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Which drugs are most reported with Affective disorder?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 7,739 reports · 346 co-occurring drugs

As of the last recalculation, Affective Disorder appears in 7,739 FAERS reports alongside 346 co-occurring drug terms. The strongest observed disproportionality signal is LITHIUM (PRR 17.5).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Lithium	161	17.5	17.6
Lithium Bromatum	161	17.5	17.6
Brivaracetam	56	16.9	17.0
Ciclesonide	69	13.7	13.8
Gentamicin	63	13.1	13.1
Aripiprazole Oral	185	12.3	12.4
Aripiprazole Orally Disintegrating	185	12.3	12.4
Gentamicin Sulfate	65	11.1	11.2
Guanfacine	32	11.0	11.0
Theophylline Anhydrous	50	10.9	11.0
Haloperidol	93	10.4	10.4
Theophylline	44	10.3	10.4
Haloperidol Lactate	93	10.2	10.2
Elexacaftor, Tezacaftor, And Ivacaftor	45	9.8	9.8
Lithium Carbonate	59	9.4	9.4
Calcium, Magnesium, Potassium, And Sodium Oxybates	30	9.4	9.4
Duloxetine	225	8.9	8.9
Aripiprazole	381	8.7	8.8
Doxepin	29	7.7	7.7
Fluticasone Furoate	33	7.4	7.4
Olanzapine	284	7.3	7.4
Zonisamide	38	6.9	7.0
Lisdexamfetamine Dimesylate	84	6.9	6.9
Divalproex Sodium	118	6.9	6.9
Pertuzumab	67	6.7	6.7
Lacosamide	90	6.6	6.6
Isotretinoin	119	6.6	6.6
Esomeprazole Magnesium Capsule, Delayed Release	35	6.5	6.5
Esomeprazole Magnesium Delayed Release Capsules	35	6.5	6.5
Esomeprazole Magnesium Dihydrate	35	6.5	6.5
Methylphenidate Hydrochloride	140	6.5	6.5
Duloxetine Hydrochloride	428	6.4	6.4
Levetiracetam	305	6.4	6.4
Paroxetine Hydrochloride	206	6.2	6.2
Mirtazapine	207	6.2	6.2
Risperidone	297	6.2	6.2
Lurasidone Hydrochloride	48	6.2	6.2
Doxepin Hydrochloride	29	6.2	6.2
Montelukast Sodium	270	6.1	6.2
Atomoxetine Hydrochloride	54	6.1	6.1
Cenobamate	19	6.1	6.1
Oxcarbazepine	73	6.1	6.1
Valproate Sodium	46	6.0	6.0
Lamotrigine	282	5.9	5.9
Buspirone Hydrochloride	24	5.9	5.9
Ipratropium Bromide	77	5.9	5.9
Valproic Acid	68	5.8	5.9
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	86	5.6	5.6
Lamotirigine	147	5.6	5.6
Lamotrigine Extended-Release	147	5.6	5.6
Lamotrigine Chewable Dispersible	147	5.6	5.6
Levofloxacin	123	5.6	5.6
Levofloxacin In 5% Dextrose	123	5.6	5.6
Ziprasidone	36	5.5	5.5
Piperacillin Sodium,Tazobactam Sodium	54	5.5	5.5
Levetiracetam In Sodium Chloride	153	5.4	5.4
Levetiracetam Oral	153	5.4	5.4
Levetiracetam Injection	153	5.4	5.4
Clobazam	48	5.3	5.3
Quetiapine	358	5.2	5.2
Dimenhydrinate	20	5.1	5.1
Fluoxetine Hydrochloride	231	5.0	5.0
Olanzapine Pamoate	75	5.0	5.0
Finasteride	110	5.0	5.0
Cariprazine	17	4.9	4.9
Ziprasidone Mesylate	26	4.9	4.9
Escitslopram	105	4.9	4.9
Quetiapine Fumarate	53	4.9	4.9
Paroxetine Hydrochloride Hemihydrate	59	4.8	4.8
Varenicline Tartrate	140	4.8	4.8
Sertraline Hydrochloride	205	4.8	4.8
