Reaction

Systemic Inflammatory Response Syndrome reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,753 reports · 237 co-occurring drugs

As of the last recalculation, Systemic Inflammatory Response Syndrome appears in 3,753 FAERS reports alongside 237 co-occurring drug terms. The strongest observed disproportionality signal is PHENOBARBITAL (PRR 26.5).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Phenobarbital	68	26.5	26.6
Meropenem	111	19.7	19.8
Midazolam Hydrochloride	93	19.6	19.7
Axicabtagene Ciloleucel	34	19.3	19.3
Piperacillin And Tazobactam	43	18.8	18.9
Nitrofurantoin (Monohydrate/Macrocrystals)	55	18.5	18.6
Nitrofurantoin	53	18.1	18.1
Cytarabine	183	17.7	17.8
Amphotericin B	39	17.4	17.5
Phenytoin	64	17.3	17.3
Piperacillin Sodium And Tazobactam Sodium	60	17.2	17.3
Piperacillin Sodium,Tazobactam Sodium	80	17.1	17.1
Midazolam	71	15.9	15.9
Ganciclovir Sodium	28	14.8	14.8
Cefepime	37	14.4	14.5
Vancomycin	145	14.4	14.5
Fludarabine Phosphate	99	14.3	14.3
Ganciclovir	26	14.2	14.2
Vancomycin Hydrochloride	161	14.1	14.1
Valproic Acid	77	13.8	13.8
Magnesium Sulfate In Water For	31	13.6	13.6
Magnesium Sulfate Heptahydrate	31	13.3	13.3
Daptomycin	22	13.3	13.3
Magnesium Sulfate	31	13.3	13.3
Cefepime Hydrochloride	38	13.2	13.2
Propofol	82	12.7	12.7
Anakinra	33	11.1	11.1
Methylprednisolone Sodium Succinate	90	11.0	11.0
Busulfan	30	10.7	10.7
Doxorubicin	163	10.6	10.6
Ceftriaxone	61	10.5	10.5
Rifampicin	19	10.5	10.5
Norepinephrine Bitartrate	25	9.7	9.7
Ceftriaxone Sodium	65	9.5	9.6
Basiliximab	20	9.5	9.5
Anti-Thymocyte Globulin (Rabbit)	13	9.0	9.0
Norepinephrine	17	8.9	8.9
Alemtuzumab	30	8.7	8.7
Fluconazole	106	8.6	8.6
Zoledronic Acid	61	8.6	8.6
Polyethylene Glycol	16	8.2	8.2
Gentamicin	19	8.1	8.1
Micafungin Sodium	11	7.2	7.2
Filgrastim	48	7.2	7.2
Gentamicin Sulfate	20	7.1	7.1
Amoxicillin And Clavulanate Potassium	34	7.0	7.0
Bendamustine Hydrochloride	15	7.0	7.0
Methylprednisolone	166	6.9	6.9
Melphalan Hydrochloride	31	6.9	6.9
Melphalan	28	6.9	6.9
Fondaparinux Sodium	10	6.9	6.9
Tretinoin	10	6.8	6.9
Ampicillin	10	6.7	6.7
Ampicillin Sodium	10	6.7	6.7
Thiamine Hydrochloride	15	6.7	6.7
Prochlorperazine	33	6.7	6.7
Mycophenolate Mofetil	157	6.6	6.7
Mycophenolate Mofetil Hydrochloride	157	6.6	6.6
Darunavir	18	6.6	6.6
Teduglutide	16	6.6	6.6
Prednisolone	204	6.6	6.6
Prednisolone Oral	204	6.6	6.6
Prednisolone Oral Solution	204	6.6	6.6
Sulfamethoxazole And Trimethoprim	97	6.5	6.5
Bleomycin Sulfate	12	6.5	6.5
Cyclophosphamide Injection, Solution	196	6.4	6.4
