Reaction

Decreased Interest reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,828 reports · 290 co-occurring drugs

As of the last recalculation, Decreased Interest appears in 5,828 FAERS reports alongside 290 co-occurring drug terms. The strongest observed disproportionality signal is TERIFLUNOMIDE (PRR 23.4).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Teriflunomide	282	23.4	23.5
Fingolimod Hcl	361	15.8	15.9
Dalfampridine	270	14.0	14.1
Interferon Beta-1B	71	13.4	13.4
Chlorhexidine Gluconate	33	13.0	13.0
Sertraline Hydrochloride	355	11.3	11.4
Clobetasol Propionate Ointment Usp, 0.05%	29	10.1	10.1
Clobetasol Propionate	29	10.1	10.1
Desvenlafaxine Succinate	72	9.6	9.7
Rotigotine	35	8.7	8.7
Venlafaxine Hydrochloride	290	8.2	8.2
Oxybutynin Chloride	17	6.9	7.0
Finasteride	115	6.9	6.9
Baclofen	162	6.9	6.9
Tolterodine Tartrate	17	6.8	6.8
Vortioxetine	32	6.7	6.8
Tizanidine Hydrochloride	33	6.6	6.6
Biotin	56	6.5	6.5
Bupropion Hydrochloride	172	6.4	6.4
Amantadine	27	6.3	6.3
Brexpiprazole	28	6.0	6.1
Ozanimod Hydrochloride	14	6.0	6.0
Temazepam	63	6.0	6.0
Lurasidone Hydrochloride	35	6.0	6.0
Trazodone Hydrochloride	26	6.0	6.0
Fluoxetine Hydrochloride	205	5.9	5.9
Varenicline Tartrate	129	5.9	5.9
Telmisartan	29	5.8	5.8
Modafinil	52	5.8	5.8
Meclizine	26	5.7	5.7
Lithium Carbonate	27	5.7	5.7
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	48	5.7	5.7
Meclizine Hydrochloride	31	5.7	5.7
Vitamin E	49	5.6	5.6
Dimethyl Fumarate	186	5.5	5.6
Meclizine Hcl 12.5Mg	21	5.5	5.5
Meclizine Hcl 25Mg	21	5.5	5.5
Meclizine Hcl 12.5 Mg	21	5.5	5.5
Meclizine Hcl 25 Mg	21	5.5	5.5
Lithium	38	5.4	5.4
Lithium Bromatum	38	5.4	5.4
Magnesium Hydroxide	20	5.3	5.3
Paroxetine Hydrochloride	130	5.2	5.2
Paroxetine	48	5.1	5.1
Clindamycin	40	5.1	5.1
Butalbital, Acetaminophen, And Caffeine	15	5.0	5.0
Paroxetine Hydrochloride Hemihydrate	46	5.0	5.0
Clindamycin Phosphate	45	4.8	4.8
Cimetidine	13	4.8	4.8
Doxepin Hydrochloride	17	4.8	4.8
Tizanidine	32	4.8	4.8
Lamotirigine	94	4.7	4.8
Lamotrigine Extended-Release	94	4.7	4.8
Lamotrigine Chewable Dispersible	94	4.7	4.8
Bupropion	58	4.7	4.7
Cephalexin	28	4.6	4.6
Ibuprofen And Diphenhydramine Citrate	30	4.6	4.6
Escitalopram	177	4.6	4.6
Doxepin	13	4.6	4.6
Buspirone Hydrochloride	14	4.5	4.5
Clonazepam	198	4.5	4.5
Aripiprazole Oral	52	4.5	4.5
Aripiprazole Orally Disintegrating	52	4.5	4.5
Ergocalciferol	455	4.5	4.5
Magnesium	102	4.5	4.5
Isotretinoin	61	4.4	4.4
Quetiapine Fumarate	36	4.4	4.4
Zolpidem Tartrate	160	4.3	4.3
Venlafaxine	85	4.3	4.3
Standardized Senna Concentrate	15	4.3	4.3
Vilazodone Hydrochloride	11	4.3	4.3
Methylphenidate Hydrochloride	70	4.3	4.3
Promethazine Hydrochloride	22	4.2	4.2
Docusate Sodium - Sennosides	38	4.2	4.2
Cariprazine	11	4.2	4.2
Meloxicam	68	4.2	4.2
Citalopram	158	4.2	4.2
Diazepam	139	4.2	4.2
Montelukast	95	4.1	4.1
Captopril	11	4.1	4.1
Naltrexone	35	4.1	4.1
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	40	4.1	4.1
Duloxetine Hydrochloride	207	4.0	4.0
Exemestane	24	4.0	4.0
Psyllium Husk	11	4.0	4.0
Mirtazapine	100	3.9	4.0
Cefazolin	10	3.9	3.9
Fulvestrant	36	3.9	3.9
Diazepam Oral Solution (Concentrate)	96	3.9	3.9
