Reaction

Varicose Vein reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,124 reports · 227 co-occurring drugs

As of the last recalculation, Varicose Vein appears in 5,124 FAERS reports alongside 227 co-occurring drug terms. The strongest observed disproportionality signal is ADO-TRASTUZUMAB EMTANSINE (PRR 20.9).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Ado-Trastuzumab Emtansine	43	20.9	21.0
Etonogestrel And Ethinyl Estradiol	101	18.9	18.9
Carboxymethylcellulose Sodium	43	18.7	18.8
Dronabinol	32	16.3	16.3
Bleomycin Sulfate	36	14.2	14.3
Alendronate Sodium	290	12.3	12.3
Fam-Trastuzumab Deruxtecan-Nxki	29	11.7	11.8
Lapatinib	43	11.3	11.4
Raloxifene Hydrochloride	35	9.8	9.8
Fosaprepitant Dimeglumine	29	8.6	8.6
Drospirenone And Ethinyl Estradiol	92	8.6	8.6
Mometasone	37	8.2	8.3
Desoximetasone	36	7.7	7.7
Fulvestrant	62	7.7	7.7
Trazodone Hydrochloride	29	7.6	7.6
Pertuzumab	46	6.9	6.9
Naproxen Sodium Tablet, Coated	23	6.9	6.9
Naproxen Sodium, Coated Tablets	23	6.9	6.9
Naproxen Sodium 220Mg	23	6.9	6.9
Aprepitant	31	6.9	6.9
Esomeprazole Magnesium Capsule, Delayed Release	24	6.7	6.8
Esomeprazole Magnesium Delayed Release Capsules	24	6.7	6.8
Esomeprazole Magnesium Dihydrate	24	6.7	6.7
Hyoscyamine Sulfate	15	6.7	6.7
Psyllium Husk	15	6.2	6.2
Ascorbic Acid	34	6.0	6.0
Amoxicillin And Clavulanate Potassium	39	5.9	5.9
Risedronate Sodium	44	5.8	5.8
Lactulose	54	5.8	5.8
Belimumab	43	5.6	5.6
Olmesartan Medoxomil	48	5.5	5.5
Torsemide	44	5.4	5.4
Valsartan And Hydrochlorothiazide	18	5.4	5.4
Ezetimibe And Simvastatin	20	5.4	5.4
Exemestane	28	5.3	5.3
Indapamide	23	5.2	5.2
Oxybutynin Chloride	11	5.1	5.1
Ibuprofen And Diphenhydramine Citrate	29	5.1	5.1
Clarithromycin	42	5.0	5.0
Filgrastim	45	4.9	4.9
Doxorubicin Hydrochloride	39	4.9	4.9
Eplerenone	15	4.8	4.8
Valsartan	120	4.7	4.7
Isosorbide Dinitrate	22	4.6	4.6
Niacin	13	4.6	4.6
Candesartan Cilexetil	29	4.5	4.5
Vitamin C	99	4.4	4.4
Valsartan Oral	58	4.4	4.4
Cephalexin	23	4.3	4.3
Enoxaparin Sodium	60	4.3	4.3
Octreotide Acetate	32	4.3	4.3
Lidocaine Hydrochloride And Epinephrine Bitartrate	54	4.1	4.1
Lidocaine, Menthol	50	4.1	4.1
Mometasone Furoate	42	4.1	4.1
Enalapril Maleate	25	4.1	4.1
Lidicaine	49	4.1	4.1
Burn Relief	49	4.1	4.1
Lidocaine Hydrochloride And Epinephrine	49	4.1	4.1
Tolterodine Tartrate	9	4.1	4.1
Levothyroxine Sodium	296	4.0	4.0
Meclizine	16	4.0	4.0
Alendronate Sodium Tablet	18	4.0	4.0
Teriparatide	108	4.0	4.0
