Reaction

Drug Tolerance reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,013 reports · 246 co-occurring drugs

As of the last recalculation, Drug Tolerance appears in 5,013 FAERS reports alongside 246 co-occurring drug terms. The strongest observed disproportionality signal is CORTISONE ACETATE (PRR 78.4).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Cortisone Acetate	223	78.4	79.9
Naproxen Sodium Tablet, Coated	185	58.9	59.7
Naproxen Sodium, Coated Tablets	185	58.9	59.7
Naproxen Sodium 220Mg	185	58.8	59.6
Desoximetasone	252	57.8	58.5
Pseudoephedrine Hydrochloride	124	51.4	52.0
Diclofenac Potassium, Film Coated	97	48.8	49.3
Diclofenac Potassium Tablets	97	48.7	49.3
Pseudoephedrine Hcl	125	48.3	48.8
Anakinra	180	46.7	47.2
Calcium Gluconate	129	45.6	46.1
Diclofenac Potassium	98	38.4	38.7
Tofacitinib Citrate	111	35.9	36.2
Cetirizine Hydrochloride Allergy	237	34.1	34.3
Cetirizine Hydrochloride Tablets	237	34.1	34.3
Risedronate Sodium	232	32.4	32.7
Adalimumab-Adaz	340	28.6	28.8
Adalimumab-Fkjp	300	28.5	28.7
Adalimumab-Aaty	299	27.8	28.0
Triamcinolone Acetonide Ointment Usp, 0.05%	147	26.8	27.0
Armodafinil	130	26.2	26.4
Human Immunoglobulin G	119	24.5	24.6
Diclofenac Sodium 1%	194	23.4	23.5
Diclofenac Sodium Topical	194	23.4	23.5
Diclofenac Sodium Topical Gel, 1%	194	23.4	23.5
Dimenhydrinate	59	23.3	23.4
Sulfasalazine	391	22.4	22.5
Hydrocodone Bitartrate And Acetaminophen	286	22.3	22.4
Febuxostat Tablets 40 Mg	54	22.3	22.4
Febuxostat Tablets 80 Mg	54	22.3	22.4
Naproxen	387	22.1	22.2
Oxycodone Hydrochloride	936	21.8	21.9
Chlorhexidine Gluconate	45	20.6	20.7
Golimumab	391	20.4	20.5
Triamcinolone Acetonide	147	20.3	20.4
Botulinum Toxin Type A	57	19.3	19.4
Leflunomide	436	18.9	18.9
Hydroxychloroquine	302	17.8	17.9
Tocilizumab	437	17.3	17.4
Alendronate Sodium	374	16.5	16.6
Hydromorphone Hydrochloride	335	16.1	16.2
Cetirizine	281	15.9	15.9
Celecoxib	448	15.4	15.5
Sarilumab	93	14.9	14.9
Febuxostat	59	14.8	14.8
Naproxen Sodium	452	14.3	14.4
Hydroxychloroquine Sulfate	289	13.9	14.0
Certolizumab Pegol	365	13.9	13.9
Doxyclycline Hyclate	54	13.3	13.3
Quetiapine Fumarate	92	13.2	13.2
Abatacept	394	12.7	12.8
Acetaminophen And Codeine	36	12.4	12.4
Diclofenac	242	12.2	12.2
Cetiirizine	121	12.1	12.2
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	118	12.1	12.1
Sodium Oxybate	185	12.1	12.1
Tramadol Hydrochloride	102	11.5	11.5
Oxycodone	463	11.2	11.3
Carisoprodol	51	11.2	11.2
Methadone	113	11.2	11.2
Ibuprofen And Diphenhydramine Citrate	61	11.0	11.0
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	91	10.9	10.9
Lisdexamfetamine Dimesylate	84	10.7	10.8
Morphine Sulfate	295	10.7	10.7
Guanfacine	20	10.6	10.6
Candesartan	86	10.2	10.2
Fentanyl	227	10.0	10.0
