Reaction

Drug Level Below Therapeutic reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,425 reports · 184 co-occurring drugs

As of the last recalculation, Drug Level Below Therapeutic appears in 5,425 FAERS reports alongside 184 co-occurring drug terms. The strongest observed disproportionality signal is INFLIXIMAB-DYYB (PRR 199.6).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Infliximab-Dyyb	1,189	199.6	208.1
Infliximab	1,484	35.5	35.8
Voriconazole Injection	176	32.1	32.4
Voriconazole	218	28.6	28.8
Mesalamine	380	27.8	28.0
Posaconazole	110	26.5	26.7
Azathioprine	508	24.3	24.4
Phenytoin	124	23.3	23.4
Anti-Itch	355	21.7	21.8
Anti-Pruritic	355	21.7	21.8
Antipruritic (Anti-Itch)	355	21.7	21.8
Cool Relief Gel With Aloe	355	21.7	21.8
Drs. Hydrocortisone	355	21.7	21.8
Hydrocortisone Continuous Spray	355	21.7	21.8
Hydrocortisone Spray	355	21.7	21.8
Anti-Itch Cream	355	21.7	21.8
Hydrocortisone Lotion	355	21.7	21.8
Hydrocortisone Cream 1%	355	21.7	21.8
Hydrocortisone Cream 1/2%	355	21.7	21.8
Hydrocortisone 1%	355	21.6	21.8
Hydrocortisone Cream	355	21.6	21.7
Hydrocortisone Acetate	380	21.5	21.6
Extended Phenytoin Sodium	86	20.0	20.1
Hydrocortisone	395	18.2	18.3
Hydrocortisone Sodium Succinate	44	18.1	18.2
Dimenhydrinate	47	17.1	17.1
Valproic Acid	132	16.4	16.5
Amphotericin B	51	15.8	15.8
Posaconazole Delayed-Release	42	14.8	14.8
Itraconazole	42	13.9	13.9
Diphenhydramine	214	13.5	13.5
Prednisone	1,177	11.2	11.2
Rifampin	40	10.6	10.6
Rifampicin	27	10.3	10.3
Cholestyramine	31	9.9	9.9
Midazolam Hydrochloride	68	9.8	9.8
Gemfibrozil	37	9.4	9.4
Sevoflurane	20	9.3	9.3
Metronidazole	148	9.1	9.1
Tenofovir Disoproxil Fumarate Tablets	20	8.9	8.9
Quetiapine Fumarate	66	8.7	8.7
Pyrazinamide	20	8.2	8.2
Valproate Sodium	43	8.0	8.1
Divalproex Sodium	94	7.9	7.9
Sirolimus	27	7.7	7.7
Diphenhydramine Hydrochloride	311	7.6	7.6
Iron	126	7.4	7.4
Midazolam	48	7.4	7.4
Carbamazepine	125	7.3	7.3
Metronidazole Topical	89	7.3	7.3
Vancomycin	107	7.2	7.2
Phenobarbital	27	7.2	7.2
Budesonide	107	7.1	7.1
Desoximetasone	35	7.1	7.1
Vancomycin Hydrochloride	119	7.1	7.1
Dalteparin Sodium	19	6.9	6.9
Norepinephrine	19	6.8	6.9
Efavirenz	19	6.6	6.6
Rocuronium Bromide	20	6.5	6.5
Oxcarbazepine	54	6.4	6.4
Isoniazid	27	6.4	6.4
Brivaracetam	15	6.4	6.4
Ustekinumab	166	6.4	6.4
Methylprednisolone Sodium Succinate	75	6.3	6.3
Meropenem	52	6.3	6.3
Vedolizumab	137	6.2	6.2
Linezolid	48	6.2	6.2
Norepinephrine Bitartrate	23	6.2	6.2
Lithium	40	6.1	6.1
Lithium Bromatum	40	6.1	6.1
Terbinafine Hydrochloride	14	6.1	6.1
Mercaptopurine	27	6.0	6.0
Ciprofolxacin	109	5.9	5.9
Ciprofloxacin Tablets	109	5.9	5.9
Adalimumab-Fkjp	68	5.7	5.7
Ciprofloxacin	131	5.6	5.6
Tacrolimus	220	5.6	5.6
Temazepam	54	5.5	5.5
Micafungin Sodium	12	5.4	5.4
Ciprofloxacin Hydrochloride	135	5.4	5.4
Propofol	51	5.4	5.4
Lamivudine Oral	35	5.3	5.3
Haloperidol Lactate	34	5.3	5.3
Adalimumab-Aaty	64	5.2	5.2
Haloperidol	33	5.2	5.2
Lithium Carbonate	23	5.2	5.2
Tacrolimus Extended-Release Capsules	159	5.0	5.0
Tacrolimus Ointment 0.1%	157	5.0	5.0
