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Which drugs are most reported with Frustration tolerance decreased?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 7,938 reports · 339 co-occurring drugs

As of the last recalculation, Frustration Tolerance Decreased appears in 7,938 FAERS reports alongside 339 co-occurring drug terms. The strongest observed disproportionality signal is CICLESONIDE (PRR 15.2).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Ciclesonide	78	15.2	15.2
Lisdexamfetamine Dimesylate	111	8.9	9.0
Rasagiline Mesylate	36	8.5	8.5
Peginterferon Beta-1A	41	8.2	8.3
Dimenhydrinate	32	7.9	7.9
Octreotide Acetate	91	7.9	7.9
Budesonide, Glycopyrrolate, And Formoterol Fumarate	31	7.8	7.8
Nitrofurantoin (Monohydrate/Macrocrystals)	49	7.7	7.8
Guanfacine	23	7.7	7.7
Nitrofurantoin	48	7.7	7.7
Instalax Polyethylene Glycol 3350	36	7.6	7.7
Polyethylene Glycol 400	36	7.5	7.5
Omalizumab	232	7.3	7.3
Timolol	33	7.2	7.2
Lifitegrast	44	7.1	7.1
Diroximel Fumarate	31	6.8	6.9
Indapamide	44	6.5	6.5
Fluticasone Furoate	29	6.3	6.3
Acetaminophen And Codeine	29	6.3	6.3
Loperamide Hydrochloride Oral	23	5.9	5.9
Lurasidone Hydrochloride	47	5.9	5.9
Bisacodyl Suppositories	29	5.9	5.9
Ipratropium Bromide	79	5.9	5.9
Biscodyl	29	5.8	5.9
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	90	5.7	5.8
Valproate Sodium	45	5.7	5.7
Bisacodyl	30	5.6	5.6
Dimethyl Fumarate	254	5.6	5.6
Rabeprazole	44	5.2	5.2
Elexacaftor, Tezacaftor, And Ivacaftor	24	5.1	5.1
Alemtuzumab	37	5.0	5.0
Rizatriptan Benzoate	19	4.9	4.9
Temazepam	69	4.8	4.8
Loperamide Hcl	23	4.7	4.7
Tiotropium Bromide Inhalation Spray	20	4.7	4.7
Primidone	18	4.6	4.6
Natalizumab	302	4.5	4.5
Asfotase Alfa	17	4.5	4.5
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	58	4.3	4.3
Fingolimod Hcl	140	4.3	4.3
Teduglutide	22	4.3	4.3
Ravulizumab	22	4.3	4.3
Human Immunoglobulin G	33	4.2	4.2
Fesoterodine Fumarate	17	4.1	4.1
Budesonide And Formoterol Fumarate Dihydrate	150	4.1	4.1
Infliximab-Dyyb	45	4.1	4.1
Pramipexole	23	3.9	3.9
Teriflunomide	67	3.9	3.9
Niraparib	32	3.8	3.8
Montelukast Sodium	173	3.8	3.8
Carbidopa And Levodopa	68	3.8	3.8
Fluticasone Furoate And Vilanterol Trifenatate	51	3.7	3.7
Vortioxetine	24	3.7	3.7
Thyroid, Porcine	15	3.7	3.7
Mepolizumab	69	3.7	3.7
Liothyronine Sodium	12	3.6	3.6
Montelukast	114	3.6	3.6
Cimetidine	13	3.5	3.5
Naltrexone	41	3.5	3.5
Brexpiprazole	22	3.5	3.5
Budesonide	77	3.5	3.5
Dalfampridine	91	3.4	3.4
Calcium, Magnesium, Potassium, And Sodium Oxybates	11	3.4	3.4
0Xygen	62	3.3	3.3
Oxygen	62	3.3	3.3
Cetirizine Hydrochloride Allergy	38	3.3	3.3
Cetirizine Hydrochloride Tablets	38	3.3	3.3
Tofacitinib	224	3.2	3.2
