Reaction

Skin Necrosis reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,139 reports · 253 co-occurring drugs

As of the last recalculation, Skin Necrosis appears in 5,139 FAERS reports alongside 253 co-occurring drug terms. The strongest observed disproportionality signal is FEBUXOSTAT TABLETS 40 MG (PRR 60.7).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Febuxostat Tablets 40 Mg	148	60.7	61.5
Febuxostat Tablets 80 Mg	148	60.7	61.5
Dimenhydrinate	149	58.3	59.1
Febuxostat	172	43.0	43.4
Sulfasalazine	538	31.0	31.2
Colchicine	164	26.0	26.2
Leflunomide	557	24.1	24.2
Alendronate Sodium	521	23.2	23.3
Tocilizumab	572	22.7	22.8
Risedronate Sodium	159	21.3	21.5
Tofacitinib Citrate	65	20.3	20.4
Adalimumab-Fkjp	217	19.8	19.9
Ibuprofen And Diphenhydramine Citrate	111	19.7	19.8
Adalimumab-Aaty	217	19.3	19.4
Fondaparinux Sodium	38	19.2	19.2
Telmisartan	80	18.4	18.5
Iron Sucrose	42	18.0	18.1
Hydroxychloroquine	312	18.0	18.0
Hydroxychloroquine Sulfate	376	18.0	18.0
Abatacept	537	17.4	17.5
Basiliximab	50	17.4	17.4
Adalimumab-Adaz	216	17.3	17.3
Pramipexole	59	15.8	15.8
Warfarin Sodium	174	15.7	15.7
Golimumab	311	15.6	15.6
Micafungin Sodium	32	15.4	15.4
Dexlansoprazole	149	14.9	14.9
Heparin Sodium	49	14.6	14.6
Doxyclycline Hyclate	56	13.5	13.5
Cyanocobalamin	105	13.2	13.2
Cyclosporine	329	12.7	12.8
Rituximab	582	12.4	12.5
Alendronate Sodium Tablet	55	12.1	12.2
Warfarin	345	11.7	11.7
Infliximab	558	11.5	11.5
Tofacitinib	461	11.0	11.0
Magnesium Oxide	111	11.0	11.0
Rifampicin	27	10.9	10.9
Azathioprine	225	10.8	10.8
Naproxen	196	10.5	10.5
Esomeprazole Magnesium Capsule, Delayed Release	37	10.4	10.4
Esomeprazole Magnesium Delayed Release Capsules	37	10.4	10.4
Posaconazole Delayed-Release	28	10.4	10.4
Esomeprazole Magnesium Dihydrate	37	10.4	10.4
Certolizumab Pegol	278	10.1	10.1
Interferon Beta-1B	47	10.0	10.0
Budesonide	131	9.2	9.2
Norepinephrine Bitartrate	32	9.1	9.1
Vancomycin	123	8.8	8.8
Diphenhydramine Hydrochloride Capsule, Liquid Filled	45	8.6	8.6
Posaconazole	34	8.5	8.5
Voriconazole Injection	45	8.5	8.5
Vancomycin Hydrochloride	131	8.2	8.2
Celecoxib	251	8.1	8.1
Enoxaparin Sodium	112	8.0	8.1
Norepinephrine	21	8.0	8.0
Amphotericin B	24	7.8	7.8
Methotrexate	697	7.6	7.6
Methotrexate Sodium	753	7.2	7.2
Bendamustine Hydrochloride	21	7.1	7.1
Meropenem	55	7.0	7.0
Ustekinumab	169	6.9	6.9
Propranolol Hydrochloride	116	6.6	6.7
Piperacillin And Tazobactam	20	6.4	6.4
Voriconazole	47	6.3	6.3
Prednisone	693	6.3	6.3
Bendamustine Hcl	24	6.3	6.3
Iron	102	6.3	6.3
Naproxen Sodium	206	6.0	6.0
Cefepime	21	6.0	6.0
Gentamicin	19	5.9	5.9
Prednisolone	246	5.7	5.8
Prednisolone Oral	246	5.7	5.8