Biotin	30	3.9	3.9
Acetylcysteine	9	3.9	3.9
Meclizine Hcl 12.5Mg	13	3.9	3.9
Meclizine Hcl 25Mg	13	3.9	3.9
Meclizine Hcl 12.5 Mg	13	3.9	3.9
Meclizine Hcl 25 Mg	13	3.9	3.9
Ribociclib	30	3.9	3.9
Lidocaine Hydrochloride	57	3.9	3.9
Diphenoxylate Hydrochloride And Atropine Sulfate	13	3.9	3.9
Hydromorphone Hydrochloride	85	3.8	3.8
Trimethoprim	11	3.8	3.8
Gemfibrozil	14	3.8	3.8
Meclizine Hydrochloride	18	3.7	3.7
Morphine	68	3.7	3.7
Lidocaine	53	3.7	3.7
Lidocaine 4%	49	3.7	3.7
Amlodipine Besylate And Valsartan	10	3.7	3.7
Conjugated Estrogens	52	3.7	3.7
Midazolam Hydrochloride	24	3.6	3.6
Cyclobenzaprine Hydrochloride	8	3.6	3.6
Sulfasalazine	69	3.6	3.6
Quinapril Hydrochloride	7	3.6	3.6
Levofloxacin	53	3.6	3.6
Levofloxacin In 5% Dextrose	53	3.6	3.6
Sitagliptin And Metformin Hydrochloride	19	3.6	3.6
Estrogens, Conjugated	52	3.6	3.6
Clobetasol Propionate Ointment Usp, 0.05%	9	3.6	3.6
Clobetasol Propionate	9	3.5	3.5
Theophylline	10	3.5	3.5
Cefepime Hydrochloride	14	3.5	3.5
Meperidine Hydrochloride	8	3.5	3.5
Amlodipine Besylate And Benazepril Hydrochloride	8	3.5	3.5
Pravastatin Sodium	17	3.5	3.5
Enalapril	47	3.5	3.5
Butalbital, Acetaminophen, And Caffeine	9	3.4	3.4
Cefepime	12	3.4	3.4
Midazolam	21	3.4	3.4
Finasteride	50	3.4	3.4
Nitroglycerin	44	3.4	3.4
Interferon Beta-1A	154	3.3	3.3
Calcium, Magnesium, Potassium, And Sodium Oxybates	7	3.3	3.3
Zinc	20	3.3	3.3
Theophylline Anhydrous	10	3.3	3.3
Zinc Chloride	20	3.3	3.3
Conjugated Estrogens And Medroxyprogesterone Acetate	19	3.3	3.3
Letrozole	49	3.3	3.3
Asfotase Alfa	8	3.2	3.2
Celecoxib	103	3.2	3.2
Amoxicillin	60	3.2	3.2
Potassium Chloride	89	3.2	3.2
Terazosin Hydrochloride	7	3.2	3.2
Losartan	135	3.2	3.2
Potassium Chloride, Dextrose Monohydrate	72	3.2	3.2
Potassium Chloride Oral	72	3.2	3.2
Potassium Chloride Extended-Release	72	3.2	3.2
Trastuzumab	53	3.2	3.2
Calcium	113	3.1	3.1
Ciprofloxacin Hydrochloride And Hydrocortisone	16	3.1	3.1
Rotigotine	11	3.1	3.1
Thyroid, Porcine	8	3.1	3.1
Rivastigmine	14	3.0	3.0
Digoxin	53	3.0	3.0
Anastrozole	27	3.0	3.0
Fentanyl	72	3.0	3.0
Spironolactone	102	3.0	3.0
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	115	3.0	3.0
Ticagrelor	23	2.9	2.9
Infliximab-Dyyb	21	2.9	2.9
Adalimumab	470	2.9	2.9
Alprazolam	142	2.8	2.9
Haloperidol	17	2.8	2.8
Insulin Glulisine	7	2.8	2.8
Haloperidol Lactate	17	2.8	2.8
Insulin Glargine-Yfgn	15	2.8	2.8
Lithium	17	2.7	2.7
Lithium Bromatum	17	2.7	2.7
