Reaction

Concomitant Disease Aggravated reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 6,094 reports · 245 co-occurring drugs

As of the last recalculation, Concomitant Disease Aggravated appears in 6,094 FAERS reports alongside 245 co-occurring drug terms. The strongest observed disproportionality signal is SELEXIPAG (PRR 23.9).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Selexipag	176	23.9	24.1
Fingolimod Hcl	463	19.7	19.8
Bosentan	256	18.1	18.2
Canakinumab	56	17.8	17.9
Macitentan	314	16.3	16.3
Sacubitril And Valsartan	504	16.1	16.1
Ribociclib	144	15.9	16.0
Tolvaptan	66	15.7	15.7
Siponimod	39	15.0	15.1
Methimazole	34	14.9	14.9
Octreotide Acetate	130	14.8	14.8
Nilotinib	118	13.9	14.0
Eplerenone	51	13.7	13.8
Sildenafil Powder,	132	12.9	13.0
0Xygen	168	12.0	12.0
Oxygen	168	12.0	12.0
Secukinumab	474	10.8	10.8
Epoprostenol	41	10.8	10.8
Febuxostat Tablets 40 Mg	30	10.1	10.1
Febuxostat Tablets 80 Mg	30	10.1	10.1
Sildenafil	161	9.7	9.7
Captopril	26	9.3	9.3
Everolimus	131	9.0	9.0
Exemestane	55	8.8	8.9
Omalizumab	203	8.4	8.4
Letrozole	147	8.3	8.3
Ciclesonide	33	8.3	8.3
Letrozole Tablets	113	8.2	8.2
Deferasirox	60	7.8	7.8
Dabrafenib	47	7.7	7.7
Trametinib	53	7.5	7.6
Riociguat	68	7.2	7.2
Tadalafil	199	7.0	7.0
Inclisiran	16	6.8	6.8
Torsemide	65	6.8	6.8
Fulvestrant	64	6.7	6.7
Rivastigmine	36	6.6	6.6
Ofatumumab	63	6.5	6.5
Sildenafil Citrate	230	6.4	6.4
Febuxostat	30	6.1	6.1
Spironolactone	240	6.0	6.0
Alendronate Sodium Tablet	32	5.9	5.9
Brinzolamide	15	5.9	5.9
Amiodarone Hydrochloride	19	5.8	5.8
Amlodipine Besylate And Valsartan	18	5.6	5.6
Colchicine	41	5.3	5.4
Pazopanib Hydrochloride	42	5.3	5.3
Imatinib	27	5.2	5.3
Ranibizumab	40	5.2	5.2
Hydroxyurea	31	5.0	5.0
Dapagliflozin	44	4.8	4.8
Valsartan And Hydrochlorothiazide	19	4.8	4.8
Tranexamic Acid	12	4.6	4.6
Felodipine Extended-Release Tablets	15	4.5	4.5
Felodipine	15	4.5	4.5
Dimenhydrinate	14	4.5	4.5
Telmisartan	23	4.4	4.4
Valsartan Oral	69	4.4	4.4
Alpelisib	11	4.3	4.3
Anastrozole Tablets	27	4.3	4.3
Moxifloxacin Hydrochloride	25	4.2	4.2
Furosemide	464	4.2	4.2
Eltrombopag Olamine	28	4.2	4.2
Desoximetasone	23	4.1	4.1
Fexofenadine Hcl	11	4.1	4.1
Meropenem	38	4.1	4.1
Valsartan	123	4.1	4.1
Cyclosporine	130	4.1	4.1
Pitavastatin Calcium	12	4.0	4.0
Prednisolone	201	3.9	3.9
Prednisolone Oral	201	3.9	3.9
Prednisolone Oral Solution	201	3.9	3.9
Everolimus Tablets	19	3.9	3.9
Sucralfate Oral	16	3.9	3.9
Sucralfate Oral Suspension	16	3.8	3.8
