Reaction

Intracranial Pressure Increased reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,496 reports · 187 co-occurring drugs

As of the last recalculation, Intracranial Pressure Increased appears in 5,496 FAERS reports alongside 187 co-occurring drug terms. The strongest observed disproportionality signal is TRETINOIN (PRR 24.5).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Tretinoin	52	24.5	24.6
Minocycline	57	18.7	18.8
Amphotericin B	55	16.8	16.9
Pyrazinamide	28	11.3	11.4
Dronabinol	22	10.4	10.4
Efavirenz	30	10.2	10.3
Elexacaftor, Tezacaftor, And Ivacaftor	33	10.1	10.1
Ado-Trastuzumab Emtansine	22	9.9	9.9
Mercaptopurine	45	9.9	9.9
Fondaparinux Sodium	18	8.4	8.5
Doxycycline Hyclate	138	7.9	7.9
Doxycycline	138	7.8	7.8
Alteplase	30	7.6	7.6
Acetylcysteine	18	7.3	7.3
Dalteparin Sodium	20	7.2	7.2
Lapatinib	29	7.1	7.1
Somatropin	135	7.1	7.1
Midazolam Hydrochloride	50	7.1	7.1
Midazolam	46	7.0	7.0
Testosterone Cypionate	16	6.8	6.8
Loperamide Hcl	23	6.8	6.8
Rifampicin	18	6.8	6.8
Instalax Polyethylene Glycol 3350	22	6.7	6.7
Loperamide Hydrochloride Oral	18	6.7	6.7
Cytarabine	104	6.7	6.7
Polyethylene Glycol 400	22	6.6	6.6
Isoniazid	28	6.6	6.6
Lamivudine Oral	43	6.5	6.5
Fam-Trastuzumab Deruxtecan-Nxki	17	6.4	6.4
Fosaprepitant Dimeglumine	23	6.4	6.4
Testosterone	39	6.4	6.4
Ceftriaxone	53	6.2	6.2
Temozolomide	33	6.0	6.0
Lamivudine	47	5.8	5.8
Vincristine Sulfate	44	5.7	5.7
Cariprazine	14	5.7	5.7
Zidovudine	20	5.7	5.7
Ceftriaxone Sodium	57	5.7	5.7
Fluconazole	103	5.7	5.7
Trazodone Hydrochloride	23	5.6	5.6
Cladribine	14	5.5	5.5
Phenytoin	30	5.5	5.5
Blinatumomab	15	5.5	5.5
Propofol	52	5.4	5.4
Pertuzumab	38	5.3	5.3
Canakinumab	15	5.3	5.3
Ursosiol	26	5.1	5.1
Abacavir Sulfate	13	5.1	5.1
Sevoflurane	11	5.0	5.0
Pegaspargase	16	5.0	5.0
Mycophenilic Acid	27	5.0	5.0
Busulfan	20	4.8	4.8
Aprepitant	23	4.7	4.7
Valganciclovir Hydrochloride Powder,	15	4.7	4.7
Cyclosporine	133	4.6	4.6
Ursodiol	26	4.5	4.5
Phytonadione	10	4.5	4.5
Doxyclycline Hyclate	20	4.5	4.5
Voriconazole Injection	25	4.4	4.4
Enoxaparin Sodium	65	4.3	4.3
Ivacaftor	9	4.3	4.3
Human Immunoglobulin G	23	4.2	4.2
Mycophenolic Acid	35	4.2	4.2
Voriconazole	33	4.1	4.1
Amphetamine	9	4.1	4.1
Gentamicin Sulfate	17	4.1	4.1
Ganciclovir	11	4.1	4.1
Gentamicin	14	4.1	4.1
Levonorgestrel	209	4.0	4.0
Valproate Sodium	22	4.0	4.0
Dabrafenib	22	4.0	4.0
Ganciclovir Sodium	11	3.9	3.9
Tacrolimus Ointment 0.1%	127	3.9	3.9
Tacrolimus Extended-Release Capsules	127	3.9	3.9
Lopinavir And Ritonavir	14	3.9	3.9
Ziprasidone	18	3.9	3.9
Mycophenolate Mofetil	136	3.9	3.9
Heparin Sodium	14	3.9	3.9
Mycophenolate Mofetil Hydrochloride	136	3.9	3.9
Candesartan	36	3.8	3.8
Hydrocortisone	89	3.8	3.8
Nystatin Ointment	26	3.8	3.8
Nystatin Cream	26	3.8	3.8
Methylphenidate Hydrochloride	58	3.7	3.7
Rizatriptan Benzoate	10	3.7	3.7
Indomethacin	13	3.7	3.7
Tacrolimus	149	3.7	3.7
Brexpiprazole	16	3.7	3.7
Valganciclovir	18	3.6	3.6
