Reaction

Multiple-Drug Resistance reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,054 reports · 178 co-occurring drugs

As of the last recalculation, Multiple-Drug Resistance appears in 3,054 FAERS reports alongside 178 co-occurring drug terms. The strongest observed disproportionality signal is PHENOBARBITAL (PRR 255.8).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Phenobarbital	462	255.8	264.3
Lacosamide	816	203.6	208.1
Clobazam	586	202.2	207.2
Levetiracetam In Sodium Chloride	1,282	193.6	196.9
Levetiracetam Oral	1,282	193.6	196.9
Levetiracetam Injection	1,282	193.6	196.9
Brivaracetam	218	177.8	182.3
Zonisamide	288	146.4	149.3
Levetiracetam	1,482	145.9	147.6
Valproic Acid	537	140.7	143.1
Phenytoin	360	133.2	135.5
Vigabatrin	176	87.3	88.3
Midazolam	292	87.2	88.2
Midazolam Hydrochloride	303	85.0	86.0
Oxcarbazepine	327	76.7	77.4
Nevirapine	82	63.6	64.2
Cenobamate	72	60.2	60.7
Lamotirigine	517	59.0	59.4
Lamotrigine Extended-Release	517	59.0	59.4
Lamotrigine Chewable Dispersible	517	59.0	59.4
Topiramate	609	55.4	55.7
Lamivudine Oral	186	53.3	53.7
Pyrazinamide	70	52.0	52.3
Lamivudine	208	49.2	49.5
Efavirenz	77	48.3	48.6
Abacavir Sulfate	61	43.5	43.8
Cannabidiol	138	42.0	42.3
Carbamazepine	361	41.5	41.7
Tenofovir Disoproxil Fumarate Tablets	48	38.5	38.7
Valproate Sodium	109	37.2	37.4
Propofol	173	34.2	34.3
Lamotrigine	543	33.9	34.1
Entecavir	57	33.9	34.0
Rifampin	70	33.4	33.6
Zidovudine	64	33.3	33.5
Isoniazid	75	32.3	32.5
Amikacin	70	28.6	28.7
Moxifloxacin	56	27.6	27.7
Meropenem	121	26.7	26.8
Erlotinib	37	26.3	26.4
Tofacitinib Citrate	47	24.8	24.9
Anakinra	54	22.6	22.6
Primidone	33	22.3	22.4
Moxifloxacin Hydrochloride	65	22.3	22.4
Ganciclovir	32	21.5	21.6
Erlotinib Hydrochloride	39	21.5	21.6
Ganciclovir Sodium	33	21.5	21.5
Rifampicin	31	21.1	21.1
Ritonavir 100 Mg	42	19.4	19.5
Tenofovir Disoproxil Fumarate	91	19.3	19.4
Human Immunoglobulin G	56	18.8	18.9
Amphotericin B	34	18.7	18.7
Lopinavir And Ritonavir	35	17.8	17.8
Raltegravir	42	17.6	17.6
Darunavir	37	16.9	16.9
Linezolid	72	16.9	16.9
Ritonavir	69	16.4	16.5
Piperacillin Sodium,Tazobactam Sodium	60	15.7	15.7
Clonazepam	327	15.5	15.5
Valganciclovir Hydrochloride Powder,	27	15.2	15.2
Vancomycin	120	14.7	14.7
Ceftriaxone	67	14.2	14.2
Imatinib	36	14.1	14.1
Vancomycin Hydrochloride	129	13.9	13.9
Crizotinib	25	13.5	13.5
Piperacillin And Tazobactam	25	13.4	13.4
Mercaptopurine	33	13.1	13.1
Magnesium Sulfate In Water For	24	12.9	12.9
Ceftriaxone Sodium	70	12.7	12.7
Magnesium Sulfate Heptahydrate	24	12.6	12.7
Magnesium Sulfate	24	12.6	12.6
Adalimumab-Fkjp	81	12.2	12.2
Dolutegravir Sodium	16	12.1	12.2
Gentamicin	23	12.1	12.1
Cefepime	25	12.0	12.0
Adalimumab-Aaty	81	12.0	12.0
Daptomycin	16	11.9	11.9
Voriconazole Injection	36	11.4	11.4
Cytarabine	96	11.2	11.2
Cefepime Hydrochloride	26	11.1	11.1
Ampicillin	13	10.7	10.8
Ampicillin Sodium	13	10.7	10.8
