Reaction

Aortic Valve Incompetence reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 4,212 reports · 292 co-occurring drugs

As of the last recalculation, Aortic Valve Incompetence appears in 4,212 FAERS reports alongside 292 co-occurring drug terms. The strongest observed disproportionality signal is CAPTOPRIL (PRR 21.3).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Captopril	41	21.3	21.4
Digoxin	254	18.6	18.6
Eplerenone	46	17.9	18.0
Torsemide	108	16.5	16.6
Gentamicin	39	14.9	14.9
Enalapril Maleate	71	14.4	14.4
Candesartan Cilexetil	74	14.1	14.2
Gentamicin Sulfate	43	13.6	13.6
Chlorhexidine Gluconate	19	10.3	10.3
Ampicillin	17	10.2	10.2
Ampicillin Sodium	17	10.2	10.2
Metolazone	22	9.7	9.7
Diltiazem Hydrochloride	67	9.7	9.7
Felodipine Extended-Release Tablets	22	9.6	9.6
Felodipine	22	9.6	9.6
Standardized Senna Concentrate	24	9.5	9.5
Paroxetine Hydrochloride	168	9.5	9.5
Doxazosin Mesylate	68	9.4	9.5
Amiodarone Hydrochloride	21	9.3	9.3
Sodium Bicarbonate	43	9.2	9.2
Sodium Bicarbonate Injection,	43	9.2	9.2
Candesartan	64	9.0	9.0
Carvedilol	233	9.0	9.0
Nitroglycerin	95	8.9	8.9
Tolterodine Tartrate	16	8.8	8.9
Brivaracetam	16	8.8	8.8
Cimetidine	17	8.8	8.8
Cephalexin	38	8.7	8.8
Alendronate Sodium	170	8.6	8.6
Meperidine Hydrochloride	16	8.6	8.6
Atropine	14	8.4	8.4
Telmisartan	30	8.4	8.4
Cenobamate	14	8.3	8.3
Tamsulosin Hydrochloride	33	8.0	8.1
Valsartan Oral	85	7.9	7.9
Cannabidiol	36	7.7	7.7
Linagliptin	28	7.6	7.6
Timolol Maleate	15	7.5	7.5
Promethazine Hydrochloride	28	7.5	7.5
Furosemide	539	7.5	7.5
Bisoprolol Fumarate	197	7.5	7.5
Spironolactone	201	7.4	7.4
Ascorbic Acid	34	7.3	7.3
Losartan Potassium And Hydrochlorothiazide	17	7.3	7.3
Esomeprazole Magnesium Capsule, Delayed Release	21	7.2	7.2
Esomeprazole Magnesium Delayed Release Capsules	21	7.2	7.2
Esomeprazole Magnesium Dihydrate	21	7.2	7.2
Vitamin E	45	7.1	7.1
Quinine	12	6.9	6.9
Meclizine Hcl 12.5Mg	19	6.9	6.9
Meclizine Hcl 25Mg	19	6.9	6.9
Meclizine Hcl 12.5 Mg	19	6.9	6.9
Meclizine Hcl 25 Mg	19	6.9	6.9
Nebivolol	22	6.9	6.9
Methoxy Polyethylene Glycol-Epoetin Beta	15	6.7	6.7
Amphotericin B	17	6.7	6.7
Ipratropium Bromide	48	6.7	6.7
Potassium Chloride	149	6.7	6.7
Enalapril	73	6.6	6.6
Warfarin Sodium	61	6.6	6.6
Docusate Sodium - Sennosides	42	6.5	6.5
Sevelamer Carbonate	15	6.5	6.5
Valsartan	133	6.4	6.4
Atropine Sulfate	14	6.4	6.4
Doxazosin	36	6.4	6.4
Rifampicin	13	6.4	6.4
Valganciclovir	24	6.3	6.3
Valganciclovir Hydrochloride	24	6.3	6.3
Clobazam	31	6.3	6.3
Epoetin Alfa	15	6.3	6.3
Magnesium Hydroxide	17	6.3	6.3
Potassium Chloride, Dextrose Monohydrate	114	6.2	6.2
Potassium Chloride Oral	114	6.2	6.2
Potassium Chloride Extended-Release	114	6.2	6.2
Carbidopa And Levodopa	59	6.2	6.2
Valsartan And Hydrochlorothiazide	17	6.2	6.2
Estrogens, Conjugated	72	6.1	6.1
Meclizine	20	6.1	6.1
Conjugated Estrogens	69	5.9	5.9
Amlodipine Besylate And Benazepril Hydrochloride	11	5.9	5.9
Agalsidase Beta	11	5.9	5.9
Gemfibrozil	18	5.9	5.9
Trastuzumab	80	5.9	5.9
Warfarin	146	5.8	5.9
Rabeprazole Sodium	32	5.8	5.8
Tolvaptan	17	5.8	5.8
