Reaction

Pre-Existing Condition Improved reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 6,228 reports · 386 co-occurring drugs

As of the last recalculation, Pre-Existing Condition Improved appears in 6,228 FAERS reports alongside 386 co-occurring drug terms. The strongest observed disproportionality signal is SODIUM OXYBATE (PRR 174.1).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Sodium Oxybate	2,218	174.1	180.2
Armodafinil	542	94.0	96.5
Calcium, Magnesium, Potassium, And Sodium Oxybates	191	76.4	78.2
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	645	68.0	69.2
Modafinil	556	63.1	64.2
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	679	61.3	62.3
Buspirone Hydrochloride	134	41.5	42.0
Liothyronine Sodium	72	27.9	28.2
Methylphenidate Hydrochloride	438	26.5	26.7
Butalbital, Acetaminophen, And Caffeine	76	24.1	24.3
Rizatriptan Benzoate	72	23.9	24.1
Thyroid, Porcine	69	21.9	22.0
Vilazodone Hydrochloride	53	19.4	19.5
Oxycodone And Acetaminophen Tablets	67	19.0	19.1
Testosterone Cypionate	48	18.1	18.2
Lisdexamfetamine Dimesylate	162	16.8	16.9
Methylphenidate	142	16.7	16.8
Fexofenadine Hydrochloride	102	15.9	16.0
Tizanidine Hydrochloride	85	15.9	16.0
Pregabalin	1,030	15.0	15.0
Sumatriptan Succinate	104	14.0	14.0
Hyoscyamine Sulfate	37	13.5	13.6
Pramipexole	60	13.2	13.3
Carisoprodol	74	13.1	13.2
Methocarbamol	86	12.8	12.9
Tretinoin	31	12.8	12.9
Eszopiclone	96	12.8	12.8
Methocarbamol Tablets	63	12.7	12.7
Lubiprostone	35	12.4	12.5
Sumatriptan	137	12.3	12.3
Bupropion Hydrochloride	341	12.2	12.2
Doxepin	36	11.9	12.0
Mometasone	64	11.8	11.8
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	105	11.8	11.8
Biotin	107	11.6	11.7
Cyclobenzaprine Hydrochloride	31	11.6	11.6
Cetirizine Hcl	31	11.3	11.4
Diclofenac Potassium	36	11.2	11.2
Cyclobenzaprine	163	11.2	11.2
Mometasone Furoate	136	11.1	11.2
Desvenlafaxine Succinate	88	11.0	11.1
Varenicline Tartrate	250	10.8	10.9
Doxyclycline Hyclate	54	10.7	10.7
Progesterone	71	10.5	10.5
Oxycodone And Acetaminophen	72	10.4	10.5
Acetaminophen, Aspirin, And Caffeine	65	10.4	10.4
Fluticasone Propionate Nasal	93	10.4	10.4
Doxepin Hydrochloride	37	9.8	9.9
Buprenorphine Hydrochloride, Naloxone Hydrochloride	70	9.8	9.8
Azelastine	52	9.7	9.8
Acetaminophen, Aspirin (Nsaid) And Caffeine	49	9.7	9.7
Dicyclomine Hydrochloride	41	9.7	9.7
Clonazepam	427	9.5	9.5
Meclizine Hydrochloride	55	9.5	9.5