Oxazepam	24	3.8	3.8
Imatinib Mesylate	31	3.8	3.8
Cefazolin Sodium	13	3.7	3.7
Bisoprolol Fumarate	144	3.7	3.7
Nebivolol	17	3.7	3.7
Lubiprostone	10	3.6	3.6
Tobramycin	25	3.6	3.6
Rabeprazole	23	3.6	3.6
Carvedilol	138	3.5	3.5
Nicotine Polacrilex Mini	15	3.4	3.4
Nicotine Polarilex	15	3.4	3.4
Linagliptin	18	3.4	3.4
Doxepin	10	3.4	3.4
Hydrocortisone	87	3.4	3.4
Anti-Itch	65	3.3	3.3
Anti-Pruritic	65	3.3	3.3
Antipruritic (Anti-Itch)	65	3.3	3.3
Cool Relief Gel With Aloe	65	3.3	3.3
Drs. Hydrocortisone	65	3.3	3.3
Hydrocortisone Continuous Spray	65	3.3	3.3
Hydrocortisone Spray	65	3.3	3.3
Anti-Itch Cream	65	3.3	3.3
Hydrocortisone Lotion	65	3.3	3.3
Hydrocortisone Cream 1%	65	3.3	3.3
Hydrocortisone Cream 1/2%	65	3.3	3.3
Hydrocortisone 1%	65	3.3	3.3
Hydrocortisone Cream	65	3.3	3.3
Fexofenadine	16	3.3	3.3
Goserelin	13	3.3	3.3
Zoledronic Acid	38	3.2	3.2
Bisacodyl	13	3.2	3.2
Hydrocortisone Acetate	66	3.1	3.1
Ipratropium Bromide	32	3.1	3.1
Diclofenac Sodium	133	3.1	3.1
Venlafaxine	63	3.0	3.0
Anastrozole	32	3.0	3.0
Candesartan	31	3.0	3.0
Theophylline	10	3.0	3.0
Fluticasone Propionate And Salmeterol Xinafoate	52	3.0	3.0
Prednisolone Acetate	9	3.0	3.0
Digoxin	62	3.0	3.0
Ramipril	105	2.9	2.9
Montelukast	71	2.9	2.9
Suvorexant	11	2.9	2.9
Meloxicam	49	2.9	2.9
Sodium Chloride	65	2.8	2.8
Micafungin Sodium	7	2.8	2.8
Diclofenac	70	2.8	2.8
Theophylline Anhydrous	10	2.8	2.8
Sodium Chloride Tablet	59	2.8	2.8
Sodium Chloride Tablets	59	2.8	2.8
Isoniazid	13	2.7	2.7
Calcium	117	2.7	2.7
Warfarin	100	2.7	2.7
Sucralfate	19	2.7	2.7
Doxepin Hydrochloride	10	2.7	2.7
Moxifloxacin	11	2.7	2.7
Itraconazole	9	2.6	2.6
Oxcarbazepine	25	2.6	2.6
Propofol	28	2.6	2.6
Cefazolin	7	2.6	2.6
Apixaban	51	2.6	2.6
Nifedipine	36	2.6	2.6
Rocuronium Bromide	9	2.6	2.6
Amikacin	13	2.6	2.6
Acetaminophen, Aspirin, And Caffeine	16	2.6	2.6
Doxazosin	21	2.6	2.6
Carbamazepine	50	2.6	2.6
Pyrazinamide	7	2.5	2.5
Carboxymethylcellulose Sodium	7	2.5	2.5
Ergocalciferol	277	2.5	2.5
Acetaminophen And Codeine	9	2.5	2.5
Iron	49	2.5	2.5
Famotidine	85	2.5	2.5
Montelukast Sodium	88	2.5	2.5
Tobramycin Sulfate	9	2.5	2.5
Baclofen	62	2.5	2.5
Enalapril	40	2.5	2.5
Levofloxacin	43	2.4	2.4
Levofloxacin In 5% Dextrose	43	2.4	2.4
Tizanidine	17	2.4	2.4
Loratadine Tablet	38	2.4	2.4
Donepezil Hydrochloride	26	2.4	2.4
Timolol Maleate	7	2.4	2.4
Linezolid	21	2.4	2.4
Acetaminophen, Aspirin (Nsaid) And Caffeine	12	2.4	2.4
Salmeterol Xinafoate	6	2.4	2.4