Erythromycin	23	3.2	3.2
Doxepin Hydrochloride	15	3.1	3.1
Doxepin	12	3.1	3.1
Ofatumumab	39	3.1	3.1
Methylphenidate Hydrochloride	69	3.1	3.1
Suvorexant	15	3.0	3.0
Cyanocobalamin	38	3.0	3.0
Lithium	29	3.0	3.0
Lithium Bromatum	29	3.0	3.0
Fluticasone Propionate And Salmeterol Xinafoate	68	3.0	3.0
Dexlansoprazole	47	3.0	3.0
Pregabalin	300	3.0	3.0
Melatonin	61	3.0	3.0
Thiamine Hydrochloride	14	3.0	3.0
Dicyclomine Hydrochloride	16	2.9	3.0
Esketamine Hydrochloride	20	2.9	2.9
Vibegron	9	2.9	2.9
Atropine Sulfate	12	2.9	2.9
Amantadine	17	2.9	2.9
Zinc	27	2.9	2.9
Tizanidine	26	2.9	2.9
Cetirizine Hcl	10	2.9	2.9
Interferon Beta-1A	207	2.9	2.9
Zinc Chloride	27	2.9	2.9
Buspirone Hydrochloride	12	2.9	2.9
Vedolizumab	93	2.9	2.9
Conjugated Estrogens	63	2.8	2.9
Cariprazine	10	2.8	2.8
Estrogens, Conjugated	63	2.8	2.8
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	32	2.8	2.8
Tiotropium Bromide	143	2.8	2.8
Albuterol Sulfate	304	2.8	2.8
Zinc Gluconate	27	2.7	2.7
Diphenoxylate Hydrochloride And Atropine Sulfate	14	2.7	2.7
Lanreotide Acetate	8	2.7	2.7
Loratadine Tablet	54	2.7	2.7
Siponimod	9	2.6	2.6
Desvenlafaxine Succinate	27	2.6	2.6
Pimavanserin Tartrate	55	2.6	2.6
Cetirizine	77	2.6	2.6
Prednisone	481	2.6	2.6
Sacubitril And Valsartan	114	2.6	2.6
Vilazodone Hydrochloride	9	2.6	2.6
Ticagrelor	31	2.6	2.6
Ibuprofen Tablets, Coated	41	2.5	2.5
Atropine	8	2.5	2.5
Loperamide Hydrochloride	43	2.5	2.5
Rosuvastatin Calcium	27	2.5	2.5
Ibuprofen Sodium	41	2.5	2.5
Fremanezumab-Vfrm	11	2.5	2.5
Testosterone	22	2.5	2.5
Lorazepam	167	2.5	2.5
Venlafaxine	67	2.5	2.5
Naltrexone Hydrochloride And Bupropion Hydrochloride	8	2.5	2.5
Duloxetine	65	2.5	2.5
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	148	2.5	2.5
Pancrelipase	36	2.5	2.5
Biotin	29	2.4	2.4
Mometasone	17	2.4	2.4
Atomoxetine Hydrochloride	22	2.4	2.4
Diphenhydramine Hydrochloride	151	2.4	2.4
Rabeprazole Sodium	25	2.4	2.4
Mesalamine	51	2.4	2.4
Metformin Hydrochloride Tablets	52	2.4	2.4
Metformin Hydrochloride Extended-Release Tablets	52	2.4	2.4
Metformin Hydrochloride Tablet	52	2.4	2.4
Docusate Sodium - Sennosides	29	2.4	2.4
Metformin Hydrochloride	53	2.4	2.4
Methocarbamol Tablets	15	2.4	2.4
Relugolix	21	2.3	2.3
Venlafaxine Hydrochloride	117	2.3	2.3
Ribociclib	28	2.3	2.3
Vitamin C	81	2.3	2.3
Valsartan Oral	48	2.3	2.3
Ocrelizumab	54	2.3	2.3
Hyoscyamine Sulfate	8	2.3	2.3
Clonazepam	138	2.3	2.3
Modafinil	28	2.3	2.3
Estradiol	74	2.3	2.3
Armodafinil	18	2.2	2.2
Ergocalciferol	321	2.2	2.2
Conjugated Estrogens And Medroxyprogesterone Acetate	20	2.2	2.2
Amphetamine	7	2.2	2.2
Escitslopram	49	2.2	2.2
Estradiol Gel 0.1%	38	2.2	2.2
Estradiol Transdermal	38	2.2	2.2
Iron	56	2.2	2.2
