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Which drugs are most reported with Bowel movement irregularity?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 7,523 reports · 389 co-occurring drugs

As of the last recalculation, Bowel Movement Irregularity appears in 7,523 FAERS reports alongside 389 co-occurring drug terms. The strongest observed disproportionality signal is LINACLOTIDE (PRR 18.7).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Linaclotide	176	18.7	18.8
Octreotide Acetate	184	17.0	17.1
Teduglutide	77	16.0	16.1
Patiromer	55	11.1	11.1
Infliximab-Dyyb	115	11.0	11.1
Polyethylene Glycol 3350	345	10.4	10.5
Psyllium Husk	36	10.1	10.2
Lanreotide Acetate	25	8.8	8.9
Niraparib	67	8.4	8.4
Mesalamine	167	8.4	8.4
Cholestyramine	33	7.6	7.6
Lubiprostone	25	7.3	7.4
Relugolix	61	7.2	7.2
Magnesium Hydroxide	33	6.8	6.8
Orlistat	59	6.3	6.4
Dimenhydrinate	24	6.2	6.3
Loperamide Hydrochloride Oral	23	6.2	6.3
Ozanimod Hydrochloride	18	6.0	6.0
Loperamide Hydrochloride	96	6.0	6.0
Oral Semaglutide	153	5.9	5.9
Ropinirole	32	5.8	5.8
Loperamide Hydrochloride And Dimethicone	65	5.6	5.7
Loperamide Hcl	26	5.6	5.6
Nintedanib	63	5.6	5.6
Vibegron	15	5.2	5.2
Rivastigmine	35	5.2	5.2
Instalax Polyethylene Glycol 3350	23	5.1	5.1
Vedolizumab	157	5.1	5.1
Polyethylene Glycol 400	23	5.0	5.0
Cyanocobalamin	58	4.9	4.9
Felodipine Extended-Release Tablets	20	4.9	4.9
Felodipine	20	4.9	4.9
Standardized Senna Concentrate	22	4.8	4.9
Bisacodyl	24	4.7	4.7
Pancrelipase	62	4.5	4.5
Iron	103	4.3	4.3
Diphenoxylate Hydrochloride And Atropine Sulfate	21	4.3	4.3
Pramipexole	23	4.2	4.2
Dutasteride	12	4.1	4.1
Budesonide	85	4.0	4.0
Azathioprine	124	3.9	3.9
Magnesium	115	3.9	3.9
Rabeprazole	31	3.9	3.9
Tofacitinib	243	3.7	3.7
Adalimumab-Adaz	70	3.7	3.7
Levodopa	16	3.7	3.7
Bisacodyl Suppositories	17	3.6	3.6
Carbidopa And Levodopa	62	3.6	3.6
Biscodyl	17	3.6	3.6
Calcium	189	3.6	3.6
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	39	3.6	3.6
Ursosiol	25	3.6	3.6
Elexacaftor, Tezacaftor, And Ivacaftor	16	3.6	3.6
Rucaparib	11	3.5	3.5
Docusate Sodium - Sennosides	40	3.4	3.4
Ergocalciferol	448	3.4	3.4
Vitamin E	38	3.4	3.4
Rifaximin	25	3.3	3.3
Lactulose	45	3.3	3.3
Esomeprazole Magnesium Capsule, Delayed Release	17	3.2	3.2
Esomeprazole Magnesium Delayed Release Capsules	17	3.2	3.2
Esomeprazole Magnesium Dihydrate	17	3.2	3.2
Ursodiol	25	3.2	3.2
Tofacitinib Citrate	15	3.2	3.2
Oxybutynin Chloride	10	3.2	3.2
Zinc	28	3.1	3.2
