Reaction

Cerebral Atrophy reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,948 reports · 243 co-occurring drugs

As of the last recalculation, Cerebral Atrophy appears in 3,948 FAERS reports alongside 243 co-occurring drug terms. The strongest observed disproportionality signal is VALPROIC ACID (PRR 18.9).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Valproic Acid	110	18.9	19.0
Phenytoin	72	18.5	18.6
Valproate Sodium	64	16.6	16.6
Phenobarbital	42	15.4	15.5
Rivastigmine	54	15.3	15.3
Extended Phenytoin Sodium	44	14.0	14.0
Donepezil Hydrochloride	94	13.8	13.8
Asenapine Maleate	19	11.6	11.6
Divalproex Sodium	97	11.2	11.3
Lithium Carbonate	35	11.0	11.0
Clobazam	48	10.5	10.5
Bicalutamide	29	10.1	10.1
Tolterodine Tartrate	17	10.0	10.0
Digoxin	126	9.5	9.5
Cimetidine	17	9.3	9.4
Amantadine	27	9.3	9.3
Rasagiline Mesylate	19	9.0	9.1
Thiotepa	16	8.9	8.9
Haloperidol Lactate	41	8.8	8.8
Captopril	16	8.8	8.8
Haloperidol	40	8.8	8.8
Theophylline	19	8.8	8.8
Chlorhexidine Gluconate	15	8.7	8.7
Magnesium Hydroxide	22	8.6	8.7
Lamotirigine	114	8.6	8.6
Lamotrigine Extended-Release	114	8.6	8.6
Lamotrigine Chewable Dispersible	114	8.6	8.6
Enalapril Maleate	40	8.6	8.6
Primidone	16	8.3	8.3
Carbamazepine	102	8.2	8.2
Memantine	21	8.1	8.1
Memantine Hydrochloride	21	8.1	8.1
Theophylline Anhydrous	19	8.1	8.1
Isosorbide Dinitrate	28	7.6	7.6
Meperidine Hydrochloride	13	7.5	7.5
Levodopa	17	7.4	7.5
Levetiracetam In Sodium Chloride	104	7.2	7.2
Levetiracetam Oral	104	7.2	7.2
Levetiracetam Injection	104	7.2	7.2
Lithium	34	7.2	7.2
Lithium Bromatum	34	7.2	7.2
Abacavir Sulfate	13	7.1	7.1
Atropine	11	7.0	7.0
Midazolam	33	7.0	7.0
Midazolam Hydrochloride	35	6.9	6.9
Quinine	11	6.8	6.8
Lubiprostone	12	6.7	6.7
Goserelin	17	6.7	6.7
Meclizine Hcl 12.5Mg	17	6.6	6.6
Meclizine Hcl 25Mg	17	6.6	6.6
Meclizine Hcl 12.5 Mg	17	6.6	6.6
Meclizine Hcl 25 Mg	17	6.6	6.6
Temazepam	46	6.5	6.5
Diltiazem Hydrochloride	42	6.5	6.5
Gefitinib	11	6.4	6.4
Timolol Maleate	12	6.4	6.4
Cephalexin	26	6.4	6.4
Atropine Sulfate	13	6.4	6.4
Erythromycin	22	6.2	6.2
Vigabatrin	17	6.2	6.2
Meclizine	19	6.2	6.2
Rabeprazole Sodium	31	6.0	6.0
Alendronate Sodium	112	6.0	6.0
Olanzapine	119	6.0	6.0
Methylprednisolone Acetate	9	5.9	5.9
Glyburide	27	5.9	5.9
Olanzapine Pamoate	45	5.9	5.9
Epoetin Alfa	13	5.8	5.8
Levetiracetam	142	5.8	5.8
Lamotrigine	140	5.8	5.8
Zonisamide	16	5.7	5.7
Fingolimod Hcl	90	5.6	5.6
Lorazepam	183	5.6	5.6
Nitroglycerin	56	5.6	5.6
Losartan Potassium And Hydrochlorothiazide	12	5.5	5.5