Escitalopram Oxalate	127	4.7	4.8
Topiramate	161	4.7	4.7
Quinine	15	4.7	4.7
Paroxetine	59	4.7	4.7
Lorazepam	299	4.6	4.6
Carbamazepine	112	4.5	4.6
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	59	4.5	4.5
Ketoprofen	22	4.5	4.5
Bupropion Hydrochloride	163	4.5	4.5
Modafinil	53	4.4	4.4
Naltrexone Hydrochloride And Bupropion Hydrochloride	14	4.4	4.4
Escitalopram	224	4.4	4.4
Methadone	69	4.4	4.4
Sertraline	185	4.3	4.3
Venlafaxine Hydrochloride	206	4.3	4.3
Brexpiprazole	26	4.2	4.2
Sodium Oxybate	102	4.2	4.2
Ketoconazole Foam	23	4.2	4.2
Ketoconazole Cream, 2%	23	4.2	4.2
Venlafaxine	110	4.2	4.2
Valsartan And Hydrochlorothiazide	21	4.2	4.2
Nicotine Polacrilex Mini	23	4.1	4.1
Nicotine Polarilex	23	4.1	4.1
Morphine	111	4.0	4.1
Fluoxetine	99	4.0	4.0
Desloratadine	16	4.0	4.0
Armodafinil	31	4.0	4.0
Clonazepam	229	3.9	3.9
Ozanimod Hydrochloride	12	3.9	3.9
Sofosbuvir	28	3.8	3.8
Magnesium Hydroxide	19	3.8	3.8
Vilazodone Hydrochloride	13	3.8	3.8
Clozapine	174	3.8	3.8
Ketoconazole	24	3.7	3.7
Liothyronine Sodium	12	3.7	3.7
Hydroxyzine Hydrochloride	18	3.7	3.7
Hydroxyzine Hydrochloride Oral	18	3.7	3.7
Carisoprodol	26	3.7	3.7
Clonidine	67	3.5	3.5
Etonogestrel And Ethinyl Estradiol	29	3.5	3.5
Hydroxyzine	62	3.5	3.5
Cetirizine Hydrochloride Allergy	39	3.5	3.5
Cetirizine Hydrochloride Tablets	39	3.5	3.5
Buprenorphine Hydrochloride, Naloxone Hydrochloride	31	3.5	3.5
Propranolol Hydrochloride	92	3.5	3.5
Diazepam	153	3.4	3.4
Loperamide Hydrochloride Oral	13	3.4	3.4
Desvenlafaxine Succinate	34	3.4	3.4
Fluticasone Propionate And Salmeterol Xinafoate	75	3.4	3.4
Pregabalin	329	3.4	3.4
Testosterone	29	3.3	3.3
Citalopram	167	3.3	3.3
Trazodone Hydrochloride	19	3.3	3.3
Methylphenidate	35	3.3	3.3
Ibuprofen And Diphenhydramine Citrate	28	3.2	3.2
Paliperidone	28	3.2	3.2
Valsartan Oral	65	3.2	3.2
Melatonin	63	3.1	3.1
Asenapine Maleate	10	3.1	3.1
Ivacaftor	9	3.0	3.1
Levonorgestrel	221	3.0	3.0
Goserelin	15	3.0	3.0
Methadone Hydrochloride	12	3.0	3.0
Sulfasalazine	86	3.0	3.0
Methocarbamol	25	3.0	3.0
Loperamide Hcl	14	2.9	2.9
Meperidine Hydrochloride	10	2.9	2.9
Trastuzumab	74	2.9	2.9
Amitriptyline Hydrochloride	19	2.9	2.9
Promethazine Hydrochloride	20	2.9	2.9
Diazepam Oral Solution (Concentrate)	95	2.9	2.9
Diazepam Oral	95	2.9	2.9
Docetaxel Anhydrous	72	2.9	2.9
Docetaxel	72	2.9	2.9
Cannabidiol	25	2.9	2.9
Hydrocodone Bitartrate And Acetaminophen	60	2.9	2.9
Temazepam	40	2.9	2.9
Citalopram Hydrobromide	113	2.9	2.9
Etonogestrel	50	2.8	2.8
Ropinirole	16	2.8	2.8
Naltrexone	32	2.8	2.8
Zolpidem Tartrate	139	2.8	2.8
Alprazolam	210	2.8	2.8
Amantadine	16	2.8	2.8
Oxybutynin Chloride	9	2.8	2.8
Psyllium Husk	10	2.7	2.7
Fluticasone Propionate Nasal	30	2.7	2.7
Tretinoin	8	2.7	2.7
Conjugated Estrogens	57	2.6	2.6
Cetirizine	75	2.6	2.6
Esomeprazole	60	2.6	2.6
Fexofenadine	16	2.6	2.6
