Reaction

Refusal Of Treatment By Patient reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 6,457 reports · 219 co-occurring drugs

As of the last recalculation, Refusal Of Treatment By Patient appears in 6,457 FAERS reports alongside 219 co-occurring drug terms. The strongest observed disproportionality signal is PALIPERIDONE PALMITATE (PRR 36.7).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Paliperidone Palmitate	347	36.7	37.1
Aflibercept	152	16.1	16.1
Romiplostim	54	11.7	11.7
Pimavanserin Tartrate	189	11.3	11.4
Haloperidol Lactate	73	9.6	9.6
Haloperidol	71	9.5	9.5
Epoetin Alfa	29	7.9	7.9
Aripiprazole	287	7.9	7.9
Aripiprazole Oral	95	7.5	7.5
Aripiprazole Orally Disintegrating	95	7.5	7.5
Olanzapine Pamoate	86	6.9	6.9
Lithium Carbonate	34	6.5	6.5
Paliperidone	46	6.4	6.4
Olanzapine	200	6.2	6.2
Digoxin	130	5.9	5.9
Risperidone	235	5.9	5.9
Warfarin Sodium	82	5.8	5.8
Erythropoietin	36	5.7	5.7
Enalapril Maleate	43	5.6	5.6
Theophylline	19	5.3	5.3
Magnesium Hydroxide	22	5.3	5.3
Clozapine	197	5.2	5.2
Panitumumab	25	5.2	5.2
Ziprasidone	28	5.1	5.1
Theophylline Anhydrous	19	5.0	5.0
Diphenhydramine Hcl	17	4.9	4.9
Ziprasidone Mesylate	21	4.8	4.8
Ascorbic Acid	34	4.7	4.7
Isosorbide Dinitrate	28	4.6	4.6
Divalproex Sodium	62	4.3	4.3
Metolazone	15	4.3	4.3
Carisoprodol	25	4.2	4.2
Leucovorin Calcium	25	4.2	4.2
Lorazepam	228	4.2	4.2
Trimethoprim	15	4.1	4.1
Standardized Senna Concentrate	16	4.1	4.1
Iron Sucrose	12	4.1	4.1
Diltiazem Hydrochloride	41	3.8	3.8
Docusate Sodium - Sennosides	38	3.8	3.8
Quinine	10	3.8	3.8
Glyburide	28	3.7	3.7
Lithium	29	3.7	3.7
Lithium Bromatum	29	3.7	3.7
Brexpiprazole	19	3.7	3.7
Amikacin	19	3.6	3.6
Valproic Acid	35	3.6	3.6
Sennosides 8.6 Mg Tablets	23	3.5	3.5
Memantine	15	3.5	3.5
Memantine Hydrochloride	15	3.5	3.5
Senna	23	3.5	3.5
Meperidine Hydrochloride	10	3.5	3.5
Enoxaparin Sodium	62	3.5	3.5
Midazolam Hydrochloride	29	3.5	3.5
Midazolam	27	3.5	3.5
Metformin Hcl	59	3.5	3.5
Remdesivir	14	3.4	3.4
Senna Leaf	24	3.4	3.4
Losartan Potassium And Hydrochlorothiazide	12	3.3	3.3
Pioglitazone	44	3.3	3.3
Extended Phenytoin Sodium	17	3.3	3.3
Morphine	75	3.3	3.3
Ciprofloxacin Hydrochloride And Hydrocortisone	21	3.3	3.3
Tolterodine Tartrate	9	3.2	3.2
Dronabinol	8	3.2	3.2
Carfilzomib	28	3.2	3.2
Warfarin	123	3.2	3.2
Diazepam Oral Solution (Concentrate)	86	3.1	3.1
Diazepam Oral	86	3.1	3.1
Promethazine Hydrochloride	18	3.1	3.1
Rifampin	14	3.1	3.1
Pyrazinamide	9	3.1	3.1
Docusate Sodium	55	3.1	3.1
Diazepam	114	3.1	3.1
Sennosides	28	3.0	3.0
Salmeterol Xinafoate	8	3.0	3.0
Cisplatin	71	3.0	3.0
Naltrexone	28	2.9	2.9
Temozolomide	19	2.9	2.9
Potassium Chloride, Dextrose Monohydrate	82	2.9	2.9
Potassium Chloride Oral	82	2.9	2.9
Potassium Chloride Extended-Release	82	2.9	2.9
Lactulose	34	2.9	2.9
Meclizine Hcl 12.5Mg	12	2.8	2.8
Meclizine Hcl 25Mg	12	2.8	2.8
Meclizine Hcl 12.5 Mg	12	2.8	2.8
Meclizine Hcl 25 Mg	12	2.8	2.8
Nitroglycerin	47	2.8	2.8
Temazepam	33	2.8	2.8
Enalapril	48	2.8	2.8
Quetiapine	164	2.8	2.8
Insulin	48	2.8	2.8
Niacin	10	2.8	2.8
Metoclopramide Hydrochloride	66	2.8	2.8
Vitamin E	27	2.8	2.8
Mirtazapine	78	2.8	2.8
Darbepoetin Alfa	46	2.8	2.8
Vancomycin	49	2.7	2.7
Donepezil Hydrochloride	31	2.7	2.7
Atropine	7	2.7	2.7
Clonidine	43	2.7	2.7
Potassium Chloride	95	2.7	2.7
Atropine Sulfate	9	2.7	2.7
Azithromycin	33	2.7	2.7
Abacavir Sulfate	8	2.6	2.7
Meclizine Hydrochloride	16	2.6	2.6
