Reaction

Which drugs are most reported with Haemophagocytic lymphohistiocytosis?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 7,131 reports · 280 co-occurring drugs

As of the last recalculation, Haemophagocytic Lymphohistiocytosis appears in 7,131 FAERS reports alongside 280 co-occurring drug terms. The strongest observed disproportionality signal is ANAKINRA (PRR 121.7).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Anakinra	631	121.7	126.5
Canakinumab	261	73.1	74.8
Axicabtagene Ciloleucel	142	42.8	43.4
Ganciclovir	144	41.9	42.5
Ganciclovir Sodium	145	40.8	41.4
Fludarabine Phosphate	431	34.0	34.4
Valganciclovir Hydrochloride Powder,	119	28.9	29.2
Mycophenilic Acid	193	27.9	28.2
Meropenem	257	24.2	24.4
Etoposide	557	23.9	24.1
Tofacitinib Citrate	104	23.5	23.7
Valganciclovir	137	21.6	21.8
Valganciclovir Hydrochloride	137	21.6	21.8
Micafungin Sodium	61	21.2	21.3
Amphotericin B	89	21.0	21.1
Anti-Thymocyte Globulin (Rabbit)	57	20.8	20.9
Piperacillin Sodium,Tazobactam Sodium	183	20.6	20.8
Basiliximab	82	20.6	20.7
Piperacillin And Tazobactam	86	19.9	20.0
Tacrolimus Ointment 0.1%	743	19.3	19.4
Tacrolimus Extended-Release Capsules	743	19.3	19.4
Baricitinib	62	18.9	19.0
Mycophenolic Acid	200	18.7	18.8
Thiotepa	60	18.5	18.6
Melphalan	141	18.4	18.5
Busulfan	94	17.7	17.8
Methylprednisolone	748	17.5	17.6
Melphalan Hydrochloride	143	17.0	17.1
Atovaquone	46	16.8	16.9
Tacrolimus	794	16.5	16.6
Alemtuzumab	106	16.2	16.3
Mycophenolate Mofetil Hydrochloride	670	15.8	15.8
Mycophenolate Mofetil	668	15.7	15.8
Human Immunoglobulin G	109	15.6	15.7
Posaconazole Delayed-Release	58	15.5	15.6
Cyclosporine	545	15.4	15.5
Adalimumab-Fkjp	235	15.3	15.4
Piperacillin Sodium And Tazobactam Sodium	100	15.1	15.1
Cefepime	71	14.6	14.7
Adalimumab-Aaty	228	14.5	14.6
Cefepime Hydrochloride	77	14.1	14.2
Cyclophosphamide Injection, Solution	757	13.8	13.9
Cyclophosphamide	757	13.8	13.9
Cyclophosphamide For Injection	757	13.8	13.9
Tocilizumab	503	13.8	13.8
Pyrazinamide	44	13.8	13.8
Adalimumab-Adaz	236	13.5	13.5
Rifampin	66	13.3	13.4
Brentuximab Vedotin	46	13.2	13.2
Moxifloxacin	63	13.2	13.2
Pemetrexed	94	13.0	13.0
Blinatumomab	46	12.9	13.0
Lamotirigine	295	12.5	12.5
Lamotrigine Extended-Release	295	12.5	12.5
Lamotrigine Chewable Dispersible	295	12.5	12.5
Pembrolizumab	419	12.3	12.3
Posaconazole	67	12.1	12.2
Voriconazole Injection	89	12.1	12.1
Ipilimumab	173	12.0	12.0
Prednisolone	674	11.9	12.0
Prednisolone Oral	674	11.9	12.0
Prednisolone Oral Solution	674	11.9	12.0
Vancomycin	229	11.9	12.0
Vancomycin Hydrochloride	251	11.5	11.5
Azacitidine For	69	11.2	11.2
Pegaspargase	46	11.0	11.1
Dabrafenib	78	10.9	11.0
Cytarabine	217	10.8	10.9
Phenytoin	75	10.6	10.6
Polatuzumab Vedotin	35	10.5	10.5
Trametinib	84	10.3	10.3
Daptomycin	32	10.2	10.2
Isoniazid	56	10.2	10.2
Mercaptopurine	59	10.0	10.0
Doxorubicin	294	10.0	10.0
Voriconazole	102	9.9	10.0
Moxifloxacin Hydrochloride	68	9.9	9.9