Methylphenidate Hydrochloride	138	9.9	9.9
Tofacitinib	407	9.9	9.9
Modafinil	75	9.8	9.8
Atomoxetine Hydrochloride	55	9.7	9.7
Buprenorphine	205	9.5	9.6
Rituximab	445	9.5	9.5
Bupropion Hydrochloride	215	9.4	9.4
Cyclobenzaprine Hydrochloride	20	9.3	9.3
Methadone Hydrochloride	24	9.2	9.3
Gefitinib	20	9.2	9.3
Diphenhydramine Hydrochloride Capsule, Liquid Filled	47	9.2	9.2
Fentanyl Citrate	39	9.1	9.1
Colchicine	57	9.1	9.1
Infliximab	436	9.0	9.0
Dronabinol	17	8.8	8.8
Cetirizine Hydrochloride	325	8.7	8.7
Oxycodone And Acetaminophen	48	8.6	8.6
Meperidine Hydrochloride	19	8.6	8.6
Cyanocobalamin	66	8.4	8.4
Tizanidine Hydrochloride	36	8.3	8.3
Pramipexole	30	8.2	8.2
Secukinumab	297	8.1	8.1
Buprenorphine Hydrochloride, Naloxone Hydrochloride	45	7.8	7.8
Tretinoin	15	7.7	7.7
Ramipril	219	7.6	7.6
Diclofenac Sodium	263	7.6	7.6
Dexlansoprazole	75	7.6	7.6
Mirabegron	69	7.5	7.5
Pantoprazole Sodium In 0.9% Sodium Chloride	107	7.3	7.3
Pantoprazole Sodium Injection	107	7.3	7.3
Zolpidem Tartrate	225	7.2	7.2
Cyclobenzaprine	85	7.2	7.2
Bupivacaine	16	7.1	7.1
Azathioprine	147	7.1	7.1
Oxycodone And Acetaminophen Tablets	20	7.0	7.0
Isopropyl Alcohol	56	6.9	7.0
Eszopiclone	42	6.9	6.9
Methylprednisolone Sodium Succinate	74	6.7	6.7
Hydrocortisone Sodium Succinate	15	6.6	6.7
Ethyl Alcohol	43	6.6	6.6
Morphine	114	6.5	6.5
Folic Acid	362	6.4	6.4
Methylphenidate	44	6.4	6.4
Pregabalin	386	6.3	6.3
Ustekinumab	148	6.2	6.2
Alcohol	57	6.2	6.2
Clonazepam	222	6.0	6.0
Doxycycline Hyclate	95	5.9	5.9
Bendamustine Hydrochloride	17	5.9	5.9
Doxycycline	95	5.9	5.9
Alprazolam	278	5.9	5.9
Oxycodone Hydrochloride And Acetaminophen	136	5.8	5.9
Nicotine Polacrilex Mini	21	5.8	5.8
Nicotine Polarilex	21	5.8	5.8
Calcium, Magnesium, Potassium, And Sodium Oxybates	12	5.8	5.8
Mepolizumab	68	5.7	5.8
Alendronate Sodium Tablet	25	5.6	5.6
Topiramate	122	5.5	5.6
Erenumab-Aooe	72	5.5	5.5
Entecavir	15	5.3	5.4
Cyclosporine	139	5.3	5.3
Lamotirigine	90	5.3	5.3
Lamotrigine Extended-Release	90	5.3	5.3
Lamotrigine Chewable Dispersible	90	5.3	5.3
Calcium Carbonate	84	5.3	5.3
Quetiapine	232	5.2	5.2
Hyoscyamine Sulfate	11	5.0	5.0
Clonidine	60	4.9	4.9
Rizatriptan Benzoate	12	4.9	4.9
Diazepam	139	4.8	4.9
Lubiprostone	11	4.8	4.8
Methotrexate Sodium	509	4.7	4.7
Methotrexate	445	4.7	4.7
Antacid	52	4.6	4.6
Temazepam	41	4.5	4.5
Amphetamine	9	4.5	4.5
Vilazodone Hydrochloride	10	4.5	4.5
Dexamethasone Sodium Phosphate	11	4.5	4.5
Hydrocortisone	92	4.3	4.3
Butalbital, Acetaminophen, And Caffeine	11	4.3	4.3
Minocycline	12	4.3	4.3
Apremilast	147	4.3	4.3
Ibuprofen Capsule	194	4.2	4.2
Ibuprofen Tablet, Film Coated	194	4.2	4.2
Ibupfrofen	194	4.2	4.2
Ibuprofen Tablets Usp, 200Mg	194	4.2	4.2
Ibuprofen Oral	194	4.2	4.2
Ibuprofen Capsules 200 Mg	194	4.2	4.2