Prednisolone Oral Solution	246	5.7	5.8
Mycophenilic Acid	29	5.7	5.7
Ramipril	169	5.7	5.7
Valganciclovir Hydrochloride Powder,	17	5.7	5.7
Ceftriaxone	45	5.6	5.6
Esomeprazole	84	5.6	5.6
Dextrose	18	5.6	5.6
Cefepime Hydrochloride	22	5.6	5.6
Dextrose Monohydrate	18	5.5	5.5
Sodium Bicarbonate	31	5.4	5.4
Sodium Bicarbonate Injection,	31	5.4	5.4
Daspone	13	5.4	5.4
Dapsone Gel, 5%	13	5.4	5.4
Ampicillin	11	5.4	5.4
Ampicillin Sodium	11	5.4	5.4
Paroxetine Hydrochloride Hemihydrate	44	5.4	5.4
Paroxetine	44	5.3	5.3
Bisoprolol Fumarate	170	5.2	5.2
Dexamethasone Sodium Phosphate	13	5.2	5.2
Piperacillin Sodium And Tazobactam Sodium	25	5.2	5.2
Paricalcitol	18	5.2	5.2
Efavirenz	14	5.1	5.1
Ceftriaxone Sodium	47	5.0	5.0
Dapsone	13	4.9	4.9
Gentamicin Sulfate	19	4.9	4.9
Glatiramer Acetate	71	4.9	4.9
Doxycycline Hyclate	80	4.9	4.9
Rifaximin	25	4.9	4.9
Lidocaine Hydrochloride And Epinephrine Bitartrate	63	4.8	4.8
Folic Acid	284	4.8	4.8
Lidocaine Hydrochloride	71	4.8	4.8
Methylprednisolone	159	4.8	4.8
Doxycycline	79	4.7	4.8
Desoximetasone	22	4.7	4.7
Apremilast	164	4.7	4.7
Nebivolol	18	4.6	4.6
Tacrolimus Ointment 0.1%	137	4.6	4.6
Erythromycin	21	4.5	4.6
Diphenhydramine Hydrochloride	181	4.5	4.6
Gemcitabine Hydrochloride	59	4.5	4.5
Tacrolimus Extended-Release Capsules	137	4.5	4.5
Sirolimus	15	4.5	4.5
Sorafenib	23	4.5	4.5
Atenolol	143	4.4	4.4
Metronidazole Topical	51	4.4	4.4
Gemcitabine	42	4.3	4.3
Bupivacaine	10	4.3	4.3
Ibuprofen Capsule	207	4.3	4.3
Ibuprofen Tablet, Film Coated	207	4.3	4.3
Ibupfrofen	207	4.3	4.3
Ibuprofen Tablets Usp, 200Mg	207	4.3	4.3
Ibuprofen Oral	207	4.3	4.3
Ibuprofen Capsules 200 Mg	207	4.3	4.3
Ibuprofen 200 Mg	207	4.3	4.3
Ibuprofen 200Mg	207	4.3	4.3
Pyrazinamide	10	4.3	4.3
Phytonadione	9	4.3	4.3
Adalimumab	667	4.2	4.2
Pantoprazole Sodium In 0.9% Sodium Chloride	64	4.2	4.2
Pantoprazole Sodium Injection	64	4.2	4.2
Dalteparin Sodium	11	4.2	4.2
Mycophenolic Acid	33	4.2	4.2
Ixekizumab	38	4.2	4.2
Doxepin Hydrochloride	13	4.2	4.2
Epoetin Alfa	12	4.1	4.1
Mycophenolate Mofetil	135	4.1	4.1
Tacrolimus	155	4.1	4.1
Mycophenolate Mofetil Hydrochloride	135	4.1	4.1
Etanercept	556	4.1	4.1
Valganciclovir	19	4.1	4.1
Valganciclovir Hydrochloride	19	4.1	4.1
Fluconazole	70	4.1	4.1
Adrenalinum	41	4.0	4.0
Tretinoin	8	4.0	4.0
Piperacillin Sodium,Tazobactam Sodium	26	4.0	4.0
Diclofenac	83	4.0	4.0
Canagliflozin	29	3.9	3.9
Oxycodone	176	3.9	3.9
Panitumumab	15	3.9	3.9
Everolimus Tablets	16	3.9	3.9
Lidicaine	46	3.8	3.8
Burn Relief	46	3.8	3.8
Lidocaine Hydrochloride And Epinephrine	46	3.8	3.8
Itraconazole	11	3.8	3.8
Quinine	8	3.8	3.8
Desloratadine	10	3.8	3.8
Lidocaine, Menthol	46	3.8	3.8
