Reaction

Necrosis reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,520 reports · 252 co-occurring drugs

As of the last recalculation, Necrosis appears in 5,520 FAERS reports alongside 252 co-occurring drug terms. The strongest observed disproportionality signal is AMPHOTERICIN B (PRR 14.9).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Amphotericin B	49	14.9	14.9
Basiliximab	40	12.9	13.0
Norepinephrine Bitartrate	44	11.6	11.6
Rifampicin	28	10.5	10.5
Pyrazinamide	26	10.5	10.5
Norepinephrine	29	10.3	10.3
Voriconazole Injection	57	10.0	10.0
Canagliflozin	74	9.4	9.5
Fondaparinux Sodium	20	9.3	9.4
Gentamicin	28	8.1	8.1
Gentamicin Sulfate	32	7.7	7.7
Voriconazole	60	7.5	7.5
Dalteparin Sodium	21	7.5	7.5
Isoniazid	32	7.5	7.5
Efavirenz	21	7.1	7.1
Pegaspargase	23	7.1	7.1
Glatiramer Acetate	106	6.8	6.8
Ampicillin	14	6.4	6.4
Ampicillin Sodium	14	6.4	6.4
Daspone	16	6.2	6.2
Dapsone Gel, 5%	16	6.2	6.2
Vancomycin	90	6.0	6.0
Melphalan	35	5.8	5.8
Tacrolimus Ointment 0.1%	186	5.8	5.8
Tacrolimus Extended-Release Capsules	186	5.8	5.8
Melphalan Hydrochloride	38	5.7	5.8
Vancomycin Hydrochloride	98	5.7	5.7
Meropenem	48	5.7	5.7
Dapsone	16	5.7	5.7
Cefuroxime	17	5.6	5.6
Mycophenolate Mofetil	193	5.5	5.5
Mycophenolate Mofetil Hydrochloride	193	5.5	5.5
Itraconazole	17	5.5	5.5
Piperacillin Sodium And Tazobactam Sodium	28	5.4	5.4
Nilotinib	42	5.4	5.4
Sodium Bicarbonate	33	5.4	5.4
Sodium Bicarbonate Injection,	33	5.4	5.4
Tacrolimus	215	5.3	5.4
Sirolimus	19	5.3	5.3
Interferon Beta-1B	27	5.3	5.3
Busulfan	22	5.3	5.3
Cisplatin	107	5.2	5.3
Posaconazole Delayed-Release	15	5.2	5.2
Human Insulin	17	5.1	5.2
Calcium Gluconate	16	5.0	5.0
Cytarabine	79	5.0	5.0
Valganciclovir Hydrochloride Powder,	16	5.0	5.0
Leucovorin Calcium	25	5.0	5.0
Clindamycin	37	4.9	4.9
Ciprofolxacin	91	4.9	4.9
Ciprofloxacin Tablets	91	4.9	4.9
Moxifloxacin	18	4.8	4.8
Clindamycin Phosphate	42	4.8	4.8
Everolimus Tablets	21	4.7	4.7
Piperacillin And Tazobactam	16	4.7	4.7
Temozolomide	26	4.7	4.7
Methylprednisolone Sodium Succinate	57	4.7	4.7
Metronidazole Topical	57	4.5	4.6
Zidovudine	16	4.5	4.5
Enoxaparin Sodium	68	4.5	4.5
Heparin Sodium	16	4.4	4.4
Ceftriaxone	38	4.4	4.4
Salmeterol Xinafoate	10	4.4	4.4
Tenofovir Disoproxil Fumarate Tablets	10	4.4	4.4
Lamivudine Oral	29	4.3	4.3
Ribociclib	36	4.3	4.3
Dorzolamide Hydrochloride And Timolol Maleate	9	4.3	4.3
Lamivudine	35	4.3	4.3
Ganciclovir Sodium	12	4.3	4.3
Ciprofloxacin Hydrochloride	108	4.3	4.3
Cefepime	16	4.2	4.2
Pazopanib Hydrochloride	30	4.2	4.2
Cephalexin	24	4.2	4.2
Clobazam	27	4.2	4.2
Metronidazole	70	4.2	4.2