Doxazosin Mesylate	25	2.4	2.4
Rifampicin	7	2.4	2.4
Dexamethasone Sodium Phosphate	7	2.4	2.4
Liothyronine Sodium	6	2.4	2.4
Rizatriptan Benzoate	7	2.4	2.4
Testosterone	16	2.3	2.3
Midazolam	17	2.3	2.3
Brimonidine Tartrate	12	2.3	2.3
Midazolam Hydrochloride	18	2.3	2.3
Tobramycin Solution	8	2.3	2.3
Rosuvastatin	134	2.3	2.3
Ganciclovir Sodium	7	2.3	2.3
Losartan	114	2.3	2.3
Nebivolol Hydrochloride	22	2.2	2.2
Ursodiol	14	2.2	2.2
Glycerin, Lidocaine	9	2.2	2.2
Fluticasone Furoate And Vilanterol Trifenatate	23	2.2	2.2
Dorzolamide Hydrochloride And Timolol Maleate	5	2.2	2.2
Metoclopramide	34	2.1	2.1
Docosanol	9	2.1	2.1
Lifitegrast	10	2.1	2.1
Clopidogrel Bisulfate	62	2.1	2.1
Benzonatate	10	2.1	2.1
Cetirizine Hydrochloride Allergy	18	2.0	2.0
Cetirizine Hydrochloride Tablets	18	2.0	2.0
Lumacaftor And Ivacaftor	5	2.0	2.0
Timolol	7	2.0	2.0
Isosorbide Mononitrate	12	2.0	2.0
Travoprost	5	2.0	2.0
Tiotropium Bromide	78	2.0	2.0
Botulinum Toxin Type A	7	1.9	1.9
Azelastine	10	1.9	1.9
Voriconazole Injection	12	1.9	1.9
Treprostinil	68	1.9	1.9
Anakinra	9	1.9	1.9
Voriconazole	16	1.8	1.8
Ethyl Alcohol	14	1.8	1.8
Memantine	7	1.7	1.7
Memantine Hydrochloride	7	1.7	1.7
Dornase Alfa	10	1.7	1.7
Lanreotide Acetate	4	1.7	1.7
Empagliflozin	34	1.7	1.7
Dexlansoprazole	21	1.7	1.7
Prasugrel Hydrochloride	5	1.7	1.7
Cyclophosphamide Injection, Solution	86	1.7	1.7
Cyclophosphamide	86	1.7	1.7
Cyclophosphamide For Injection	86	1.7	1.7
Iohexol	4	1.6	1.6
Isopropyl Alcohol	16	1.6	1.6
Icosapent Ethyl	4	1.6	1.6
Trifluridine And Tipiracil	5	1.6	1.6
Fexofenadine Hydrochloride	10	1.6	1.6
Doxorubicin Hydrochloride	15	1.6	1.6
Mometasone Furoate And Formoterol Fumarate Dihydrate	7	1.5	1.5
Fentanyl Citrate	8	1.5	1.5
Nicotine	18	1.5	1.5
Bosutinib	4	1.5	1.5
Nicotine Polacrilex	17	1.5	1.5
Pertuzumab	12	1.5	1.5
Entecavir	5	1.5	1.5
Ifosfamide	9	1.4	1.4
Paclitaxel (Aibumin-Bound)	32	1.3	1.3
Aflibercept	12	1.3	1.3
Paclitaxel	36	1.2	1.2
Alcohol	14	1.2	1.2
Bimatoprost	10	1.2	1.2
Brivaracetam	3	1.1	1.1
Gefitinib	3	1.1	1.1
Docetaxel Anhydrous	22	1.1	1.1
Docetaxel	22	1.1	1.1
Lapatinib	5	1.1	1.1
Rimegepant Sulfate	4	1.1	1.1
Lutetium Lu 177 Vipivotide Tetraxetan	4	1.0	1.0
Erenumab-Aooe	16	1.0	1.0
Ambrisentan	36	1.0	1.0
Paricalcitol	4	1.0	1.0
Dalfampridine	20	1.0	1.0
Palbociclib	25	0.9	0.9
Apremilast	37	0.9	0.9
Ixekizumab	8	0.7	0.7
Guselkumab	5	0.5	0.5
Cinacalcet Hydrochloride	5	0.4	0.4
Copper	3	0.2	0.2

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.