Reaction

Hepatic Enzyme Abnormal reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 4,916 reports · 191 co-occurring drugs

As of the last recalculation, Hepatic Enzyme Abnormal appears in 4,916 FAERS reports alongside 191 co-occurring drug terms. The strongest observed disproportionality signal is DESOXIMETASONE (PRR 18.7).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Desoximetasone	83	18.7	18.8
Icosapent Ethyl	34	17.0	17.1
Sulfasalazine	231	13.1	13.1
Calcium Gluconate	33	11.7	11.7
Hydroxychloroquine Sulfate	238	11.6	11.6
Leflunomide	255	10.8	10.9
Ursosiol	35	7.7	7.7
Olmesartan Medoxomil	64	7.6	7.6
Cefazolin Sodium	21	7.4	7.4
Rucaparib	15	7.2	7.2
Rosuvastatin Calcium	47	7.1	7.1
Hydroxychloroquine	122	7.1	7.1
Ursodiol	36	7.0	7.1
Moxifloxacin Hydrochloride	32	6.7	6.7
Ribociclib	48	6.5	6.5
Tocilizumab	166	6.3	6.3
Rabeprazole	32	6.1	6.2
Tofacitinib	243	5.8	5.8
Methotrexate Sodium	584	5.6	5.6
Avapritinib	16	5.6	5.6
Fingolimod Hcl	110	5.5	5.5
Naproxen	100	5.5	5.5
Adalimumab-Fkjp	59	5.4	5.5
Lumacaftor And Ivacaftor	11	5.4	5.5
Adalimumab-Adaz	65	5.3	5.3
Atovaquone	10	5.3	5.3
Cabozantinib	59	5.3	5.3
Adalimumab-Aaty	58	5.2	5.2
Dimenhydrinate	13	5.2	5.2
Ozanimod Hydrochloride	10	5.1	5.1
Prochlorperazine Maleate	11	5.1	5.1
Basiliximab	14	5.1	5.1
Teriflunomide	53	5.0	5.0
Methotrexate	457	5.0	5.0
Risedronate Sodium	36	4.9	4.9
Zinc Gluconate	30	4.9	4.9
Interferon Beta-1B	22	4.9	4.9
Elexacaftor, Tezacaftor, And Ivacaftor	14	4.8	4.8
Siponimod	10	4.8	4.8
Goserelin	15	4.7	4.7
Nifedipine	52	4.7	4.7
Alemtuzumab	21	4.6	4.6
Rifampicin	11	4.6	4.6
Cholestyramine	13	4.6	4.6
Tofacitinib Citrate	14	4.5	4.5
Micafungin Sodium	9	4.5	4.5
Fulvestrant	34	4.4	4.4
Posaconazole Delayed-Release	11	4.2	4.3
Bosutinib	9	4.2	4.3
Nintedanib	30	4.1	4.1
Magnesium	78	4.1	4.1
Ado-Trastuzumab Emtansine	8	4.0	4.0
Niraparib	21	4.0	4.0
Phytonadione	8	4.0	4.0
Golimumab	79	3.9	4.0
Abatacept	126	3.9	3.9
Pazopanib Hydrochloride	25	3.9	3.9
Axitinib	18	3.9	3.9
Psyllium Husk	9	3.9	3.9
Lapatinib	14	3.8	3.8
Vitamin C	81	3.8	3.8
Teduglutide	12	3.8	3.8
Cyclobenzaprine Hydrochloride	8	3.8	3.8
Nilotinib	26	3.7	3.7
Rabeprazole Sodium	24	3.7	3.7
Azacitidine For	16	3.7	3.7
Crizotinib	11	3.7	3.7
Isoniazid	14	3.7	3.7
Dabrafenib	18	3.6	3.6
Azathioprine	74	3.6	3.6
Docusate Sodium 100Mg	20	3.6	3.6
Voriconazole Injection	18	3.5	3.5
Fluconazole	57	3.5	3.5
Naproxen Sodium	115	3.5	3.5
Ergocalciferol	299	3.4	3.4
Mercaptopurine	14	3.4	3.4
Imatinib	14	3.4	3.4
Cetirizine Hydrochloride Allergy	24	3.4	3.4
Cetirizine Hydrochloride Tablets	24	3.4	3.4
Voriconazole	24	3.4	3.4
Mycophenolic Acid	25	3.3	3.3
Cyclosporine	86	3.3	3.3
Tramadol Hydrochloride	29	3.3	3.3
Lithium Carbonate	13	3.2	3.2
Peginterferon Beta-1A	10	3.2	3.2
Oxybutynin	22	3.2	3.2
