Reaction

Pathological Fracture reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,013 reports · 247 co-occurring drugs

As of the last recalculation, Pathological Fracture appears in 5,013 FAERS reports alongside 247 co-occurring drug terms. The strongest observed disproportionality signal is RISEDRONATE SODIUM (PRR 34.8).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Risedronate Sodium	248	34.8	35.1
Alendronate Sodium	618	28.9	29.0
Denosumab	825	20.0	20.1
Zoledronic Acid	177	18.9	19.0
Alendronate Sodium Tablet	80	18.2	18.3
Chlorhexidine Gluconate	38	17.4	17.5
Romosozumab-Aqqg	56	17.3	17.4
Exemestane	85	16.7	16.8
Goserelin	47	14.7	14.7
Fulvestrant	107	13.7	13.8
Letrozole	188	13.1	13.2
Thalidomide	107	12.3	12.4
Doxepin	27	11.1	11.1
Letrozole Tablets	121	10.7	10.7
Doxepin Hydrochloride	32	10.6	10.6
Docusate Sodium - Sennosides	80	10.5	10.5
Standardized Senna Concentrate	31	10.3	10.3
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Disoproxil Fumarate	22	10.2	10.2
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Alafenamide	24	9.9	10.0
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	42	9.7	9.7
Carfilzomib	65	9.7	9.7
Bortezomib	200	9.6	9.6
Emtricitabine And Tenofovir Alafenamide	26	9.6	9.6
Tenofovir Disoproxil Fumarate Tablets	18	8.7	8.7
Anastrozole	74	8.5	8.5
Daratumumab	79	8.3	8.3
Tenofovir Disoproxil Fumarate	64	8.1	8.1
Emtricitabine And Tenofovir Disoproxil Fumarate	86	7.9	8.0
Bicalutamide	29	7.9	8.0
Docusate Sodium	107	7.8	7.9
Raloxifene Hydrochloride	27	7.7	7.7
Ribociclib	57	7.6	7.6
Melphalan	41	7.5	7.5
Melphalan Hydrochloride	45	7.5	7.5
Anastrozole Tablets	38	7.4	7.4
Abiraterone	24	7.3	7.4
Quinine	15	7.3	7.3
Meperidine Hydrochloride	16	7.2	7.2
Tolterodine Tartrate	15	7.0	7.0
Dexamethasone 1.5 Mg	442	6.8	6.8
Calcium	232	6.7	6.8
Antacid	76	6.7	6.7
Dexamethasone	442	6.7	6.7
Clindamycin	45	6.6	6.6
Dexamethasone Sodium Phosphate	16	6.6	6.6
Everolimus Tablets	26	6.5	6.5
Epoetin Alfa	18	6.3	6.3
Prochlorperazine Maleate	14	6.3	6.3
Clindamycin Phosphate	50	6.3	6.3
Magnesium Hydroxide	20	6.2	6.2
Teriparatide	162	6.1	6.1
Gefitinib	13	6.0	6.0
Sennosides 8.6 Mg Tablets	30	6.0	6.0
Lamivudine Oral	36	5.9	6.0
Senna	30	5.9	5.9
Erythropoietin	29	5.9	5.9
Morphine	101	5.7	5.7
Cefuroxime	15	5.5	5.5
Senna Leaf	30	5.4	5.4
Lamivudine	40	5.4	5.4
Fentanyl	124	5.3	5.3
Calcium Carbonate	85	5.3	5.3
Acetylcysteine	12	5.3	5.3
Selinexor	11	5.3	5.3
Prochlorperazine	35	5.3	5.3
Enoxaparin Sodium	72	5.3	5.3
Docusate Sodium 100Mg	30	5.2	5.2
Cimetidine	12	5.2	5.2
Sennosides	37	5.2	5.2
Fluconazole	85	5.1	5.1
Ketoprofen	16	5.1	5.1