Zinc Chloride	28	3.1	3.1
Thyroid, Porcine	12	3.1	3.1
Inclisiran	9	3.1	3.1
Finasteride	67	3.1	3.1
Zinc Gluconate	29	3.1	3.1
Polyethylene Glycol	12	3.1	3.1
Melatonin	60	3.1	3.1
Rotigotine	16	3.1	3.1
Sennosides	33	3.1	3.1
Meclizine Hcl 12.5Mg	15	3.0	3.1
Meclizine Hcl 25Mg	15	3.0	3.1
Meclizine Hcl 12.5 Mg	15	3.0	3.0
Meclizine Hcl 25 Mg	15	3.0	3.0
Hyoscyamine Sulfate	10	3.0	3.0
Prochlorperazine Maleate	10	3.0	3.0
Everolimus	55	3.0	3.0
Rasagiline Mesylate	12	3.0	3.0
Lisinopril And Hydrochlorothiazide	11	3.0	3.0
Hydrocortisone Sodium Succinate	10	2.9	2.9
Sucralfate Oral	15	2.9	2.9
Ezetimibe And Simvastatin	16	2.9	2.9
Sucralfate Oral Suspension	15	2.9	2.9
Hydrocortisone Acetate	76	2.9	2.9
Hydrocortisone	93	2.9	2.9
Selexipag	27	2.9	2.9
Adalimumab-Fkjp	48	2.9	2.9
Brinzolamide	9	2.9	2.9
Amantadine	16	2.9	2.9
Lamivudine Oral	26	2.8	2.9
Biotin	32	2.8	2.8
Morphine	76	2.8	2.8
Anti-Itch	68	2.8	2.8
Anti-Pruritic	68	2.8	2.8
Antipruritic (Anti-Itch)	68	2.8	2.8
Cool Relief Gel With Aloe	68	2.8	2.8
Drs. Hydrocortisone	68	2.8	2.8
Hydrocortisone Continuous Spray	68	2.8	2.8
Hydrocortisone Spray	68	2.8	2.8
Anti-Itch Cream	68	2.8	2.8
Hydrocortisone Lotion	68	2.8	2.8
Hydrocortisone Cream 1%	68	2.8	2.8
Hydrocortisone Cream 1/2%	68	2.8	2.8
Hydrocortisone 1%	68	2.8	2.8
Hydrocortisone Cream	68	2.8	2.8
Sucralfate	24	2.8	2.8
Abemaciclib	20	2.8	2.8
Dabrafenib	21	2.8	2.8
Docusate Sodium	57	2.7	2.7
Avapritinib	12	2.7	2.7
Cetirizine Hcl	9	2.7	2.7
Metolazone	11	2.7	2.7
Liraglutide	48	2.7	2.7
Enzalutamide	57	2.7	2.7
Calcium Carbonate	65	2.7	2.7
Infliximab	208	2.7	2.7
Antacid	45	2.6	2.6
Desoximetasone	18	2.6	2.6
Vitamin C	86	2.6	2.6
Tizanidine Hydrochloride	17	2.6	2.6
Exemestane	20	2.6	2.6
Valsartan Oral	50	2.6	2.6
Meclizine	15	2.5	2.5
Alpelisib	8	2.5	2.5
Pantoprazole	228	2.5	2.5
Dicyclomine Hydrochloride	13	2.5	2.5
Pantoprazole Sodium In 0.9% Sodium Chloride	56	2.5	2.5
Pantoprazole Sodium Injection	56	2.5	2.5
Labetalol	12	2.5	2.5
Metoprolol Succinate Er Tablets	56	2.5	2.5
Metronidazole	57	2.5	2.5
Bosutinib	8	2.5	2.5
Cyclobenzaprine Hydrochloride	8	2.5	2.5
Adalimumab-Aaty	42	2.5	2.5
Dexamethasone Sodium Phosphate	9	2.5	2.5
Mirabegron	34	2.4	2.4
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	139	2.4	2.4
Lamivudine	27	2.4	2.4
Clobetasol Propionate Ointment Usp, 0.05%	9	2.4	2.4
Amlodipine	231	2.4	2.4
Isosorbide Dinitrate	17	2.4	2.4
Clobetasol Propionate	9	2.4	2.4
Apremilast	126	2.4	2.4
Meclizine Hydrochloride	17	2.4	2.4
