	289	6.5	6.5
Folic Acid	556	6.4	6.4
Secukinumab	363	6.3	6.3
Tofacitinib	407	6.2	6.3
Infliximab	473	6.2	6.2
Vitamin C	205	6.2	6.2
Hydrocodone Bitartrate	97	6.1	6.1
Celecoxib	282	6.0	6.0
Rituximab	442	5.9	5.9
Oxycodone	393	5.9	5.9
Sevoflurane	18	5.9	5.9
Lamivudine	64	5.6	5.7
Meperidine Hydrochloride	19	5.6	5.6
Doxyclycline Hyclate	35	5.6	5.6
Ampicillin	17	5.6	5.6
Ampicillin Sodium	17	5.6	5.6
Metformin Hydrochloride Tablets	114	5.4	5.5
Metformin Hydrochloride Extended-Release Tablets	114	5.4	5.5
Metformin Hydrochloride Tablet	114	5.4	5.5
Buprenorphine Hydrochloride, Naloxone Hydrochloride	48	5.4	5.4
Efavirenz	22	5.3	5.4
Fosaprepitant Dimeglumine	27	5.3	5.3
Metformin Hydrochloride	114	5.3	5.3
Triamcinolone Acetonide	59	5.2	5.2
Lamivudine Oral	47	5.0	5.1
Acetaminophen Tablet Extended Release	449	5.0	5.0
Pain Reliever	449	5.0	5.0
Acetaminophen 500Mg	449	5.0	5.0
Sertraline	210	4.9	5.0
Morphine Sulfate	213	4.9	4.9
Promethazine Hydrochloride	33	4.8	4.8
Erythromycin	33	4.8	4.8
Misoprostol	17	4.7	4.7
Methadone	71	4.5	4.5
Emtricitabine And Tenofovir Disoproxil Fumarate	75	4.5	4.5
Abacavir Sulfate	16	4.4	4.5
Oxycodone And Acetaminophen	38	4.4	4.4
Umeclidinium	14	4.2	4.2
Ondansetron Hydrochloride	185	4.2	4.2
Paroxetine Hydrochloride Hemihydrate	49	4.0	4.0
Paroxetine	49	3.9	3.9
Carbamazepine	96	3.9	3.9
Dolutegravir Sodium	13	3.9	3.9
Hydrocortisone Sodium Succinate	13	3.7	3.7
Apremilast	195	3.7	3.7
Tretinoin	11	3.7	3.7
Pantoprazole Sodium In 0.9% Sodium Chloride	83	3.6	3.7
Pantoprazole Sodium Injection	83	3.6	3.7
Acetaminophen	561	3.6	3.6
Isotretinoin	64	3.5	3.5
Olanzapine	138	3.5	3.5
Thiamine Hydrochloride	16	3.5	3.5
Ibuprofen Tablets, Coated	53	3.4	3.4
Alendronate Sodium Tablet	23	3.4	3.4
Ibuprofen Sodium	53	3.4	3.4
Valproic Acid	39	3.4	3.4
Candesartan Cilexetil	31	3.2	3.2
Captopril	11	3.1	3.1
Ondansetron	123	3.1	3.1
Ondansetron Tablets	123	3.1	3.1
Phenytoin	23	3.0	3.0
Azithromycin Dihydrate	64	3.0	3.0
Prednisone	520	2.9	2.9
Cephalexin	23	2.9	2.9
Indomethacin	14	2.9	2.9
Mesalamine	59	2.9	2.9
Methotrexate	410	2.7	2.7
Fluoxetine Hydrochloride	124	2.7	2.7
Methotrexate Sodium	459	2.7	2.7
Labetalol	13	2.6	2.6
Nitrofurantoin	16	2.6	2.6
Diltiazem Hydrochloride Extended-Release Tablets	11	2.6	2.6
Ibuprofen Capsule	189	2.6	2.6
Ibuprofen Tablet, Film Coated	189	2.6	2.6
Ibupfrofen	189	2.6	2.6
Ibuprofen Tablets Usp, 200Mg	189	2.6	2.6
Ibuprofen Oral	189	2.6	2.6
Ibuprofen Capsules 200 Mg	189	2.6	2.6
Ibuprofen 200 Mg	189	2.6	2.6
Ibuprofen 200Mg	189	2.6	2.6
Nitrofurantoin (Monohydrate/Macrocrystals)	16	2.6	2.6
Clobazam	23	2.6	2.6
Butalbital, Acetaminophen, And Caffeine	10	2.5	2.5
Ibuprofen	249	2.5	2.5
Citalopram	126	2.5	2.5
Escitalopram	128	2.5	2.5
Methimazole	7	2.4	2.4
Zonisamide	13	2.4	2.4
Amoxicillin	66	2.3	2.4
Oxycodone Hydrochloride And Acetaminophen	85	2.3	2.3
Magnesium Sulfate In Water For	11	2.3	2.3
Diphenhydramine Hydrochloride	141	2.3	2.3
Cyanocobalamin	28	2.3	2.3
Magnesium Sulfate Heptahydrate	11	2.3	2.3
Epoetin Alfa	10	2.3	2.3
Magnesium Sulfate	11	2.3	2.3
Norepinephrine	9	2.3	2.3
Ranitidine Hydrochloride	44	2.2	2.2
Dexamethasone Sodium Phosphate	8	2.1	2.1
Drs. Clotrimazole	9	2.1	2.1
Family Wellness Clotrimazole	9	2.1	2.1
Clotrimazole Topical	9	2.1	2.1
Venlafaxine Hydrochloride	101	2.1	2.1
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	121	2.1	2.1
Aprepitant	14	2.1	2.1
Doxycycline Hyclate	51	2.1	2.1
Dalteparin Sodium	8	2.0	2.0
Doxycycline	51	2.0	2.0
Etanercept	434	2.0	2.0
Clotrimazole	9	2.0	2.0
Sulfamethoxazole And Trimethoprim	61	2.0	2.0
Adalimumab	490	1.9	1.9
Citalopram Hydrobromide	76	1.9	1.9
Icosapent Ethyl	6	1.9	1.9
Norepinephrine Bitartrate	10	1.9	1.9
Phenobarbital	10	1.9	1.9
Quetiapine	130	1.8	1.8
Fluoxetine	45	1.8	1.8
Goserelin	9	1.8	1.8
Oseltamivir Phosphate	16	1.8	1.8
Miconazole Nitrate	5	1.5	1.6
Vigabatrin	8	1.5	1.5
Loratadine And Pseudoephedrine Sulfate	4	1.4	1.4
Bleomycin Sulfate	5	1.3	1.3
Ranitidine	89	1.2	1.2
Oxymorphone Hydrochloride	5	1.2	1.2
Omalizumab	36	1.1	1.1
Umeclidinium Bromide And Vilanterol Trifenatate	7	1.1	1.1
Ifosfamide	9	1.1	1.1
Oseltamivir	3	1.0	1.0
Emtricitabine And Tenofovir Alafenamide	4	1.0	1.0
Medroxyprogesterone Acetate	13	0.7	0.7
Palivizumab	4	0.7	0.7
Orlistat	5	0.5	0.5
Adapalene	3	0.0	0.0

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.