Ampicillin	10	5.0	5.0
Ampicillin Sodium	10	5.0	5.0
Cephalexin	26	5.0	5.0
Diphenoxylate Hydrochloride And Atropine Sulfate	16	4.9	4.9
Abacavir Sulfate	11	4.7	4.7
Losartan Potassium And Hydrochlorothiazide	13	4.7	4.7
Dronabinol	9	4.7	4.7
Atazanavir	16	4.6	4.6
Polyethylene Glycol	12	4.6	4.6
Carisoprodol	21	4.6	4.6
Abiraterone Acetate	45	4.6	4.6
Hyoscyamine Sulfate	10	4.5	4.5
Efavirenz	12	4.5	4.5
Everolimus	54	4.4	4.4
Ado-Trastuzumab Emtansine	9	4.4	4.4
Methocarbamol	24	4.4	4.4
Granisetron	11	4.4	4.4
Lenalidomide	413	4.3	4.3
Lopinavir And Ritonavir	14	4.3	4.3
Rabeprazole Sodium	28	4.3	4.3
Lactulose	39	4.2	4.3
Terazosin Hydrochloride	9	4.2	4.2
Trastuzumab	68	4.2	4.2
Calcium Gluconate	12	4.1	4.1
Gentamicin	13	4.1	4.1
Vitamin E	31	4.1	4.1
Capecitabine	89	4.1	4.1
Zidovudine	13	4.0	4.0
Pertuzumab	26	4.0	4.0
Granisetron Hydrochloride	10	4.0	4.0
Methocarbamol Tablets	16	4.0	4.0
Nystatin Ointment	25	4.0	4.0
Nystatin Cream	25	4.0	4.0
Nystatin	26	4.0	4.0
Diclofenac	81	4.0	4.0
Celecoxib	123	4.0	4.0
Acyclovir	106	3.9	3.9
Enalapril Maleate	23	3.9	3.9
Ciprofolxacin	66	3.9	3.9
Ciprofloxacin Tablets	66	3.9	3.9
Bisacodyl Suppositories	12	3.9	3.9
Biscodyl	12	3.8	3.8
Tobramycin Solution	11	3.8	3.8
Filgrastim	34	3.8	3.8
Pomalidomide	92	3.8	3.8
Temazepam	34	3.8	3.8
Bendamustine Hcl	14	3.8	3.8
Ciprofloxacin	82	3.8	3.8
Lapatinib	14	3.8	3.8
Palbociclib	85	3.7	3.7
Calcitriol Capsules 0.25 Mcg	18	3.7	3.7
Calcitriol Capsules 0.5 Mcg	18	3.7	3.7
Calcitriol	18	3.7	3.7
Tobramycin Sulfate	11	3.7	3.7
Amoxicillin And Clavulanate Potassium	24	3.7	3.7
Lorazepam	155	3.7	3.7
Loratadine And Pseudoephedrine Sulfate	7	3.7	3.7
Tramadol Hydrochloride	33	3.7	3.7
Cabozantinib	42	3.7	3.7
Cefazolin	8	3.6	3.6
Ciprofloxacin Hydrochloride	84	3.6	3.6
Nivolumab	83	3.6	3.6
Hydromorphone Hydrochloride	79	3.6	3.6
Piperacillin Sodium And Tazobactam Sodium	17	3.6	3.6
Zolpidem Tartrate	115	3.6	3.6
Metoclopramide Hydrochloride	66	3.6	3.6
Doxorubicin Hydrochloride	28	3.6	3.6
Ritonavir	25	3.6	3.6
Enzalutamide	50	3.6	3.6
Bisacodyl	12	3.5	3.5
Dalteparin Sodium	9	3.5	3.5
Apalutamide	10	3.5	3.5
Trimethoprim	10	3.5	3.5
Benzonatate	14	3.5	3.5
Cyclophosphamide Injection, Solution	145	3.5	3.5
Cyclophosphamide	145	3.5	3.5
Cyclophosphamide For Injection	145	3.5	3.5
Ergocalciferol	307	3.5	3.5
Amoxicillin	63	3.5	3.5
Gentamicin Sulfate	13	3.4	3.4
Misoprostol	8	3.4	3.4
Polatuzumab Vedotin	8	3.4	3.4
Morphine Sulfate	98	3.4	3.4
Paclitaxel	80	3.4	3.4
Sulfamethoxazole And Trimethoprim	68	3.4	3.4
Salmeterol Xinafoate	7	3.4	3.4
Ritonavir 100 Mg	12	3.3	3.3
Darbepoetin Alfa	43	3.3	3.3
Abemaciclib	16	3.3	3.3
Midazolam	20	3.3	3.3
