Reaction

Which drugs are most reported with Onychoclasis?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 6,780 reports · 255 co-occurring drugs

As of the last recalculation, Onychoclasis appears in 6,780 FAERS reports alongside 255 co-occurring drug terms. The strongest observed disproportionality signal is IBRUTINIB (PRR 26.7).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Ibrutinib	638	26.7	26.9
Osimertinib	215	21.2	21.4
Desoximetasone	110	18.0	18.1
Biotin	130	13.0	13.1
Abemaciclib	83	12.9	12.9
Letrozole Tablets	190	12.4	12.5
Trastuzumab	265	12.3	12.3
Ribociclib	124	12.3	12.3
Cortisone Acetate	48	12.0	12.1
Lapatinib	58	11.6	11.6
Letrozole	222	11.4	11.4
Fulvestrant	110	10.4	10.4
Gefitinib	30	10.2	10.3
Exemestane	70	10.1	10.2
Erlotinib	29	9.2	9.2
Ado-Trastuzumab Emtansine	25	9.1	9.2
Anastrozole	102	8.6	8.7
Pertuzumab	74	8.4	8.5
Palbociclib	245	8.1	8.2
Liothyronine Sodium	22	7.8	7.8
Clobetasol Propionate Ointment Usp, 0.05%	26	7.8	7.8
Clobetasol Propionate	26	7.7	7.8
Erlotinib Hydrochloride	31	7.6	7.7
Anastrozole Tablets	52	7.5	7.5
Psyllium Husk	24	7.5	7.5
Everolimus	116	7.1	7.1
Teriflunomide	96	6.6	6.6
Methimazole	16	6.3	6.3
Thyroid, Porcine	20	5.8	5.8
Standardized Senna Concentrate	22	5.4	5.4
Goserelin	23	5.3	5.3
Sulfasalazine	130	5.2	5.2
Loperamide Hydrochloride Oral	17	5.1	5.1
Calcium	238	5.1	5.1
Loperamide Hcl	21	5.0	5.0
Prochlorperazine Maleate	15	5.0	5.0
Loperamide Hydrochloride	72	5.0	5.0
Panitumumab	25	4.9	4.9
Docusate Sodium - Sennosides	51	4.9	4.9
Loperamide Hydrochloride And Dimethicone	50	4.8	4.8
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	47	4.8	4.8
Niraparib	34	4.7	4.7
Vitamin C	139	4.7	4.7
Alpelisib	13	4.6	4.6
Diclofenac	126	4.6	4.6
Diphenoxylate Hydrochloride And Atropine Sulfate	20	4.5	4.5
Melatonin	75	4.3	4.3
Levothyroxine Sodium	415	4.3	4.3
Cetuximab	43	4.2	4.2
Raloxifene Hydrochloride	20	4.2	4.2
Hydroxychloroquine	100	4.2	4.2
Tranexamic Acid	12	4.1	4.2
Octreotide Acetate	39	3.9	3.9
Oxybutynin Chloride	11	3.9	3.9
Hydrocortisone	108	3.8	3.8
Docusate Sodium	70	3.8	3.8
Capecitabine	110	3.7	3.7
Magnesium	98	3.7	3.7
Clindamycin Phosphate	40	3.7	3.7
Teriparatide	131	3.6	3.6
Diclofenac Sodium	174	3.6	3.6
Meclizine Hydrochloride	23	3.6	3.6
Meclizine Hcl 12.5Mg	16	3.6	3.6
Meclizine Hcl 25Mg	16	3.6	3.6
Meclizine Hcl 12.5 Mg	16	3.6	3.6
Meclizine Hcl 25 Mg	16	3.6	3.6
Clindamycin	33	3.6	3.6
Lanreotide Acetate	9	3.5	3.5
Ascorbic Acid	26	3.4	3.4
Ergocalciferol	412	3.4	3.4
Doxyclycline Hyclate	19	3.4	3.4
Meclizine	18	3.4	3.4
Fam-Trastuzumab Deruxtecan-Nxki	11	3.4	3.4