Clopidogrel	219	5.7	5.7
Risedronate Sodium	35	5.6	5.6
Isosorbide Dinitrate	22	5.6	5.6
Meclizine Hydrochloride	22	5.6	5.6
Methylprednisolone Acetate	9	5.6	5.6
Hydrochlorothiazide	158	5.5	5.6
Nifedipine	52	5.5	5.5
Irbesartan	49	5.5	5.5
Azithromycin Dihydrate	64	5.5	5.5
Melphalan	25	5.5	5.5
Clopidogrel Bisulfate	109	5.4	5.4
Sotalol Hydrochloride	18	5.4	5.4
Zonisamide	16	5.4	5.4
Melphalan Hydrochloride	27	5.3	5.4
Glyburide	26	5.3	5.3
Aspirin 325 Mg	499	5.3	5.3
Aspirin 81 Mg	499	5.3	5.3
Pantoprazole Sodium	155	5.3	5.3
Aspirin	518	5.3	5.3
Insulin	59	5.3	5.3
Thalidomide	39	5.3	5.3
Bumetanide	28	5.3	5.3
Pantoprazole Sodium In 0.9% Sodium Chloride	65	5.2	5.3
Pantoprazole Sodium Injection	65	5.2	5.3
Ramipril	128	5.2	5.2
Human Insulin	13	5.2	5.2
Exemestane	22	5.1	5.1
Sertraline Hydrochloride	119	5.1	5.1
Metoprolol Tartrate	264	5.0	5.0
Enoxaparin Sodium	56	4.9	4.9
Esomeprazole	60	4.8	4.8
Goserelin	13	4.8	4.8
Theophylline Anhydrous	12	4.8	4.8
Ciprofloxacin Hydrochloride And Hydrocortisone	20	4.8	4.8
Docusate Sodium	55	4.8	4.8
Rifampin	14	4.8	4.8
Raloxifene Hydrochloride	14	4.8	4.8
Metoprolol Succinate	82	4.7	4.8
Metoprolol Succinate Er Tablets	59	4.7	4.7
Dofetilide	10	4.7	4.7
Niacin	11	4.7	4.7
Lovastatin	24	4.6	4.6
Salmeterol Xinafoate	8	4.6	4.6
Ezetimibe And Simvastatin	14	4.6	4.6
Bicalutamide	14	4.6	4.6
Nystatin Ointment	24	4.5	4.5
Nystatin Cream	24	4.5	4.5
Midazolam	23	4.5	4.5
Temazepam	34	4.5	4.5
Testosterone	21	4.5	4.5
Dapagliflozin	28	4.4	4.4
Metoroprolol Tartrate	58	4.4	4.4
Quinapril Hydrochloride	7	4.4	4.4
Nystatin	24	4.4	4.4
Metoprolol	215	4.3	4.4
Fenofibrate	31	4.3	4.3
Amoxicillin	66	4.3	4.3
Amlodipine Besylate	125	4.3	4.3
Theophylline	10	4.3	4.3
Letrozole	53	4.3	4.3
Sacubitril And Valsartan	99	4.3	4.3
Simvastatin	209	4.3	4.3
Vancomycin Hydrochloride	56	4.2	4.2
Vancomycin	49	4.2	4.2
Metoprolol Tartrate Injection	157	4.2	4.2
Zolpidem Tartrate	112	4.2	4.2
Pantoprazole	206	4.2	4.2
Glipizide	51	4.2	4.2
Ceftriaxone Sodium	32	4.1	4.1
0Xygen	41	4.1	4.1
Oxygen	41	4.1	4.1
Bendamustine Hydrochloride	10	4.1	4.1
Nebivolol Hydrochloride	28	4.1	4.1
Remdesivir	11	4.1	4.1
Allopurinol	126	4.1	4.1
Losartan Potassium	64	4.1	4.1
Ibuprofen And Diphenhydramine Citrate	19	4.0	4.0
Mycophenolic Acid	26	4.0	4.0
Amlodipine Besylate And Valsartan	9	4.0	4.0
Levothyroxine Sodium Anhydrous	80	4.0	4.0
Ezetimibe	60	4.0	4.0
Erythromycin	15	4.0	4.0
Atorvastatin Calcium	191	4.0	4.0
Ceftriaxone	26	3.9	3.9
Febuxostat Tablets 40 Mg	8	3.9	3.9
Febuxostat Tablets 80 Mg	8	3.9	3.9
Lactulose	30	3.9	3.9
Senna Leaf	18	3.9	3.9
Cyclobenzaprine Hydrochloride	7	3.9	3.9
Famotidine	90	3.8	3.8
Amoxicillin And Clavulanate Potassium	21	3.8	3.8
Bleomycin Sulfate	8	3.8	3.8
Isosorbide Mononitrate	16	3.8	3.8
Anastrozole	28	3.8	3.8
Darbepoetin Alfa	41	3.8	3.8
Norepinephrine Bitartrate	11	3.8	3.8
Ferrous Sulfate	38	3.8	3.8
Dorzolamide Hydrochloride And Timolol Maleate	6	3.8	3.8
Methocarbamol	17	3.7	3.7
Celecoxib	97	3.7	3.7
Levothyroxine Sodium	226	3.7	3.7
Atenolol	98	3.7	3.7
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	37	3.7	3.7