Oxycodone And Acetaminophen Tablets	8	2.7	2.7
Tizanidine	16	2.7	2.7
Simvastatin	163	2.7	2.7
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	33	2.7	2.7
Loperamide Hydrochloride And Dimethicone	21	2.7	2.7
Metoprolol Succinate	56	2.6	2.6
Duloxetine Hydrochloride	119	2.6	2.6
Triamcinolone Acetonide Ointment Usp, 0.05%	15	2.6	2.6
Loratadine Oral	31	2.6	2.6
Metoprolol Succinate Er Tablets	39	2.5	2.5
Capecitabine	57	2.5	2.5
Letrozole Tablets	30	2.5	2.5
Oxycodone Hydrochloride And Acetaminophen	61	2.5	2.5
Denosumab	124	2.5	2.5
Modafinil	20	2.5	2.5
Omalizumab	52	2.5	2.5
Fexofenadine	10	2.5	2.5
Alirocumab	15	2.4	2.4
Bicalutamide	9	2.4	2.4
Secukinumab	94	2.4	2.4
Dronedarone	6	2.4	2.4
Riociguat	19	2.4	2.4
Selexipag	15	2.4	2.4
Sumatriptan	22	2.4	2.4
Nilotinib	17	2.3	2.3
Sildenafil Powder,	20	2.3	2.3
Insulin Aspart	37	2.3	2.3
Linagliptin	10	2.2	2.2
Medroxyprogesterone Acetate	27	2.2	2.2
Loratadine	58	2.2	2.2
Docetaxel Anhydrous	36	2.2	2.2
Docetaxel	36	2.2	2.2
Insulin Human	21	2.2	2.2
Rifaximin	11	2.1	2.1
Romosozumab-Aqqg	7	2.1	2.1
Tafamidis	6	2.1	2.1
Rivaroxaban	104	2.1	2.1
Timolol	6	2.0	2.0
Avapritinib	6	2.0	2.0
Golimumab	42	2.0	2.0
Sorafenib	10	2.0	2.0
Dofetilide	5	1.9	1.9
Rimegepant Sulfate	6	1.9	1.9
Travoprost	4	1.9	1.9
Fesoterodine Fumarate	5	1.9	1.9
Bosentan	23	1.9	1.9
Dabigatran Etexilate Mesylate	33	1.9	1.9
Dabigatran Etexilate	35	1.8	1.8
Siponimod	4	1.8	1.8
Peginterferon Alfa-2A	24	1.8	1.8
Vedolizumab	38	1.8	1.8
Etanercept	257	1.8	1.8
Atezolizumab	17	1.8	1.8
Ibrutinib	35	1.8	1.8
Macitentan	30	1.8	1.8
Upadacitinib	35	1.7	1.7
Risankizumab-Rzaa	35	1.7	1.7
Fluticasone Propionate And Salmeterol	17	1.7	1.7
Doxorubicin	36	1.6	1.6
Pegfilgrastim	38	1.6	1.6
Ranolazine	4	1.6	1.6
Sacubitril And Valsartan	44	1.5	1.5
Ruxolitinib	27	1.5	1.5
Ribavirin	24	1.5	1.5
Naproxen Sodium Tablet	19	1.5	1.5
Sofosbuvir	7	1.4	1.4
Abemaciclib	7	1.4	1.4
Fingolimod Hcl	30	1.4	1.4
Rucaparib	3	1.4	1.4
Isotretinoin	15	1.2	1.2
Ambrisentan	35	1.1	1.1
Sarilumab	7	1.1	1.1
Ledipasvir And Sofosbuvir	5	1.1	1.1
Somatropin	19	1.1	1.1
Hydrocodone Bitartrate	11	1.0	1.0
Exenatide	13	1.0	1.0
Velpatasvir And Sofosbuvir	3	0.9	0.9
Aflibercept	7	0.9	0.9
Lenalidomide	93	0.9	0.9
Apremilast	32	0.9	0.9
Evolocumab	35	0.9	0.9
Abaloparatide	6	0.8	0.8
Guselkumab	7	0.8	0.8
Levonorgestrel	35	0.7	0.7
Pirfenidone	7	0.7	0.7
Galcanezumab-Gnlm	5	0.6	0.6
Pomalidomide	15	0.6	0.6
Copper	4	0.4	0.4

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.