Diazepam Oral	96	3.9	3.9
Fluoxetine	72	3.9	3.9
Docusate Sodium	62	3.9	3.9
Tamsulosin Hydrochloride	22	3.9	3.9
Paliperidone Palmitate	34	3.8	3.8
Atomoxetine Hydrochloride	25	3.8	3.8
Donepezil Hydrochloride	38	3.7	3.7
Carbidopa And Levodopa	49	3.7	3.7
Aripiprazole	125	3.7	3.7
Olanzapine Pamoate	42	3.7	3.7
Gabapentin	358	3.7	3.7
Lamotrigine	133	3.7	3.7
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	42	3.6	3.6
Ciprofloxacin Hydrochloride And Hydrocortisone	21	3.6	3.6
Testosterone Cypionate	9	3.6	3.6
Montelukast Sodium	121	3.6	3.6
Lisdexamfetamine Dimesylate	33	3.6	3.6
Rasagiline Mesylate	11	3.5	3.5
Quetiapine	186	3.5	3.5
Sertraline	114	3.5	3.5
Fish Oil	88	3.5	3.5
Escitalopram Oxalate	71	3.5	3.5
Hyoscyamine Sulfate	9	3.5	3.5
Meperidine Hydrochloride	9	3.5	3.5
Nitrofurantoin	16	3.5	3.5
Cenobamate	8	3.4	3.4
Nitrofurantoin (Monohydrate/Macrocrystals)	16	3.4	3.4
Methocarbamol Tablets	16	3.4	3.4
Sennosides 8.6 Mg Tablets	20	3.4	3.4
Citalopram Hydrobromide	101	3.4	3.4
Senna	20	3.4	3.4
Niacin	11	3.4	3.4
Vitamin C	86	3.4	3.4
Zinc	23	3.3	3.3
Escitslopram	54	3.3	3.3
Carbamazepine	62	3.3	3.3
Zinc Chloride	23	3.3	3.3
Methocarbamol	21	3.3	3.3
Diroximel Fumarate	11	3.3	3.3
Ibuprofen Tablets, Coated	39	3.3	3.3
Ibuprofen Sodium	39	3.3	3.3
Buprenorphine Hydrochloride, Naloxone Hydrochloride	22	3.3	3.3
Benzonatate	15	3.2	3.2
Melatonin	49	3.2	3.2
Letrozole	55	3.2	3.2
Alprazolam	181	3.2	3.2
Goserelin	12	3.2	3.2
Carisoprodol	17	3.2	3.2
Guanfacine	7	3.2	3.2
Amoxicillin And Clavulanate Potassium	24	3.2	3.2
Multivitamin	44	3.2	3.2
Zinc Gluconate	23	3.2	3.2
Docusate Sodium 100Mg	21	3.1	3.1
Hydrocodone Bitartrate And Acetaminophen	49	3.1	3.1
Mometasone	16	3.1	3.1
Senna Leaf	20	3.1	3.1
Doxazosin	24	3.1	3.1
Ezetimibe And Simvastatin	13	3.1	3.1
Armodafinil	18	3.1	3.1
Bicalutamide	13	3.1	3.1
Duloxetine	59	3.0	3.0
Trimethoprim	10	3.0	3.0
Lubiprostone	8	3.0	3.0
Divalproex Sodium	39	3.0	3.0
Peginterferon Beta-1A	11	3.0	3.0
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	132	3.0	3.0
Topiramate	77	3.0	3.0
Cefazolin Sodium	10	3.0	3.0
Anastrozole	30	2.9	2.9
Lorazepam	144	2.9	2.9
Glatiramer Acetate	48	2.9	2.9
Amitriptyline Hydrochloride	14	2.9	2.9
Lovastatin	20	2.8	2.8
Dicyclomine Hydrochloride	11	2.8	2.8
Enalapril Maleate	19	2.7	2.7
Budesonide, Glycopyrrolate, And Formoterol Fumarate	8	2.7	2.7
Thalidomide	28	2.7	2.7
Amoxicillin	58	2.7	2.7
Estradiol Gel 0.1%	34	2.7	2.7
Estradiol Transdermal	34	2.7	2.7
Oxycodone Hydrochloride And Acetaminophen	73	2.7	2.7
Oxcarbazepine	24	2.6	2.6
Oxycodone Hydrochloride	158	2.6	2.6
Sennosides	22	2.6	2.6
Ribavirin	47	2.6	2.6
Metoprolol Succinate	63	2.6	2.6
Erythropoietin	15	2.6	2.6
Methylphenidate	21	2.6	2.6
Gemfibrozil	11	2.6	2.6
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	36	2.6	2.6
Doxazosin Mesylate	26	2.6	2.6
Oxybutynin	21	2.6	2.6
Ropinirole	11	2.6	2.6
Acetaminophen, Aspirin, And Caffeine	15	2.5	2.5
Metolazone	8	2.5	2.5
Acetaminophen, Aspirin (Nsaid) And Caffeine	12	2.5	2.5
Naltrexone Hydrochloride And Bupropion Hydrochloride	6	2.5	2.5
Diltiazem Hydrochloride Extended-Release Tablets	8	2.5	2.5