Topiramate	252	9.4	9.4
Meclizine Hcl 12.5Mg	38	9.4	9.4
Meclizine Hcl 25Mg	38	9.4	9.4
Meclizine Hcl 12.5 Mg	38	9.4	9.4
Meclizine Hcl 25 Mg	38	9.4	9.4
Meclizine	45	9.3	9.3
Regorafenib	32	9.3	9.3
Cyanocobalamin	90	9.3	9.3
Pravastatin Sodium	54	9.2	9.2
Magnesium Oxide	112	9.1	9.1
Testosterone	61	8.8	8.8
Diclofenac Potassium, Film Coated	22	8.8	8.8
Diclofenac Potassium Tablets	22	8.8	8.8
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	128	8.7	8.7
Meloxicam	145	8.5	8.5
Naproxen Sodium Tablet	132	8.5	8.5
Melatonin	135	8.4	8.5
Lurasidone Hydrochloride	52	8.4	8.4
Ibuprofen Sodium	105	8.3	8.3
Montelukast Sodium	288	8.2	8.3
Duloxetine Hydrochloride	434	8.2	8.2
Fexofenadine Hcl	22	8.0	8.0
Propranolol Hydrochloride	168	8.0	8.0
Ketoconazole Foam	35	8.0	8.0
Ketoconazole Cream, 2%	35	7.9	7.9
Minocycline	27	7.8	7.8
Loratadine Oral	112	7.7	7.8
Sucralfate	55	7.7	7.7
Ibuprofen Tablets, Coated	97	7.7	7.7
Zolpidem Tartrate	299	7.7	7.7
Lithium Carbonate	39	7.7	7.7
Loratadine	235	7.5	7.6
Fluticasone Propionate	279	7.5	7.5
Ketoconazole	38	7.4	7.4
Guaifenesin	66	7.3	7.3
Ascorbic Acid	50	7.2	7.2
Naproxen Sodium, Pseudoephedrine Hydrochloride	44	7.2	7.2
Esomeprazole Magnesium Capsule, Delayed Release	31	7.2	7.2
Esomeprazole Magnesium Delayed Release Capsules	31	7.2	7.2
Amantadine	33	7.2	7.2
Hydroxyzine Hydrochloride	28	7.1	7.2
Hydroxyzine Hydrochloride Oral	28	7.1	7.2
Esomeprazole Magnesium Dihydrate	31	7.1	7.2
Sertraline Hydrochloride	244	7.1	7.1
Mometasone Furoate And Formoterol Fumarate Dihydrate	33	7.1	7.1
Dronabinol	17	7.1	7.1
Linaclotide	56	7.1	7.1
Ergocalciferol	729	7.0	7.0
Alprazolam	409	7.0	7.0
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	43	7.0	7.0
Loratadine Tablet	111	7.0	7.0
Naproxen Sodium	287	7.0	7.0
Primidone	21	6.9	6.9
Lisinopril And Hydrochlorothiazide Tablets	16	6.8	6.8
Fish Oil	179	6.8	6.8
Naproxen Sodium Tablet, Coated	27	6.7	6.7
Naproxen Sodium, Coated Tablets	27	6.7	6.7
Metformin Hcl	109	6.7	6.7
Naproxen Sodium 220Mg	27	6.7	6.7
Conjugated Estrogens	114	6.6	6.7
Temazepam	74	6.6	6.6
Asenapine Maleate	17	6.6	6.6
Venlafaxine Hydrochloride	250	6.5	6.5
Estradiol	165	6.5	6.5
Tofacitinib	342	6.5	6.5
Estrogens, Conjugated	113	6.5	6.5
Levocetirizine Dihydrochloride	46	6.4	6.4
Ibuprofen And Diphenhydramine Citrate	44	6.4	6.4
Gabapentin	630	6.3	6.3
Fluticasone Propionate And Salmeterol Xinafoate	111	6.3	6.3
