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Which drugs are most reported with Cardiotoxicity?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 8,750 reports · 254 co-occurring drugs

As of the last recalculation, Cardiotoxicity appears in 8,750 FAERS reports alongside 254 co-occurring drug terms. The strongest observed disproportionality signal is TRASTUZUMAB (PRR 48.1).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Trastuzumab	1,202	48.1	49.0
Doxorubicin	1,221	37.7	38.2
Pertuzumab	335	30.4	30.8
Doxorubicin Hydrochloride	399	30.4	30.8
Bleomycin Sulfate	95	22.1	22.3
Ado-Trastuzumab Emtansine	76	21.6	21.8
Ifosfamide	180	20.3	20.5
Cyclophosphamide Injection, Solution	1,211	18.7	18.8
Cyclophosphamide	1,211	18.7	18.8
Cyclophosphamide For Injection	1,211	18.7	18.8
Fluorouracil Cream, 0.5%	493	16.2	16.3
Fluorouracil	493	16.0	16.1
Itraconazole	74	15.2	15.3
Etoposide	425	14.4	14.5
Mesna Injection	49	14.2	14.3
Mesna	49	13.9	14.0
Docetaxel Anhydrous	377	13.9	13.9
Docetaxel	377	13.9	13.9
Vincristine Sulfate	161	13.3	13.4
Oxaliplatin	391	13.1	13.1
Capecitabine	453	12.4	12.4
Cytarabine	293	12.0	12.0
Lapatinib	76	11.7	11.8
Imatinib	85	11.6	11.6
Norepinephrine	50	11.2	11.2
Loperamide Hydrochloride Oral	47	11.0	11.0
Cisplatin	344	10.9	10.9
Paclitaxel (Aibumin-Bound)	357	10.7	10.8
Busulfan	68	10.4	10.4
Thiotepa	39	9.8	9.8
Loperamide Hcl	51	9.5	9.5
Acalabrutinib	48	9.5	9.5
Paclitaxel	375	9.4	9.4
Norepinephrine Bitartrate	55	9.1	9.2
Melphalan Hydrochloride	95	9.1	9.1
Melphalan	83	8.8	8.8
Carfilzomib	100	8.5	8.5
Fludarabine Phosphate	126	7.7	7.7
Mercaptopurine	55	7.6	7.6
Carboplatin	382	7.4	7.5
Gemcitabine	120	7.3	7.4
Blinatumomab	31	7.1	7.1
Leucovorin Calcium	56	7.0	7.0
Venlafaxine	204	6.9	6.9
Gemcitabine Hydrochloride	149	6.8	6.8
Fam-Trastuzumab Deruxtecan-Nxki	28	6.6	6.6
Bupropion	116	6.3	6.3
Phenobarbital	38	6.3	6.3
Aprepitant	47	6.1	6.1
Tocilizumab	279	6.0	6.0
Rituximab	494	5.8	5.8
Hydroxychloroquine	176	5.7	5.7
Osimertinib	73	5.5	5.5
Adrenalinum	90	5.2	5.2
Midazolam Hydrochloride	57	5.1	5.1
Filgrastim	79	5.0	5.0
Polyethylene Glycol	22	4.8	4.9
Lacosamide	73	4.7	4.7
Insulin Glargine-Yfgn	43	4.7	4.7
Fosaprepitant Dimeglumine	27	4.7	4.7
Pemetrexed	42	4.7	4.7
Brentuximab Vedotin	20	4.6	4.7
Piperacillin And Tazobactam	24	4.5	4.5
Dexamethasone Sodium Phosphate	19	4.5	4.5
Midazolam	47	4.5	4.5
Trametinib	44	4.3	4.4
Irinotecan Hydrochloride	23	4.3	4.3
Piperacillin Sodium,Tazobactam Sodium	47	4.2	4.2
Anastrozole Tablets	38	4.2	4.2
Lidicaine	83	4.1	4.1
Burn Relief	83	4.1	4.1