Crisaborole	8	2.2	2.2
Loratadine	89	2.2	2.2
Nintedanib	26	2.2	2.2
Levodopa	10	2.2	2.2
Selexipag	21	2.1	2.1
Albuterol	97	2.1	2.1
Pirfenidone	33	2.1	2.1
Paroxetine Hydrochloride Hemihydrate	27	2.1	2.1
Travoprost	7	2.1	2.1
Timolol Maleate	8	2.1	2.1
Magnesium	66	2.1	2.1
Cetiirizine	34	2.1	2.1
Memantine	11	2.1	2.1
Memantine Hydrochloride	11	2.1	2.1
Paroxetine	27	2.1	2.1
Diphenhydramine	50	2.1	2.1
Methocarbamol	18	2.1	2.1
Polyethylene Glycol 3350	75	2.1	2.1
Escitalopram Oxalate	57	2.1	2.1
Eplerenone	10	2.0	2.0
Hydroxyzine	37	2.0	2.0
Topiramate	72	2.0	2.0
Loratadine Oral	38	2.0	2.0
Sucralfate Oral	11	2.0	2.0
Sucralfate Oral Suspension	11	2.0	2.0
Mometasone Furoate And Formoterol Fumarate Dihydrate	12	2.0	2.0
Duloxetine Hydrochloride	143	2.0	2.0
Insulin Degludec	18	2.0	2.0
Tafamidis	9	2.0	2.0
Lisinopril And Hydrochlorothiazide Tablets	6	2.0	2.0
Levetiracetam	101	2.0	2.0
Cetirizine Hydrochloride	123	2.0	2.0
Fluticasone Propionate	96	2.0	2.0
Lubiprostone	7	1.9	1.9
Secukinumab	118	1.9	1.9
Paliperidone	17	1.9	1.9
Sildenafil	42	1.9	1.9
Lacosamide	27	1.9	1.9
Mirabegron	28	1.9	1.9
Atenolol	96	1.9	1.9
Extended Phenytoin Sodium	12	1.9	1.9
Ropinirole	11	1.9	1.9
Fluoxetine Hydrochloride	90	1.9	1.9
Amikacin	12	1.8	1.8
Trazodone Hydrochloride	11	1.8	1.8
Treprostinil	87	1.8	1.8
Ibuprofen And Diphenhydramine Citrate	16	1.8	1.8
Baclofen	59	1.8	1.8
Minocycline	8	1.8	1.8
Lisinopril And Hydrochlorothiazide	7	1.8	1.8
Oxybutynin Chloride	6	1.8	1.8
Hydroxyzine Hydrochloride	9	1.8	1.8
Hydroxyzine Hydrochloride Oral	9	1.8	1.8
Triamcinolone Acetonide Ointment Usp, 0.05%	16	1.8	1.8
Leflunomide	71	1.8	1.8
Insulin Glargine	166	1.8	1.8
Adalimumab	468	1.8	1.8
Umeclidinium	6	1.8	1.8
Bosutinib	6	1.8	1.8
Levocetirizine Dihydrochloride	16	1.7	1.7
Aripiprazole	81	1.7	1.7
Belimumab	21	1.7	1.7
Acalabrutinib	8	1.7	1.7
Levetiracetam In Sodium Chloride	51	1.7	1.7
Levetiracetam Oral	51	1.7	1.7
Levetiracetam Injection	51	1.7	1.7
Ruxolitinib	47	1.7	1.7
Progesterone	15	1.7	1.7
Gabapentin	236	1.7	1.7
Macitentan	45	1.7	1.7
Zoledronic Acid	26	1.7	1.7
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	32	1.7	1.7
Metformin	224	1.7	1.7
Quinapril Hydrochloride	5	1.7	1.7
Sumatriptan Succinate	16	1.7	1.7
Interferon Beta-1B	12	1.6	1.6
Rotigotine	9	1.6	1.6
Buprenorphine Hydrochloride, Naloxone Hydrochloride	15	1.6	1.6
Insulin Aspart	41	1.6	1.6
Ibrutinib	50	1.6	1.6
Bupropion Hydrochloride	61	1.6	1.6
Sertraline	72	1.6	1.6
Triamcinolone Acetonide	19	1.6	1.6
Oxybutynin	18	1.6	1.6
Clobazam	15	1.6	1.6
Pegvaliase-Pqpz	5	1.6	1.6
Benzonatate	10	1.6	1.6
Letrozole Tablets	29	1.6	1.6
Anakinra	10	1.6	1.6
Ozanimod Hydrochloride	5	1.6	1.6
Letrozole	37	1.6	1.6
