Reaction

Activated Partial Thromboplastin Time Prolonged reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,015 reports · 349 co-occurring drugs

As of the last recalculation, Activated Partial Thromboplastin Time Prolonged appears in 5,015 FAERS reports alongside 349 co-occurring drug terms. The strongest observed disproportionality signal is PHYTONADIONE (PRR 77.2).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Phytonadione	153	77.2	78.6
Heparin Sodium	202	63.5	64.4
Dalteparin Sodium	144	58.1	58.9
Oseltamivir	106	56.4	57.2
Norepinephrine Bitartrate	166	49.5	50.0
Dextrose	129	41.7	42.1
Dextrose Monohydrate	129	41.1	41.5
Amiodarone Hydrochloride	96	36.2	36.5
Bisacodyl Suppositories	108	35.4	35.7
Biscodyl	108	35.1	35.3
Instalax Polyethylene Glycol 3350	100	34.1	34.4
Polyethylene Glycol 400	100	33.4	33.6
Bisacodyl	109	32.8	33.1
Norepinephrine	81	31.9	32.2
Dabigatran Etexilate	517	30.7	30.9
Dabigatran Etexilate Mesylate	476	29.9	30.1
Emicizumab	78	26.6	26.8
Calcitriol Capsules 0.25 Mcg	107	22.6	22.7
Calcitriol Capsules 0.5 Mcg	107	22.6	22.7
Calcitriol	108	22.6	22.7
Sodium Bicarbonate	123	22.5	22.6
Sodium Bicarbonate Injection,	123	22.5	22.6
Oseltamivir Phosphate	116	20.2	20.2
Theophylline	54	19.7	19.8
Fondaparinux Sodium	38	19.6	19.7
Theophylline Anhydrous	56	18.9	19.0
Salmeterol Xinafoate	39	18.9	19.0
Ceftriaxone Sodium	164	18.3	18.4
Warfarin Sodium	197	18.3	18.4
Calcium Gluconate	52	18.1	18.2
Docusate Sodium 100Mg	92	16.2	16.3
Ipratropium Bromide	134	16.0	16.0
Fluticasone Furoate	44	15.2	15.3
Pegaspargase	41	14.0	14.0
Metronidazole Topical	149	13.3	13.4
Darbepoetin Alfa	164	13.0	13.1
Insulin Degludec	71	12.7	12.8
Warfarin	351	12.3	12.3
Amphotericin B	36	12.0	12.0
Magnesium Oxide	118	12.0	12.0
Rifampicin	29	12.0	12.0
Dexlansoprazole	115	11.7	11.7
Ceftriaxone	90	11.6	11.6
Metronidazole	165	11.1	11.1
Tretinoin	21	10.8	10.8
Torsemide	84	10.7	10.7
Ascorbic Acid	59	10.6	10.7
Enoxaparin Sodium	143	10.6	10.6
Biotin	78	10.5	10.5
Cefepime	36	10.5	10.5
Vincristine Sulfate	71	10.2	10.2
Polyethylene Glycol	26	10.0	10.0
Cefepime Hydrochloride	38	9.9	9.9
Potassium Chloride, Dextrose Monohydrate	209	9.7	9.7
Potassium Chloride Oral	209	9.7	9.7
Potassium Chloride Extended-Release	209	9.7	9.7
Vitamin E	72	9.6	9.6
Cefazolin Sodium	27	9.3	9.4
Valganciclovir	42	9.3	9.3
Valganciclovir Hydrochloride	42	9.3	9.3
Blinatumomab	23	9.2	9.2
Eplerenone	27	8.8	8.8
Docusate Sodium	119	8.7	8.8
Cefazolin	19	8.7	8.7
Mercaptopurine	36	8.7	8.7
Piperacillin Sodium And Tazobactam Sodium	40	8.5	8.5
Antacid	94	8.4	8.4
Digoxin	138	8.2	8.2
Fluticasone Furoate And Vilanterol Trifenatate	70	8.2	8.2
Potassium Chloride	214	8.1	8.1
Magnesium Hydroxide	26	8.0	8.1
Psyllium Husk	19	8.0	8.0
Acetylcysteine	18	8.0	8.0