Ibuprofen 200 Mg	194	4.2	4.2
Ibuprofen 200Mg	194	4.2	4.2
Prednisone	467	4.1	4.2
Lamotrigine	129	4.1	4.1
Hydrocodone Bitartrate	43	4.1	4.1
Midazolam	25	4.1	4.1
Tapentadol Hydrochloride	33	4.1	4.1
Hydrocortisone Acetate	70	4.0	4.0
Lorazepam	170	4.0	4.0
Midazolam Hydrochloride	26	4.0	4.0
Bendamustine Hcl	15	4.0	4.0
Fexofenadine Hydrochloride	21	4.0	4.0
Diltiazem Hydrochloride Extended-Release Tablets	11	4.0	4.0
Progesterone	22	4.0	4.0
Sertraline Hydrochloride	111	4.0	4.0
Pantoprazole Sodium	135	3.9	3.9
Diphenhydramine Hydrochloride	150	3.8	3.8
Liothyronine Sodium	8	3.8	3.8
Alpelisib	8	3.8	3.8
Magnesium Oxide	38	3.8	3.8
Ibuprofen	238	3.8	3.8
Magnesium Hydroxide	12	3.7	3.7
Meloxicam	51	3.7	3.7
Vitamin C	77	3.5	3.5
Mirtazapine	76	3.5	3.5
Levocetirizine Dihydrochloride	20	3.5	3.5
Pantoprazole	203	3.4	3.4
Diazepam Oral Solution (Concentrate)	72	3.4	3.4
Diazepam Oral	72	3.4	3.4
Aprepitant	15	3.4	3.4
Mycophenolate Mofetil Hydrochloride	109	3.4	3.4
Zonisamide	12	3.4	3.4
Etanercept	453	3.4	3.4
Mycophenolate Mofetil	108	3.4	3.4
Adalimumab	526	3.3	3.3
Sumatriptan	30	3.3	3.3
Ziprasidone Mesylate	11	3.2	3.2
Ranitidine Hydrochloride	41	3.1	3.2
Propranolol Hydrochloride	54	3.1	3.1
Thyroid, Porcine	8	3.1	3.1
Meclizine	12	3.1	3.1
Fluoxetine Hydrochloride	92	3.0	3.0
Rasagiline Mesylate	8	3.0	3.0
Meclizine Hydrochloride	14	3.0	3.0
Ibuprofen Tablets, Coated	30	2.9	2.9
Trazodone Hydrochloride	11	2.9	2.9
Ibuprofen Sodium	30	2.9	2.9
Suvorexant	9	2.9	2.9
Osimertinib	22	2.9	2.9
Testosterone	16	2.8	2.8
Oxybutynin Chloride	6	2.8	2.8
Gabapentin	241	2.8	2.8
Testosterone Cypionate	6	2.8	2.8
Tizanidine	16	2.8	2.8
Dolutegravir Sodium	6	2.8	2.8
Acetaminophen, Aspirin (Nsaid) And Caffeine	11	2.7	2.7
Bupropion	28	2.6	2.6
Ziprasidone	11	2.6	2.6
Phenobarbital	9	2.6	2.6
Sevoflurane	5	2.5	2.5
Oxcarbazepine	19	2.4	2.4
Rivastigmine	11	2.4	2.4
Nicotine Polacrilex	22	2.4	2.4
Brivaracetam	5	2.3	2.3
Nicotine	22	2.3	2.3
Lurasidone Hydrochloride	11	2.2	2.2
Acetaminophen, Aspirin, And Caffeine	11	2.2	2.2
Amantadine	8	2.1	2.1
Bortezomib	45	2.1	2.1
Esketamine Hydrochloride	9	2.1	2.1
Asenapine Maleate	4	1.9	1.9
Naproxen Sodium Tablet	21	1.6	1.6
Rimegepant Sulfate	5	1.6	1.6
Dronedarone	4	1.6	1.6
Cenobamate	3	1.5	1.5
Ixazomib	10	1.4	1.4
Oxymorphone Hydrochloride	4	1.4	1.4
Cannabidiol	8	1.4	1.4
Tenofovir Disoproxil Fumarate	11	1.4	1.4
Onabotulinumtoxina	25	1.3	1.3
Encorafenib	3	1.3	1.3
Brexpiprazole	5	1.3	1.3
Paliperidone	7	1.2	1.2
Varenicline Tartrate	24	1.2	1.2
Glatiramer Acetate	17	1.2	1.2
Fremanezumab-Vfrm	3	1.1	1.1
Ixekizumab	8	0.9	0.9
Glycerin, Lidocaine	3	0.9	0.9
Docosanol	3	0.8	0.8
Droxidopa	3	0.6	0.6
Salicylic Acid	3	0.2	0.2

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.