Reaction

Hepatitis Cholestatic reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,919 reports · 258 co-occurring drugs

As of the last recalculation, Hepatitis Cholestatic appears in 5,919 FAERS reports alongside 258 co-occurring drug terms. The strongest observed disproportionality signal is AMOXICILLIN AND CLAVULANATE POTASSIUM (PRR 29.9).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Amoxicillin And Clavulanate Potassium	223	29.9	30.2
Rifampicin	50	17.5	17.6
Darunavir	70	16.5	16.5
Isoniazid	68	14.9	15.0
Raltegravir	62	13.3	13.4
Piperacillin Sodium,Tazobactam Sodium	99	13.3	13.4
Piperacillin And Tazobactam	46	12.7	12.8
Rifampin	51	12.4	12.4
Pegaspargase	42	12.1	12.2
Pyrazinamide	32	12.0	12.1
Ganciclovir Sodium	36	12.0	12.1
Lopinavir And Ritonavir	46	12.0	12.1
Meropenem	106	11.8	11.8
Ceftriaxone	105	11.4	11.5
Ganciclovir	33	11.4	11.4
Ritonavir 100 Mg	48	11.4	11.4
Ritonavir	91	11.1	11.1
Ceftriaxone Sodium	116	10.8	10.9
Basiliximab	36	10.8	10.9
Dalteparin Sodium	32	10.7	10.7
Oseltamivir	24	10.6	10.7
Daptomycin	27	10.3	10.4
Voriconazole Injection	63	10.3	10.3
Linezolid	84	10.1	10.1
Cefazolin Sodium	34	10.0	10.0
Cefazolin	25	9.7	9.7
Voriconazole	81	9.5	9.5
Abacavir Sulfate	26	9.4	9.4
Enoxaparin Sodium	150	9.4	9.4
Ketoprofen	34	9.2	9.2
Methimazole	20	9.0	9.0
Lamivudine	76	8.7	8.8
Piperacillin Sodium And Tazobactam Sodium	48	8.7	8.7
Levofloxacin	141	8.4	8.4
Levofloxacin In 5% Dextrose	141	8.4	8.4
Dolutegravir Sodium	21	8.2	8.2
Efavirenz	25	7.9	7.9
Lamivudine Oral	56	7.8	7.9
Sulfamethoxazole And Trimethoprim	162	6.9	6.9
Terbinafine Hydrochloride	17	6.7	6.8
Clindamycin	54	6.7	6.8
Clarithromycin	65	6.7	6.7
Amoxicillin	137	6.4	6.4
Clindamycin Phosphate	58	6.2	6.2
Pravastatin Sodium	34	6.1	6.1
Itraconazole	20	6.0	6.0
Posaconazole Delayed-Release	18	5.8	5.8
Metronidazole	102	5.7	5.7
Gentamicin	21	5.7	5.7
Posaconazole	26	5.6	5.7
Ciprofolxacin	113	5.6	5.6
Ciprofloxacin Tablets	113	5.6	5.6
Valganciclovir	30	5.6	5.6
Valganciclovir Hydrochloride	30	5.6	5.6
Enalapril	86	5.5	5.5
Valganciclovir Hydrochloride Powder,	19	5.5	5.5
Ursosiol	30	5.4	5.5
Pantoprazole	372	5.4	5.5
Ticagrelor	49	5.4	5.4
Amikacin	26	5.4	5.4
Gentamicin Sulfate	24	5.4	5.4
Oseltamivir Phosphate	37	5.4	5.4
Amiodarone Hydrochloride	17	5.3	5.4
Amphotericin B	19	5.3	5.4
Emtricitabine And Tenofovir Disoproxil Fumarate	65	5.1	5.1
Esomeprazole	88	5.0	5.1
Ciprofloxacin Hydrochloride	137	5.0	5.1
Ursodiol	31	5.0	5.0
Enalapril Maleate	35	5.0	5.0
Aprepitant	26	5.0	5.0
Cholestyramine	17	5.0	5.0
Pembrolizumab	143	4.9	4.9
Atorvastatin Calcium, Film Coated	94	4.8	4.8
Mycophenilic Acid	28	4.8	4.8
Bisoprolol Fumarate	178	4.7	4.7
Tacrolimus	203	4.7	4.7
Ciprofloxacin	120	4.7	4.7
