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Which drugs are most reported with Large intestine perforation?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 6,857 reports · 315 co-occurring drugs

As of the last recalculation, Large Intestine Perforation appears in 6,857 FAERS reports alongside 315 co-occurring drug terms. The strongest observed disproportionality signal is BEVACIZUMAB (PRR 17.5).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Bevacizumab	651	17.5	17.6
Granisetron Hydrochloride	42	12.3	12.3
Ipilimumab	162	11.6	11.7
Fluorouracil Cream, 0.5%	259	10.7	10.7
Fluorouracil	260	10.6	10.6
Leucovorin Calcium	61	9.8	9.8
Irinotecan Hydrochloride	40	9.5	9.5
Oxaliplatin	221	9.3	9.3
Lenvatinib	95	8.9	8.9
Aprepitant	52	8.6	8.6
Paclitaxel (Aibumin-Bound)	222	8.4	8.5
Atropine Sulfate	29	8.2	8.2
Granisetron	28	8.1	8.2
Dalteparin Sodium	28	8.1	8.1
Fosaprepitant Dimeglumine	35	7.8	7.8
Paclitaxel	244	7.7	7.7
Piperacillin Sodium And Tazobactam Sodium	48	7.5	7.5
Atropine	20	7.3	7.4
Piperacillin And Tazobactam	30	7.1	7.2
Cisplatin	177	7.0	7.0
Pemetrexed Disodium	87	7.0	7.0
Pemetrexed	49	7.0	7.0
Metronidazole Topical	105	6.8	6.8
Metronidazole	140	6.8	6.8
Panitumumab	34	6.6	6.6
Piperacillin Sodium,Tazobactam Sodium	57	6.6	6.6
Sorafenib	44	6.5	6.5
Micafungin Sodium	18	6.5	6.5
Carboplatin	255	6.3	6.3
Basiliximab	24	6.2	6.2
Loperamide Hcl	25	5.9	5.9
Cetuximab	60	5.9	5.9
Methylprednisolone	254	5.8	5.8
Prednisolone	328	5.7	5.8
Prednisolone Oral	328	5.7	5.8
Prednisolone Oral Solution	328	5.7	5.8
Pembrolizumab	194	5.7	5.7
Anti-Thymocyte Globulin (Rabbit)	15	5.7	5.7
Docetaxel Anhydrous	122	5.6	5.6
Docetaxel	122	5.6	5.6
Ganciclovir Sodium	19	5.5	5.5
Everolimus Tablets	30	5.5	5.5
Atezolizumab	69	5.4	5.4
Temozolomide	37	5.4	5.4
Erlotinib Hydrochloride	22	5.4	5.4
Diphenoxylate Hydrochloride And Atropine Sulfate	24	5.3	5.3
Regorafenib	20	5.2	5.2
Loperamide Hydrochloride Oral	17	5.1	5.1
Diclofenac	140	5.0	5.0
Mycophenilic Acid	34	5.0	5.0
Hydrocortisone Sodium Succinate	15	4.9	4.9
Dexamethasone Sodium Phosphate	16	4.8	4.8
Polyethylene Glycol	17	4.8	4.8
Magnesium Sulfate In Water For	20	4.8	4.8
Ganciclovir	16	4.8	4.8
Magnesium Sulfate Heptahydrate	20	4.7	4.7
Magnesium Sulfate	20	4.7	4.7
Senna Leaf	35	4.6	4.6
Capecitabine	137	4.6	4.6
Sennosides 8.6 Mg Tablets	31	4.5	4.5
Senna	31	4.5	4.5
Meropenem	47	4.5	4.5
Mesalamine	81	4.4	4.4
Ketoprofen	19	4.4	4.4
Tocilizumab	162	4.4	4.4