Fluorouracil Cream, 0.5%	83	4.2	4.2
Epoetin Alfa	13	4.1	4.1
Gemcitabine	43	4.1	4.1
Chlorhexidine Gluconate	10	4.1	4.1
Prednisolone	192	4.1	4.1
Prednisolone Oral	192	4.1	4.1
Prednisolone Oral Solution	192	4.1	4.1
Enalapril	60	4.1	4.1
Fluorouracil	83	4.1	4.1
Ifosfamide	23	4.0	4.1
Propofol	39	4.0	4.0
Cyclophosphamide Injection, Solution	185	4.0	4.0
Cyclophosphamide	185	4.0	4.0
Cyclophosphamide For Injection	185	4.0	4.0
Ciprofloxacin	97	4.0	4.0
Morphine	79	4.0	4.0
Bleomycin Sulfate	11	4.0	4.0
Vincristine Sulfate	31	4.0	4.0
Cefepime Hydrochloride	17	4.0	4.0
Azathioprine	92	4.0	4.0
Ceftriaxone Sodium	40	4.0	4.0
Bevacizumab	127	3.9	3.9
Methylprednisolone	141	3.9	3.9
Risedronate Sodium	32	3.9	3.9
Gemcitabine Hydrochloride	54	3.9	3.9
Cyclosporine	111	3.8	3.8
Atovaquone	8	3.8	3.8
Mercaptopurine	17	3.7	3.7
Ganciclovir	10	3.7	3.7
Fludarabine Phosphate	38	3.7	3.7
Atropine	8	3.6	3.6
Filgrastim	36	3.6	3.6
Valganciclovir	18	3.6	3.6
Valganciclovir Hydrochloride	18	3.6	3.6
Fluconazole	66	3.6	3.6
Moxifloxacin Hydrochloride	19	3.5	3.5
Clarithromycin	32	3.5	3.5
Oxazepam	20	3.5	3.5
Midazolam Hydrochloride	25	3.5	3.5
Misoprostol	9	3.5	3.5
Posaconazole	15	3.5	3.5
Abacavir Sulfate	9	3.5	3.5
Gemfibrozil	14	3.5	3.5
Pertuzumab	25	3.5	3.5
Paricalcitol	13	3.5	3.5
Piperacillin Sodium,Tazobactam Sodium	24	3.4	3.4
Acetaminophen And Codeine	11	3.4	3.4
Telmisartan	16	3.4	3.4
Nifedipine	42	3.4	3.4
Rifampin	13	3.4	3.4
Enalapril Maleate	22	3.4	3.4
Cefazolin	8	3.3	3.3
Linezolid	26	3.3	3.3
Inclisiran	7	3.3	3.3
Mycophenilic Acid	18	3.3	3.3
Anti-Thymocyte Globulin (Rabbit)	7	3.3	3.3
Doxorubicin Hydrochloride	28	3.2	3.2
Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride And Dextrose	7	3.2	3.2
Doxorubicin	75	3.2	3.2
Midazolam	21	3.1	3.2
Atropine Sulfate	9	3.1	3.1
Ado-Trastuzumab Emtansine	7	3.1	3.1
Insulin	46	3.1	3.1
Dapagliflozin	26	3.1	3.1
Warfarin Sodium	38	3.1	3.1
Docetaxel Anhydrous	55	3.1	3.1
Docetaxel	55	3.1	3.1
Nebivolol	13	3.1	3.1
Mycophenolic Acid	26	3.1	3.1
Etoposide	59	3.0	3.0
Everolimus	40	3.0	3.0
Fulvestrant	26	3.0	3.0
Tranexamic Acid	7	3.0	3.0
Insulin Glulisine	8	3.0	3.0
Letrozole	48	3.0	3.0
Indapamide	14	3.0	3.0
Gefitinib	7	2.9	2.9
Cetuximab	24	2.9	2.9
Sunitinib Malate	30	2.9	2.9
Carboplatin	96	2.9	2.9
Warfarin	95	2.9	2.9
Bupivacaine	7	2.8	2.8
Cefazolin Sodium	9	2.8	2.8
Sulfamethoxazole And Trimethoprim	62	2.8	2.8
Nicotine Polacrilex Mini	11	2.8	2.8
Nicotine Polarilex	11	2.8	2.8
Amiodarone Hydrochloride	8	2.7	2.7
Letrozole Tablets	34	2.7	2.7
Bisoprolol Fumarate	95	2.7	2.7
Fentanyl	69	2.7	2.7
Valacyclovir	29	2.6	2.6
