Reaction

Exercise Tolerance Decreased reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,635 reports · 309 co-occurring drugs

As of the last recalculation, Exercise Tolerance Decreased appears in 5,635 FAERS reports alongside 309 co-occurring drug terms. The strongest observed disproportionality signal is EPLERENONE (PRR 29.6).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Eplerenone	101	29.6	29.9
Labetalol	76	21.3	21.5
Regorafenib	64	20.6	20.7
Calcium Gluconate	55	17.0	17.1
0Xygen	162	12.5	12.5
Oxygen	162	12.5	12.5
Risedronate Sodium	99	12.0	12.0
Methocarbamol Tablets	53	11.8	11.8
Sildenafil Powder,	108	11.4	11.4
Epoprostenol	40	11.4	11.4
Torsemide	99	11.2	11.3
Sildenafil	170	11.1	11.2
Macitentan	190	10.5	10.5
Treprostinil	324	10.1	10.1
Riociguat	87	10.0	10.0
Selexipag	69	10.0	10.0
Nintedanib	82	9.8	9.8
Bosentan	129	9.7	9.7
Ambrisentan	299	9.3	9.3
Methocarbamol	54	8.9	8.9
Ciclesonide	32	8.7	8.7
Mometasone	42	8.5	8.5
Fluticasone Propionate Nasal	69	8.5	8.5
Tadalafil	220	8.4	8.4
Nebivolol	36	8.4	8.4
Sildenafil Citrate	264	8.0	8.0
Cyanocobalamin	67	7.6	7.6
Dornase Alfa	40	7.6	7.6
Dolutegravir Sodium	18	7.4	7.4
Telmisartan	35	7.3	7.3
Antacid	91	7.2	7.2
Amiodarone Hydrochloride	21	6.9	7.0
Valsartan Oral	97	6.7	6.7
Tiotropium Bromide Inhalation Spray	20	6.6	6.6
Bisoprolol Fumarate	234	6.6	6.6
Relugolix	41	6.5	6.5
Theophylline	20	6.4	6.5
Theophylline Anhydrous	21	6.3	6.3
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Alafenamide	17	6.3	6.3
Candesartan	59	6.2	6.2
Ivacaftor	13	6.1	6.1
Pramipexole	25	6.0	6.1
Ciprofolxacin	115	6.0	6.0
Ciprofloxacin Tablets	115	6.0	6.0
Mepolizumab	80	6.0	6.0
Fluticasone Furoate And Vilanterol Trifenatate	58	6.0	6.0
Mometasone Furoate	67	6.0	6.0
Sacubitril And Valsartan	182	6.0	6.0
Ramipril	193	5.9	5.9
Digoxin	112	5.9	5.9
Azithromycin	63	5.8	5.8
Benralizumab	31	5.7	5.8
Elexacaftor, Tezacaftor, And Ivacaftor	19	5.6	5.6
Azithromycin Monohydrate	63	5.6	5.6
Calcium Carbonate	101	5.6	5.6
Metolazone	17	5.6	5.6
Fluticasone Furoate	18	5.5	5.5
Ciprofloxacin	134	5.5	5.5
Pirfenidone	60	5.5	5.5
Fluticasone Propionate	186	5.4	5.4
Ciprofloxacin Hydrochloride	139	5.4	5.4
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Disoproxil Fumarate	13	5.3	5.3
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	26	5.3	5.3
Omalizumab	120	5.3	5.3
Sitagliptin	101	5.3	5.3
Tramadol Hydrochloride	53	5.2	5.2