Lidocaine Hydrochloride And Epinephrine	83	4.1	4.1
Bortezomib	150	4.0	4.0
Pembrolizumab	176	4.0	4.0
Lidocaine, Menthol	83	4.0	4.0
Venlafaxine Hydrochloride	218	4.0	4.0
Bevacizumab	201	3.9	3.9
Magnesium Sulfate In Water For	21	3.9	3.9
Dabrafenib	34	3.8	3.9
Magnesium Sulfate Heptahydrate	21	3.8	3.8
Magnesium Sulfate	21	3.8	3.8
Letrozole Tablets	77	3.8	3.8
Pemetrexed Disodium	61	3.8	3.8
Ibrutinib	127	3.8	3.8
Lidocaine Hydrochloride And Epinephrine Bitartrate	83	3.7	3.7
Cimetidine	15	3.7	3.7
Oxazepam	33	3.7	3.7
Lidocaine 4%	83	3.6	3.7
Basiliximab	18	3.6	3.7
Quinapril Hydrochloride	12	3.6	3.6
Sodium Bicarbonate	35	3.6	3.6
Sodium Bicarbonate Injection,	35	3.6	3.6
Lidocaine Hydrochloride	88	3.5	3.5
Dexamethasone 1.5 Mg	415	3.5	3.5
Dexamethasone	415	3.4	3.4
Pazopanib Hydrochloride	39	3.4	3.4
Letrozole	88	3.4	3.4
Granisetron Hydrochloride	15	3.4	3.4
Lidocaine	83	3.4	3.4
Granisetron	15	3.4	3.4
Vemurafenib	17	3.4	3.4
Lithium Carbonate	24	3.4	3.4
Methimazole	11	3.3	3.3
Propofol	51	3.3	3.3
Epinephrine	91	3.3	3.3
Bupivacaine	13	3.3	3.3
Dronabinol	11	3.3	3.3
Anastrozole	50	3.3	3.3
Sorafenib	28	3.2	3.2
Fluoxetine	89	3.2	3.2
Fulvestrant	44	3.2	3.2
Polatuzumab Vedotin	13	3.2	3.2
Piperacillin Sodium And Tazobactam Sodium	25	3.0	3.0
Lithium	31	2.9	2.9
Lithium Bromatum	31	2.9	2.9
Dutasteride	10	2.9	2.9
Propranolol Hydrochloride	88	2.9	2.9
Loperamide Hydrochloride	54	2.9	2.9
Atropine Sulfate	13	2.9	2.9
Goserelin	16	2.8	2.8
Diazepam Oral Solution (Concentrate)	104	2.8	2.8
Diazepam Oral	104	2.8	2.8
Exemestane	25	2.8	2.8
Bendamustine Hcl	18	2.8	2.8
Azacitidine For	21	2.8	2.8
Clobazam	28	2.7	2.7
Sotalol Hydrochloride	19	2.7	2.7
Erlotinib	11	2.7	2.7
Durvalumab	23	2.7	2.7
Amphotericin B	14	2.7	2.7
Haloperidol	27	2.6	2.7
Abiraterone	15	2.6	2.6
Haloperidol Lactate	27	2.6	2.6
Atropine	9	2.6	2.6
Sevoflurane	9	2.6	2.6
Methadone	46	2.6	2.6
Sunitinib Malate	42	2.5	2.6
Meropenem	34	2.5	2.5
Voriconazole Injection	23	2.5	2.5
Felodipine Extended-Release Tablets	12	2.5	2.5
Felodipine	12	2.5	2.5
Levetiracetam In Sodium Chloride	81	2.5	2.5
Levetiracetam Oral	81	2.5	2.5
Levetiracetam Injection	81	2.5	2.5
Azacitidine	31	2.5	2.5
Linezolid	31	2.5	2.5
Bupropion Hydrochloride	102	2.5	2.5
Abacavir Sulfate	10	2.4	2.4
Ribociclib	32	2.4	2.4
Citalopram Hydrobromide	108	2.4	2.4
Phenytoin	21	2.4	2.4
Dasatinib	37	2.4	2.4
Doxepin	10	2.3	2.3
Tretinoin	8	2.3	2.3
Nilotinib	29	2.3	2.3
Pegaspargase	12	2.3	2.3
Ondansetron	106	2.3	2.3
Ondansetron Tablets	106	2.3	2.3
Panitumumab	15	2.3	2.3
Atezolizumab	36	2.2	2.2