Exemestane	22	5.4	5.4
Raloxifene Hydrochloride	15	5.4	5.4
Lacosamide	38	5.4	5.4
Oxybutynin Chloride	9	5.4	5.4
Meclizine Hydrochloride	20	5.4	5.4
Risperidone	130	5.3	5.3
Lactulose	38	5.3	5.3
Ropinirole	15	5.2	5.2
Zidovudine	13	5.1	5.1
Raltegravir	16	5.1	5.1
Vitamin E	30	5.1	5.1
Hydrocortisone Sodium Succinate	9	5.1	5.1
Gentamicin Sulfate	15	5.0	5.0
Diphenoxylate Hydrochloride And Atropine Sulfate	13	5.0	5.0
Zolpidem Tartrate	124	5.0	5.0
Lovastatin	24	5.0	5.0
Enoxaparin Sodium	53	4.9	4.9
Bisacodyl Suppositories	12	4.9	4.9
Biscodyl	12	4.9	4.9
Azithromycin Dihydrate	53	4.8	4.8
Warfarin Sodium	42	4.8	4.8
Cefepime	13	4.8	4.8
Paroxetine Hydrochloride Hemihydrate	30	4.8	4.8
Paroxetine Hydrochloride	81	4.8	4.8
Pegaspargase	11	4.7	4.8
Carbidopa And Levodopa	42	4.7	4.7
Brivaracetam	8	4.7	4.7
Paroxetine	30	4.7	4.7
Lisinopril And Hydrochlorothiazide	9	4.7	4.7
Sucralfate	21	4.6	4.6
Candesartan Cilexetil	23	4.6	4.6
Cefazolin	8	4.6	4.6
Standardized Senna Concentrate	11	4.6	4.6
Docusate Sodium - Sennosides	28	4.6	4.6
Oxcarbazepine	28	4.6	4.6
Bisacodyl	12	4.5	4.5
Enalapril	47	4.5	4.5
Pyrazinamide	8	4.5	4.5
Carisoprodol	16	4.4	4.4
Metoclopramide Hydrochloride	64	4.4	4.4
Ocrelizumab	51	4.4	4.4
Erythropoietin	17	4.4	4.4
Guaifenesin	25	4.3	4.3
Diazepam Oral Solution (Concentrate)	72	4.3	4.3
Diazepam Oral	72	4.3	4.3
Ciprofloxacin Hydrochloride And Hydrocortisone	17	4.3	4.3
Salmeterol Xinafoate	7	4.3	4.3
Lamivudine	25	4.3	4.3
Cefepime Hydrochloride	13	4.3	4.3
Efavirenz	9	4.3	4.3
Diazepam	96	4.2	4.2
Amitriptyline Hydrochloride	14	4.2	4.2
Citalopram Hydrobromide	84	4.2	4.2
Pramipexole	12	4.1	4.1
Citalopram	105	4.1	4.1
Mirtazapine	70	4.1	4.1
Prochlorperazine Maleate	7	4.0	4.0
Insulin	42	4.0	4.0
Potassium Chloride	85	4.0	4.0
Dalteparin Sodium	8	4.0	4.0
Melphalan	17	4.0	4.0
Azithromycin	30	4.0	4.0
Cefazolin Sodium	9	3.9	3.9
Clonazepam	116	3.9	3.9
Lopinavir And Ritonavir	10	3.9	3.9
Metoclopramide	40	3.9	3.9
Gemfibrozil	11	3.8	3.8
Azithromycin Monohydrate	30	3.8	3.8
Human Insulin	9	3.8	3.8
Oxybutynin	21	3.8	3.8
Diphenhydramine Hcl	8	3.8	3.8
Piperacillin Sodium And Tazobactam Sodium	14	3.8	3.8
Amiodarone Hydrochloride	8	3.8	3.8
Lamivudine Oral	18	3.8	3.8
Diltiazem Hydrochloride Extended-Release Tablets	8	3.7	3.7
Zoledronic Acid	28	3.7	3.7
Aspirin 325 Mg	336	3.7	3.7
Aspirin 81 Mg	336	3.7	3.7
Clopidogrel	135	3.7	3.7
Niacin	8	3.6	3.6
Aspirin	347	3.6	3.6
Gentamicin	9	3.6	3.6
Metoroprolol Tartrate	45	3.6	3.6
Letrozole	42	3.6	3.6
Atenolol	90	3.6	3.6