Enzalutamide	41	2.5	2.5
Fluticasone Propionate	90	2.5	2.5
Interferon Beta-1A	133	2.5	2.5
Guaifenesin	21	2.5	2.5
Primidone	7	2.5	2.5
Testosterone	16	2.4	2.4
Risperidone	90	2.4	2.4
Ziprasidone	12	2.4	2.4
Zonisamide	10	2.4	2.4
Pregabalin	180	2.4	2.4
Cetirizine Hcl	6	2.3	2.3
Elexacaftor, Tezacaftor, And Ivacaftor	8	2.3	2.3
Melphalan Hydrochloride	16	2.3	2.3
Lanreotide Acetate	5	2.3	2.3
Olanzapine	68	2.3	2.3
Losartan Potassium	50	2.3	2.3
Lisinopril And Hydrochlorothiazide Tablets	5	2.3	2.3
Ziprasidone Mesylate	9	2.3	2.3
Sumatriptan	24	2.3	2.3
Metformin Hydrochloride Tablets	36	2.2	2.3
Metformin Hydrochloride Extended-Release Tablets	36	2.2	2.3
Metformin Hydrochloride Tablet	36	2.2	2.3
Metformin Hydrochloride	37	2.2	2.2
Glipizide	38	2.2	2.2
Vibegron	5	2.2	2.2
Melphalan	14	2.2	2.2
Dornase Alfa	12	2.2	2.2
Nintedanib	19	2.2	2.2
Estradiol	52	2.2	2.2
Chlorthalidone	7	2.2	2.2
Fluticasone Propionate And Salmeterol	25	2.1	2.1
Linaclotide	16	2.1	2.1
Eszopiclone	15	2.1	2.1
Valsartan And Hydrochlorothiazide	8	2.1	2.1
Polyethylene Glycol 3350	56	2.1	2.1
Lisinopril And Hydrochlorothiazide	6	2.1	2.1
Lisinopril	176	2.1	2.1
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	12	2.1	2.1
Naproxen Sodium, Pseudoephedrine Hydrochloride	12	2.1	2.1
Prednisolone Acetate	6	2.1	2.1
Hydromorphone Hydrochloride	53	2.1	2.1
Oxycodone	107	2.1	2.1
Azelastine	10	2.0	2.0
Loratadine Tablet	29	1.9	1.9
Darbepoetin Alfa	29	1.9	1.9
Morphine Sulfate	65	1.9	1.9
Methadone	23	1.9	1.9
Medroxyprogesterone Acetate	26	1.9	1.9
Sevelamer Carbonate	6	1.9	1.9
Ethyl Alcohol	14	1.8	1.8
Naproxen Sodium Tablet	27	1.8	1.8
Pimavanserin Tartrate	28	1.8	1.8
Hydrocodone Bitartrate	22	1.8	1.8
Amphetamine	4	1.7	1.7
Rivastigmine	9	1.7	1.7
Oxycodone And Acetaminophen	11	1.7	1.7
Cannabidiol	11	1.7	1.7
Lumacaftor And Ivacaftor	4	1.7	1.7
Methadone Hydrochloride	5	1.7	1.7
Capecitabine	42	1.6	1.6
Clobazam	11	1.6	1.6
Peginterferon Alfa-2A	24	1.6	1.6
Isopropyl Alcohol	15	1.6	1.6
Memantine	6	1.6	1.6
Memantine Hydrochloride	6	1.6	1.6
Alcohol	17	1.6	1.6
Tafamidis	5	1.5	1.5
Avapritinib	5	1.5	1.5
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate	17	1.5	1.5
Brimonidine Tartrate	7	1.4	1.4
Lapatinib	6	1.4	1.4
Paliperidone	9	1.4	1.4
Blinatumomab	4	1.4	1.4
Sarilumab	10	1.4	1.4
Pseudoephedrine Hcl	4	1.3	1.3
Valbenazine	9	1.3	1.3
Oral Semaglutide	26	1.3	1.3
Natalizumab	63	1.2	1.2
Travoprost	3	1.2	1.2
Apalutamide	4	1.2	1.2
Relugolix	8	1.2	1.2
Siponimod	3	1.2	1.2
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	6	1.2	1.2
Pirfenidone	13	1.1	1.1
Sofosbuvir	6	1.1	1.1
Drospirenone And Ethinyl Estradiol	13	1.1	1.1
Ranolazine	3	1.0	1.0
Alirocumab	7	1.0	1.0
Emtricitabine And Tenofovir Alafenamide	3	0.9	0.9
Ledipasvir And Sofosbuvir	5	0.9	0.9
Leuprolide Acetate	20	0.9	0.9
Apremilast	37	0.9	0.9
Benralizumab	5	0.9	0.9
Buprenorphine	23	0.9	0.9
Dupilumab	119	0.9	0.9
Rimegepant Sulfate	3	0.8	0.8
Cabozantinib	11	0.8	0.8
Levonorgestrel	46	0.8	0.8
Esketamine Hydrochloride	4	0.8	0.8
Tirzepatide	29	0.6	0.6
Etonogestrel	7	0.5	0.5
Erenumab-Aooe	8	0.5	0.5
Copper	4	0.3	0.3

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.