Acetaminophen Tablet Extended Release	322	4.6	4.6
Pain Reliever	322	4.6	4.6
Acetaminophen 500Mg	322	4.6	4.6
Pemetrexed	28	4.6	4.6
Instalax Polyethylene Glycol 3350	16	4.5	4.5
Moxifloxacin Hydrochloride	26	4.5	4.5
Acetylcysteine	12	4.5	4.5
Pemetrexed Disodium	48	4.5	4.5
Polyethylene Glycol 400	16	4.4	4.4
Azathioprine	108	4.4	4.4
Tacrolimus Ointment 0.1%	149	4.3	4.3
Ramipril	148	4.3	4.3
Tacrolimus Extended-Release Capsules	149	4.3	4.3
Desloratadine	13	4.3	4.3
Clopidogrel Bisulfate	122	4.3	4.3
Fluconazole	84	4.3	4.3
Mycophenolate Mofetil	161	4.3	4.3
Ribavirin	77	4.3	4.3
Mycophenolate Mofetil Hydrochloride	161	4.2	4.3
Sevoflurane	10	4.2	4.2
Trimethoprim	14	4.2	4.2
Atazanavir	17	4.2	4.2
Fosaprepitant Dimeglumine	16	4.1	4.1
Nitrofurantoin	19	4.1	4.1
Azithromycin	46	4.0	4.0
Vancomycin Hydrochloride	75	4.0	4.0
Nitrofurantoin (Monohydrate/Macrocrystals)	19	4.0	4.0
Indomethacin	15	4.0	4.0
Vancomycin	64	3.9	3.9
Fondaparinux Sodium	9	3.9	3.9
Azithromycin Monohydrate	46	3.9	3.9
Candesartan Cilexetil	29	3.9	3.9
Methylprednisolone Sodium Succinate	51	3.9	3.9
Propofol	40	3.9	3.9
Mycophenolic Acid	35	3.9	3.9
Moxifloxacin	15	3.8	3.8
Gemfibrozil	16	3.7	3.7
Diltiazem Hydrochloride Extended-Release Tablets	12	3.7	3.7
Zidovudine	14	3.7	3.7
Azithromycin Dihydrate	61	3.7	3.7
Midazolam Hydrochloride	28	3.7	3.7
Cimetidine	10	3.7	3.7
Midazolam	26	3.6	3.6
Minocycline	12	3.6	3.6
Trifluridine And Tipiracil	11	3.6	3.6
Metronidazole Topical	48	3.6	3.6
Methylprednisolone	137	3.5	3.5
Nebivolol	16	3.5	3.5
Erythropoietin	20	3.4	3.4
Ibuprofen 200 Mg	187	3.4	3.4
Insulin	53	3.4	3.4
Valproic Acid	30	3.4	3.4
Ibuprofen Capsule	186	3.4	3.4
Ibuprofen Tablet, Film Coated	186	3.4	3.4
Ibupfrofen	186	3.4	3.4
Ibuprofen Tablets Usp, 200Mg	186	3.4	3.4
Ibuprofen Oral	186	3.4	3.4
Ibuprofen Capsules 200 Mg	186	3.4	3.4
Ibuprofen 200Mg	186	3.3	3.4
Gemcitabine Hydrochloride	50	3.3	3.3
Exemestane	20	3.3	3.3
Pantoprazole Sodium In 0.9% Sodium Chloride	57	3.3	3.3
Pantoprazole Sodium Injection	57	3.3	3.3
Carbamazepine	61	3.2	3.2
Cefepime	13	3.2	3.2
Sodium Bicarbonate	21	3.2	3.2
Sodium Bicarbonate Injection,	21	3.2	3.2
Brentuximab Vedotin	9	3.1	3.1
Cefepime Hydrochloride	14	3.1	3.1
Clopidogrel	169	3.1	3.1
Finasteride	52	3.0	3.1
Gemcitabine	34	3.0	3.0
Romiplostim	13	3.0	3.0
Lansoprazole	151	3.0	3.0
Allopurinol	132	3.0	3.0
Doxazosin	23	2.9	2.9
Metoclopramide	45	2.9	2.9
Spironolactone	114	2.9	2.9
Sofosbuvir	16	2.9	2.9
Escitslopram	46	2.8	2.8
Fenofibrate	28	2.8	2.8
Ibuprofen	210	2.8	2.8
Ipilimumab	34	2.8	2.8
Cyclosporine	87	2.8	2.8
Bicalutamide	12	2.8	2.8
Escitalopram Oxalate	57	2.8	2.8
Indapamide	14	2.8	2.8
Mirtazapine	71	2.7	2.7
Acetaminophen	336	2.7	2.7