Doxorubicin Hydrochloride	30	3.7	3.7
Octreotide Acetate	28	3.7	3.7
Metronidazole	58	3.7	3.7
Paroxetine Hydrochloride	82	3.7	3.7
Secukinumab	142	3.6	3.6
Doxepin	9	3.6	3.6
Ifosfamide	19	3.6	3.6
Cephalexin	19	3.6	3.6
Atovaquone	7	3.5	3.5
Lidocaine 4%	47	3.5	3.5
Hydroxyurea	18	3.5	3.5
Ibuprofen	224	3.4	3.4
Anakinra	14	3.4	3.4
Azacitidine	25	3.4	3.4
Bupropion	37	3.4	3.4
Lidocaine	48	3.4	3.4
Amikacin	14	3.3	3.3
Diclofenac Sodium 1%	29	3.3	3.3
Diclofenac Sodium Topical	29	3.3	3.3
Naproxen Sodium Tablet, Coated	11	3.3	3.3
Naproxen Sodium, Coated Tablets	11	3.3	3.3
Diclofenac Sodium Topical Gel, 1%	29	3.3	3.3
Naproxen Sodium 220Mg	11	3.3	3.3
Insulin	45	3.3	3.3
Amoxicillin And Clavulanate Potassium	22	3.3	3.3
Amiodarone Hydrochloride	9	3.3	3.3
Prasugrel Hydrochloride	8	3.2	3.2
Hydrochlorothiazide	112	3.2	3.2
Indapamide	14	3.2	3.2
Rifampin	11	3.1	3.1
Calcitriol Capsules 0.25 Mcg	15	3.0	3.0
Calcitriol Capsules 0.5 Mcg	15	3.0	3.0
Anti-Thymocyte Globulin (Rabbit)	6	3.0	3.0
Bevacizumab	91	3.0	3.0
Isoniazid	12	3.0	3.0
Calcitriol	15	3.0	3.0
Imatinib	13	3.0	3.0
Cladribine	7	3.0	3.0
Morphine Sulfate	86	2.9	2.9
Bortezomib	63	2.9	2.9
Diclofenac Sodium	104	2.8	2.8
Tenofovir Disoproxil Fumarate Tablets	6	2.8	2.8
Sertraline	80	2.8	2.8
Bleomycin Sulfate	7	2.7	2.7
Terbinafine Hydrochloride	6	2.7	2.7
Tranexamic Acid	6	2.7	2.7
Clarithromycin	23	2.7	2.7
Daptomycin	6	2.6	2.6
Epinephrine	42	2.6	2.6
Simvastatin	158	2.6	2.6
Lamivudine Oral	16	2.6	2.6
Fluorouracil Cream, 0.5%	47	2.5	2.5
Fluorouracil	47	2.5	2.5
Iohexol	5	2.4	2.4
Paclitaxel (Aibumin-Bound)	49	2.4	2.4
Lamivudine	18	2.4	2.4
Cetuximab	18	2.3	2.3
Valproic Acid	18	2.3	2.3
Cytarabine	34	2.3	2.3
Gefitinib	5	2.2	2.2
Etoposide	40	2.2	2.2
Thalidomide	20	2.2	2.2
Irinotecan Hydrochloride	7	2.2	2.2
Paclitaxel	53	2.2	2.2
Doxorubicin	47	2.1	2.1
Cyclophosphamide Injection, Solution	92	2.1	2.1
Cyclophosphamide	92	2.1	2.1
Cyclophosphamide For Injection	92	2.1	2.1
Sunitinib Malate	20	2.1	2.1
Busulfan	8	2.1	2.1
Oxaliplatin	37	2.0	2.0
Pegaspargase	6	2.0	2.0
Brentuximab Vedotin	5	2.0	2.0
Carboplatin	59	1.9	1.9
Rivaroxaban	96	1.9	1.9
Apixaban	31	1.9	1.9
Cisplatin	36	1.9	1.9
Capecitabine	42	1.9	1.9
Siponimod	4	1.8	1.8
Azacitidine For	8	1.8	1.8
Oxycodone Hydrochloride	93	1.7	1.7
Dapagliflozin	13	1.7	1.7
Dabigatran Etexilate	30	1.6	1.6
Docetaxel Anhydrous	26	1.6	1.6
Docetaxel	26	1.6	1.6
Peginterferon Beta-1A	5	1.5	1.5
Interferon Beta-1A	71	1.5	1.5
Sevelamer Carbonate	4	1.4	1.4
Ixazomib	10	1.4	1.4
Dabigatran Etexilate Mesylate	25	1.4	1.4
Apalutamide	4	1.4	1.4
Pazopanib Hydrochloride	9	1.3	1.3
Buprenorphine	21	0.9	0.9

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.