Cyclophosphamide	196	6.4	6.4
Cyclophosphamide For Injection	196	6.4	6.4
Iron Sucrose	11	6.4	6.4
Dabrafenib	24	6.4	6.4
Magnesium Hydroxide	15	6.2	6.2
Ciprofloxacin Hydrochloride And Hydrocortisone	23	6.2	6.2
Trimethoprim	13	6.1	6.1
Posaconazole Delayed-Release	12	6.1	6.1
Heparin Sodium	15	6.1	6.1
Adalimumab-Fkjp	50	6.1	6.1
Iohexol	9	6.0	6.0
Sodium Bicarbonate	25	6.0	6.0
Sodium Bicarbonate Injection,	25	6.0	6.0
Metronidazole	68	6.0	6.0
Antacid	50	5.9	5.9
Amikacin	18	5.9	5.9
Ciprofloxacin	95	5.9	5.9
Enoxaparin Sodium	60	5.9	5.9
Isoniazid	17	5.8	5.8
Linezolid	31	5.8	5.8
Adalimumab-Aaty	49	5.8	5.8
Captopril	10	5.8	5.8
Trametinib	25	5.8	5.8
Ciprofolxacin	73	5.7	5.8
Ciprofloxacin Tablets	73	5.7	5.8
Docusate Sodium - Sennosides	33	5.7	5.7
Docusate Sodium 100Mg	24	5.6	5.6
Ciprofloxacin Hydrochloride	96	5.6	5.6
Pemetrexed Disodium	38	5.6	5.6
Levetiracetam In Sodium Chloride	76	5.5	5.5
Levetiracetam Oral	76	5.5	5.5
Levetiracetam Injection	76	5.5	5.5
Atovaquone	8	5.5	5.5
Docusate Sodium	56	5.4	5.5
Prochlorperazine Maleate	9	5.4	5.4
Mycophenolic Acid	31	5.4	5.4
Clindamycin	27	5.3	5.3
Phytonadione	8	5.2	5.2
Ritonavir 100 Mg	14	5.2	5.2
Adalimumab-Adaz	49	5.2	5.2
Azathioprine	81	5.2	5.2
Moxifloxacin	13	5.1	5.1
Dextrose	12	5.1	5.1
Cholestyramine	11	5.1	5.1
Raltegravir	15	5.1	5.1
Ipilimumab	39	5.1	5.1
Atezolizumab	35	5.0	5.0
Levofloxacin	54	5.0	5.0
Levofloxacin In 5% Dextrose	54	5.0	5.0
Valganciclovir Hydrochloride Powder,	11	5.0	5.0
Pegaspargase	11	5.0	5.0
Dextrose Monohydrate	12	5.0	5.0
Erythropoietin	18	4.9	4.9
Mycophenilic Acid	18	4.8	4.8
Lacosamide	32	4.8	4.8
Blinatumomab	9	4.8	4.8
Posaconazole	14	4.8	4.8
Calcium Carbonate	57	4.8	4.8
Carfilzomib	24	4.7	4.7
Clindamycin Phosphate	28	4.7	4.7
Magnesium Oxide	35	4.7	4.7
Canagliflozin	25	4.7	4.7
Everolimus Tablets	14	4.6	4.6
Tacrolimus	126	4.6	4.6
Valproate Sodium	17	4.6	4.6
Vincristine Sulfate	24	4.6	4.6
Levetiracetam	107	4.5	4.5
Clotrimazole	10	4.5	4.5
Allopurinol	123	4.5	4.5
Cyclosporine	88	4.5	4.5
Diphenoxylate Hydrochloride And Atropine Sulfate	11	4.5	4.5
Metolazone	9	4.4	4.5
Doxorubicin Hydrochloride	26	4.4	4.4
Valganciclovir	15	4.4	4.4
Valganciclovir Hydrochloride	15	4.4	4.4
Pemetrexed	17	4.4	4.4
Gemcitabine	31	4.4	4.4
Ritonavir	23	4.4	4.4
Potassium Chloride, Dextrose Monohydrate	72	4.4	4.4
Potassium Chloride Oral	72	4.4	4.4
Potassium Chloride Extended-Release	72	4.4	4.4
Fentanyl Citrate	14	4.4	4.4
Brentuximab Vedotin	8	4.3	4.3
Drs. Clotrimazole	9	4.3	4.3
Family Wellness Clotrimazole	9	4.3	4.3