Oxycodone Hydrochloride And Acetaminophen	179	6.2	6.2
Ibuprofen	471	6.2	6.2
Estradiol Gel 0.1%	82	6.1	6.1
Estradiol Transdermal	82	6.1	6.1
Cariprazine	17	6.1	6.1
Ziprasidone Mesylate	26	6.1	6.1
Vitamin E	57	6.1	6.1
Naproxen	139	6.0	6.0
Guanfacine	14	6.0	6.0
Sildenafil Citrate	220	6.0	6.0
Docusate Sodium 100Mg	42	5.9	5.9
Fesoterodine Fumarate	19	5.9	5.9
Mupirocin Calcium	24	5.9	5.9
Diphenhydramine Hydrochloride Capsule, Liquid Filled	37	5.8	5.8
Ferrous Sulfate	86	5.8	5.8
Nystatin	47	5.8	5.8
Escitalopram	235	5.8	5.8
Nystatin Ointment	45	5.8	5.8
Nystatin Cream	45	5.8	5.8
Cetirizine Hydrochloride	273	5.7	5.7
Mupirocin	23	5.7	5.7
Amphetamine	14	5.7	5.7
Oxcarbazepine	54	5.6	5.6
Ibuprofen Capsule	319	5.6	5.6
Ibuprofen Tablet, Film Coated	319	5.6	5.6
Ibupfrofen	319	5.6	5.6
Ibuprofen Tablets Usp, 200Mg	319	5.6	5.6
Ibuprofen Oral	319	5.6	5.6
Ibuprofen Capsules 200 Mg	319	5.6	5.6
Ibuprofen 200 Mg	319	5.6	5.6
Ibuprofen 200Mg	319	5.6	5.6
Lamotrigine	212	5.5	5.5
Metoprolol Succinate	136	5.3	5.3
Dapsone	17	5.3	5.3
Ethyl Alcohol	43	5.3	5.3
Gemfibrozil	24	5.3	5.3
Iron	104	5.3	5.3
Zinc Gluconate	41	5.3	5.3
Lisinopril And Hydrochlorothiazide	16	5.2	5.2
Fluoxetine Hydrochloride	195	5.2	5.2
Tolterodine Tartrate	14	5.2	5.2
Baclofen	132	5.2	5.2
Multivitamin	77	5.2	5.2
Epinephrine	100	5.2	5.2
Vortioxetine	26	5.1	5.1
Loratadine And Pseudoephedrine Sulfate	12	5.1	5.1
Docusate Sodium	86	5.0	5.0
Losartan Potassium	117	5.0	5.0
Oxybutynin Chloride	13	5.0	5.0
Vitamin C	134	5.0	5.0
Ziprasidone	26	4.9	5.0
Sucralfate Oral	21	4.9	5.0
Atomoxetine Hydrochloride	35	4.9	4.9
Sucralfate Oral Suspension	21	4.9	4.9
Trazodone Hydrochloride	23	4.9	4.9
Chlorthalidone	17	4.9	4.9
Niacin	17	4.9	4.9
Diclofenac Sodium 1%	52	4.9	4.9
Diclofenac Sodium Topical	52	4.9	4.9
Diclofenac Sodium Topical Gel, 1%	52	4.9	4.9
Aripiprazole	175	4.9	4.9
Lorazepam	247	4.7	4.7
Diazepam	167	4.7	4.7
Tizanidine	33	4.6	4.6
Metoprolol Succinate Er Tablets	85	4.6	4.6
Docusate Sodium - Sennosides	44	4.6	4.6
Cetirizine Hydrochloride Allergy	41	4.5	4.6
Cetirizine Hydrochloride Tablets	41	4.5	4.6
Pantoprazole Sodium In 0.9% Sodium Chloride	83	4.5	4.5
Pantoprazole Sodium Injection	83	4.5	4.5
Oxybutynin	39	4.5	4.5
Benzonatate	22	4.5	4.5
Metoroprolol Tartrate	86	4.4	4.4
Psyllium Husk	13	4.4	4.4
Etonogestrel And Ethinyl Estradiol	29	4.4	4.4
Lidicaine	63	4.3	4.3
Burn Relief	63	4.3	4.3
Lidocaine Hydrochloride And Epinephrine	63	4.3	4.3