Esomeprazole	49	3.3	3.3
Azithromycin Dihydrate	46	3.3	3.3
Cyclobenzaprine	39	3.3	3.3
Midazolam Hydrochloride	21	3.2	3.2
Ciprofloxacin Hydrochloride And Hydrocortisone	16	3.2	3.2
Esomeprazole Magnesium	172	3.1	3.1
Famotidine	87	3.1	3.1
Paclitaxel (Aibumin-Bound)	61	3.1	3.1
Oxycodone Hydrochloride And Acetaminophen	73	3.1	3.1
Fondaparinux Sodium	6	3.1	3.1
Sunitinib Malate	29	3.1	3.1
Pemetrexed Disodium	28	3.1	3.1
Metoclopramide	40	3.0	3.0
Methadone	31	3.0	3.0
Ezetimibe And Simvastatin	11	3.0	3.0
Ipilimumab	31	3.0	3.0
Meclizine Hydrochloride	14	3.0	3.0
Lenvatinib	23	2.9	2.9
Felodipine Extended-Release Tablets	8	2.9	2.9
Felodipine	8	2.9	2.9
Atezolizumab	27	2.9	2.9
Fam-Trastuzumab Deruxtecan-Nxki	7	2.9	2.9
Leflunomide	72	2.9	2.9
Ibuprofen And Diphenhydramine Citrate	16	2.9	2.9
Doxorubicin	60	2.8	2.8
Duloxetine	47	2.8	2.8
Sorafenib	14	2.8	2.8
Pioglitazone	29	2.8	2.8
Docetaxel Anhydrous	45	2.8	2.8
Docetaxel	45	2.8	2.8
Carboplatin	84	2.8	2.8
Diclofenac Sodium	99	2.8	2.8
Nevirapine	6	2.8	2.8
Ondansetron	72	2.8	2.8
Ondansetron Tablets	72	2.8	2.8
Vancomycin	38	2.7	2.7
Cortisone Acetate	8	2.7	2.7
Omeprazole Magnesium	279	2.7	2.7
Oxycodone Hydrochloride	138	2.7	2.7
Ondansetron Hydrochloride	78	2.7	2.7
Oxycodone	118	2.7	2.7
Meloxicam	37	2.7	2.7
Axitinib	12	2.6	2.6
Vancomycin Hydrochloride	40	2.5	2.5
Valacyclovir	24	2.4	2.4
Acetaminophen And Codeine	7	2.4	2.4
Bevacizumab	69	2.3	2.3
Pemetrexed	12	2.3	2.3
Eszopiclone	14	2.3	2.3
Ranitidine Hydrochloride	29	2.2	2.2
Gemcitabine	21	2.2	2.2
Alteplase	8	2.2	2.2
Fluticasone Propionate And Salmeterol	22	2.2	2.2
Erlotinib	5	2.1	2.1
Pembrolizumab	54	2.1	2.1
Oxycodone And Acetaminophen	12	2.1	2.1
Conjugated Estrogens And Medroxyprogesterone Acetate	12	2.1	2.1
Leuprolide Acetate	39	2.1	2.1
Cisplatin	39	2.1	2.1
Tobramycin	12	2.1	2.1
Asfotase Alfa	5	2.1	2.1
Timolol	6	2.1	2.1
Gemcitabine Hydrochloride	26	2.0	2.0
Ixazomib	14	2.0	2.0
Pazopanib Hydrochloride	13	2.0	2.0
Trifluridine And Tipiracil	5	1.9	1.9
Travoprost	4	1.9	1.9
Methadone Hydrochloride	5	1.9	1.9
Fluorouracil Cream, 0.5%	35	1.9	1.9
Fluorouracil	35	1.9	1.9
Daptomycin	4	1.8	1.8
Cinacalcet Hydrochloride	20	1.8	1.8
Paricalcitol	6	1.8	1.8
Ifosfamide	9	1.7	1.7
Encorafenib	4	1.7	1.7
Erlotinib Hydrochloride	5	1.7	1.7
Lutetium Lu 177 Vipivotide Tetraxetan	5	1.6	1.6
Diclofenac Potassium, Film Coated	3	1.5	1.5
Diclofenac Potassium Tablets	3	1.5	1.5
Cetuximab	10	1.3	1.3
Crizotinib	4	1.3	1.3
Ledipasvir And Sofosbuvir	6	1.3	1.3
Abaloparatide	9	1.3	1.3
Osimertinib	8	1.0	1.0
Olaparib	5	1.0	1.0
Relugolix	4	0.7	0.7

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.