Methotrexate	381	2.2	2.2
Ondansetron Hydrochloride	111	2.2	2.2
Prednisone	442	2.1	2.1
Sodium Chloride Tablet	66	2.1	2.1
Sodium Chloride Tablets	66	2.1	2.1
Sirolimus	12	2.1	2.1
Guanfacine	7	2.1	2.1
Gefitinib	8	2.1	2.1
Methotrexate Sodium	420	2.1	2.1
Valsartan Oral	48	2.1	2.1
Lamotirigine	63	2.1	2.1
Lamotrigine Extended-Release	63	2.1	2.1
Lamotrigine Chewable Dispersible	63	2.1	2.1
Erlotinib Hydrochloride	11	2.1	2.1
Daratumumab	35	2.1	2.1
Sodium Chloride	69	2.1	2.1
Abiraterone Acetate	36	2.1	2.1
Doxepin Hydrochloride	11	2.1	2.1
Ritonavir 100 Mg	13	2.1	2.1
Fluoxetine Hydrochloride	110	2.1	2.1
Cabotegravir	7	2.1	2.1
Imatinib Mesylate	24	2.0	2.1
Diazepam	104	2.0	2.0
Voriconazole	26	2.0	2.0
Quetiapine	158	2.0	2.0
Labetalol	11	2.0	2.0
Dextrose Monohydrate	11	2.0	2.0
Quetiapine Fumarate	24	1.9	1.9
Citalopram	110	1.9	1.9
Amlodipine	214	1.9	1.9
Fluconazole	56	1.9	1.9
Bosutinib	7	1.9	1.9
Aripiprazole Oral	32	1.8	1.8
Aripiprazole Orally Disintegrating	32	1.8	1.8
Mycophenilic Acid	16	1.8	1.8
Bisoprolol Fumarate	103	1.8	1.8
Temozolomide	16	1.8	1.8
Dextrose	10	1.8	1.8
Prednisolone	136	1.8	1.8
Prednisolone Oral	136	1.8	1.8
Prednisolone Oral Solution	136	1.8	1.8
Bendamustine Hydrochloride	9	1.8	1.8
Venetoclax	46	1.8	1.8
Mirtazapine	68	1.8	1.8
Fondaparinux Sodium	6	1.8	1.8
Ixazomib	21	1.7	1.7
Amphetamine	6	1.7	1.7
Hydroxyzine	34	1.7	1.7
Clozapine	89	1.7	1.7
Vancomycin	41	1.7	1.7
Encorafenib	7	1.7	1.7
Olanzapine	75	1.7	1.7
Nifedipine	33	1.7	1.7
Regorafenib	8	1.6	1.6
Escitslopram	40	1.6	1.6
Testosterone	16	1.6	1.6
Oxcarbazepine	22	1.6	1.6
Tranexamic Acid	6	1.6	1.6
Nivolumab	65	1.6	1.6
Ipilimumab	29	1.6	1.6
Vancomycin Hydrochloride	44	1.6	1.6
Levetiracetam	89	1.6	1.6
Axitinib	13	1.6	1.6
Carvedilol	89	1.6	1.6
Crizotinib	8	1.5	1.5
Lenvatinib	20	1.5	1.5
Ceftriaxone	20	1.5	1.5
Thalidomide	22	1.4	1.4
Micafungin Sodium	5	1.4	1.4
Ethyl Alcohol	16	1.4	1.4
Cannabidiol	13	1.3	1.3
Methadone Hydrochloride	6	1.3	1.3
Ticagrelor	17	1.3	1.3
Cladribine	5	1.2	1.2
Cetuximab	16	1.2	1.2
Rocuronium Bromide	6	1.2	1.2
Obinutuzumab	8	1.2	1.2
Paliperidone	11	1.1	1.1
Alcohol	18	1.1	1.1
Remdesivir	6	1.1	1.1
Isopropyl Alcohol	15	1.1	1.1
Apalutamide	5	1.0	1.0
Olaparib	8	0.9	0.9
Oseltamivir	3	0.9	0.9
Ledipasvir And Sofosbuvir	7	0.9	0.9
Abemaciclib	7	0.8	0.8
Cabozantinib	16	0.8	0.8
Avapritinib	4	0.8	0.8
Pegfilgrastim	31	0.7	0.7
Ranolazine	3	0.7	0.7
Trifluridine And Tipiracil	3	0.7	0.7
Lenalidomide	114	0.6	0.6
Pomalidomide	16	0.4	0.4
Salicylic Acid	3	0.1	0.1

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.