Sertraline Hydrochloride	96	2.6	2.6
Quetiapine Fumarate	24	2.6	2.6
Rasagiline Mesylate	9	2.6	2.6
Diphenoxylate Hydrochloride And Atropine Sulfate	11	2.6	2.6
Nicotine Polacrilex Mini	12	2.6	2.6
Nicotine Polarilex	12	2.6	2.6
Erlotinib Hydrochloride	10	2.6	2.6
Hydroxyzine	38	2.6	2.6
Oxybutynin Chloride	7	2.6	2.6
Meclizine	13	2.6	2.6
Azithromycin Monohydrate	33	2.6	2.6
Vancomycin Hydrochloride	52	2.6	2.6
Ezetimibe And Simvastatin	12	2.5	2.5
Infliximab-Dyyb	23	2.5	2.5
Vincristine Sulfate	23	2.5	2.5
Metoroprolol Tartrate	51	2.5	2.5
Gefitinib	7	2.5	2.5
Valproate Sodium	16	2.5	2.5
Glipizide	47	2.5	2.5
Filgrastim	29	2.5	2.5
Oxcarbazepine	25	2.5	2.5
Cefepime	11	2.5	2.5
Cetuximab	24	2.5	2.5
Doxorubicin Hydrochloride	25	2.5	2.5
Bendamustine Hydrochloride	9	2.4	2.4
Cefepime Hydrochloride	12	2.4	2.4
Clonazepam	118	2.4	2.4
Amlodipine Besylate	108	2.4	2.4
Escitalopram	103	2.4	2.4
Denosumab	148	2.4	2.4
Carbidopa And Levodopa	35	2.4	2.4
Zolpidem Tartrate	99	2.4	2.4
Lopinavir And Ritonavir	10	2.4	2.4
Pegfilgrastim	72	2.4	2.4
Ibuprofen And Diphenhydramine Citrate	17	2.4	2.4
Atenolol	96	2.3	2.3
Gemfibrozil	11	2.3	2.3
Buspirone Hydrochloride	8	2.3	2.3
Misoprostol	7	2.3	2.3
Piperacillin Sodium And Tazobactam Sodium	14	2.3	2.3
Amiodarone Hydrochloride	8	2.3	2.3
Furosemide	279	2.3	2.3
Lovastatin	18	2.3	2.3
Irinotecan Hydrochloride	9	2.3	2.3
Thalidomide	25	2.2	2.2
Alprazolam	137	2.2	2.2
Phenytoin	14	2.2	2.2
Blinatumomab	7	2.2	2.2
Granisetron Hydrochloride	7	2.2	2.2
Bicalutamide	10	2.1	2.1
Amantadine	10	2.1	2.1
Insulin Glargine-Yfgn	14	2.1	2.1
Levetiracetam	85	2.1	2.1
Carvedilol	86	2.1	2.1
Lisinopril	191	2.0	2.0
Loratadine And Pseudoephedrine Sulfate	5	2.0	2.0
Losartan Potassium	49	2.0	2.0
Tolvaptan	9	2.0	2.0
Isoniazid	10	2.0	2.0
Sevelamer Carbonate	7	2.0	2.0
Fluorouracil Cream, 0.5%	46	2.0	2.0
Metoclopramide	33	1.9	1.9
Cytarabine	36	1.9	1.9
Fluorouracil	46	1.9	1.9
Rifampicin	6	1.9	1.9
Brentuximab Vedotin	6	1.9	1.9
Rivastigmine	11	1.9	1.9
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	18	1.9	1.9
Patiromer	8	1.9	1.9
Interferon Beta-1B	11	1.9	1.9
Granisetron	6	1.8	1.8
Pegaspargase	7	1.8	1.8
Paricalcitol	8	1.8	1.8
Agalsidase Beta	5	1.7	1.7
Insulin Human	21	1.7	1.7
Teduglutide	7	1.7	1.7
Axicabtagene Ciloleucel	5	1.6	1.6
Encorafenib	5	1.6	1.6
Fentanyl Citrate	9	1.6	1.6
Isopropyl Alcohol	17	1.6	1.6
Derma Foam Excel Hand Sanitizer	4	1.6	1.6
Ethanol	4	1.6	1.6
Fam-Trastuzumab Deruxtecan-Nxki	5	1.6	1.6
Botulinum Toxin Type A	6	1.6	1.6
Pemetrexed	10	1.5	1.5
Asenapine Maleate	4	1.5	1.5
Pseudoephedrine Hcl	5	1.5	1.5
Pemetrexed Disodium	17	1.4	1.4
Lacosamide	16	1.4	1.4
Cannabidiol	10	1.4	1.4
Gemcitabine Hydrochloride	22	1.3	1.3
Erlotinib	4	1.3	1.3
Sofosbuvir	8	1.3	1.3
Carboplatin	51	1.3	1.3
Morphine Sulfate	47	1.3	1.3
Gemcitabine	15	1.2	1.2
Vibegron	3	1.2	1.2
Ribavirin	23	1.2	1.2
Interferon Beta-1A	67	1.1	1.1
Alpelisib	3	1.1	1.1
Eptinezumab-Jjmr	3	1.1	1.1
Lapatinib	5	1.0	1.0
Ledipasvir And Sofosbuvir	6	1.0	1.0
Velpatasvir And Sofosbuvir	4	1.0	1.0
Leuprolide Acetate	23	1.0	1.0
Methoxy Polyethylene Glycol-Epoetin Beta	3	0.9	0.9
Cinacalcet Hydrochloride	12	0.8	0.8
Valbenazine	6	0.8	0.8
Ambrisentan	29	0.7	0.7
Esketamine Hydrochloride	4	0.7	0.7
Droxidopa	4	0.6	0.6
Minoxidil Foam 5% (Womens)	6	0.6	0.6
Evolocumab	27	0.5	0.5
Minoxidil	6	0.4	0.4

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.