Pemetrexed Disodium	125	9.7	9.8
Atezolizumab	125	9.5	9.6
Mesna	25	8.7	8.7
Dexamethasone 1.5 Mg	785	8.7	8.7
Remdesivir	39	8.6	8.6
Dexamethasone	786	8.6	8.6
Mesna Injection	24	8.5	8.5
Filgrastim	108	8.5	8.5
Ruxolitinib	202	8.4	8.5
Nivolumab	270	8.4	8.5
Everolimus Tablets	48	8.4	8.4
Azathioprine	245	8.4	8.4
Ceftriaxone	91	8.2	8.2
Azacitidine	82	8.1	8.2
Dexamethasone Sodium Phosphate	28	8.1	8.1
Lamotrigine	348	8.1	8.1
Ceftriaxone Sodium	103	7.9	8.0
Doxorubicin Hydrochloride	86	7.8	7.8
Norepinephrine	27	7.4	7.4
Rituximab	500	7.3	7.4
Itraconazole	29	7.3	7.3
Carboplatin	301	7.2	7.2
Levetiracetam In Sodium Chloride	179	6.9	6.9
Levetiracetam Oral	179	6.9	6.9
Levetiracetam Injection	179	6.9	6.9
Phenobarbital	34	6.9	6.9
Valacyclovir	97	6.9	6.9
Fluconazole	159	6.8	6.8
Linezolid	68	6.7	6.7
Ampicillin	19	6.7	6.7
Ampicillin Sodium	19	6.7	6.7
Amikacin	38	6.5	6.5
Minocycline	26	6.5	6.5
Prednisone	990	6.5	6.5
Vincristine Sulfate	64	6.4	6.4
Sirolimus	29	6.3	6.3
Midazolam	54	6.3	6.3
Levofloxacin	128	6.3	6.3
Levofloxacin In 5% Dextrose	128	6.3	6.3
Bendamustine Hcl	33	6.2	6.2
Methylprednisolone Sodium Succinate	97	6.2	6.2
Norepinephrine Bitartrate	30	6.1	6.1
Midazolam Hydrochloride	54	5.9	5.9
Paclitaxel (Aibumin-Bound)	162	5.9	5.9
Clobazam	48	5.8	5.8
Entecavir	23	5.8	5.8
Febuxostat Tablets 40 Mg	20	5.8	5.8
Febuxostat Tablets 80 Mg	20	5.8	5.8
Terbinafine Hydrochloride	17	5.6	5.6
Acyclovir	211	5.5	5.5
Cladribine	18	5.5	5.5
Ifosfamide	40	5.5	5.5
Hydroxychloroquine	137	5.4	5.4
Methotrexate	711	5.4	5.4
Methotrexate Sodium	785	5.2	5.2
Paclitaxel	170	5.1	5.1
Sulfamethoxazole And Trimethoprim	142	5.0	5.0
Calcium Gluconate	20	4.9	4.9
Phytonadione	14	4.8	4.8
Daspone	16	4.8	4.8
Dapsone Gel, 5%	16	4.8	4.8
Venetoclax	98	4.7	4.7
Ursosiol	31	4.7	4.7
Levetiracetam	204	4.6	4.6
Lamivudine Oral	39	4.5	4.5
Thiamine Hydrochloride	19	4.5	4.5
Bendamustine Hydrochloride	18	4.4	4.4
Dapsone	16	4.4	4.4
Valacyclovir Hydrochloride	104	4.4	4.4
Hydrocortisone Sodium Succinate	14	4.4	4.4
Metronidazole Topical	70	4.3	4.3
Prednisolone Acetate	15	4.2	4.2
Thalidomide	53	4.2	4.2
Cisplatin	111	4.2	4.2
Ursodiol	31	4.2	4.2
Magnesium Sulfate In Water For	18	4.1	4.1
Obinutuzumab	23	4.1	4.1
Magnesium Sulfate Heptahydrate	18	4.0	4.0
Magnesium Sulfate	18	4.0	4.0
Gentamicin	18	4.0	4.0
Methylprednisolone Acetate	11	4.0	4.0
Gentamicin Sulfate	20	3.7	3.7
Lamivudine	39	3.7	3.7
Bleomycin Sulfate	13	3.7	3.7
Gemcitabine	49	3.6	3.7
Gemcitabine Hydrochloride	65	3.6	3.6
Encorafenib	12	3.5	3.5
Febuxostat	20	3.5	3.5
Infliximab	253	3.5	3.5
Esomeprazole Magnesium Capsule, Delayed Release	17	3.4	3.4
Esomeprazole Magnesium Delayed Release Capsules	17	3.4	3.4
Esomeprazole Magnesium Dihydrate	17	3.4	3.4
Efavirenz	13	3.4	3.4
Metronidazole	74	3.4	3.4
Sodium Bicarbonate	27	3.4	3.4
Sodium Bicarbonate Injection,	27	3.4	3.4
Valproate Sodium	24	3.4	3.4
Daratumumab	45	3.3	3.3
Zidovudine	15	3.3	3.3
Doxycycline Hyclate	75	3.3	3.3
Doxycycline	75	3.2	3.2