Acetaminophen Tablet Extended Release	313	4.9	4.9
Pain Reliever	313	4.9	4.9
Acetaminophen 500Mg	313	4.9	4.9
Adalimumab-Adaz	67	4.9	4.9
Clobazam	31	4.9	4.9
Piperacillin And Tazobactam	16	4.8	4.8
Ursosiol	24	4.8	4.8
Abacavir Sulfate	12	4.7	4.7
Instalax Polyethylene Glycol 3350	15	4.6	4.7
Levetiracetam In Sodium Chloride	91	4.6	4.6
Levetiracetam Oral	91	4.6	4.6
Levetiracetam Injection	91	4.6	4.6
Polyethylene Glycol 400	15	4.5	4.6
Calcium	171	4.5	4.5
Paliperidone	27	4.5	4.5
Ciprofloxacin Hydrochloride And Hydrocortisone	24	4.4	4.4
Brexpiprazole	19	4.4	4.4
Lamivudine	35	4.4	4.4
Ursodiol	24	4.2	4.2
Propranolol Hydrochloride	78	4.2	4.2
Methylprednisolone	148	4.2	4.2
Ceftriaxone	35	4.1	4.1
Cyanocobalamin	35	4.1	4.1
Diazepam Oral Solution (Concentrate)	92	4.0	4.0
Diazepam Oral	92	4.0	4.0
Aripiprazole Oral	43	4.0	4.0
Aripiprazole Orally Disintegrating	43	4.0	4.0
Ziprasidone	18	3.9	3.9
Amikacin	17	3.8	3.8
Gentamicin	13	3.8	3.8
Methotrexate	394	3.8	3.8
Valganciclovir Hydrochloride Powder,	12	3.8	3.8
Loperamide Hydrochloride And Dimethicone	31	3.7	3.7
Levetiracetam	126	3.7	3.7
Acetaminophen	406	3.7	3.7
Lamotirigine	68	3.7	3.7
Lamotrigine Extended-Release	68	3.7	3.7
Lamotrigine Chewable Dispersible	68	3.7	3.7
Everolimus Tablets	16	3.7	3.7
Everolimus	48	3.6	3.6
Piperacillin Sodium,Tazobactam Sodium	25	3.6	3.6
Ritonavir 100 Mg	14	3.6	3.6
Pantoprazole Sodium In 0.9% Sodium Chloride	57	3.6	3.6
Pantoprazole Sodium Injection	57	3.6	3.6
Piperacillin Sodium And Tazobactam Sodium	18	3.5	3.5
Methotrexate Sodium	421	3.5	3.5
Ceftriaxone Sodium	35	3.5	3.5
Olanzapine	97	3.5	3.5
Cefepime	13	3.5	3.5
Pantoprazole	219	3.4	3.4
Gentamicin Sulfate	14	3.4	3.4
Nystatin Ointment	23	3.4	3.4
Nystatin Cream	23	3.4	3.4
Heparin Sodium	12	3.4	3.4
Meperidine Hydrochloride	8	3.3	3.3
Daptomycin	8	3.3	3.3
Basiliximab	10	3.3	3.3
Valganciclovir	16	3.3	3.3
Valganciclovir Hydrochloride	16	3.3	3.3
Lacosamide	31	3.2	3.2
Loperamide Hydrochloride	37	3.2	3.2
Diazepam	99	3.2	3.2
Zonisamide	12	3.1	3.1
Cefepime Hydrochloride	13	3.1	3.1
Folic Acid	195	3.1	3.1
Sucralfate Oral	11	3.0	3.0
Sucralfate Oral Suspension	11	3.0	3.0
Quetiapine	145	2.9	2.9
Iron Sucrose	7	2.8	2.8
Lamotrigine	95	2.8	2.8
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	112	2.7	2.7
Loperamide Hydrochloride Oral	7	2.6	2.6
Dextrose	9	2.6	2.6
Clozapine	85	2.6	2.6
Dextrose Monohydrate	9	2.6	2.6
Indapamide	12	2.6	2.6
Nevirapine	6	2.6	2.6
Linagliptin	12	2.5	2.5
Warfarin Sodium	29	2.4	2.4
Dutasteride	5	2.4	2.4
Aripiprazole	74	2.3	2.3
Tenofovir Disoproxil Fumarate	20	2.3	2.3
Cenobamate	5	2.3	2.3
Sulfasalazine	46	2.3	2.3
Lumacaftor And Ivacaftor	5	2.2	2.2
Brinzolamide	5	2.2	2.2
Vigabatrin	8	2.1	2.1
Thiotepa	5	2.0	2.0
Dexlansoprazole	19	1.8	1.8
Etonogestrel And Ethinyl Estradiol	10	1.7	1.7
Pegaspargase	5	1.6	1.6
Buprenorphine Hydrochloride, Naloxone Hydrochloride	9	1.4	1.4
Cannabidiol	8	1.3	1.3
Bendamustine Hydrochloride	4	1.3	1.3
Paliperidone Palmitate	10	1.2	1.2
Pseudoephedrine Hcl	3	1.0	1.0

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.