Reaction

Metabolic Encephalopathy reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 2,960 reports · 219 co-occurring drugs

As of the last recalculation, Metabolic Encephalopathy appears in 2,960 FAERS reports alongside 219 co-occurring drug terms. The strongest observed disproportionality signal is CEFEPIME HYDROCHLORIDE (PRR 22.6).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Cefepime Hydrochloride	51	22.6	22.7
Cefepime	44	21.9	22.0
Valproic Acid	63	14.3	14.4
Epoetin Alfa	21	12.5	12.6
Magnesium Sulfate Heptahydrate	22	12.0	12.0
Piperacillin Sodium And Tazobactam Sodium	33	12.0	12.0
Magnesium Sulfate	22	11.9	12.0
Magnesium Sulfate In Water For	21	11.6	11.7
Norepinephrine Bitartrate	23	11.3	11.3
Polyethylene Glycol	17	11.1	11.1
Magnesium Hydroxide	21	11.0	11.0
Docusate Sodium 100Mg	36	10.7	10.7
Valproate Sodium	31	10.6	10.7
Baclofen	125	10.6	10.6
Norepinephrine	16	10.6	10.6
Canagliflozin	44	10.5	10.5
Sevelamer Carbonate	17	10.5	10.5
Docusate Sodium	83	10.4	10.4
Methocarbamol Tablets	24	10.2	10.2
Erythropoietin	29	10.0	10.0
Bisacodyl Suppositories	18	9.8	9.8
Lacosamide	51	9.8	9.8
Biscodyl	18	9.7	9.8
Docusate Sodium - Sennosides	44	9.7	9.7
Dronabinol	11	9.7	9.7
Lithium	34	9.6	9.6
Lithium Bromatum	34	9.6	9.6
Bisacodyl	19	9.5	9.6
Diphenoxylate Hydrochloride And Atropine Sulfate	18	9.3	9.3
Vancomycin Hydrochloride	82	9.0	9.0
Voriconazole Injection	27	8.8	8.8
Methocarbamol	28	8.7	8.8
Bumetanide	32	8.6	8.6
Vancomycin	69	8.6	8.6
Mesna Injection	10	8.5	8.5
Amphetamine	10	8.5	8.5
Phenytoin	25	8.5	8.5
Standardized Senna Concentrate	15	8.4	8.4
Mesna	10	8.4	8.4
Amantadine	18	8.2	8.2
Metolazone	13	8.2	8.2
Dextrose	15	8.0	8.1
Cefuroxime	13	8.0	8.0
Dextrose Monohydrate	15	7.9	7.9
Entecavir	13	7.9	7.9
Divalproex Sodium	51	7.8	7.8
Potassium Chloride	121	7.7	7.8
Rifampicin	11	7.7	7.7
Sodium Bicarbonate	25	7.6	7.6
Sodium Bicarbonate Injection,	25	7.6	7.6
Promethazine Hydrochloride	20	7.6	7.6
Potassium Chloride, Dextrose Monohydrate	97	7.6	7.6
Potassium Chloride Oral	97	7.6	7.6
Potassium Chloride Extended-Release	97	7.6	7.6
Blinatumomab	11	7.4	7.4
Salmeterol Xinafoate	9	7.4	7.4
Piperacillin And Tazobactam	13	7.2	7.2
Zonisamide	15	7.2	7.2
Sennosides	30	7.1	7.1
Sennosides 8.6 Mg Tablets	21	7.1	7.1
Enoxaparin Sodium	57	7.1	7.1
Lithium Carbonate	17	7.1	7.1
Senna	21	7.0	7.1
Piperacillin Sodium,Tazobactam Sodium	26	6.9	7.0
Sitagliptin And Metformin Hydrochloride	21	6.9	6.9
Meperidine Hydrochloride	9	6.9	6.9
Senna Leaf	22	6.7	6.8
Memantine	13	6.7	6.7
Memantine Hydrochloride	13	6.7	6.7
Clobazam	23	6.7	6.7
Dalteparin Sodium	10	6.7	6.7
Iron Sucrose	9	6.7	6.7
Tizanidine Hydrochloride	17	6.6	6.7
Voriconazole	28	6.5	6.5
Lactulose	35	6.5	6.5
Insulin Glargine-Yfgn	20	6.5	6.5
Ropinirole	14	6.4	6.4
Axicabtagene Ciloleucel	9	6.4	6.4
Levetiracetam	118	6.4	6.4
Posaconazole Delayed-Release	10	6.4	6.4
Dextrose Monohydrate, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	8	6.4	6.4
Pegaspargase	11	6.3	6.3
Telmisartan	16	6.3	6.3
Insulin	49	6.3	6.3
Nevirapine	8	6.2	6.3
Temazepam	33	6.2	6.2
Amphotericin B	11	6.2	6.2
Isosorbide Mononitrate	18	6.1	6.1
Ceftriaxone	28	6.0	6.1
Levetiracetam In Sodium Chloride	65	6.0	6.0
Levetiracetam Oral	65	6.0	6.0
Levetiracetam Injection	65	6.0	6.0
Sucralfate Oral	12	6.0	6.0
Atropine	7	6.0	6.0
Sucralfate Oral Suspension	12	5.9	5.9
Cefazolin Sodium	10	5.9	5.9
Phenobarbital	12	5.8	5.8
Cholestyramine	10	5.8	5.8