Nevirapine	7	2.7	2.7
Bleomycin Sulfate	8	2.7	2.7
Omeprazole	259	2.7	2.7
Nivolumab	74	2.7	2.7
Peginterferon Alfa-2A	41	2.7	2.7
Temozolomide	16	2.7	2.7
Tenofovir Disoproxil Fumarate	25	2.7	2.7
Norepinephrine	8	2.6	2.6
Atovaquone	6	2.6	2.6
Oxaliplatin	55	2.6	2.6
Oxazepam	16	2.6	2.6
Esomeprazole Magnesium	170	2.6	2.6
Levetiracetam In Sodium Chloride	56	2.6	2.6
Levetiracetam Oral	56	2.6	2.6
Levetiracetam Injection	56	2.6	2.6
Doxazosin Mesylate	26	2.5	2.5
Levetiracetam	94	2.5	2.5
Hydroxyurea	15	2.5	2.5
Micafungin Sodium	6	2.5	2.5
Abemaciclib	14	2.5	2.5
Etoposide	51	2.5	2.5
Ezetimibe	52	2.5	2.5
Ketoconazole	12	2.4	2.4
Paroxetine Hydrochloride Hemihydrate	23	2.4	2.4
Metoclopramide Hydrochloride	53	2.4	2.4
Entecavir	8	2.4	2.4
Fluorouracil Cream, 0.5%	52	2.4	2.4
Paroxetine	23	2.4	2.4
Ketoconazole Foam	10	2.4	2.4
Bosentan	34	2.4	2.4
Isosorbide Mononitrate	14	2.4	2.4
Fluorouracil	52	2.4	2.4
Vismodegib	6	2.4	2.4
Ketoconazole Cream, 2%	10	2.4	2.4
Phenytoin	14	2.4	2.4
Tramadol Hydrochloride	25	2.3	2.3
Ezetimibe And Simvastatin	10	2.3	2.3
Alprazolam	133	2.3	2.3
Vincristine Sulfate	19	2.3	2.3
Warfarin Sodium	30	2.3	2.3
Sorafenib	13	2.2	2.2
Azacitidine	18	2.1	2.1
Encorafenib	6	2.1	2.1
Pazopanib Hydrochloride	16	2.1	2.1
Naproxen Sodium Tablet, Coated	8	2.1	2.1
Naproxen Sodium, Coated Tablets	8	2.1	2.1
Naproxen Sodium 220Mg	8	2.1	2.1
Letrozole Tablets	28	2.1	2.1
Levocetirizine Dihydrochloride	14	2.1	2.1
Carboplatin	71	2.0	2.0
Metformin Hcl	31	2.0	2.0
Norepinephrine Bitartrate	8	2.0	2.0
Rasagiline Mesylate	6	1.9	1.9
Bupivacaine	5	1.9	1.9
Cytarabine	32	1.9	1.9
Panitumumab	8	1.8	1.8
Dapagliflozin	16	1.8	1.8
Cyclophosphamide Injection, Solution	89	1.8	1.8
Cyclophosphamide	89	1.8	1.8
Cyclophosphamide For Injection	89	1.8	1.8
Azacitidine For	9	1.7	1.7
Darbepoetin Alfa	26	1.7	1.7
Rivastigmine	9	1.7	1.7
Dabigatran Etexilate Mesylate	34	1.6	1.7
Dabigatran Etexilate	35	1.6	1.6
Risperidone	58	1.5	1.5
Lacosamide	16	1.5	1.5
Ifosfamide	9	1.5	1.5
Vemurafenib	5	1.5	1.5
Paclitaxel (Aibumin-Bound)	33	1.4	1.4
Doxorubicin	35	1.4	1.4
Dronedarone	4	1.4	1.4
Irinotecan Hydrochloride	5	1.4	1.4
Remdesivir	5	1.3	1.3
Methadone Hydrochloride	4	1.3	1.3
Methoxy Polyethylene Glycol-Epoetin Beta	4	1.3	1.3
Atezolizumab	14	1.3	1.3
Carfilzomib	10	1.2	1.2
Apalutamide	4	1.2	1.2
Bendamustine Hydrochloride	4	1.2	1.2
Elexacaftor, Tezacaftor, And Ivacaftor	4	1.1	1.1
Cetuximab	10	1.1	1.1
Ledipasvir And Sofosbuvir	6	1.1	1.1
Durvalumab	6	1.0	1.0
Abiraterone	4	1.0	1.0
Cabozantinib	14	1.0	1.0
Daratumumab	11	1.0	1.0
Orlistat	7	1.0	1.0
Dornase Alfa	4	0.7	0.7
Pegfilgrastim	20	0.7	0.7
Osimertinib	6	0.7	0.7
Salicylic Acid	4	0.3	0.3

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.