Meloxicam	56	2.6	2.6
Amphetamine	8	2.6	2.6
Estrogens, Conjugated	57	2.6	2.6
Drs. Clotrimazole	11	2.6	2.6
Family Wellness Clotrimazole	11	2.6	2.6
Clotrimazole Topical	11	2.6	2.6
Nebivolol	15	2.5	2.5
Thyroid, Porcine	10	2.5	2.5
Butalbital, Acetaminophen, And Caffeine	10	2.5	2.5
Baclofen	80	2.5	2.5
Montelukast	78	2.5	2.5
Estradiol Gel 0.1%	42	2.5	2.5
Estradiol Transdermal	42	2.5	2.5
Budesonide And Formoterol Fumarate Dihydrate	88	2.5	2.5
Levodopa	11	2.5	2.5
Diphenhydramine Hcl	10	2.4	2.4
Clotrimazole	11	2.4	2.4
Letrozole	54	2.4	2.4
Letrozole Tablets	42	2.4	2.4
Standardized Senna Concentrate	11	2.4	2.4
Hyoscyamine Sulfate	8	2.3	2.3
Minocycline	10	2.3	2.3
Oxycodone And Acetaminophen Tablets	10	2.3	2.3
Methocarbamol Tablets	14	2.3	2.3
Bupropion	37	2.2	2.2
Fesoterodine Fumarate	9	2.2	2.2
Eszopiclone	21	2.2	2.2
Morphine Sulfate	99	2.2	2.2
Gabapentin	293	2.2	2.2
Mometasone	15	2.2	2.2
Cetiirizine	34	2.2	2.2
Cetirizine Hydrochloride	130	2.1	2.1
Clarithromycin	27	2.1	2.1
Rizatriptan Benzoate	8	2.1	2.1
Testosterone Cypionate	7	2.1	2.1
Pramipexole	12	2.1	2.1
Pitavastatin Calcium	8	2.1	2.1
Estradiol	67	2.1	2.1
Paliperidone Palmitate	25	2.1	2.1
Extended Phenytoin Sodium	13	2.1	2.1
Amoxicillin	59	2.1	2.1
Dicyclomine Hydrochloride	11	2.1	2.1
Drospirenone And Ethinyl Estradiol	34	2.1	2.1
Granisetron Hydrochloride	8	2.1	2.1
Zinc Gluconate	20	2.1	2.1
Cetirizine Hcl	7	2.1	2.1
Granisetron	8	2.1	2.1
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	23	2.0	2.0
Phenobarbital	11	2.0	2.0
Diclofenac Sodium 1%	27	2.0	2.0
Diclofenac Sodium Topical	27	2.0	2.0
Diclofenac Sodium Topical Gel, 1%	27	2.0	2.0
Loratadine Oral	37	2.0	2.0
Sumatriptan Succinate	19	2.0	2.0
Levocetirizine Dihydrochloride	18	2.0	2.0
Anastrozole Tablets	16	2.0	2.0
Diclofenac	64	2.0	2.0
Valsartan	78	2.0	2.0
Paclitaxel (Aibumin-Bound)	61	2.0	2.0
Lubiprostone	7	2.0	2.0
Memantine	10	2.0	2.0
Memantine Hydrochloride	10	2.0	2.0
Tizanidine Hydrochloride	13	1.9	1.9
Phenytoin	15	1.9	1.9
Rasagiline Mesylate	8	1.9	1.9
Daspone	7	1.9	1.9
Dapsone Gel, 5%	7	1.9	1.9
Tiotropium Bromide Inhalation Spray	8	1.9	1.9
Oxycodone Hydrochloride	153	1.9	1.9
Biotin	22	1.9	1.9
Magnesium Sulfate In Water For	9	1.9	1.9
Fluticasone Propionate	91	1.9	1.9
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	35	1.9	1.9
Progesterone	16	1.9	1.9
Ribociclib	22	1.9	1.9
Nicotine	28	1.9	1.9
Oxycodone Hydrochloride And Acetaminophen	68	1.9	1.9
Rivastigmine	13	1.9	1.9
Primidone	7	1.8	1.8
Oxycodone And Acetaminophen	16	1.8	1.8
Lisinopril And Hydrochlorothiazide	7	1.8	1.8
Basiliximab	8	1.8	1.8
Nicotine Polacrilex	26	1.8	1.8
Relugolix	16	1.8	1.8
Midazolam	17	1.8	1.8
Metformin Hcl	37	1.8	1.8
Ethyl Alcohol	18	1.8	1.8
Avapritinib	8	1.8	1.8
Dapsone	7	1.8	1.8
Ribavirin	42	1.8	1.8
Anastrozole	24	1.8	1.8
Buprenorphine	60	1.7	1.8