Levofloxacin	84	5.2	5.2
Levofloxacin In 5% Dextrose	84	5.2	5.2
Darunavir	21	5.1	5.1
Potassium Chloride, Dextrose Monohydrate	125	5.1	5.1
Potassium Chloride Oral	125	5.1	5.1
Potassium Chloride Extended-Release	125	5.1	5.1
Nebivolol Hydrochloride	46	5.1	5.1
Allopurinol	208	5.1	5.1
Bumetanide	36	5.1	5.1
Clopidogrel Bisulfate	137	5.0	5.1
Imatinib	24	5.0	5.0
Apixaban	89	5.0	5.0
Spironolactone	182	4.9	4.9
Furosemide	488	4.8	4.8
Asfotase Alfa	13	4.8	4.8
Azithromycin Dihydrate	75	4.8	4.8
Albuterol	150	4.7	4.7
Rosuvastatin	250	4.7	4.7
Sirolimus	17	4.7	4.7
Potassium Chloride	141	4.7	4.7
Atazanavir	18	4.6	4.6
Diltiazem Hydrochloride	43	4.6	4.6
Warfarin	154	4.6	4.6
Montelukast Sodium	146	4.5	4.5
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	36	4.4	4.4
Valsartan	123	4.4	4.4
Mupirocin	16	4.4	4.4
Albuterol Sulfate	336	4.4	4.4
Budesonide And Formoterol Fumarate Dihydrate	113	4.4	4.4
Levothyroxine Sodium Anhydrous	116	4.3	4.3
Mupirocin Calcium	16	4.3	4.3
Fluticasone Propionate And Salmeterol Xinafoate	68	4.2	4.2
Tobramycin	27	4.2	4.2
Terazosin Hydrochloride	10	4.2	4.2
Inclisiran	9	4.2	4.2
Niacin	13	4.1	4.1
Bicalutamide	17	4.1	4.1
Psyllium Husk	11	4.1	4.1
Sorafenib	23	4.1	4.1
Ropinirole	17	4.1	4.1
Ritonavir	32	4.1	4.1
Ipratropium Bromide	39	4.1	4.1
Pantoprazole	267	4.0	4.0
Magnesium	88	4.0	4.0
Montelukast	89	4.0	4.0
Emtricitabine And Tenofovir Alafenamide	12	3.9	3.9
Zinc	26	3.9	3.9
Vitamin E	33	3.9	3.9
Zinc Chloride	26	3.9	3.9
Tiotropium Bromide	141	3.9	3.9
Doxazosin	29	3.8	3.8
Zinc Gluconate	27	3.8	3.8
Liothyronine Sodium	9	3.8	3.8
Mometasone Furoate And Formoterol Fumarate Dihydrate	16	3.8	3.8
Simvastatin	248	3.8	3.8
Emtricitabine And Tenofovir Disoproxil Fumarate	46	3.7	3.8
Testosterone Cypionate	9	3.7	3.7
Metoprolol Tartrate Injection	186	3.7	3.7
Atorvastatin Calcium, Film Coated	69	3.7	3.7
Tamsulosin Hydrochloride	20	3.6	3.6
Agalsidase Beta	9	3.6	3.6
Fexofenadine	16	3.6	3.6
Melphalan	22	3.6	3.6
Carvedilol	129	3.6	3.6
Finasteride	58	3.6	3.6
Diltiazem Hydrochloride Extended-Release Tablets	11	3.6	3.6
Meclizine Hcl 12.5Mg	13	3.5	3.5
Meclizine Hcl 25Mg	13	3.5	3.5
Meclizine Hcl 12.5 Mg	13	3.5	3.5
Meclizine Hcl 25 Mg	13	3.5	3.5
Warfarin Sodium	44	3.5	3.5
Nilotinib	28	3.5	3.5
Aspirin 325 Mg	458	3.5	3.5
Aspirin 81 Mg	458	3.5	3.5
Metoprolol	232	3.5	3.5
Nicotine Polacrilex Mini	14	3.5	3.5
Nicotine Polarilex	14	3.5	3.5
Aspirin	471	3.4	3.4