Valganciclovir Hydrochloride	18	3.6	3.6
Nystatin	26	3.6	3.6
Etonogestrel And Ethinyl Estradiol	21	3.6	3.6
Calcium, Magnesium, Potassium, And Sodium Oxybates	8	3.5	3.5
Tenofovir Disoproxil Fumarate Tablets	8	3.5	3.5
Amoxicillin And Clavulanate Potassium	25	3.5	3.5
Acetaminophen Tablet Extended Release	227	3.5	3.5
Pain Reliever	227	3.5	3.5
Acetaminophen 500Mg	227	3.5	3.5
Anakinra	15	3.4	3.4
Methylphenidate	26	3.4	3.4
Trastuzumab	61	3.4	3.4
Doxepin	9	3.4	3.4
Nevirapine	8	3.4	3.4
Gefitinib	8	3.4	3.4
Eptinezumab-Jjmr	8	3.3	3.3
Linezolid	26	3.3	3.3
Ethanol	7	3.3	3.3
Erythromycin	16	3.2	3.2
Rocuronium Bromide	10	3.2	3.2
Norepinephrine	9	3.2	3.2
Fludarabine Phosphate	33	3.2	3.2
Extended Phenytoin Sodium	14	3.2	3.2
Norepinephrine Bitartrate	12	3.2	3.2
Levofloxacin	50	3.2	3.2
Levofloxacin In 5% Dextrose	50	3.2	3.2
Trametinib	20	3.1	3.1
Valproic Acid	26	3.1	3.1
Axicabtagene Ciloleucel	8	3.1	3.1
Asfotase Alfa	8	3.0	3.0
Isotretinoin	39	3.0	3.0
Derma Foam Excel Hand Sanitizer	6	2.8	2.8
Vemurafenib	9	2.8	2.8
Valacyclovir	31	2.8	2.8
Dutasteride	6	2.8	2.8
Drospirenone And Ethinyl Estradiol	32	2.8	2.8
Nitrofurantoin (Monohydrate/Macrocrystals)	12	2.7	2.7
Cyclophosphamide Injection, Solution	124	2.7	2.7
Cyclophosphamide	124	2.7	2.7
Cyclophosphamide For Injection	124	2.7	2.7
Meropenem	22	2.6	2.6
Terbinafine Hydrochloride	6	2.6	2.6
Risperidone	87	2.5	2.5
Aripiprazole Oral	27	2.5	2.5
Aripiprazole Orally Disintegrating	27	2.5	2.5
Omalizumab	55	2.5	2.5
Amikacin	11	2.4	2.4
Vancomycin	37	2.4	2.4
Levetiracetam	85	2.4	2.4
Carboxymethylcellulose Sodium	6	2.4	2.4
Amlodipine Besylate And Valsartan	7	2.4	2.4
Vancomycin Hydrochloride	41	2.4	2.4
Imatinib	11	2.4	2.4
Olanzapine	66	2.3	2.3
Rifampin	9	2.3	2.3
Capecitabine	53	2.2	2.2
Botulinum Toxin Type A	7	2.1	2.1
Obinutuzumab	9	2.1	2.1
Dexamethasone 1.5 Mg	157	2.1	2.1
Dexamethasone	158	2.0	2.0
Doxorubicin	47	2.0	2.0
Imatinib Mesylate	14	1.9	1.9
Etoposide	36	1.9	1.9
Lacosamide	18	1.8	1.8
Eculizumab	26	1.8	1.8
Budesonide, Glycopyrrolate, And Formoterol Fumarate	5	1.8	1.8
Crizotinib	6	1.8	1.8
Atomoxetine Hydrochloride	11	1.8	1.8
Etonogestrel	22	1.7	1.7
Bendamustine Hcl	7	1.7	1.7
Fentanyl Citrate	8	1.7	1.7
Docetaxel Anhydrous	30	1.7	1.7
Docetaxel	30	1.7	1.7
Alcohol	17	1.7	1.7
Dasatinib	16	1.6	1.6
Ifosfamide	9	1.6	1.6
Ipilimumab	18	1.6	1.6
Paclitaxel (Aibumin-Bound)	34	1.6	1.6
Niraparib	9	1.5	1.5
Ethyl Alcohol	11	1.5	1.5
Bevacizumab	50	1.5	1.5
Dabigatran Etexilate	31	1.5	1.5
Esketamine Hydrochloride	7	1.5	1.5
Nivolumab	36	1.4	1.4
Dabigatran Etexilate Mesylate	27	1.4	1.4
Iohexol	3	1.4	1.4
Dornase Alfa	7	1.4	1.4
Voclosporin	3	1.3	1.3
Osimertinib	11	1.3	1.3
Romiplostim	5	1.3	1.3
Tenofovir Disoproxil Fumarate	10	1.1	1.1
Erenumab-Aooe	16	1.1	1.1
Fremanezumab-Vfrm	3	1.0	1.0
Onabotulinumtoxina	20	1.0	1.0
Pegfilgrastim	24	0.9	0.9
Palivizumab	3	0.7	0.7
Droxidopa	3	0.5	0.5
Adapalene	6	0.1	0.1

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.