Ketoconazole	15	2.4	2.4
Prednisone	417	2.4	2.4
Butalbital, Acetaminophen, And Caffeine	9	2.3	2.3
Oxazepam	18	2.3	2.3
Rosuvastatin	169	2.3	2.3
Fesoterodine Fumarate	9	2.3	2.3
Trametinib	20	2.3	2.3
Metoprolol Succinate	71	2.3	2.3
Teriflunomide	37	2.3	2.3
Fenofibrate	29	2.3	2.3
Ciprofloxacin Hydrochloride And Hydrocortisone	17	2.3	2.3
Ketoconazole Foam	12	2.2	2.2
Ketoconazole Cream, 2%	12	2.2	2.2
Olmesartan Medoxomil	29	2.2	2.2
Fluticasone Furoate And Vilanterol Trifenatate	29	2.2	2.2
Ibuprofen Tablets, Coated	34	2.2	2.2
Multivitamin	40	2.2	2.2
Fish Oil	72	2.2	2.2
Ibuprofen Sodium	34	2.2	2.2
Potassium Chloride, Dextrose Monohydrate	73	2.2	2.2
Potassium Chloride Oral	73	2.2	2.2
Potassium Chloride Extended-Release	73	2.2	2.2
Nitrofurantoin	13	2.2	2.2
Terazosin Hydrochloride	7	2.2	2.2
Nifedipine	37	2.2	2.2
Dulaglutide	69	2.2	2.2
Tolterodine Tartrate	7	2.2	2.2
Nitrofurantoin (Monohydrate/Macrocrystals)	13	2.2	2.2
Loratadine Oral	38	2.1	2.1
Tirzepatide	124	2.1	2.1
Olaparib	16	2.1	2.1
Tafamidis	9	2.1	2.1
Sennosides 8.6 Mg Tablets	16	2.1	2.1
Losartan	132	2.1	2.1
Dofetilide	8	2.1	2.1
Senna	16	2.1	2.1
Potassium Chloride	86	2.1	2.1
Fulvestrant	25	2.1	2.1
Imatinib Mesylate	21	2.1	2.1
Montelukast	63	2.1	2.1
Metoprolol Tartrate Injection	141	2.1	2.1
Fluticasone Furoate	9	2.1	2.1
Sitagliptin And Metformin Hydrochloride	16	2.1	2.1
Nebivolol Hydrochloride	25	2.1	2.1
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	26	2.0	2.0
Rabeprazole Sodium	20	2.0	2.0
Metoprolol Tartrate	198	2.0	2.0
Ondansetron Hydrochloride	89	2.0	2.0
Lisdexamfetamine Dimesylate	24	2.0	2.0
Azelastine	13	2.0	2.0
Metoprolol	182	2.0	2.0
Teriparatide	81	2.0	2.0
Carvedilol	97	2.0	2.0
Axitinib	14	2.0	2.0
Sunitinib Malate	28	2.0	2.0
Losartan Potassium	56	2.0	2.0
Famotidine	83	2.0	2.0
Valsartan	74	2.0	2.0
Acetaminophen, Aspirin (Nsaid) And Caffeine	12	2.0	2.0
Diltiazem Hydrochloride Extended-Release Tablets	8	1.9	1.9
Fluticasone Propionate And Salmeterol Xinafoate	42	1.9	1.9
Amlodipine Besylate	102	1.9	1.9
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	29	1.9	1.9
Omeprazole	237	1.9	1.9
Senna Leaf	16	1.9	1.9
Omeprazole Magnesium	304	1.9	1.9
Voclosporin	6	1.9	1.9
Loratadine	74	1.9	1.9
Meloxicam	40	1.9	1.9
Liothyronine Sodium	6	1.9	1.9
Venlafaxine	49	1.9	1.9
Esomeprazole Magnesium	158	1.9	1.9
Apalutamide	8	1.9	1.9
Ixekizumab	25	1.9	1.9
Terbinafine Hydrochloride	6	1.9	1.9
Siponimod	6	1.9	1.9
Lisinopril	203	1.9	1.9