Salmeterol Xinafoate	8	3.4	3.4
Cetiirizine	39	3.4	3.4
Dapagliflozin	29	3.4	3.4
Abacavir Sulfate	9	3.4	3.4
Meclizine	15	3.4	3.4
Doxazosin Mesylate	33	3.4	3.4
Calcium	134	3.4	3.4
Ciprofloxacin Hydrochloride And Hydrocortisone	19	3.4	3.4
Pancrelipase	35	3.4	3.4
Raltegravir	15	3.4	3.4
Metoprolol Tartrate	239	3.3	3.3
Methimazole	7	3.3	3.3
Tobramycin Sulfate	11	3.3	3.3
Ticagrelor	28	3.3	3.3
Melphalan Hydrochloride	22	3.2	3.3
Ergocalciferol	318	3.2	3.2
Acetylcysteine	8	3.1	3.1
Thyroid, Porcine	9	3.1	3.1
Atropine	7	3.1	3.1
Desloratadine	9	3.1	3.1
Ketoprofen	11	3.1	3.1
Tobramycin Solution	10	3.1	3.1
Goserelin	11	3.0	3.0
Lovastatin	21	3.0	3.0
Budesonide	48	3.0	3.0
Lopinavir And Ritonavir	11	3.0	3.0
Lactulose	31	3.0	3.0
Dasatinib	30	3.0	3.0
Nitroglycerin	43	3.0	3.0
Ezetimibe	60	3.0	3.0
Vitamin C	73	3.0	3.0
Candesartan Cilexetil	21	3.0	3.0
Metformin Er 500 Mg	234	3.0	3.0
Metformin Er 750 Mg	234	3.0	3.0
Sucralfate	19	2.9	2.9
Melatonin	43	2.9	2.9
Gemfibrozil	12	2.9	2.9
Ezetimibe And Simvastatin	12	2.9	2.9
Tenofovir Disoproxil Fumarate	26	2.9	2.9
Benzonatate	13	2.9	2.9
Insulin Glulisine	8	2.9	2.9
Irbesartan	35	2.9	2.9
Atorvastatin Calcium	190	2.9	2.9
Umeclidinium	7	2.9	2.9
Amoxicillin	59	2.9	2.9
Amoxicillin And Clavulanate Potassium	21	2.9	2.9
Pertuzumab	21	2.9	2.9
Paliperidone	18	2.9	2.9
Meclizine Hydrochloride	15	2.8	2.8
Leuprolide Acetate	59	2.8	2.8
Tafamidis	9	2.8	2.8
Ferrous Sulfate	38	2.8	2.8
Enalapril	42	2.8	2.8
Metformin	262	2.8	2.8
Metoprolol Succinate Er Tablets	47	2.8	2.8
Butalbital, Acetaminophen, And Caffeine	8	2.8	2.8
Amlodipine Besylate	108	2.8	2.8
Oxazepam	16	2.8	2.8
Glyburide	18	2.8	2.8
Tretinoin	6	2.7	2.7
Heparin Sodium	10	2.7	2.7
Amlodipine	192	2.7	2.7
Azelastine	13	2.7	2.7
Clopidogrel	141	2.7	2.7
Sotalol Hydrochloride	12	2.7	2.7
Hydroxyzine	34	2.6	2.6
Atomoxetine Hydrochloride	17	2.6	2.6
Metoprolol Succinate	61	2.6	2.6
Drospirenone And Ethinyl Estradiol	31	2.6	2.6
Fish Oil	63	2.6	2.6
Metoroprolol Tartrate	46	2.6	2.6
Fluoxetine	46	2.6	2.6
Itraconazole	8	2.5	2.5
Hydroxyzine Hydrochloride	9	2.5	2.5
Hydroxyzine Hydrochloride Oral	9	2.5	2.5
Apalutamide	8	2.5	2.5
Rucaparib	6	2.5	2.5
Mirtazapine	61	2.5	2.5
Dofetilide	7	2.5	2.5
Cetirizine	51	2.4	2.4
Loratadine Oral	32	2.4	2.4
Prochlorperazine Maleate	6	2.4	2.4
Calcitriol Capsules 0.25 Mcg	13	2.4	2.4
Calcitriol Capsules 0.5 Mcg	13	2.4	2.4
Amikacin	11	2.4	2.4
Biotin	20	2.4	2.4