Clotrimazole Topical	9	4.3	4.3
Bendamustine Hcl	12	4.3	4.3
Gemcitabine Hydrochloride	40	4.2	4.2
Sodium Chloride	59	4.2	4.2
Sodium Chloride Tablet	55	4.2	4.2
Sodium Chloride Tablets	55	4.2	4.2
Rifampin	11	4.2	4.2
Ondansetron	81	4.2	4.2
Ondansetron Tablets	81	4.2	4.2
Vemurafenib	9	4.2	4.2
Carboplatin	93	4.1	4.1
Sirolimus	10	4.1	4.1
Metronidazole Topical	35	4.1	4.1
Ondansetron Hydrochloride	88	4.1	4.1
Tacrolimus Ointment 0.1%	89	4.0	4.0
Mesna Injection	6	4.0	4.0
Tacrolimus Extended-Release Capsules	89	4.0	4.0
Human Insulin	9	4.0	4.0
Loperamide Hydrochloride	32	4.0	4.0
Abacavir Sulfate	7	4.0	4.0
Etoposide	52	4.0	4.0
Mesna	6	4.0	4.0
Azacitidine	21	3.9	3.9
Haloperidol	17	3.9	3.9
Loperamide Hcl	9	3.9	3.9
Sitagliptin And Metformin Hydrochloride	15	3.9	3.9
Voriconazole Injection	15	3.8	3.8
Loperamide Hydrochloride And Dimethicone	22	3.8	3.8
Haloperidol Lactate	17	3.8	3.8
Loperamide Hydrochloride Oral	7	3.8	3.8
Nivolumab	65	3.8	3.8
Rituximab	138	3.7	3.7
Voriconazole	20	3.7	3.7
Metoclopramide Hydrochloride	50	3.6	3.6
Ifosfamide	14	3.6	3.6
Aprepitant	12	3.6	3.6
Pyrazinamide	6	3.5	3.5
Acyclovir	71	3.5	3.5
Leucovorin Calcium	12	3.5	3.5
Thiotepa	6	3.5	3.5
Fexofenadine	10	3.4	3.4
Azacitidine For	11	3.4	3.4
Clopidogrel Bisulfate	61	3.3	3.3
Dexamethasone 1.5 Mg	171	3.3	3.3
Pembrolizumab	62	3.3	3.3
Dexamethasone	171	3.3	3.3
Alpelisib	5	3.2	3.2
Miconazole Nitrate	5	3.2	3.2
Glimepiride	22	3.1	3.1
Brimonidine Tartrate	10	3.1	3.1
Dolutegravir Sodium	5	3.1	3.1
Obinutuzumab	9	3.0	3.0
Irinotecan Hydrochloride	7	3.0	3.0
Daratumumab	21	2.9	2.9
Remdesivir	7	2.9	2.9
Paclitaxel	51	2.9	2.9
Regorafenib	6	2.9	2.9
Cisplatin	40	2.9	2.9
Paclitaxel (Aibumin-Bound)	42	2.9	2.9
Oseltamivir	4	2.8	2.8
Oxaliplatin	36	2.7	2.7
Rifaximin	10	2.7	2.7
Clozapine	57	2.5	2.5
Bortezomib	40	2.5	2.5
Panitumumab	7	2.5	2.5
Oseltamivir Phosphate	10	2.3	2.3
Erlotinib Hydrochloride	5	2.2	2.2
Dasatinib	14	2.1	2.1
Abiraterone	5	2.0	2.0
Liraglutide	18	2.0	2.0
Sevelamer Carbonate	4	1.9	1.9
Pegfilgrastim	34	1.9	1.9
Pirfenidone	14	1.9	1.9
Botulinum Toxin Type A	4	1.8	1.8
Cetuximab	10	1.8	1.8
Belimumab	10	1.8	1.8
Ledipasvir And Sofosbuvir	6	1.7	1.7
Sofosbuvir	6	1.7	1.7
Eltrombopag Olamine	7	1.7	1.7
Ofatumumab	10	1.7	1.7
Pazopanib Hydrochloride	8	1.6	1.6
Methoxy Polyethylene Glycol-Epoetin Beta	3	1.5	1.5
Voxelotor	6	1.5	1.5
Abiraterone Acetate	9	1.2	1.2
Lenalidomide	80	1.1	1.1
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	5	0.9	0.9

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.