Lidocaine, Menthol	63	4.3	4.3
Isopropyl Alcohol	43	4.3	4.3
Citalopram	171	4.3	4.3
Valacyclovir Hydrochloride	88	4.2	4.2
Sorafenib	26	4.2	4.2
Hydrochlorothiazide	178	4.2	4.2
Carbidopa And Levodopa	59	4.2	4.2
Lovastatin	32	4.2	4.2
Hydrocodone Bitartrate And Acetaminophen	69	4.1	4.1
Lidocaine Hydrochloride And Epinephrine Bitartrate	65	4.1	4.1
Nebivolol Hydrochloride	41	4.1	4.1
Levothyroxine Sodium	366	4.1	4.1
Divalproex Sodium	56	4.0	4.1
Lidocaine 4%	65	4.0	4.0
Promethazine Hydrochloride	22	4.0	4.0
Diazepam Oral Solution (Concentrate)	104	4.0	4.0
Diazepam Oral	104	4.0	4.0
Doxycycline Hyclate	79	3.9	4.0
Zinc	29	3.9	3.9
Amlodipine Besylate	169	3.9	3.9
Naltrexone	36	3.9	3.9
Zinc Chloride	29	3.9	3.9
Budesonide And Formoterol Fumarate Dihydrate	111	3.9	3.9
Doxycycline	78	3.9	3.9
Crisaborole	11	3.8	3.8
Citalopram Hydrobromide	120	3.8	3.8
Indomethacin	15	3.8	3.8
Dexlansoprazole	47	3.8	3.8
Lidocaine Hydrochloride	67	3.7	3.7
Alcohol	43	3.7	3.7
Cephalexin	24	3.7	3.7
Montelukast	92	3.7	3.7
Albuterol Sulfate	314	3.7	3.7
Celecoxib	142	3.7	3.7
Lisinopril	322	3.7	3.7
Lidocaine	63	3.6	3.6
Suvorexant	14	3.6	3.6
Calcium Carbonate	72	3.6	3.6
Cholestyramine	13	3.6	3.6
Hydroxyzine	51	3.6	3.6
Mirtazapine	97	3.6	3.6
Lamotirigine	76	3.6	3.6
Lamotrigine Extended-Release	76	3.6	3.6
Lamotrigine Chewable Dispersible	76	3.6	3.6
Rotigotine	15	3.5	3.5
Medroxyprogesterone Acetate	51	3.4	3.4
Cetirizine	79	3.4	3.4
Spironolactone	142	3.4	3.4
Brexpiprazole	17	3.4	3.4
Diphenoxylate Hydrochloride And Atropine Sulfate	14	3.4	3.4
Fenofibrate	36	3.4	3.4
Diltiazem Hydrochloride	35	3.4	3.4
Terazosin Hydrochloride	9	3.4	3.4
Nicotine Polacrilex Mini	15	3.3	3.3
Nicotine Polarilex	15	3.3	3.3
Omeprazole Magnesium	426	3.3	3.3
Methylprednisolone Acetate	8	3.3	3.3
Omeprazole	329	3.3	3.3
Fluconazole	68	3.3	3.3
Oxycodone	178	3.2	3.2
Cyclosporine	106	3.2	3.2
Ciprofloxacin Hydrochloride And Hydrocortisone	20	3.2	3.2
Clindamycin Phosphate	32	3.2	3.2
Diclofenac	82	3.2	3.2
Carboxymethylcellulose Sodium	9	3.2	3.2
Famotidine	111	3.2	3.2
Diphenhydramine Hydrochloride	155	3.2	3.2
Rimegepant Sulfate	12	3.2	3.2
Tamsulosin Hydrochloride	19	3.1	3.1
Bisacodyl Suppositories	12	3.1	3.1
Bisacodyl	13	3.1	3.1
Biscodyl	12	3.1	3.1
Azithromycin Dihydrate	53	3.0	3.0
Pantoprazole Sodium	130	3.0	3.0
Amoxicillin And Clavulanate Potassium	24	3.0	3.0
Valsartan And Hydrochlorothiazide	12	3.0	3.0
Zonisamide	13	2.9	2.9