Hyoscyamine Sulfate	10	3.3	3.3
Ketoconazole Foam	16	3.3	3.3
Ketoconazole Cream, 2%	16	3.3	3.3
Cyclobenzaprine	53	3.3	3.3
Insulin Degludec	25	3.3	3.3
Acetylcysteine	10	3.3	3.3
Phytonadione	9	3.3	3.3
Felodipine Extended-Release Tablets	12	3.2	3.2
Felodipine	12	3.2	3.2
Vitamin E	33	3.2	3.2
Trifluridine And Tipiracil	11	3.2	3.2
Iron	68	3.1	3.1
Zinc Chloride	25	3.1	3.1
Progesterone	23	3.1	3.1
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	50	3.1	3.1
Rabeprazole	22	3.1	3.1
Acalabrutinib	12	3.0	3.0
Abaloparatide	29	3.0	3.0
Leflunomide	102	3.0	3.0
Zinc	24	3.0	3.0
Zoledronic Acid	39	3.0	3.0
Abatacept	131	2.9	2.9
Tofacitinib	169	2.9	2.9
Mometasone	17	2.8	2.9
Ketoconazole	16	2.8	2.8
Zinc Gluconate	24	2.8	2.8
Ruxolitinib	65	2.8	2.8
Rucaparib	8	2.8	2.8
Prochlorperazine	25	2.8	2.8
Terbinafine Hydrochloride	8	2.8	2.8
Lovastatin	23	2.8	2.8
Mupirocin	12	2.7	2.7
Rizatriptan Benzoate	9	2.7	2.7
Tamsulosin Hydrochloride	18	2.7	2.7
Fish Oil	79	2.7	2.7
Loratadine Tablet	47	2.7	2.7
Mupirocin Calcium	12	2.7	2.7
Dronabinol	7	2.7	2.7
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	137	2.7	2.7
Losartan Potassium	68	2.7	2.7
Levothyroxine Sodium Anhydrous	86	2.7	2.7
Denosumab	170	2.6	2.6
Losartan	146	2.6	2.6
Brimonidine Tartrate	15	2.6	2.6
Hydroxychloroquine Sulfate	76	2.6	2.6
Docusate Sodium 100Mg	20	2.6	2.6
Diclofenac Potassium, Film Coated	7	2.6	2.6
Diclofenac Potassium Tablets	7	2.6	2.6
Avapritinib	10	2.5	2.5
Linagliptin	15	2.5	2.5
Rituximab	171	2.5	2.5
Docetaxel Anhydrous	55	2.5	2.5
Docetaxel	55	2.5	2.5
Naproxen	63	2.5	2.5
Hydroxyurea	17	2.5	2.5
Metoprolol Succinate	69	2.5	2.5
Cyclobenzaprine Hydrochloride	7	2.4	2.4
Ferrous Sulfate	39	2.4	2.4
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	16	2.4	2.4
Naproxen Sodium, Pseudoephedrine Hydrochloride	16	2.4	2.4
Niacin	9	2.4	2.4
Doxycycline Hyclate	51	2.3	2.3
Oxybutynin	22	2.3	2.3
Doxycycline	51	2.3	2.3
Dapsone	8	2.3	2.3
Trametinib	18	2.3	2.3
Diclofenac Potassium	8	2.3	2.3
Metoprolol Succinate Er Tablets	46	2.3	2.3
Fludarabine Phosphate	29	2.3	2.3
Venetoclax	45	2.3	2.3
Secukinumab	117	2.2	2.2
Lactulose	28	2.2	2.2
Benzonatate	12	2.2	2.2
Ondansetron Hydrochloride	88	2.2	2.2
Guaifenesin	22	2.2	2.2
Atenolol	94	2.2	2.2
Meloxicam	41	2.2	2.2
Amlodipine Besylate	101	2.1	2.1
Fluticasone Propionate	89	2.1	2.1
Dronedarone	7	2.1	2.1
Vismodegib	6	2.1	2.1
Oxycodone And Acetaminophen Tablets	8	2.1	2.1
Olaparib	14	2.1	2.1
Dapagliflozin	21	2.1	2.1
Estradiol Gel 0.1%	30	2.0	2.0
Estradiol Transdermal	30	2.0	2.0
Loratadine	71	2.0	2.0
Sunitinib Malate	26	2.0	2.0