Carisoprodol	14	3.6	3.6
Rosuvastatin	145	3.6	3.6
Guaifenesin	22	3.6	3.6
Extended Phenytoin Sodium	12	3.6	3.6
Sennosides 8.6 Mg Tablets	15	3.5	3.5
Senna	15	3.5	3.5
Donepezil Hydrochloride	26	3.5	3.5
Eszopiclone	18	3.5	3.5
Propranolol Hydrochloride	50	3.5	3.5
Phenobarbital	10	3.4	3.4
Lisinopril	203	3.4	3.4
Colchicine	18	3.4	3.4
Erythropoietin	14	3.4	3.4
Conjugated Estrogens And Medroxyprogesterone Acetate	16	3.4	3.4
Metformin Hcl	37	3.3	3.3
Lansoprazole	117	3.3	3.3
Minoxidil Foam 5% (Womens)	22	3.3	3.3
Ribociclib	21	3.3	3.3
Benzonatate	11	3.3	3.3
Everolimus Tablets	11	3.2	3.2
Nilotinib	19	3.2	3.2
Esomeprazole Magnesium	146	3.2	3.2
Finasteride	38	3.1	3.1
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	13	3.1	3.1
Naproxen Sodium, Pseudoephedrine Hydrochloride	13	3.1	3.1
Everolimus	32	3.1	3.1
Amlodipine	163	3.1	3.1
Doxorubicin Hydrochloride	20	3.0	3.0
Ibuprofen Sodium	26	3.0	3.0
Pravastatin Sodium	12	3.0	3.0
Propofol	22	3.0	3.0
Atorvastatin Calcium, Film Coated	42	3.0	3.0
Loratadine Tablet	32	3.0	3.0
Prasugrel Hydrochloride	6	2.9	2.9
Apixaban	39	2.9	2.9
Clobetasol Propionate Ointment Usp, 0.05%	6	2.9	2.9
Clobetasol Propionate	6	2.9	2.9
Pioglitazone	25	2.9	2.9
Levodopa	7	2.9	2.9
Norepinephrine	6	2.8	2.8
Oxycodone Hydrochloride And Acetaminophen	55	2.8	2.8
Cefepime Hydrochloride	9	2.8	2.8
Cefepime	8	2.8	2.8
Letrozole Tablets	26	2.7	2.7
Imatinib Mesylate	15	2.7	2.7
Febuxostat	9	2.7	2.7
Insulin Human	21	2.6	2.6
Capecitabine	48	2.6	2.6
Iron Sucrose	5	2.6	2.6
Ibuprofen Tablets, Coated	22	2.6	2.6
Romosozumab-Aqqg	7	2.6	2.6
Lanreotide Acetate	4	2.5	2.5
Tafamidis	6	2.5	2.5
Loratadine And Pseudoephedrine Sulfate	4	2.5	2.5
Fondaparinux Sodium	4	2.4	2.4
Minoxidil	22	2.4	2.4
Atazanavir	7	2.4	2.4
Mesna Injection	4	2.4	2.4
Amphetamine	4	2.4	2.4
Mesna	4	2.3	2.3
Dabrafenib	10	2.3	2.3
Ado-Trastuzumab Emtansine	4	2.3	2.3
Pancrelipase	18	2.3	2.3
Brinzolamide	4	2.3	2.3
Trametinib	11	2.3	2.3
Bendamustine Hcl	7	2.2	2.2
Lapatinib	7	2.2	2.2
Memantine	6	2.2	2.2
Memantine Hydrochloride	6	2.2	2.2
Hydrocodone Bitartrate	19	2.2	2.2
Lacosamide	16	2.1	2.1
Bortezomib	38	2.1	2.1
Daratumumab	17	2.1	2.1
Thiotepa	4	2.1	2.1
Interferon Beta-1B	8	2.1	2.1
Dabigatran Etexilate Mesylate	30	2.0	2.0
Timolol	5	2.0	2.0
Dabigatran Etexilate	32	2.0	2.0
Ticagrelor	13	2.0	2.0
Pertuzumab	11	2.0	2.0
Carfilzomib	11	1.9	1.9
Irinotecan Hydrochloride	5	1.9	1.9
Bimatoprost	11	1.9	1.9
Peginterferon Beta-1A	5	1.9	1.9
Temozolomide	8	1.9	1.9
Methadone Hydrochloride	4	1.8	1.8
Clozapine	46	1.8	1.8
Asenapine Maleate	3	1.7	1.7
Voclosporin	3	1.7	1.7
Teriparatide	38	1.7	1.7
Siponimod	3	1.7	1.7
Cortisone Acetate	4	1.6	1.6
Ranibizumab	8	1.5	1.5
Paliperidone	7	1.5	1.5
Ranolazine	3	1.4	1.4
Hydrocodone Bitartrate And Acetaminophen	16	1.4	1.4
Paricalcitol	4	1.4	1.4
Abiraterone Acetate	10	1.2	1.2
Etonogestrel	10	1.0	1.0
Vigabatrin	3	1.0	1.0
Cinacalcet Hydrochloride	8	0.8	0.8
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	5	0.8	0.8
Pirfenidone	6	0.7	0.7

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.