Reaction

Sinus Headache reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,902 reports · 253 co-occurring drugs

As of the last recalculation, Sinus Headache appears in 5,902 FAERS reports alongside 253 co-occurring drug terms. The strongest observed disproportionality signal is DIPHENHYDRAMINE HYDROCHLORIDE CAPSULE, LIQUID FILLED (PRR 9.2).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Diphenhydramine Hydrochloride Capsule, Liquid Filled	55	9.2	9.2
Cyclobenzaprine Hydrochloride	23	9.1	9.1
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	115	8.2	8.3
Elexacaftor, Tezacaftor, And Ivacaftor	29	8.2	8.3
Fluticasone Propionate	241	6.8	6.8
Fluticasone Propionate Nasal	51	6.0	6.0
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	33	5.7	5.7
Naproxen Sodium, Pseudoephedrine Hydrochloride	33	5.7	5.7
Desoximetasone	30	5.6	5.6
Azelastine	28	5.5	5.5
Captopril	15	5.5	5.5
Cortisone Acetate	19	5.4	5.4
Hyoscyamine Sulfate	14	5.4	5.4
Mometasone Furoate	63	5.4	5.4
Human Immunoglobulin G	31	5.3	5.3
Felodipine Extended-Release Tablets	17	5.3	5.3
Felodipine	17	5.3	5.3
Guaifenesin	45	5.2	5.2
Etanercept	778	5.1	5.1
Eptinezumab-Jjmr	13	5.0	5.1
Thyroid, Porcine	15	5.0	5.0
Cenegermin-Bkbj	17	5.0	5.0
Promethazine Hydrochloride	26	5.0	5.0
Fexofenadine Hydrochloride	30	4.9	4.9
Carboxymethylcellulose Sodium	13	4.9	4.9
Armodafinil	29	4.9	4.9
Rizatriptan Benzoate	14	4.9	4.9
Ciclesonide	18	4.7	4.7
Loratadine Tablet	70	4.6	4.6
Meperidine Hydrochloride	12	4.6	4.6
Acetaminophen, Aspirin, And Caffeine	27	4.5	4.5
Liothyronine Sodium	11	4.5	4.5
Montelukast Sodium	148	4.4	4.4
Treprostinil	152	4.4	4.4
Macitentan	84	4.3	4.3
Butalbital, Acetaminophen, And Caffeine	13	4.3	4.3
Omalizumab	100	4.2	4.2
Levocetirizine Dihydrochloride	28	4.1	4.1
Meclizine	19	4.1	4.1
Cannabidiol	27	4.1	4.1
Loratadine	121	4.0	4.0
Adrenalinum	47	4.0	4.0
Cetirizine Hydrochloride Allergy	34	4.0	4.0
Cetirizine Hydrochloride Tablets	34	4.0	4.0
Vitamin E	34	3.8	3.8
Fexofenadine Hcl	10	3.8	3.8
Epoprostenol	14	3.8	3.8
Acetaminophen, Aspirin (Nsaid) And Caffeine	18	3.7	3.7
Cetirizine Hydrochloride	171	3.7	3.7
Tadalafil	104	3.7	3.7
Sodium Oxybate	68	3.7	3.7
Sumatriptan	39	3.6	3.6
Desloratadine	11	3.6	3.6
Ivacaftor	8	3.6	3.6
Loratadine And Pseudoephedrine Sulfate	8	3.6	3.6
Fish Oil	90	3.5	3.6
Multivitamin	50	3.5	3.5
Doxyclycline Hyclate	17	3.5	3.5
Buspirone Hydrochloride	11	3.5	3.5
Tizanidine Hydrochloride	18	3.5	3.5
Diphenhydramine Hcl	11	3.5	3.5
Dicyclomine Hydrochloride	14	3.5	3.5
Amiodarone Hydrochloride	11	3.5	3.5
0Xygen	48	3.5	3.5
Oxygen	48	3.5	3.5
Zinc	24	3.4	3.4
Meclizine Hydrochloride	19	3.4	3.4
Diphenhydramine Hydrochloride	158	3.4	3.4
Selexipag	25	3.4	3.4
Zinc Chloride	24	3.4	3.4
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	152	3.4	3.4
Meclizine Hcl 12.5Mg	13	3.4	3.4
Meclizine Hcl 25Mg	13	3.4	3.4