Oxaliplatin	51	2.6	2.6
Clopidogrel Bisulfate	70	2.6	2.6
Niacin	8	2.6	2.6
Raloxifene Hydrochloride	10	2.6	2.6
Pemetrexed Disodium	26	2.6	2.6
Imatinib Mesylate	19	2.6	2.6
Imatinib	12	2.6	2.6
Diclofenac Sodium 1%	24	2.5	2.5
Diclofenac Sodium Topical	24	2.5	2.5
Diclofenac Sodium Topical Gel, 1%	24	2.5	2.5
Phenytoin	14	2.5	2.5
Oxycodone And Acetaminophen Tablets	8	2.5	2.5
Tenofovir Disoproxil Fumarate	22	2.5	2.5
Tramadol Hydrochloride	25	2.5	2.5
Linagliptin	12	2.5	2.5
Pemetrexed	14	2.5	2.5
Amikacin	11	2.4	2.4
Insulin Glargine-Yfgn	14	2.4	2.4
Erlotinib Hydrochloride	8	2.4	2.4
Trastuzumab	43	2.4	2.4
Paclitaxel (Aibumin-Bound)	51	2.4	2.4
Erlotinib	6	2.3	2.3
Hydroxyurea	13	2.3	2.3
Polatuzumab Vedotin	6	2.3	2.3
Pembrolizumab	64	2.3	2.3
Sevoflurane	5	2.3	2.3
Fam-Trastuzumab Deruxtecan-Nxki	6	2.2	2.2
Capecitabine	54	2.2	2.2
Acyclovir	67	2.2	2.2
Micafungin Sodium	5	2.2	2.2
Lapatinib	9	2.2	2.2
Panitumumab	9	2.2	2.2
Thalidomide	21	2.2	2.2
Paclitaxel	56	2.1	2.1
Deferasirox	15	2.1	2.1
Axitinib	11	2.1	2.1
Bosutinib	5	2.1	2.1
Nevirapine	5	2.1	2.1
Prochlorperazine Maleate	5	2.0	2.0
Empagliflozin	36	2.0	2.0
Eculizumab	29	2.0	2.0
Nivolumab	50	2.0	2.0
Entecavir	6	1.9	1.9
Rocuronium Bromide	6	1.9	1.9
Loratadine And Pseudoephedrine Sulfate	4	1.9	1.9
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	9	1.9	1.9
Bortezomib	44	1.9	1.9
Iohexol	4	1.8	1.8
Sorafenib	10	1.8	1.8
Interferon Beta-1A	91	1.8	1.8
Oxycodone And Acetaminophen	11	1.8	1.8
Dexamethasone 1.5 Mg	135	1.8	1.8
Emtricitabine And Tenofovir Disoproxil Fumarate	21	1.7	1.7
Bosentan	23	1.7	1.7
Bendamustine Hcl	7	1.7	1.7
Ipilimumab	19	1.7	1.7
Dabrafenib	9	1.6	1.6
Bendamustine Hydrochloride	5	1.6	1.6
Vemurafenib	5	1.6	1.6
Atezolizumab	16	1.6	1.6
Ibrutinib	33	1.5	1.5
Emicizumab	5	1.5	1.5
Denosumab	81	1.5	1.5
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Alafenamide	4	1.5	1.5
Lenvatinib	13	1.5	1.5
Crizotinib	5	1.5	1.5
Dasatinib	14	1.4	1.4
Emtricitabine And Tenofovir Alafenamide	4	1.3	1.3
Sevelamer Carbonate	4	1.3	1.3
Alpelisib	3	1.3	1.3
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Disoproxil Fumarate	3	1.3	1.3
Romiplostim	5	1.3	1.3
Acalabrutinib	4	1.2	1.2
Daratumumab	13	1.2	1.2
Naltrexone	10	1.2	1.2
Belimumab	10	1.2	1.2
Bimatoprost	9	1.2	1.2
Peginterferon Beta-1A	4	1.2	1.2
Romosozumab-Aqqg	4	1.1	1.1
Abiraterone Acetate	11	1.0	1.0
Cabozantinib	12	0.9	0.9
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	7	0.8	0.8
Patiromer	3	0.8	0.8
Bimekizumab	4	0.7	0.7
Guselkumab	6	0.6	0.6
Salicylic Acid	3	0.2	0.2

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.