Reaction

General Physical Condition Abnormal reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 6,702 reports · 212 co-occurring drugs

As of the last recalculation, General Physical Condition Abnormal appears in 6,702 FAERS reports alongside 212 co-occurring drug terms. The strongest observed disproportionality signal is HYDROCODONE BITARTRATE AND ACETAMINOPHEN (PRR 13.7).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Hydrocodone Bitartrate And Acetaminophen	241	13.7	13.8
Oxycodone Hydrochloride	560	8.6	8.7
Clozapine	288	7.4	7.4
Hydromorphone Hydrochloride	206	7.1	7.2
Buprenorphine Hydrochloride, Naloxone Hydrochloride	54	7.0	7.0
Methadone	82	6.0	6.0
Ozanimod Hydrochloride	14	5.2	5.3
Ribociclib	52	5.1	5.2
Morphine Sulfate	190	5.0	5.0
Levodopa	17	4.4	4.4
Amikacin	23	4.2	4.2
Octreotide Acetate	40	4.1	4.1
Phytonadione	11	4.0	4.0
Trametinib	31	4.0	4.0
Dabrafenib	27	4.0	4.0
Ketoprofen	16	3.8	3.8
Ruxolitinib	84	3.7	3.7
Rivastigmine	22	3.6	3.6
Hydrocodone Bitartrate	50	3.6	3.6
Indomethacin	15	3.5	3.5
Letrozole	68	3.5	3.5
Cefepime Hydrochloride	17	3.3	3.3
Tramadol Hydrochloride	39	3.2	3.2
Ravulizumab	14	3.2	3.2
Lopinavir And Ritonavir	14	3.2	3.2
Bendamustine Hcl	16	3.2	3.2
Nivolumab	97	3.1	3.1
Haloperidol	24	3.1	3.1
Ganciclovir	10	3.0	3.0
Meperidine Hydrochloride	9	3.0	3.0
Haloperidol Lactate	24	3.0	3.0
Goserelin	13	3.0	3.0
Ganciclovir Sodium	10	2.9	2.9
Letrozole Tablets	45	2.9	2.9
Buprenorphine	86	2.9	2.9
Epoetin Alfa	11	2.9	2.9
Ixazomib	26	2.8	2.8
Valganciclovir Hydrochloride Powder,	11	2.8	2.8
Upadacitinib	73	2.8	2.8
Risankizumab-Rzaa	73	2.8	2.8
Teduglutide	12	2.8	2.8
Omalizumab	75	2.8	2.8
Valsartan And Hydrochlorothiazide	12	2.7	2.7
Heparin Sodium	12	2.7	2.7
Eplerenone	11	2.7	2.7
Amitriptyline Hydrochloride	15	2.7	2.7
Fulvestrant	28	2.6	2.6
Everolimus	43	2.6	2.6
Onabotulinumtoxina	65	2.6	2.6
Pemetrexed Disodium	32	2.6	2.6
Esketamine Hydrochloride	15	2.6	2.6
Pemetrexed	18	2.6	2.6
Deferasirox	22	2.6	2.6
Amlodipine Besylate And Valsartan	9	2.5	2.5
Fentanyl	78	2.5	2.5
Olanzapine	85	2.5	2.5
Fam-Trastuzumab Deruxtecan-Nxki	8	2.5	2.5
Thalidomide	29	2.5	2.5
Tobramycin	19	2.5	2.5
Tamsulosin Hydrochloride	16	2.4	2.4
Sodium Bicarbonate	18	2.4	2.4
Sodium Bicarbonate Injection,	18	2.4	2.4
Cefepime	11	2.4	2.4
Ranolazine	8	2.4	2.4
Ipilimumab	33	2.4	2.4
Granisetron Hydrochloride	8	2.4	2.4
Dextrose	10	2.4	2.4
Valsartan	79	2.4	2.4
Bendamustine Hydrochloride	9	2.3	2.3
Dextrose Monohydrate	10	2.3	2.3
Exemestane	16	2.3	2.3
Bisoprolol Fumarate	100	2.3	2.3
Dupilumab	345	2.3	2.3
Bortezomib	64	2.2	2.2
Everolimus Tablets	12	2.2	2.2
Budesonide And Formoterol Fumarate Dihydrate	69	2.2	2.2
Olanzapine Pamoate	29	2.2	2.2
Carbidopa And Levodopa	33	2.2	2.2
Valganciclovir	13	2.1	2.1
Valganciclovir Hydrochloride	13	2.1	2.1
Venlafaxine	49	2.1	2.1
Apalutamide	8	2.1	2.1
Midazolam	17	2.1	2.1
Granisetron	7	2.1	2.1
Raltegravir	11	2.1	2.1
Tobramycin Solution	8	2.1	2.1
Sotalol Hydrochloride	11	2.1	2.1
Melphalan	15	2.1	2.1
Bimekizumab	14	2.0	2.0
Oxazepam	14	2.0	2.0
Eltrombopag Olamine	15	2.0	2.0
Tobramycin Sulfate	8	2.0	2.0
Melphalan Hydrochloride	16	2.0	2.0
Midazolam Hydrochloride	17	2.0	2.0
Iron Sucrose	6	2.0	2.0
Rotigotine	9	1.9	1.9
Hydroxyurea	13	1.9	1.9
Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride And Dextrose	5	1.9	1.9
Imatinib Mesylate	17	1.9	1.9
Eculizumab	33	1.9	1.9
Linezolid	18	1.9	1.9
Darunavir	9	1.8	1.8
Insulin Glargine-Yfgn	13	1.8	1.8
Naltrexone	18	1.8	1.8
Ritonavir	17	1.8	1.8
Acalabrutinib	7	1.8	1.8
Budesonide, Glycopyrrolate, And Formoterol Fumarate	6	1.8	1.8
Sarilumab	15	1.8	1.8
Ziprasidone Mesylate	8	1.7	1.7
Sunitinib Malate	22	1.7	1.7
Canakinumab	6	1.7	1.7
Dolutegravir Sodium	5	1.7	1.7
Carboplatin	69	1.7	1.7
Selexipag	14	1.7	1.7
Durvalumab	11	1.7	1.7
Cisplatin	42	1.7	1.7
Teriflunomide	24	1.7	1.7
Pimavanserin Tartrate	29	1.6	1.6
Adalimumab	359	1.6	1.6
Ziprasidone	9	1.6	1.6
Fosaprepitant Dimeglumine	7	1.6	1.6
Nilotinib	15	1.6	1.6
Dexamethasone 1.5 Mg	146	1.6	1.6
Dexamethasone	147	1.6	1.6
Asfotase Alfa	5	1.6	1.6
Carfilzomib	14	1.5	1.5
Pancrelipase	19	1.5	1.5
Venetoclax	30	1.5	1.5
Bleomycin Sulfate	5	1.5	1.5
Darbepoetin Alfa	26	1.5	1.5
Sorafenib	10	1.5	1.5
Sevoflurane	4	1.5	1.5
Pazopanib Hydrochloride	13	1.5	1.5
Ledipasvir And Sofosbuvir	9	1.5	1.5
Risperidone	62	1.5	1.5
Relugolix	11	1.4	1.4
Alpelisib	4	1.4	1.4
Palivizumab	7	1.4	1.4
Etonogestrel And Ethinyl Estradiol	10	1.4	1.4
Nevirapine	4	1.4	1.4
Atezolizumab	17	1.4	1.4
Pembrolizumab	46	1.4	1.4
Bevacizumab	54	1.4	1.4
Daptomycin	4	1.3	1.3
Regorafenib	5	1.3	1.3
Dasatinib	16	1.3	1.3
Temozolomide	9	1.3	1.3
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	13	1.3	1.3
Vemurafenib	5	1.3	1.3
Axitinib	8	1.3	1.3
Polatuzumab Vedotin	4	1.3	1.3
Gemcitabine	16	1.3	1.3
Ribavirin	26	1.3	1.3
Encorafenib	4	1.3	1.3
Paclitaxel (Aibumin-Bound)	33	1.2	1.2
Teriparatide	45	1.2	1.2
Erlotinib Hydrochloride	5	1.2	1.2
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Alafenamide	4	1.2	1.2
Gemcitabine Hydrochloride	21	1.2	1.2
Enzalutamide	23	1.2	1.2
Ustekinumab	40	1.2	1.2
Irinotecan Hydrochloride	5	1.2	1.2
Golimumab	33	1.2	1.2
Paclitaxel	38	1.2	1.2
Panitumumab	6	1.2	1.2
Daratumumab	15	1.2	1.2
Cabozantinib	18	1.2	1.2
Azacitidine	11	1.2	1.2
Abatacept	51	1.1	1.1
Abiraterone	5	1.1	1.1
Glecaprevir And Pibrentasvir	4	1.1	1.1
Medroxyprogesterone Acetate	18	1.1	1.1
Secukinumab	58	1.1	1.1
Cenobamate	3	1.1	1.1
Bosentan	18	1.1	1.1
Cetuximab	11	1.1	1.1
Fingolimod Hcl	30	1.1	1.1
Gefitinib	3	1.0	1.0
Azacitidine For	6	1.0	1.0
Docetaxel Anhydrous	22	1.0	1.0
Docetaxel	22	1.0	1.0
Cariprazine	3	1.0	1.0
Lapatinib	5	1.0	1.0
Crizotinib	4	1.0	1.0
Dornase Alfa	6	1.0	1.0
Brexpiprazole	5	0.9	0.9
Ofatumumab	10	0.9	0.9
Romosozumab-Aqqg	4	0.9	0.9
Abiraterone Acetate	12	0.9	0.9
Patiromer	4	0.9	0.9
Olaparib	6	0.9	0.9
Emtricitabine And Tenofovir Disoproxil Fumarate	13	0.9	0.9
Certolizumab Pegol	33	0.9	0.9
Osimertinib	9	0.9	0.9
Pomalidomide	28	0.8	0.8
Methoxy Polyethylene Glycol-Epoetin Beta	3	0.8	0.8
Leuprolide Acetate	21	0.8	0.8
Sacubitril And Valsartan	31	0.8	0.8
Dalfampridine	19	0.8	0.8
Diroximel Fumarate	3	0.8	0.8
Guselkumab	9	0.8	0.8
Ixekizumab	9	0.8	0.8
Pegfilgrastim	24	0.8	0.8
Abaloparatide	7	0.7	0.7
Rimegepant Sulfate	3	0.7	0.7
Lutetium Lu 177 Vipivotide Tetraxetan	3	0.7	0.7
Drospirenone And Ethinyl Estradiol	10	0.7	0.7
Lenalidomide	95	0.7	0.7
Paliperidone Palmitate	7	0.7	0.7
Aflibercept	6	0.6	0.6
Droxidopa	4	0.6	0.6
Cinacalcet Hydrochloride	6	0.4	0.4

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.