Meclizine Hcl 12.5 Mg	13	3.4	3.4
Meclizine Hcl 25 Mg	13	3.4	3.4
Apremilast	137	3.4	3.4
Niacin	11	3.3	3.3
Nebivolol	15	3.3	3.3
Methocarbamol	21	3.3	3.3
Epinephrine	60	3.3	3.3
Docusate Sodium 100Mg	22	3.3	3.3
Zinc Gluconate	24	3.2	3.2
Azithromycin Dihydrate	53	3.2	3.2
Erythromycin	17	3.2	3.2
Niraparib	20	3.2	3.2
Biotin	28	3.2	3.2
Mometasone Furoate And Formoterol Fumarate Dihydrate	14	3.2	3.2
Methocarbamol Tablets	15	3.2	3.2
Magnesium	73	3.2	3.2
Quinapril Hydrochloride	7	3.1	3.1
Abaloparatide	26	3.1	3.1
Loratadine Oral	43	3.1	3.1
Triamcinolone Acetonide	27	3.1	3.1
Peginterferon Alfa-2A	47	3.1	3.1
Fosaprepitant Dimeglumine	12	3.1	3.1
Amlodipine Besylate And Benazepril Hydrochloride	8	3.1	3.1
Cyclobenzaprine	43	3.1	3.1
Lifitegrast	14	3.0	3.0
Docusate Sodium	49	3.0	3.0
Adalimumab	563	3.0	3.0
Acetylcysteine	8	3.0	3.0
Lubiprostone	8	3.0	3.0
Fluticasone Propionate And Salmeterol	35	3.0	3.0
Naproxen Sodium Tablet	44	2.9	2.9
Diphenhydramine	52	2.9	2.9
Fluticasone Furoate	10	2.9	2.9
Vitamin C	75	2.9	2.9
Hydroxychloroquine Sulfate	74	2.9	2.9
Aprepitant	15	2.9	2.9
Calcium	119	2.9	2.9
Amoxicillin And Clavulanate Potassium	22	2.9	2.9
Rabeprazole Sodium	22	2.9	2.9
Naproxen Sodium	114	2.8	2.9
Naproxen	63	2.8	2.8
Cetiirizine	34	2.8	2.8
Cetirizine	62	2.8	2.8
Fluticasone Propionate And Salmeterol Xinafoate	48	2.8	2.8
Riociguat	26	2.8	2.8
Nintedanib	25	2.8	2.8
Oxybutynin Chloride	7	2.8	2.8
Sulfasalazine	62	2.8	2.8
Montelukast	66	2.8	2.8
Benzonatate	13	2.8	2.8
Ergocalciferol	293	2.8	2.8
Lisinopril And Hydrochlorothiazide	8	2.8	2.8
Meloxicam	45	2.7	2.7
Etonogestrel And Ethinyl Estradiol	17	2.7	2.7
Dofetilide	8	2.7	2.7
Alirocumab	19	2.7	2.7
Budesonide And Formoterol Fumarate Dihydrate	73	2.7	2.7
Zolpidem Tartrate	101	2.7	2.7
Ibuprofen Tablets, Coated	32	2.7	2.7
Sumatriptan Succinate	19	2.7	2.7
Ibuprofen Sodium	32	2.6	2.6
Ibuprofen	199	2.6	2.6
Ibuprofen Capsule	146	2.6	2.6
Ibuprofen Tablet, Film Coated	146	2.6	2.6
Ibupfrofen	146	2.6	2.6
Ibuprofen Tablets Usp, 200Mg	146	2.6	2.6
Ibuprofen Oral	146	2.6	2.6
Levothyroxine Sodium	228	2.6	2.6
Ibuprofen Capsules 200 Mg	146	2.6	2.6
Ibuprofen 200 Mg	146	2.6	2.6
Ibuprofen 200Mg	146	2.6	2.6
Lidocaine	43	2.6	2.6
Sertraline Hydrochloride	86	2.6	2.6
Ibuprofen And Diphenhydramine Citrate	17	2.6	2.6
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	22	2.6	2.6
Gemfibrozil	11	2.6	2.6
Metoprolol Succinate Er Tablets	45	2.6	2.6
Doxycycline	49	2.5	2.5
Tiotropium Bromide Inhalation Spray	8	2.5	2.5
Nebivolol Hydrochloride	24	2.5	2.5
Rimegepant Sulfate	9	2.5	2.5
Sildenafil	41	2.5	2.5
Exenatide	37	2.5	2.5
Ambrisentan	87	2.5	2.5
Leflunomide	73	2.5	2.5
Lovastatin	18	2.5	2.5
Sodium Chloride	55	2.5	2.5
Doxycycline Hyclate	47	2.5	2.5
Mesalamine	39	2.5	2.5
Sodium Chloride Tablet	51	2.5	2.5
Sodium Chloride Tablets	51	2.5	2.5
Eculizumab	37	2.4	2.4