Latanoprost	33	2.0	2.0
Nebivolol Hydrochloride	22	2.0	2.0
Acyclovir	74	2.0	2.0
Omeprazole Magnesium	285	2.0	2.0
Fesoterodine Fumarate	7	2.0	2.0
Triamcinolone Acetonide Ointment Usp, 0.05%	15	2.0	2.0
Valacyclovir Hydrochloride	45	2.0	2.0
Metoroprolol Tartrate	42	2.0	2.0
Carboxymethylcellulose Sodium	6	2.0	2.0
Omeprazole	216	2.0	2.0
Infliximab	137	1.9	1.9
Tizanidine	15	1.9	1.9
Estradiol	54	1.9	1.9
Imatinib	11	1.9	1.9
Inclisiran	5	1.9	1.9
Multivitamin	31	1.9	1.9
Polyethylene Glycol 3350	59	1.9	1.9
Azelastine	11	1.9	1.9
Regorafenib	7	1.9	1.9
Ondansetron	65	1.8	1.8
Ondansetron Tablets	65	1.8	1.8
Fluorouracil	46	1.8	1.8
Teduglutide	8	1.8	1.8
Fluorouracil Cream, 0.5%	45	1.8	1.8
Risankizumab-Rzaa	48	1.8	1.8
Triamcinolone Acetonide	18	1.8	1.8
Voclosporin	5	1.8	1.8
Estrogens, Conjugated	33	1.7	1.7
Sumatriptan	21	1.7	1.7
Conjugated Estrogens	32	1.7	1.7
Nilotinib	16	1.7	1.7
Crisaborole	5	1.6	1.6
Ocrelizumab	32	1.6	1.6
Adalimumab	358	1.6	1.6
Entecavir	6	1.6	1.6
Pemetrexed	11	1.6	1.6
Peginterferon Alfa-2A	27	1.5	1.5
Levocetirizine Dihydrochloride	12	1.5	1.5
Asfotase Alfa	5	1.5	1.5
Mirabegron	19	1.5	1.5
Paclitaxel (Aibumin-Bound)	39	1.5	1.5
Dabrafenib	10	1.5	1.5
Bimekizumab	10	1.4	1.4
Relugolix	11	1.4	1.4
Selinexor	4	1.4	1.4
Paclitaxel	45	1.4	1.4
Naproxen Sodium Tablet	24	1.4	1.4
Pazopanib Hydrochloride	12	1.4	1.4
Apremilast	64	1.3	1.3
Cabozantinib	21	1.3	1.3
Certolizumab Pegol	51	1.3	1.3
Fremanezumab-Vfrm	5	1.3	1.3
Etanercept	256	1.3	1.3
Obinutuzumab	7	1.3	1.3
Oxaliplatin	31	1.3	1.3
Bimatoprost	12	1.3	1.3
Linaclotide	11	1.3	1.3
Carboplatin	50	1.2	1.2
Irinotecan Hydrochloride	5	1.2	1.2
Upadacitinib	31	1.2	1.2
Vibegron	3	1.1	1.1
Romosozumab-Aqqg	5	1.1	1.1
Oral Semaglutide	27	1.1	1.1
Leuprolide Acetate	27	1.1	1.1
Apalutamide	4	1.0	1.0
Lenalidomide	142	1.0	1.0
Lurasidone Hydrochloride	7	1.0	1.0
Sodium Oxybate	22	1.0	1.0
Naltrexone	10	1.0	1.0
Medroxyprogesterone Acetate	16	1.0	1.0
Alirocumab	8	1.0	1.0
Suvorexant	4	0.9	0.9
Axitinib	6	0.9	0.9
Encorafenib	3	0.9	0.9
Conjugated Estrogens And Medroxyprogesterone Acetate	7	0.9	0.9
Patiromer	4	0.9	0.9
Isotretinoin	14	0.9	0.9
Dalfampridine	20	0.9	0.9
Glecaprevir And Pibrentasvir	3	0.8	0.8
Dupilumab	131	0.8	0.8
Orlistat	7	0.8	0.8
Tafamidis	3	0.8	0.8
Exenatide	13	0.8	0.8
Lifitegrast	4	0.8	0.8
Pomalidomide	24	0.7	0.7
Sarilumab	6	0.7	0.7
Evolocumab	36	0.7	0.7
Dimethyl Fumarate	26	0.6	0.6
Pegfilgrastim	20	0.6	0.6
Erenumab-Aooe	10	0.6	0.6
Minoxidil	7	0.5	0.5
Tirzepatide	24	0.5	0.5
Levonorgestrel	25	0.4	0.4
Salicylic Acid	4	0.2	0.2

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.