Melatonin	102	7.9	7.9
Allopurinol	282	7.9	7.9
Hydrocortisone Acetate	131	7.7	7.7
Candesartan	64	7.5	7.5
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate	74	7.5	7.5
Candesartan Cilexetil	47	7.5	7.5
Diphenhydramine Hcl	20	7.5	7.5
Nitroglycerin	95	7.5	7.5
Sennosides 8.6 Mg Tablets	37	7.4	7.4
Dronedarone	18	7.3	7.4
Senna	37	7.3	7.3
Quinine	15	7.3	7.3
Gentamicin Sulfate	27	7.1	7.1
Cytarabine	101	7.1	7.1
Gentamicin	22	7.0	7.0
Tamsulosin Hydrochloride	34	7.0	7.0
Senna Leaf	38	6.9	6.9
Micafungin Sodium	14	6.9	6.9
Sennosides	49	6.9	6.9
Magnesium Sulfate In Water For	21	6.8	6.9
Insulin Aspart	107	6.8	6.9
Magnesium Sulfate Heptahydrate	21	6.7	6.7
Magnesium Sulfate	21	6.7	6.7
Pantoprazole Sodium In 0.9% Sodium Chloride	98	6.7	6.7
Pantoprazole Sodium Injection	98	6.7	6.7
Calcium Carbonate	106	6.7	6.7
Sorafenib	33	6.6	6.6
Vancomycin	90	6.6	6.6
Vancomycin Hydrochloride	102	6.5	6.5
Hydrocortisone	136	6.5	6.5
Hydrocortisone Cream 1%	102	6.4	6.4
Hydrocortisone Cream 1/2%	102	6.4	6.4
Anti-Itch	101	6.4	6.4
Anti-Pruritic	101	6.4	6.4
Antipruritic (Anti-Itch)	101	6.4	6.4
Cool Relief Gel With Aloe	101	6.4	6.4
Drs. Hydrocortisone	101	6.4	6.4
Hydrocortisone Continuous Spray	101	6.4	6.4
Hydrocortisone Spray	101	6.4	6.4
Anti-Itch Cream	101	6.4	6.4
Hydrocortisone Lotion	101	6.4	6.4
Hydrocortisone 1%	101	6.4	6.4
Hydrocortisone Cream	101	6.3	6.3
Hydrocortisone Sodium Succinate	14	6.2	6.2
Sodium Chloride Tablet	107	6.1	6.2
Sodium Chloride Tablets	107	6.1	6.2
Leucovorin Calcium	28	6.1	6.1
Alteplase	22	6.1	6.1
Sodium Chloride	111	5.9	5.9
Ondansetron Hydrochloride	169	5.9	5.9
Lansoprazole	240	5.8	5.8
Doxazosin Mesylate	50	5.8	5.8
Polyethylene Glycol 3350	130	5.8	5.8
Colchicine	36	5.7	5.7
Epoetin Alfa	16	5.6	5.6
Tranexamic Acid	12	5.6	5.6
Alemtuzumab	26	5.6	5.6
Hydromorphone Hydrochloride	121	5.6	5.6
Ampicillin	11	5.5	5.5
Ampicillin Sodium	11	5.5	5.5
Ondansetron	142	5.5	5.5
Ondansetron Tablets	142	5.5	5.5
Propofol	48	5.5	5.5
Cefuroxime	15	5.5	5.5
Acetaminophen Tablet Extended Release	318	5.5	5.5
Pain Reliever	318	5.5	5.5
Acetaminophen 500Mg	318	5.5	5.5
Pramipexole	20	5.4	5.4
Enalapril Maleate	32	5.4	5.4
Piperacillin Sodium,Tazobactam Sodium	34	5.3	5.4
Lactulose	49	5.3	5.4
Standardized Senna Concentrate	16	5.3	5.3
Tobramycin Solution	15	5.2	5.2
Lidicaine	60	5.1	5.1
Burn Relief	60	5.1	5.1
Lidocaine Hydrochloride And Epinephrine	60	5.1	5.1
Umeclidinium	11	5.1	5.1
Rivaroxaban	246	5.1	5.1
Rabeprazole	27	5.1	5.1
Doxazosin	34	5.1	5.1
Lidocaine, Menthol	60	5.1	5.1
Tobramycin Sulfate	15	5.0	5.0
Mesalamine	67	5.0	5.0
Mometasone	22	5.0	5.0
Albuterol	141	5.0	5.0
Lidocaine Hydrochloride And Epinephrine Bitartrate	63	4.9	5.0
Promethazine Hydrochloride	22	4.9	4.9
Crizotinib	15	4.9	4.9
Isoniazid	19	4.9	4.9
Ciprofolxacin	83	4.9	4.9