Adalimumab-Adaz	81	10.7	10.7
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Disoproxil Fumarate	14	10.6	10.7
Posaconazole Delayed-Release	17	10.6	10.6
Valganciclovir	29	10.6	10.6
Valganciclovir Hydrochloride	29	10.6	10.6
Itraconazole	18	10.6	10.6
Gentamicin Sulfate	24	10.4	10.4
Busulfan	23	10.0	10.0
Atazanavir	21	10.0	10.0
Pemetrexed	31	9.9	10.0
Gefitinib	13	9.9	9.9
Fluconazole	96	9.6	9.6
Piperacillin Sodium And Tazobactam Sodium	27	9.5	9.5
Minocycline	16	9.4	9.4
Azithromycin	54	9.3	9.3
Methylprednisolone	178	9.3	9.3
Levofloxacin	79	9.1	9.1
Levofloxacin In 5% Dextrose	79	9.1	9.1
Azithromycin Monohydrate	54	9.0	9.0
Diazepam Oral Solution (Concentrate)	113	8.9	9.0
Diazepam Oral	113	8.9	9.0
Ciprofloxacin Tablets	89	8.7	8.7
Ciprofolxacin	88	8.6	8.6
Voriconazole	37	8.4	8.4
Clarithromycin	41	8.2	8.2
Ifosfamide	24	7.7	7.7
Tobramycin Solution	13	7.4	7.4
Divalproex Sodium	49	7.3	7.3
Fludarabine Phosphate	41	7.2	7.2
Lorazepam	180	7.2	7.2
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	19	7.2	7.2
Tobramycin Sulfate	13	7.2	7.2
Posaconazole	17	7.2	7.2
Azithromycin Dihydrate	60	7.1	7.1
Osimertinib	32	6.9	6.9
Diazepam	118	6.8	6.8
Ciprofloxacin	89	6.8	6.8
Sirolimus	13	6.6	6.6
Extended Phenytoin Sodium	16	6.5	6.6
Temozolomide	20	6.5	6.5
Ciprofloxacin Hydrochloride	90	6.5	6.5
Cortisone Acetate	11	6.1	6.1
Cefazolin	8	6.0	6.0
Bleomycin Sulfate	9	6.0	6.0
Prednisolone	151	5.9	6.0
Prednisolone Oral	151	5.9	6.0
Prednisolone Oral Solution	151	5.9	6.0
Basiliximab	10	5.8	5.8
Pemetrexed Disodium	32	5.8	5.8
Cyclophosphamide Injection, Solution	144	5.8	5.8
Cyclophosphamide	144	5.8	5.8
Cyclophosphamide For Injection	144	5.8	5.8
Melphalan Hydrochloride	21	5.7	5.7
Melphalan	19	5.7	5.7
Icosapent Ethyl	7	5.6	5.6
Daspone	8	5.6	5.6
Dapsone Gel, 5%	8	5.6	5.6
Gemcitabine	32	5.6	5.6
Hydroxyurea	16	5.2	5.2
Oseltamivir	6	5.1	5.1
Dapsone	8	5.1	5.1
Cefazolin Sodium	9	5.1	5.1
Cetuximab	23	5.0	5.0
Thiotepa	7	5.0	5.0
Fluorouracil Cream, 0.5%	54	4.9	4.9
Tobramycin	17	4.8	4.8
Micafungin Sodium	6	4.8	4.8
Fluorouracil	54	4.8	4.8
Panitumumab	11	4.8	4.8
Sulfasalazine	53	4.7	4.7
Dasatinib	25	4.6	4.6
Progesterone	15	4.5	4.5
Everolimus Tablets	11	4.5	4.5
Norepinephrine	7	4.5	4.5
Gemcitabine Hydrochloride	33	4.3	4.3
Aflibercept	19	4.2	4.2
Nilotinib	17	3.9	3.9
Paclitaxel (Aibumin-Bound)	45	3.8	3.8
Emtricitabine And Tenofovir Disoproxil Fumarate	25	3.8	3.8
Acyclovir	62	3.8	3.8
Axicabtagene Ciloleucel	5	3.5	3.5
Etoposide	35	3.3	3.3
Canakinumab	5	3.2	3.2
Carboplatin	58	3.2	3.2
Paclitaxel	45	3.1	3.1
Bevacizumab	53	3.0	3.0
Dabrafenib	9	2.9	2.9
Oxaliplatin	31	2.9	2.9
Avapritinib	5	2.8	2.8
Paliperidone	9	2.6	2.6
Trametinib	9	2.5	2.5
Lapatinib	5	2.2	2.2
Sarilumab	8	2.1	2.1
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Alafenamide	3	2.0	2.0
Dornase Alfa	4	1.4	1.4
Adapalene	6	0.2	0.2

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.