Durvalumab	22	3.2	3.2
Valproic Acid	34	3.2	3.2
Lenvatinib	35	3.1	3.1
Colchicine	28	3.1	3.1
Voclosporin	9	3.0	3.0
Allopurinol	157	3.0	3.0
Haloperidol Lactate	25	3.0	3.0
Vemurafenib	12	2.9	2.9
Romiplostim	15	2.9	2.9
Cefazolin Sodium	12	2.9	2.9
Cefazolin	9	2.9	2.9
Everolimus	50	2.9	2.9
Anti-Itch	65	2.8	2.8
Anti-Pruritic	65	2.8	2.8
Antipruritic (Anti-Itch)	65	2.8	2.8
Cool Relief Gel With Aloe	65	2.8	2.8
Drs. Hydrocortisone	65	2.8	2.8
Hydrocortisone Continuous Spray	65	2.8	2.8
Hydrocortisone Spray	65	2.8	2.8
Anti-Itch Cream	65	2.8	2.8
Hydrocortisone Lotion	65	2.8	2.8
Hydrocortisone Cream 1%	65	2.8	2.8
Hydrocortisone Cream 1/2%	65	2.8	2.8
Hydrocortisone 1%	65	2.8	2.8
Hydrocortisone Cream	65	2.8	2.8
Carfilzomib	27	2.8	2.8
Haloperidol	23	2.8	2.8
Hydrocortisone Acetate	67	2.7	2.7
Polyethylene Glycol	10	2.7	2.7
Azithromycin	37	2.7	2.7
Esomeprazole	56	2.6	2.7
Azithromycin Monohydrate	37	2.6	2.6
Belimumab	28	2.6	2.6
Oseltamivir	7	2.6	2.6
Cefuroxime	10	2.6	2.6
Granisetron Hydrochloride	9	2.5	2.5
Sodium Chloride Tablet	62	2.5	2.5
Sodium Chloride Tablets	62	2.5	2.5
Desloratadine	9	2.5	2.5
Dextrose	11	2.4	2.4
Dextrose Monohydrate	11	2.4	2.4
Metoclopramide	45	2.4	2.4
Acetaminophen Tablet Extended Release	205	2.4	2.4
Pain Reliever	205	2.4	2.4
Acetaminophen 500Mg	205	2.4	2.4
Rifampicin	8	2.3	2.3
Nitrofurantoin	13	2.3	2.3
Sodium Chloride	62	2.3	2.3
Tranexamic Acid	7	2.3	2.3
Enoxaparin Sodium	45	2.3	2.3
Brivaracetam	7	2.3	2.3
Nitrofurantoin (Monohydrate/Macrocrystals)	13	2.3	2.3
Regorafenib	9	2.3	2.3
Dorzolamide Hydrochloride And Timolol Maleate	6	2.2	2.2
Ibrutinib	61	2.2	2.2
Sulfasalazine	58	2.2	2.2
Bevacizumab	91	2.2	2.2
Alteplase	11	2.1	2.1
Bortezomib	65	2.1	2.1
Iohexol	6	2.1	2.1
Leflunomide	75	2.1	2.1
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	13	2.1	2.1
Ondansetron	77	2.1	2.1
Ondansetron Tablets	77	2.1	2.1
Fenofibrate	25	2.1	2.1
Selinexor	6	2.0	2.0
Metoclopramide Hydrochloride	53	2.0	2.0
Propofol	25	2.0	2.0
Ondansetron Hydrochloride	83	2.0	2.0
Rocuronium Bromide	8	2.0	2.0
Prochlorperazine	18	1.9	1.9
Fexofenadine Hcl	6	1.9	1.9
Eltrombopag Olamine	14	1.8	1.8
Tofacitinib	110	1.8	1.8
Lopinavir And Ritonavir	8	1.7	1.7
Granisetron	6	1.7	1.7
Eculizumab	31	1.7	1.7
Temozolomide	12	1.7	1.7
Nevirapine	5	1.6	1.6
Oxaliplatin	40	1.6	1.6
Ixazomib	15	1.5	1.5
Lacosamide	19	1.5	1.5
Guanfacine	4	1.5	1.5
Tolvaptan	7	1.4	1.4
Icosapent Ethyl	4	1.4	1.4
Tenofovir Disoproxil Fumarate Tablets	4	1.4	1.4
Upadacitinib	37	1.3	1.3
Trastuzumab	31	1.3	1.3
Pazopanib Hydrochloride	12	1.3	1.3
Oseltamivir Phosphate	10	1.2	1.2
Abatacept	56	1.2	1.2
Docetaxel Anhydrous	27	1.2	1.2
Docetaxel	27	1.2	1.2
Methadone Hydrochloride	4	1.1	1.1
Cabozantinib	17	1.0	1.0
Emtricitabine And Tenofovir Alafenamide	4	1.0	1.0
Acalabrutinib	4	1.0	1.0
Dasatinib	12	0.9	0.9
Olaparib	6	0.8	0.8
Sarilumab	7	0.8	0.8
Osimertinib	8	0.7	0.7
Lenalidomide	85	0.6	0.6

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.