Ciprofloxacin Tablets	83	4.9	4.9
Budesonide	67	4.8	4.8
Lidocaine 4%	61	4.7	4.7
Telmisartan	20	4.7	4.7
Lidocaine Hydrochloride	67	4.7	4.7
Dronabinol	9	4.7	4.7
Midazolam Hydrochloride	30	4.6	4.7
Insulin	61	4.6	4.6
Ciprofloxacin	99	4.5	4.6
Ramipril	132	4.5	4.5
Atropine	9	4.5	4.5
Mometasone Furoate	45	4.5	4.5
Ciprofloxacin Hydrochloride	104	4.5	4.5
Febuxostat Tablets 40 Mg	11	4.5	4.5
Febuxostat Tablets 80 Mg	11	4.5	4.5
Furosemide	404	4.5	4.5
Lidocaine	62	4.5	4.5
Nystatin Ointment	28	4.5	4.5
Nystatin Cream	28	4.4	4.4
Mesna	9	4.4	4.4
Pyrazinamide	10	4.4	4.4
Pantoprazole Sodium	153	4.4	4.4
Simvastatin	254	4.4	4.4
Amlodipine Besylate	150	4.3	4.4
Captopril	10	4.3	4.3
Midazolam	26	4.3	4.3
Meropenem	33	4.3	4.3
Nystatin	28	4.3	4.3
Voriconazole	31	4.3	4.3
Valproate Sodium	21	4.2	4.2
Piperacillin And Tazobactam	13	4.2	4.2
Clopidogrel Bisulfate	100	4.1	4.1
Spironolactone	136	4.1	4.1
Diltiazem Hydrochloride	34	4.1	4.1
Metolazone	11	4.1	4.1
Vitamin C	88	4.0	4.0
Mesna Injection	8	4.0	4.0
Ursodiol	21	4.0	4.0
Bumetanide	25	3.9	3.9
Iron Sucrose	9	3.9	3.9
Pantoprazole	231	3.9	3.9
Morphine	69	3.9	3.9
Atropine Sulfate	10	3.8	3.9
Voriconazole Injection	20	3.8	3.8
Fluconazole	64	3.8	3.8
Linezolid	27	3.8	3.8
Mycophenolic Acid	29	3.8	3.8
Acetaminophen	384	3.8	3.8
Bisoprolol Fumarate	120	3.7	3.7
Rifampin	13	3.7	3.7
Gefitinib	8	3.7	3.7
Diltiazem Hydrochloride Extended-Release Tablets	10	3.7	3.7
Isosorbide Dinitrate	17	3.6	3.6
Docusate Sodium - Sennosides	28	3.6	3.6
Deferasirox	23	3.6	3.6
Daptomycin	8	3.6	3.6
Loperamide Hcl	11	3.6	3.6
Zinc	21	3.5	3.5
Imatinib	15	3.5	3.5
Zinc Chloride	21	3.5	3.5
Rabeprazole Sodium	23	3.5	3.5
Zinc Gluconate	22	3.5	3.5
Levothyroxine Sodium Anhydrous	83	3.5	3.5
Tobramycin	20	3.5	3.5
Mepolizumab	41	3.4	3.4
Glyburide	20	3.4	3.4
Temazepam	31	3.4	3.4
Ursosiol	16	3.4	3.4
Ciprofloxacin Hydrochloride And Hydrocortisone	17	3.4	3.4
Valsartan Oral	44	3.4	3.4
Metoclopramide Hydrochloride	61	3.3	3.3
Valproic Acid	25	3.3	3.3
Carvedilol	106	3.3	3.3
Felodipine Extended-Release Tablets	9	3.3	3.3
Felodipine	9	3.3	3.3
Doxepin	8	3.3	3.3
Terazosin Hydrochloride	7	3.3	3.3
Pitavastatin Calcium	8	3.2	3.3
Erythropoietin	16	3.2	3.2
Extended Phenytoin Sodium	13	3.2	3.2
Febuxostat	13	3.2	3.2
Isosorbide Mononitrate	16	3.2	3.2
Fluticasone Propionate	99	3.2	3.2
Phenytoin	16	3.2	3.2
Methimazole	6	3.2	3.2
Trimethoprim	9	3.2	3.2
Clarithromycin	26	3.2	3.2
Fentanyl	74	3.2	3.2
Clopidogrel	147	3.1	3.1
Imatinib Mesylate	21	3.1	3.1
Derma Foam Excel Hand Sanitizer	6	3.1	3.1
Valsartan	78	3.1	3.1
Ethanol	6	3.1	3.1
Filgrastim	28	3.1	3.1
Anti-Thymocyte Globulin (Rabbit)	6	3.1	3.1
Metformin Hydrochloride Tablets	42	3.1	3.1
Metformin Hydrochloride Extended-Release Tablets	42	3.1	3.1
Metformin Hydrochloride Tablet	42	3.1	3.1