Remdesivir	19	4.3	4.3
Nivolumab	135	4.3	4.3
Encorafenib	14	4.3	4.3
Magnesium Hydroxide	19	4.3	4.3
Sennosides	42	4.3	4.3
Ceftriaxone	46	4.3	4.3
Valganciclovir Hydrochloride Powder,	17	4.2	4.2
Magnesium Oxide	58	4.2	4.2
Dexamethasone 1.5 Mg	390	4.2	4.2
Ceftriaxone Sodium	53	4.2	4.2
Diclofenac Sodium 1%	49	4.2	4.2
Diclofenac Sodium Topical	49	4.2	4.2
Diclofenac Sodium Topical Gel, 1%	49	4.2	4.2
Dexamethasone	390	4.2	4.2
Thalidomide	50	4.2	4.2
Posaconazole Delayed-Release	15	4.2	4.2
Upadacitinib	109	4.1	4.1
Epoetin Alfa	16	4.1	4.1
Erlotinib	13	4.1	4.1
Valganciclovir	25	4.0	4.0
Valganciclovir Hydrochloride	25	4.0	4.0
Tacrolimus Ointment 0.1%	162	4.0	4.0
Tacrolimus Extended-Release Capsules	162	4.0	4.0
Morphine	97	4.0	4.0
Bortezomib	115	4.0	4.0
Indomethacin	17	3.9	3.9
Tacrolimus	197	3.9	3.9
Mycophenolate Mofetil	170	3.9	3.9
Mycophenolate Mofetil Hydrochloride	170	3.9	3.9
Azathioprine	110	3.8	3.8
Cabozantinib	59	3.8	3.8
Misoprostol	12	3.7	3.7
Gentamicin	16	3.7	3.7
Psyllium Husk	12	3.7	3.7
Diclofenac Sodium	179	3.7	3.7
Azacitidine For	22	3.7	3.7
Gentamicin Sulfate	19	3.7	3.7
Mycophenolic Acid	38	3.6	3.6
Enoxaparin Sodium	68	3.6	3.6
Phytonadione	10	3.6	3.6
Rabeprazole	26	3.6	3.6
Methylprednisolone Sodium Succinate	53	3.5	3.5
Pegaspargase	14	3.5	3.5
Sevelamer Carbonate	13	3.4	3.4
Docusate Sodium 100Mg	27	3.4	3.4
Vincristine Sulfate	33	3.4	3.4
Loperamide Hydrochloride	50	3.4	3.4
Fluconazole	78	3.4	3.4
Norepinephrine Bitartrate	16	3.4	3.4
Posaconazole	18	3.4	3.4
Bisacodyl Suppositories	14	3.3	3.3
Etoposide	79	3.3	3.3
Gemcitabine Hydrochloride	57	3.3	3.3
Biscodyl	14	3.3	3.3
Lubiprostone	10	3.2	3.2
Isotretinoin	52	3.2	3.2
Vedolizumab	90	3.2	3.2
Loperamide Hydrochloride And Dimethicone	33	3.1	3.1
Norepinephrine	11	3.1	3.1
Vancomycin Hydrochloride	67	3.1	3.1
Valproate Sodium	21	3.1	3.1
Ondansetron Hydrochloride	121	3.0	3.0
Bisacodyl	14	3.0	3.0
Gemcitabine	39	3.0	3.0
Cholestyramine	12	3.0	3.0
Febuxostat Tablets 40 Mg	10	3.0	3.0
Febuxostat Tablets 80 Mg	10	3.0	3.0
Azacitidine	29	3.0	3.0
Cytarabine	58	2.9	2.9
Pazopanib Hydrochloride	26	2.9	2.9
Ondansetron	104	2.9	2.9
Ondansetron Tablets	104	2.9	2.9
Vancomycin	55	2.9	2.9
Telmisartan	17	2.9	2.9
Everolimus	48	2.9	2.9
Crizotinib	12	2.9	2.9
Lactulose	36	2.9	2.9
Nintedanib	29	2.8	2.8
Mercaptopurine	16	2.8	2.8
Valproic Acid	29	2.8	2.8
Tofacitinib Citrate	12	2.8	2.8
Candesartan Cilexetil	24	2.8	2.8
Calcium Gluconate	11	2.8	2.8
Cyclophosphamide Injection, Solution	159	2.8	2.8