Risankizumab-Rzaa	49	1.6	1.6
Oral Semaglutide	44	1.6	1.6
Cenobamate	5	1.6	1.6
Olanzapine	64	1.6	1.6
Insulin Lispro	82	1.6	1.6
Methylphenidate	17	1.5	1.5
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	12	1.5	1.5
Naproxen Sodium, Pseudoephedrine Hydrochloride	12	1.5	1.5
Metformin Er 500 Mg	173	1.5	1.5
Metformin Er 750 Mg	173	1.5	1.5
Voclosporin	5	1.5	1.5
Alpelisib	5	1.5	1.5
Hydrocodone Bitartrate And Acetaminophen	32	1.5	1.5
Sildenafil Powder,	20	1.5	1.5
Brimonidine Tartrate	10	1.5	1.5
Testosterone Cypionate	5	1.5	1.5
Brivaracetam	5	1.5	1.5
Rimegepant Sulfate	7	1.4	1.4
Fexofenadine Hydrochloride	12	1.4	1.4
Palbociclib	52	1.4	1.4
Riociguat	17	1.4	1.4
Cladribine	5	1.4	1.4
Glatiramer Acetate	31	1.4	1.4
Sodium Oxybate	34	1.4	1.4
Axitinib	10	1.3	1.3
Rivaroxaban	106	1.3	1.3
Benralizumab	10	1.3	1.3
Inclisiran	4	1.3	1.3
Avapritinib	6	1.3	1.3
Sarilumab	13	1.3	1.3
Botulinum Toxin Type A	6	1.3	1.3
Galcanezumab-Gnlm	15	1.2	1.2
Sildenafil Citrate	60	1.2	1.2
Cannabidiol	11	1.2	1.2
Nicotine	19	1.2	1.2
Icosapent Ethyl	4	1.2	1.2
Bimekizumab	10	1.2	1.2
Osimertinib	15	1.2	1.2
Risperidone	62	1.2	1.2
Asenapine Maleate	4	1.2	1.2
Upadacitinib	37	1.2	1.2
Oseltamivir Phosphate	11	1.2	1.2
Linaclotide	12	1.2	1.2
Empagliflozin	30	1.2	1.2
Nilotinib	13	1.2	1.2
Etonogestrel	20	1.1	1.1
Pembrolizumab	43	1.1	1.1
Dornase Alfa	8	1.1	1.1
Fam-Trastuzumab Deruxtecan-Nxki	4	1.0	1.0
Enzalutamide	23	1.0	1.0
Varenicline Tartrate	31	1.0	1.0
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate	16	1.0	1.0
Liraglutide	19	1.0	1.0
Naproxen Sodium Tablet	20	1.0	1.0
Venetoclax	22	0.9	0.9
Emtricitabine And Tenofovir Alafenamide	4	0.9	0.9
Acetaminophen, Aspirin (Nsaid) And Caffeine	6	0.9	0.9
Clozapine	44	0.9	0.9
Lumacaftor And Ivacaftor	3	0.9	0.9
Etanercept	208	0.9	0.9
Certolizumab Pegol	40	0.9	0.9
Abaloparatide	10	0.9	0.9
Guselkumab	12	0.9	0.9
Olaparib	7	0.9	0.9
Acetaminophen, Aspirin, And Caffeine	7	0.9	0.9
Ambrisentan	41	0.9	0.9
Copper	14	0.9	0.9
Leuprolide Acetate	24	0.8	0.8
Polatuzumab Vedotin	3	0.8	0.8
Dulaglutide	27	0.8	0.8
Obinutuzumab	5	0.8	0.8
Evolocumab	49	0.8	0.8
Ranibizumab	8	0.8	0.8
Erenumab-Aooe	16	0.8	0.8
Paliperidone Palmitate	9	0.7	0.7
Cabozantinib	13	0.7	0.7
Onabotulinumtoxina	20	0.7	0.7
Durvalumab	5	0.6	0.6
Somatropin	18	0.6	0.6
Aflibercept	7	0.6	0.6
Nirmatrelvir And Ritonavir	12	0.6	0.6
Ixekizumab	8	0.6	0.6
Vigabatrin	3	0.5	0.5
Alirocumab	5	0.5	0.5
Valbenazine	5	0.5	0.5
Apremilast	29	0.5	0.5
Levonorgestrel	34	0.4	0.4
Pegfilgrastim	16	0.4	0.4
Dupilumab	76	0.4	0.4
Tirzepatide	23	0.4	0.4
Droxidopa	3	0.4	0.4
Salicylic Acid	3	0.1	0.1
Adapalene	4	0.1	0.1

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.