Metoroprolol Tartrate	48	3.0	3.0
Posaconazole Delayed-Release	8	3.0	3.0
Nitrofurantoin	12	3.0	3.0
Enalapril	40	3.0	3.0
Etonogestrel And Ethinyl Estradiol	16	3.0	3.0
Umeclidinium Bromide And Vilanterol Trifenatate	12	3.0	3.0
Nitrofurantoin (Monohydrate/Macrocrystals)	12	3.0	3.0
Polatuzumab Vedotin	7	3.0	3.0
Metformin Hydrochloride	42	3.0	3.0
Quetiapine Fumarate	21	3.0	3.0
Hydroxyurea	15	2.9	3.0
Amikacin	12	2.9	2.9
Levofloxacin	42	2.9	2.9
Levofloxacin In 5% Dextrose	42	2.9	2.9
Aspirin 325 Mg	342	2.9	2.9
Aspirin 81 Mg	342	2.9	2.9
Nebivolol	11	2.9	2.9
Itraconazole	8	2.8	2.8
Albuterol Sulfate	198	2.8	2.8
Aspirin	347	2.8	2.8
Levocetirizine Dihydrochloride	16	2.8	2.8
Sotalol Hydrochloride	11	2.7	2.8
Valganciclovir Hydrochloride Powder,	8	2.7	2.7
Ibuprofen And Diphenhydramine Citrate	15	2.7	2.7
Atorvastatin Calcium, Film Coated	45	2.7	2.7
Famotidine	75	2.7	2.7
Fluticasone Propionate And Salmeterol Xinafoate	38	2.6	2.6
Metoclopramide	34	2.6	2.6
Tolvaptan	9	2.6	2.6
Metoprolol Tartrate	166	2.6	2.6
Fludarabine Phosphate	24	2.5	2.5
Ifosfamide	13	2.5	2.5
Oxazepam	13	2.5	2.5
Chlorthalidone	7	2.5	2.5
Thalidomide	22	2.5	2.5
Insulin Glargine-Yfgn	13	2.5	2.5
Valsartan And Hydrochlorothiazide	8	2.4	2.4
Gemcitabine	23	2.4	2.4
Minoxidil Foam 5% (Womens)	19	2.4	2.4
Miconazole Nitrate	5	2.4	2.4
Apixaban	38	2.4	2.4
Fentanyl Citrate	10	2.3	2.3
Etoposide	41	2.3	2.3
Erlotinib Hydrochloride	7	2.3	2.3
Pravastatin Sodium	11	2.3	2.3
Canakinumab	6	2.3	2.3
Donepezil Hydrochloride	20	2.3	2.3
Irinotecan Hydrochloride	7	2.3	2.3
Cyclophosphamide Injection, Solution	94	2.2	2.2
Cyclophosphamide	94	2.2	2.2
Cyclophosphamide For Injection	94	2.2	2.2
Temozolomide	11	2.2	2.2
Dorzolamide Hydrochloride And Timolol Maleate	4	2.1	2.1
Morphine Sulfate	61	2.1	2.1
Posaconazole	8	2.0	2.0
Prasugrel Hydrochloride	5	2.0	2.0
Doxorubicin Hydrochloride	16	2.0	2.0
Metformin Hcl	27	2.0	2.0
Gemcitabine Hydrochloride	25	2.0	2.0
Icosapent Ethyl	4	2.0	2.0
Cisplatin	35	1.9	1.9
Cetuximab	14	1.9	1.9
Memantine	6	1.8	1.8
Memantine Hydrochloride	6	1.8	1.8
Bevacizumab	54	1.8	1.8
Fosaprepitant Dimeglumine	6	1.8	1.8
Rocuronium Bromide	5	1.8	1.8
Minoxidil	19	1.8	1.8
Vemurafenib	5	1.7	1.7
Levodopa	5	1.7	1.7
Ribavirin	26	1.7	1.7
Paclitaxel (Aibumin-Bound)	33	1.7	1.7
Ranitidine	78	1.6	1.6
Bosentan	19	1.6	1.6
Loratadine And Pseudoephedrine Sulfate	3	1.6	1.6
Remdesivir	5	1.6	1.6
Paclitaxel	37	1.6	1.6
Methoxy Polyethylene Glycol-Epoetin Beta	4	1.5	1.5
Sevoflurane	3	1.5	1.5
Ado-Trastuzumab Emtansine	3	1.5	1.5
Sevelamer Carbonate	4	1.4	1.4
Eltrombopag Olamine	8	1.4	1.4
Dabrafenib	7	1.4	1.4
Clozapine	41	1.4	1.4
Erlotinib	3	1.3	1.3
Alcohol	12	1.3	1.3
Brentuximab Vedotin	3	1.2	1.2
Cinacalcet Hydrochloride	5	0.4	0.4

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.