Cyclophosphamide	159	2.8	2.8
Cyclophosphamide For Injection	159	2.8	2.8
Docusate Sodium	52	2.7	2.7
Doxorubicin	80	2.7	2.7
Prednisone	434	2.7	2.7
Amiodarone Hydrochloride	10	2.7	2.7
Infliximab	191	2.7	2.7
Anti-Itch	58	2.6	2.6
Anti-Pruritic	58	2.6	2.6
Antipruritic (Anti-Itch)	58	2.6	2.6
Cool Relief Gel With Aloe	58	2.6	2.6
Drs. Hydrocortisone	58	2.6	2.6
Hydrocortisone Continuous Spray	58	2.6	2.6
Hydrocortisone Spray	58	2.6	2.6
Anti-Itch Cream	58	2.6	2.6
Hydrocortisone Lotion	58	2.6	2.6
Hydrocortisone Cream 1%	58	2.6	2.6
Hydrocortisone Cream 1/2%	58	2.6	2.6
Hydrocortisone 1%	58	2.6	2.6
Prochlorperazine	24	2.6	2.6
Hydrocortisone Cream	58	2.6	2.6
Itraconazole	10	2.6	2.6
Metoclopramide	46	2.6	2.6
Cefepime	12	2.5	2.5
Durvalumab	17	2.5	2.5
Tamsulosin Hydrochloride	17	2.5	2.5
Diclofenac Potassium, Film Coated	7	2.5	2.5
Diclofenac Potassium Tablets	7	2.5	2.5
Baricitinib	8	2.5	2.5
Nifedipine	39	2.5	2.5
Pertuzumab	22	2.5	2.5
Rabeprazole Sodium	22	2.5	2.5
Dabrafenib	17	2.5	2.5
Bumetanide	21	2.4	2.4
Melphalan	18	2.4	2.4
Sunitinib Malate	31	2.4	2.4
Ciprofolxacin	56	2.4	2.4
Ciprofloxacin Tablets	56	2.4	2.4
Metoclopramide Hydrochloride	60	2.4	2.4
Adalimumab	526	2.4	2.4
Gefitinib	7	2.4	2.4
Sodium Bicarbonate	18	2.4	2.4
Sodium Bicarbonate Injection,	18	2.4	2.4
Lisinopril And Hydrochlorothiazide Tablets	6	2.3	2.3
Sulfamethoxazole And Trimethoprim	64	2.3	2.3
Melphalan Hydrochloride	19	2.3	2.3
Pravastatin Sodium	15	2.3	2.3
Alendronate Sodium Tablet	14	2.3	2.3
Doxazosin	21	2.3	2.3
Cyclosporine	83	2.3	2.3
Cefazolin Sodium	9	2.3	2.3
Dronabinol	6	2.3	2.3
Filgrastim	28	2.3	2.3
Cefepime Hydrochloride	12	2.3	2.3
Diclofenac Potassium	8	2.2	2.2
Risankizumab-Rzaa	60	2.2	2.2
Ursodiol	16	2.2	2.2
Doxazosin Mesylate	26	2.2	2.2
Valsartan Oral	39	2.2	2.2
Daspone	7	2.2	2.2
Dapsone Gel, 5%	7	2.2	2.2
Valsartan	74	2.1	2.2
Midazolam Hydrochloride	19	2.1	2.1
Trametinib	17	2.1	2.1
Daratumumab	28	2.1	2.1
Calcitriol Capsules 0.25 Mcg	14	2.1	2.1
Calcitriol Capsules 0.5 Mcg	14	2.1	2.1
Calcitriol	14	2.1	2.1
Trastuzumab	47	2.1	2.1
Infliximab-Dyyb	20	2.1	2.1
Imatinib Mesylate	19	2.1	2.1
Bisoprolol Fumarate	92	2.1	2.1
Lansoprazole	120	2.1	2.1
Ursosiol	13	2.0	2.0
Enalapril	37	2.0	2.0
Sulfasalazine	52	2.0	2.0
Tobramycin Solution	8	2.0	2.0
Levofloxacin	40	2.0	2.0
Levofloxacin In 5% Dextrose	40	2.0	2.0
Propofol	24	2.0	2.0
Febuxostat	11	2.0	2.0
Heparin Sodium	9	2.0	2.0
Prochlorperazine Maleate	6	2.0	2.0