Carboxymethylcellulose Sodium	6	1.7	1.7
Tramadol Hydrochloride	24	1.7	1.7
Fingolimod Hcl	55	1.7	1.7
Glecaprevir And Pibrentasvir	7	1.7	1.7
Loratadine	68	1.7	1.7
Ofatumumab	21	1.7	1.7
Fish Oil	57	1.7	1.7
Sumatriptan	24	1.7	1.7
Tizanidine	15	1.7	1.7
Paclitaxel	62	1.7	1.7
Ledipasvir And Sofosbuvir	12	1.7	1.7
Leflunomide	65	1.7	1.7
Nebivolol Hydrochloride	21	1.7	1.7
Rotigotine	9	1.7	1.7
Vigabatrin	9	1.7	1.7
Rifampin	9	1.7	1.7
Hydromorphone Hydrochloride	56	1.6	1.6
Oxazepam	13	1.6	1.6
Vortioxetine	10	1.6	1.6
Diroximel Fumarate	7	1.6	1.6
Polyethylene Glycol 3350	55	1.6	1.6
Teriflunomide	26	1.5	1.5
Donepezil Hydrochloride	21	1.5	1.5
Oxycodone	106	1.5	1.5
Isopropyl Alcohol	19	1.5	1.5
Dornase Alfa	11	1.5	1.5
Carbidopa And Levodopa	26	1.5	1.5
Pancrelipase	21	1.5	1.5
Nilotinib	16	1.5	1.5
Alcohol	21	1.5	1.5
Loratadine Tablet	29	1.5	1.5
Apremilast	78	1.4	1.4
Linaclotide	14	1.4	1.4
Lanreotide Acetate	4	1.4	1.4
Lisinopril And Hydrochlorothiazide Tablets	4	1.4	1.4
Conjugated Estrogens And Medroxyprogesterone Acetate	12	1.4	1.4
Derma Foam Excel Hand Sanitizer	4	1.3	1.3
Ethanol	4	1.3	1.3
Cabotegravir	4	1.3	1.3
Acetaminophen And Codeine	6	1.3	1.3
Instalax Polyethylene Glycol 3350	6	1.3	1.3
Ranitidine	95	1.3	1.3
Rimegepant Sulfate	6	1.3	1.3
Rucaparib	4	1.2	1.2
Dupilumab	217	1.2	1.2
Esketamine Hydrochloride	8	1.2	1.2
Secukinumab	71	1.2	1.2
Agalsidase Beta	4	1.2	1.2
Pyrazinamide	4	1.1	1.1
Bimekizumab	9	1.1	1.1
Baricitinib	4	1.1	1.1
Fexofenadine Hydrochloride	9	1.1	1.1
Denosumab	83	1.1	1.1
Somatropin	30	1.1	1.1
Peginterferon Alfa-2A	22	1.1	1.1
Medroxyprogesterone Acetate	20	1.1	1.1
Fam-Trastuzumab Deruxtecan-Nxki	4	1.1	1.1
Minoxidil Foam 5% (Womens)	13	1.1	1.1
Velpatasvir And Sofosbuvir	5	1.0	1.0
Suvorexant	5	1.0	1.0
Loratadine And Pseudoephedrine Sulfate	3	1.0	1.0
Golimumab	32	1.0	1.0
Canakinumab	4	1.0	1.0
Hydrocodone Bitartrate	16	1.0	1.0
Interferon Beta-1B	7	1.0	1.0
Ocrelizumab	22	1.0	1.0
Acetaminophen, Aspirin (Nsaid) And Caffeine	6	0.9	0.9
Fremanezumab-Vfrm	4	0.9	0.9
Dalfampridine	24	0.9	0.9
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	6	0.9	0.9
Erenumab-Aooe	18	0.9	0.9
Mometasone Furoate And Formoterol Fumarate Dihydrate	5	0.9	0.9
Valbenazine	8	0.9	0.9
Obinutuzumab	5	0.8	0.8
Liraglutide	15	0.8	0.8
Copper	13	0.8	0.8
Minoxidil	13	0.8	0.8
Pimavanserin Tartrate	16	0.8	0.8
Patiromer	4	0.8	0.8
Natalizumab	50	0.7	0.7
Leuprolide Acetate	21	0.7	0.7
Emtricitabine And Tenofovir Alafenamide	3	0.7	0.7
Emtricitabine And Tenofovir Disoproxil Fumarate	12	0.7	0.7
Palbociclib	25	0.7	0.7
Cortisone Acetate	3	0.7	0.7
Tapentadol Hydrochloride	8	0.6	0.6
Peginterferon Beta-1A	3	0.6	0.6
Galcanezumab-Gnlm	7	0.6	0.6
Dimethyl Fumarate	24	0.5	0.5
Droxidopa	4	0.5	0.5
Adapalene	3	0.0	0.0

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.