Trametinib	18	3.2	3.2
Posaconazole	12	3.1	3.1
Imatinib Mesylate	20	3.0	3.0
Azacitidine	21	3.0	3.0
Oxazepam	15	3.0	3.0
Valganciclovir	13	2.9	2.9
Valganciclovir Hydrochloride	13	2.9	2.9
Pitavastatin Calcium	7	2.9	2.9
Rosuvastatin	136	2.9	2.9
Atorvastatin Calcium, Film Coated	47	2.9	2.9
Phenytoin	14	2.8	2.8
Sirolimus	9	2.8	2.8
Etanercept	374	2.8	2.8
Valganciclovir Hydrochloride Powder,	8	2.8	2.8
Letrozole	40	2.8	2.8
Atorvastatin Calcium	158	2.8	2.8
Isotretinoin	32	2.8	2.8
Secukinumab	103	2.7	2.7
Sarilumab	17	2.7	2.7
Infliximab	138	2.7	2.7
Efavirenz	7	2.7	2.7
Baricitinib	6	2.6	2.6
Palbociclib	58	2.6	2.6
Letrozole Tablets	29	2.6	2.6
Anakinra	10	2.6	2.6
Regorafenib	7	2.6	2.6
Abemaciclib	12	2.5	2.5
Interferon Beta-1A	114	2.5	2.5
Sunitinib Malate	23	2.5	2.5
Prochlorperazine	16	2.4	2.4
Adalimumab	390	2.4	2.4
Lisdexamfetamine Dimesylate	19	2.4	2.4
Alpelisib	5	2.4	2.4
Valproic Acid	18	2.4	2.4
Diclofenac Potassium	6	2.4	2.4
Lamivudine Oral	14	2.3	2.3
Tolvaptan	8	2.3	2.3
Rifampin	8	2.3	2.3
Atomoxetine Hydrochloride	13	2.3	2.3
Selexipag	14	2.3	2.3
Certolizumab Pegol	63	2.3	2.3
Voxelotor	12	2.3	2.3
Everolimus	27	2.3	2.3
Eltrombopag Olamine	12	2.2	2.2
Abiraterone	7	2.2	2.2
Entecavir	6	2.2	2.2
Liraglutide	25	2.1	2.1
Upadacitinib	41	2.1	2.1
Ivacaftor	4	2.1	2.1
Vemurafenib	6	2.1	2.1
Lenvatinib	16	2.1	2.1
Cenobamate	4	2.0	2.0
Venetoclax	29	2.0	2.0
Insulin Degludec	11	2.0	2.0
Tenofovir Disoproxil Fumarate Tablets	4	2.0	2.0
Abiraterone Acetate	19	2.0	2.0
Naltrexone	14	1.9	1.9
Vedolizumab	39	1.9	1.9
Deferasirox	12	1.9	1.9
Pembrolizumab	47	1.9	1.9
Guselkumab	16	1.9	1.9
Ruxolitinib	32	1.9	1.9
Gefitinib	4	1.9	1.9
Rifaximin	9	1.8	1.8
Cortisone Acetate	5	1.7	1.7
Encorafenib	4	1.7	1.7
Dronedarone	4	1.7	1.7
Pseudoephedrine Hydrochloride	4	1.6	1.6
Cannabidiol	9	1.6	1.6
Blinatumomab	4	1.6	1.6
Relugolix	9	1.6	1.6
Bosentan	19	1.6	1.6
Inclisiran	3	1.6	1.6
Canakinumab	4	1.6	1.6
Pseudoephedrine Hcl	4	1.5	1.5
Sevoflurane	3	1.5	1.5
Dornase Alfa	7	1.5	1.5
Diclofenac Potassium, Film Coated	3	1.5	1.5
Diclofenac Potassium Tablets	3	1.5	1.5
Sodium Oxybate	23	1.5	1.5
Ixazomib	10	1.5	1.5
Selinexor	3	1.5	1.5
Ustekinumab	35	1.5	1.5
Vismodegib	3	1.4	1.4
Diroximel Fumarate	4	1.4	1.4
Dalfampridine	24	1.4	1.4
Canagliflozin	10	1.4	1.4
Ethyl Alcohol	9	1.4	1.4
Ledipasvir And Sofosbuvir	6	1.3	1.3
Dasatinib	11	1.3	1.3
Durvalumab	6	1.2	1.2
Glatiramer Acetate	17	1.2	1.2
Osimertinib	9	1.2	1.2
Trifluridine And Tipiracil	3	1.2	1.2
Alirocumab	7	1.2	1.2
Natalizumab	44	1.0	1.0
Olaparib	5	1.0	1.0
Lenalidomide	92	0.9	0.9
Orlistat	5	0.8	0.8
Evolocumab	28	0.7	0.7
Pirfenidone	7	0.7	0.7
Dulaglutide	15	0.7	0.7
Minoxidil Foam 5% (Womens)	5	0.6	0.6
Apremilast	22	0.6	0.6
Erenumab-Aooe	8	0.6	0.6

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.