Tobramycin Sulfate	8	2.0	2.0
Doxorubicin Hydrochloride	21	2.0	2.0
Famotidine	75	1.9	1.9
Midazolam	16	1.9	1.9
Aripiprazole Oral	26	1.9	1.9
Aripiprazole Orally Disintegrating	26	1.9	1.9
Iron Sucrose	6	1.9	1.9
Voriconazole	19	1.9	1.9
Phenobarbital	9	1.9	1.9
Fondaparinux Sodium	5	1.9	1.9
Allopurinol	96	1.9	1.9
Suvorexant	8	1.9	1.9
Polatuzumab Vedotin	6	1.9	1.9
Fentanyl	60	1.9	1.9
Dabigatran Etexilate Mesylate	44	1.8	1.8
Dabigatran Etexilate	47	1.8	1.8
Sumatriptan Succinate	15	1.8	1.8
Lopinavir And Ritonavir	8	1.8	1.8
Pitavastatin Calcium	6	1.8	1.8
Erythropoietin	12	1.8	1.8
Blinatumomab	6	1.7	1.7
Pancrelipase	22	1.7	1.7
Instalax Polyethylene Glycol 3350	7	1.7	1.7
Trifluridine And Tipiracil	6	1.7	1.7
Desvenlafaxine Succinate	15	1.7	1.7
Canakinumab	6	1.7	1.7
Voriconazole Injection	12	1.7	1.7
Polyethylene Glycol 400	7	1.7	1.7
Amlodipine Besylate And Valsartan	6	1.6	1.6
Venetoclax	33	1.6	1.6
Polyethylene Glycol 3350	51	1.6	1.6
Thiotepa	5	1.6	1.6
Teduglutide	7	1.6	1.6
Ravulizumab	7	1.6	1.6
Acyclovir	59	1.6	1.6
Oxycodone	95	1.6	1.6
Rocuronium Bromide	6	1.5	1.5
Vemurafenib	6	1.5	1.5
Morphine Sulfate	60	1.5	1.5
Paricalcitol	7	1.5	1.5
Methadone	21	1.5	1.5
Tolvaptan	7	1.5	1.5
Eszopiclone	12	1.4	1.4
Travoprost	4	1.4	1.4
Tofacitinib	85	1.4	1.4
Clozapine	57	1.4	1.4
Oxycodone Hydrochloride	98	1.4	1.4
Levetiracetam In Sodium Chloride	35	1.4	1.4
Levetiracetam Oral	35	1.4	1.4
Levetiracetam Injection	35	1.4	1.4
Bendamustine Hcl	7	1.4	1.4
Linaclotide	12	1.4	1.4
Vismodegib	4	1.4	1.4
Aflibercept	14	1.4	1.4
Ixekizumab	15	1.2	1.2
Dasatinib	15	1.2	1.2
Ustekinumab	41	1.2	1.2
Fam-Trastuzumab Deruxtecan-Nxki	4	1.2	1.2
Hydrocodone Bitartrate And Acetaminophen	22	1.2	1.2
Darbepoetin Alfa	21	1.2	1.2
Interferon Beta-1A	75	1.2	1.2
Lenalidomide	162	1.2	1.2
Acetaminophen, Aspirin, And Caffeine	8	1.2	1.2
Romosozumab-Aqqg	5	1.1	1.1
Interferon Beta-1B	7	1.1	1.1
Patiromer	5	1.1	1.1
Axitinib	7	1.1	1.1
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	11	1.1	1.1
Sarilumab	9	1.0	1.0
Acalabrutinib	4	1.0	1.0
Elexacaftor, Tezacaftor, And Ivacaftor	4	1.0	1.0
Carfilzomib	9	1.0	1.0
Orlistat	8	0.9	0.9
Axicabtagene Ciloleucel	3	0.9	0.9
Pegfilgrastim	29	0.9	0.9
Pomalidomide	29	0.9	0.9
Copper	12	0.8	0.8
Abiraterone Acetate	11	0.8	0.8
Apalutamide	3	0.8	0.8
Dornase Alfa	5	0.8	0.8
Cinacalcet Hydrochloride	10	0.7	0.7
Hydrocodone Bitartrate	8	0.6	0.6
Pimavanserin Tartrate	7	0.4	0.4

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.