Lorazepam	142	5.8	5.8
Magnesium Oxide	34	5.8	5.8
Meropenem	26	5.7	5.7
Ceftriaxone Sodium	31	5.7	5.7
Ferrous Sulfate	40	5.7	5.7
Posaconazole	13	5.6	5.7
Nicotine Polacrilex Mini	12	5.6	5.6
Nicotine Polarilex	12	5.6	5.6
Calcitriol Capsules 0.25 Mcg	16	5.6	5.6
Calcitriol Capsules 0.5 Mcg	16	5.6	5.6
Sucralfate	19	5.6	5.6
Oxazepam	17	5.6	5.6
Digoxin	56	5.6	5.6
Valacyclovir Hydrochloride	55	5.6	5.6
Calcitriol	16	5.6	5.6
Nitroglycerin	42	5.6	5.6
Fentanyl Citrate	14	5.5	5.5
Sotalol Hydrochloride	13	5.5	5.5
Pitavastatin Calcium	8	5.5	5.5
Linezolid	23	5.5	5.5
Niacin	9	5.5	5.5
Furosemide	286	5.4	5.5
Propofol	28	5.4	5.4
Linagliptin	14	5.4	5.4
Quinapril Hydrochloride	6	5.4	5.4
Lubiprostone	7	5.2	5.2
Ritonavir 100 Mg	11	5.2	5.2
Indapamide	13	5.1	5.1
Ciprofloxacin Hydrochloride And Hydrocortisone	15	5.1	5.1
Amiodarone Hydrochloride	8	5.0	5.0
Donepezil Hydrochloride	26	5.0	5.0
Carvedilol	94	5.0	5.0
Tacrolimus	108	5.0	5.0
Enalapril	38	4.9	4.9
Mirtazapine	62	4.8	4.8
Tacrolimus Ointment 0.1%	83	4.8	4.8
Fenofibrate	24	4.8	4.8
Tacrolimus Extended-Release Capsules	83	4.8	4.8
Remdesivir	9	4.8	4.8
Valacyclovir	28	4.8	4.8
Zidovudine	9	4.7	4.7
Glimepiride	26	4.7	4.7
Midazolam Hydrochloride	18	4.7	4.7
Fentanyl	65	4.7	4.7
Rifaximin	14	4.7	4.7
Famotidine	77	4.7	4.7
Mupirocin	9	4.7	4.7
Carbidopa And Levodopa	31	4.6	4.6
Heparin Sodium	9	4.6	4.6
Finasteride	39	4.6	4.6
Vincristine Sulfate	19	4.6	4.6
Gabapentin	223	4.6	4.6
Bupivacaine	6	4.5	4.5
Insulin Aspart	42	4.5	4.5
Melphalan Hydrochloride	16	4.5	4.5
Midazolam	16	4.5	4.5
Bupropion	28	4.5	4.5
Haloperidol	15	4.4	4.4
Dutasteride	5	4.3	4.3
Ifosfamide	13	4.3	4.3
Encorafenib	6	4.3	4.3
Nebivolol Hydrochloride	20	4.2	4.2
Modafinil	19	4.2	4.2
Micafungin Sodium	5	4.2	4.2
Fluorouracil	45	4.1	4.1
Fludarabine Phosphate	23	4.1	4.1
Prochlorperazine	16	4.1	4.1
Melphalan	13	4.0	4.0
Rucaparib	5	4.0	4.0
Glipizide	34	4.0	4.0
Testosterone Cypionate	5	3.9	3.9
Erlotinib Hydrochloride	7	3.9	3.9
Fluorouracil Cream, 0.5%	42	3.9	3.9
Daptomycin	5	3.8	3.8
Armodafinil	11	3.7	3.7
Nicotine	21	3.7	3.7
Oxycodone	95	3.7	3.7
Lanreotide Acetate	4	3.6	3.6
Dapagliflozin	16	3.6	3.6
Metformin Hcl	27	3.5	3.5
Cetuximab	15	3.4	3.4
Brinzolamide	4	3.2	3.2
Miconazole Nitrate	4	3.2	3.2
Bimatoprost	13	3.2	3.2
Bortezomib	40	3.2	3.2
Nicotine Polacrilex	17	3.1	3.1
Pimavanserin Tartrate	24	3.1	3.1
Oxaliplatin	32	3.1	3.1
Morphine Sulfate	52	3.1	3.1
Oxycodone And Acetaminophen	10	3.0	3.0
Risperidone	56	3.0	3.0
Apalutamide	5	3.0	3.0
Brexpiprazole	7	3.0	3.0
Erlotinib	4	2.9	2.9
Sofosbuvir	8	2.9	2.9
Brentuximab Vedotin	4	2.7	2.7
Deferasirox	10	2.7	2.7
Derma Foam Excel Hand Sanitizer	3	2.6	2.6
Ethanol	3	2.6	2.6
Methadone Hydrochloride	4	2.6	2.6
Lenvatinib	12	2.6	2.6
Carfilzomib	10	2.5	2.5
Oxycodone Hydrochloride	75	2.5	2.5
Diroximel Fumarate	4	2.4	2.4
Temozolomide	7	2.3	2.3
Azacitidine For	6	2.3	2.3
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Alafenamide	3	2.1	2.1
Abiraterone	4	2.1	2.1
Paricalcitol	4	2.0	2.0
Trifluridine And Tipiracil	3	2.0	2.0
Droxidopa	6	2.0	2.0
Hydrocodone Bitartrate And Acetaminophen	15	1.9	1.9
Ledipasvir And Sofosbuvir	5	1.8	1.8
Tafamidis	3	1.8	1.8
Dalfampridine	17	1.7	1.7
Lenalidomide	96	1.6	1.6
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	7	1.6	1.6
Natalizumab	40	1.6	1.6
Pomalidomide	20	1.4	1.4
Cinacalcet Hydrochloride	8	1.2	1.2
Valbenazine	3	0.8	0.8

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.