Ondansetron	73	1.9	1.9
Ondansetron Tablets	73	1.9	1.9
Conjugated Estrogens	39	1.9	1.9
Indapamide	12	1.9	1.9
Metoroprolol Tartrate	44	1.9	1.9
Eszopiclone	17	1.8	1.8
Acetaminophen, Aspirin, And Caffeine	14	1.8	1.8
Baclofen	57	1.8	1.8
Estrogens, Conjugated	39	1.8	1.8
Ruxolitinib	47	1.8	1.8
Sildenafil	38	1.8	1.8
Aspirin	346	1.8	1.8
Adrenalinum	27	1.8	1.8
Tadalafil	65	1.8	1.8
Amlodipine Besylate And Benazepril Hydrochloride	6	1.8	1.8
Fexofenadine Hcl	6	1.8	1.8
Calcitriol Capsules 0.25 Mcg	13	1.8	1.8
Calcitriol Capsules 0.5 Mcg	13	1.8	1.8
Ustekinumab	66	1.8	1.8
Cabozantinib	31	1.8	1.8
Cetirizine	50	1.8	1.8
Glipizide	39	1.8	1.8
Calcitriol	13	1.8	1.8
Triamcinolone Acetonide Ointment Usp, 0.05%	15	1.8	1.8
Tamsulosin Hydrochloride	13	1.8	1.8
Latanoprost	32	1.8	1.8
Quinapril Hydrochloride	5	1.8	1.8
Gabapentin	228	1.8	1.8
Hydromorphone Hydrochloride	58	1.8	1.8
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	13	1.7	1.8
Naproxen Sodium, Pseudoephedrine Hydrochloride	13	1.7	1.7
Tizanidine	15	1.7	1.7
Cetirizine Hydrochloride Allergy	19	1.7	1.7
Cetirizine Hydrochloride Tablets	19	1.7	1.7
Levocetirizine Dihydrochloride	15	1.7	1.7
Dexlansoprazole	26	1.7	1.7
Naproxen Sodium Tablet	33	1.7	1.7
Sildenafil Powder,	22	1.7	1.7
Adalimumab	427	1.7	1.7
Naltrexone	19	1.7	1.7
Glimepiride	24	1.7	1.7
Warfarin	78	1.7	1.7
Triamcinolone Acetonide	19	1.7	1.7
Oxybutynin	18	1.7	1.7
Sevelamer Carbonate	7	1.7	1.7
Timolol Maleate	6	1.7	1.7
Benzonatate	10	1.7	1.7
Deferasirox	16	1.7	1.7
Pioglitazone	26	1.7	1.7
Loratadine Tablet	32	1.7	1.7
Desvenlafaxine Succinate	16	1.6	1.6
Guaifenesin	18	1.6	1.6
Exenatide	31	1.6	1.6
Dronedarone	6	1.6	1.6
Lumacaftor And Ivacaftor	5	1.6	1.6
Timolol	7	1.6	1.6
Secukinumab	93	1.6	1.6
Isosorbide Mononitrate	12	1.6	1.6
Macitentan	40	1.6	1.6
Travoprost	5	1.6	1.6
Metformin Er 500 Mg	172	1.6	1.6
Metformin Er 750 Mg	172	1.6	1.6
Armodafinil	12	1.6	1.6
Insulin Aspart	37	1.6	1.6
Trifluridine And Tipiracil	6	1.5	1.5
Oxycodone	104	1.5	1.5
Cannabidiol	13	1.5	1.5
Fexofenadine Hydrochloride	12	1.5	1.5
Erenumab-Aooe	30	1.5	1.5
Irinotecan Hydrochloride	7	1.5	1.5
Aprepitant	10	1.5	1.5
Pirfenidone	22	1.5	1.5
Cariprazine	5	1.5	1.5
Empagliflozin	36	1.5	1.5
Treprostinil	67	1.5	1.5
Epoprostenol	7	1.5	1.5
Ixazomib	15	1.4	1.4
Abiraterone	7	1.4	1.4
Dasatinib	19	1.4	1.4
Lisinopril And Hydrochlorothiazide Tablets	4	1.4	1.4
Certolizumab Pegol	59	1.4	1.4
Loratadine And Pseudoephedrine Sulfate	4	1.4	1.4
Acalabrutinib	6	1.4	1.4