Clobetasol Propionate Ointment Usp, 0.05%	7	2.4	2.4
Clobetasol Propionate	7	2.4	2.4
Ribavirin	43	2.4	2.4
Metformin Hcl	37	2.4	2.4
Umeclidinium	6	2.4	2.4
Fexofenadine	11	2.4	2.4
Naproxen Sodium Tablet, Coated	9	2.3	2.3
Naproxen Sodium, Coated Tablets	9	2.3	2.3
Naproxen Sodium 220Mg	9	2.3	2.3
Dornase Alfa	13	2.3	2.3
Metoprolol Succinate	57	2.3	2.3
Cetirizine Hcl	6	2.3	2.3
Bupropion Hydrochloride	64	2.3	2.3
Modafinil	21	2.3	2.3
Sildenafil Citrate	81	2.3	2.3
Propranolol Hydrochloride	46	2.3	2.3
Lisinopril And Hydrochlorothiazide Tablets	5	2.2	2.2
Sildenafil Powder,	22	2.2	2.2
Fluticasone Furoate And Vilanterol Trifenatate	22	2.2	2.2
Timolol Maleate	6	2.1	2.1
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	25	2.1	2.1
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	21	2.1	2.1
Estradiol	51	2.1	2.1
Dronedarone	6	2.1	2.1
Naltrexone Hydrochloride And Bupropion Hydrochloride	5	2.1	2.1
Nirmatrelvir And Ritonavir	31	2.0	2.0
Galcanezumab-Gnlm	18	2.0	2.0
Fingolimod Hcl	49	2.0	2.0
Tiotropium Bromide	77	2.0	2.0
Natalizumab	101	2.0	2.0
Teriparatide	62	1.9	1.9
Conjugated Estrogens	32	1.9	1.9
Glecaprevir And Pibrentasvir	6	1.9	1.9
Estrogens, Conjugated	32	1.9	1.9
Tofacitinib	98	1.9	1.9
Desvenlafaxine Succinate	14	1.8	1.8
Onabotulinumtoxina	39	1.8	1.8
Tobramycin	12	1.8	1.8
Timolol	6	1.8	1.8
Acetaminophen And Codeine	6	1.7	1.7
Pseudoephedrine Hydrochloride	5	1.7	1.7
Budesonide, Glycopyrrolate, And Formoterol Fumarate	5	1.7	1.7
Icosapent Ethyl	4	1.7	1.7
Romiplostim	7	1.6	1.6
Travoprost	4	1.6	1.6
Pseudoephedrine Hcl	5	1.6	1.6
Dupilumab	201	1.5	1.5
Ofatumumab	14	1.5	1.5
Atomoxetine Hydrochloride	10	1.5	1.5
Umeclidinium Bromide And Vilanterol Trifenatate	7	1.5	1.5
Avapritinib	5	1.5	1.5
Botulinum Toxin Type A	5	1.4	1.4
Prasugrel Hydrochloride	4	1.4	1.4
Certolizumab Pegol	45	1.4	1.4
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate	15	1.3	1.3
Ozanimod Hydrochloride	3	1.3	1.3
Ocrelizumab	22	1.3	1.3
Teriflunomide	16	1.2	1.2
Lumacaftor And Ivacaftor	3	1.2	1.2
Dasatinib	13	1.2	1.2
Ruxolitinib	25	1.2	1.2
Fremanezumab-Vfrm	4	1.2	1.2
Secukinumab	56	1.2	1.2
Dimethyl Fumarate	42	1.2	1.2
Ranibizumab	9	1.2	1.2
Esketamine Hydrochloride	6	1.2	1.2
Dalfampridine	24	1.2	1.2
Acalabrutinib	4	1.2	1.2
Varenicline Tartrate	26	1.1	1.1
Naltrexone	10	1.1	1.1
Ixekizumab	12	1.1	1.1
Ledipasvir And Sofosbuvir	6	1.1	1.1
Evolocumab	50	1.1	1.1
Sarilumab	8	1.1	1.1
Relugolix	7	1.0	1.0
Pazopanib Hydrochloride	8	1.0	1.0
Erenumab-Aooe	16	1.0	1.0
Hydrocodone Bitartrate	12	1.0	1.0
Drospirenone And Ethinyl Estradiol	12	1.0	1.0
Cabozantinib	13	1.0	1.0
Nemolizumab-Ilto	3	0.8	0.8
Bimekizumab	5	0.8	0.8
Velpatasvir And Sofosbuvir	3	0.8	0.8
Droxidopa	5	0.8	0.8
Pegfilgrastim	22	0.8	0.8
Pirfenidone	7	0.6	0.6
Voxelotor	3	0.5	0.5
Levonorgestrel	22	0.4	0.4

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.