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	14	3.6	3.6
Nifedipine	32	3.6	3.6
Naproxen Sodium, Pseudoephedrine Hydrochloride	14	3.6	3.6
Baclofen	58	3.6	3.6
Melphalan Hydrochloride	17	3.6	3.6
Interferon Beta-1A	128	3.6	3.6
Labetalol	9	3.6	3.6
Sotalol Hydrochloride	11	3.5	3.5
Ezetimibe And Simvastatin	10	3.5	3.5
Pravastatin Sodium	13	3.5	3.5
Cytarabine	39	3.4	3.4
Amlodipine Besylate And Benazepril Hydrochloride	6	3.4	3.4
Estrogens, Conjugated	38	3.4	3.4
Fulvestrant	21	3.4	3.4
Loratadine And Pseudoephedrine Sulfate	5	3.3	3.3
Leucovorin Calcium	12	3.3	3.3
Mycophenilic Acid	13	3.3	3.3
Interferon Beta-1B	12	3.3	3.3
Piperacillin And Tazobactam	8	3.3	3.3
Conjugated Estrogens	36	3.3	3.3
Hydroxyurea	13	3.2	3.2
Darbepoetin Alfa	33	3.2	3.2
Alteplase	9	3.2	3.2
Metoprolol Succinate Er Tablets	37	3.1	3.1
Rifampicin	6	3.1	3.1
Modafinil	19	3.1	3.1
Valsartan And Hydrochlorothiazide	8	3.1	3.1
Ritonavir	17	3.1	3.1
Clobetasol Propionate Ointment Usp, 0.05%	6	3.1	3.1
Insulin Human	23	3.1	3.1
Polyethylene Glycol 3350	55	3.1	3.1
Clobetasol Propionate	6	3.1	3.1
Glipizide	35	3.0	3.0
Propofol	21	3.0	3.0
Blinatumomab	6	3.0	3.0
Busulfan	9	3.0	3.0
Oxazepam	12	2.9	2.9
Clozapine	69	2.9	2.9
Prochlorperazine	15	2.9	2.9
Natalizumab	96	2.8	2.8
Metformin Hcl	29	2.8	2.8
Oxycodone Hydrochloride And Acetaminophen	50	2.7	2.7
Dorzolamide Hydrochloride And Timolol Maleate	4	2.7	2.7
Etoposide	37	2.7	2.7
Fentanyl Citrate	9	2.7	2.7
Fondaparinux Sodium	4	2.6	2.6
Dutasteride	4	2.6	2.6
Pioglitazone	21	2.6	2.6
Dalfampridine	34	2.5	2.5
Crizotinib	6	2.5	2.5
Siponimod	4	2.4	2.4
Nevirapine	4	2.3	2.3
Thalidomide	16	2.3	2.3
Glatiramer Acetate	26	2.3	2.3
Carboplatin	55	2.3	2.3
Rifaximin	9	2.3	2.3
Tenofovir Disoproxil Fumarate	14	2.2	2.2
Axicabtagene Ciloleucel	4	2.1	2.1
Conjugated Estrogens And Medroxyprogesterone Acetate	9	2.0	2.0
Canakinumab	4	2.0	2.0
Atezolizumab	14	1.9	1.9
Cenobamate	3	1.9	1.9
Enzalutamide	21	1.9	1.9
Sofosbuvir	7	1.9	1.9
Hydrocodone Bitartrate	15	1.8	1.8
Paliperidone	8	1.8	1.8
Temozolomide	7	1.8	1.8
Tapentadol Hydrochloride	11	1.7	1.7
Axitinib	6	1.6	1.6
Peginterferon Beta-1A	4	1.6	1.6
Remdesivir	4	1.6	1.6
Palivizumab	4	1.4	1.4
Leuprolide Acetate	20	1.4	1.4
Diroximel Fumarate	3	1.3	1.3
Dimethyl Fumarate	29	1.2	1.2
Droxidopa	5	1.2	1.2
Ranibizumab	6	1.2	1.2
Osimertinib	7	1.2	1.2
Ixazomib	6	1.1	1.1
Paliperidone Palmitate	6	1.0	1.0
Ranitidine Hydrochloride	10	1.0	1.0
Valbenazine	3	0.6	0.6
Pimavanserin Tartrate	6	0.6	0.6

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.