Methadone	21	1.4	1.4
Voxelotor	11	1.4	1.4
Umeclidinium Bromide And Vilanterol Trifenatate	8	1.3	1.3
Clozapine	60	1.3	1.3
Alirocumab	12	1.3	1.3
Abaloparatide	14	1.3	1.3
Ledipasvir And Sofosbuvir	9	1.3	1.3
Palbociclib	44	1.3	1.3
Asenapine Maleate	4	1.3	1.3
Dornase Alfa	9	1.3	1.3
Buprenorphine Hydrochloride, Naloxone Hydrochloride	11	1.3	1.3
Fingolimod Hcl	39	1.2	1.2
Brimonidine Tartrate	8	1.2	1.2
Mepolizumab	22	1.2	1.2
Sacubitril And Valsartan	51	1.2	1.2
Memantine	6	1.2	1.2
Memantine Hydrochloride	6	1.2	1.2
Lenalidomide	184	1.2	1.2
Fremanezumab-Vfrm	5	1.2	1.2
Vilazodone Hydrochloride	4	1.2	1.2
Risankizumab-Rzaa	35	1.2	1.2
Lenvatinib	14	1.2	1.2
Insulin Degludec	10	1.2	1.2
Varenicline Tartrate	34	1.2	1.2
Bimekizumab	9	1.2	1.2
Vigabatrin	6	1.1	1.1
Morphine Sulfate	49	1.1	1.1
Encorafenib	4	1.1	1.1
Asfotase Alfa	4	1.1	1.1
Ibrutinib	32	1.1	1.1
Sodium Oxybate	26	1.1	1.1
Prasugrel Hydrochloride	4	1.1	1.1
Ofatumumab	13	1.1	1.1
Velpatasvir And Sofosbuvir	5	1.1	1.1
Panitumumab	6	1.1	1.1
Ticagrelor	12	1.0	1.0
Osimertinib	12	1.0	1.0
Droxidopa	8	1.0	1.0
Pazopanib Hydrochloride	10	1.0	1.0
Nirmatrelvir And Ritonavir	20	1.0	1.0
Upadacitinib	30	1.0	1.0
Cenobamate	3	1.0	1.0
Naltrexone Hydrochloride And Bupropion Hydrochloride	3	1.0	1.0
Pomalidomide	36	1.0	1.0
Eltrombopag Olamine	8	1.0	1.0
Nivolumab	33	0.9	0.9
Drospirenone And Ethinyl Estradiol	15	0.9	0.9
Ambrisentan	42	0.9	0.9
Palivizumab	5	0.9	0.9
Pimavanserin Tartrate	18	0.9	0.9
Agalsidase Beta	3	0.9	0.9
Cortisone Acetate	4	0.9	0.9
Hydrocodone Bitartrate And Acetaminophen	18	0.9	0.9
Bimatoprost	9	0.9	0.9
Denosumab	61	0.8	0.8
Paliperidone	7	0.8	0.8
Ravulizumab	4	0.8	0.8
Evolocumab	48	0.8	0.8
Abiraterone Acetate	12	0.8	0.8
Ranolazine	3	0.8	0.8
Budesonide, Glycopyrrolate, And Formoterol Fumarate	3	0.8	0.8
Leuprolide Acetate	22	0.8	0.8
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	5	0.8	0.8
Diroximel Fumarate	3	0.7	0.7
Glatiramer Acetate	15	0.7	0.7
Dalfampridine	18	0.7	0.7
Minoxidil Foam 5% (Womens)	8	0.7	0.7
Crizotinib	3	0.7	0.7
Peginterferon Beta-1A	3	0.6	0.6
Lutetium Lu 177 Vipivotide Tetraxetan	3	0.6	0.6
Onabotulinumtoxina	17	0.6	0.6
Dimethyl Fumarate	25	0.6	0.6
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	6	0.5	0.5
Minoxidil	8	0.5	0.5
Cinacalcet Hydrochloride	8	0.5	0.5
Copper	7	0.4	0.4
Galcanezumab-Gnlm	5	0.4	0.4
Dupilumab	77	0.4	0.4
Levonorgestrel	30	0.4	0.4
Guselkumab	5	0.4	0.4

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.