Multivitamin	32	2.4	2.4
Rivaroxaban	131	2.4	2.4
Guanfacine	5	2.3	2.3
Quinapril Hydrochloride	5	2.3	2.3
Leucovorin Calcium	12	2.3	2.3
Fludarabine Phosphate	24	2.3	2.3
Loratadine	65	2.2	2.2
Metformin Hcl	33	2.2	2.2
Diclofenac Potassium, Film Coated	5	2.2	2.2
Diclofenac Potassium Tablets	5	2.2	2.2
Dronedarone	6	2.2	2.2
Abiraterone	8	2.2	2.2
Etonogestrel And Ethinyl Estradiol	13	2.2	2.2
Lumacaftor And Ivacaftor	5	2.2	2.2
Loratadine Tablet	31	2.1	2.1
Pioglitazone	25	2.1	2.1
Isosorbide Mononitrate	12	2.1	2.1
Asenapine Maleate	5	2.1	2.1
Budesonide, Glycopyrrolate, And Formoterol Fumarate	6	2.1	2.1
Hydroxyurea	12	2.1	2.1
Alirocumab	14	2.1	2.1
Fluticasone Propionate And Salmeterol	23	2.0	2.0
Lamivudine	17	2.0	2.0
Glipizide	33	2.0	2.0
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate	22	2.0	2.0
Ruxolitinib	38	2.0	2.0
Sitagliptin And Metformin Hydrochloride	11	1.9	1.9
Avapritinib	6	1.8	1.8
Nicotine	20	1.8	1.8
Trastuzumab	33	1.8	1.8
Ranolazine	5	1.8	1.8
Umeclidinium Bromide And Vilanterol Trifenatate	8	1.8	1.8
Ado-Trastuzumab Emtansine	4	1.8	1.8
Rimegepant Sulfate	6	1.7	1.7
Icosapent Ethyl	4	1.7	1.7
Irinotecan Hydrochloride	6	1.7	1.7
Diclofenac Potassium	5	1.7	1.7
Ofatumumab	15	1.7	1.7
Niraparib	10	1.7	1.7
Rasagiline Mesylate	5	1.7	1.7
Panitumumab	7	1.7	1.7
Nicotine Polacrilex	17	1.6	1.6
Mirabegron	17	1.6	1.6
Imatinib Mesylate	12	1.6	1.6
Ranitidine	85	1.6	1.6
Ocrelizumab	26	1.6	1.6
Axitinib	8	1.5	1.5
Prasugrel Hydrochloride	4	1.5	1.5
Brimonidine Tartrate	7	1.5	1.5
Enzalutamide	23	1.4	1.4
Lapatinib	6	1.4	1.4
Loratadine And Pseudoephedrine Sulfate	3	1.4	1.4
Teriflunomide	17	1.4	1.4
Vortioxetine	6	1.3	1.3
Travoprost	3	1.3	1.3
Ribavirin	22	1.3	1.3
Abiraterone Acetate	14	1.3	1.3
Denosumab	68	1.2	1.2
Peginterferon Alfa-2A	18	1.2	1.2
Acalabrutinib	4	1.2	1.2
Teriparatide	37	1.2	1.2
Droxidopa	7	1.2	1.2
Natalizumab	57	1.2	1.2
Fam-Trastuzumab Deruxtecan-Nxki	3	1.1	1.1
Ranitidine Hydrochloride	16	1.1	1.1
Dabigatran Etexilate Mesylate	21	1.1	1.1
Trifluridine And Tipiracil	3	1.0	1.0
Dalfampridine	19	1.0	1.0
Diroximel Fumarate	3	0.9	0.9
Osimertinib	8	0.9	0.9
Paliperidone Palmitate	8	0.9	0.9
Olaparib	5	0.9	0.9
Ledipasvir And Sofosbuvir	4	0.8	0.8
Abaloparatide	6	0.8	0.8
Galcanezumab-Gnlm	6	0.7	0.7
Evolocumab	30	0.7	0.7
Cinacalcet Hydrochloride	7	0.6	0.6
Levonorgestrel	26	0.5	0.5
Copper	3	0.3	0.3

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.