Pseudoephedrine Hydrochloride	9	2.9	2.9
Metformin Hydrochloride	51	2.9	2.9
Ondansetron Hydrochloride	105	2.9	2.9
Escitslopram	50	2.9	2.9
Losartan	148	2.9	2.9
Amitriptyline Hydrochloride	15	2.9	2.9
Polyethylene Glycol 3350	81	2.9	2.9
Duloxetine	59	2.8	2.8
Potassium Chloride	96	2.8	2.8
Magnesium	69	2.8	2.8
Triamcinolone Acetonide	26	2.8	2.8
Extended Phenytoin Sodium	14	2.8	2.8
Esomeprazole Magnesium	192	2.8	2.8
Avapritinib	10	2.8	2.8
Sertraline	96	2.8	2.8
Pseudoephedrine Hcl	9	2.7	2.7
Tapentadol Hydrochloride	27	2.7	2.7
Diphenhydramine Hcl	9	2.7	2.7
Metformin Hydrochloride Tablets	46	2.7	2.7
Metformin Hydrochloride Extended-Release Tablets	46	2.7	2.7
Metformin Hydrochloride Tablet	46	2.7	2.7
Escitalopram Oxalate	58	2.7	2.7
Drospirenone And Ethinyl Estradiol	35	2.7	2.7
Quetiapine	149	2.6	2.6
Ondansetron	84	2.6	2.6
Ondansetron Tablets	84	2.6	2.6
Sulfasalazine	60	2.6	2.6
Diclofenac Sodium	114	2.6	2.6
Tafamidis	9	2.6	2.6
Pimavanserin Tartrate	42	2.5	2.5
Quinapril Hydrochloride	6	2.5	2.5
Atenolol	97	2.5	2.5
Oxycodone Hydrochloride	157	2.5	2.5
Clonidine	37	2.4	2.4
Ropinirole	11	2.4	2.4
Metoprolol	177	2.4	2.4
Icosapent Ethyl	6	2.4	2.4
Rabeprazole Sodium	19	2.3	2.3
0Xygen	34	2.3	2.3
Oxygen	34	2.3	2.3
Metoprolol Tartrate	186	2.3	2.3
Cannabidiol	16	2.3	2.3
Clobetasol Propionate Ointment Usp, 0.05%	7	2.3	2.3
Nifedipine	32	2.3	2.3
Clobetasol Propionate	7	2.3	2.3
Onabotulinumtoxina	52	2.3	2.3
Terbinafine Hydrochloride	6	2.3	2.3
Mirabegron	26	2.3	2.3
Glimepiride	26	2.2	2.2
Timolol	8	2.2	2.2
Linagliptin	12	2.2	2.2
Carvedilol	88	2.2	2.2
Bupropion	29	2.2	2.2
Cortisone Acetate	8	2.2	2.2
Nicotine	26	2.2	2.2
Rosuvastatin	130	2.1	2.1
Upadacitinib	52	2.1	2.1
Metoclopramide Hydrochloride	49	2.1	2.1
Conjugated Estrogens And Medroxyprogesterone Acetate	15	2.1	2.1
Timolol Maleate	6	2.0	2.0
Atorvastatin Calcium	144	2.0	2.0
Pitavastatin Calcium	6	2.0	2.0
Rifaximin	12	1.9	1.9
Insulin Aspart	37	1.9	1.9
Sitagliptin And Metformin Hydrochloride	12	1.9	1.9
Methadone Hydrochloride	6	1.9	1.9
Pancrelipase	21	1.8	1.8
Fluticasone Furoate And Vilanterol Trifenatate	19	1.8	1.8
Palbociclib	50	1.8	1.8
Somatropin	38	1.7	1.7
Methadone	22	1.7	1.7
Vibegron	4	1.7	1.7
Acetaminophen And Codeine	6	1.6	1.6
Liraglutide	24	1.6	1.6
Naltrexone Hydrochloride And Bupropion Hydrochloride	4	1.6	1.6
Canagliflozin	14	1.6	1.6
Pioglitazone	20	1.5	1.5
Travoprost	4	1.5	1.5
Adalimumab	321	1.5	1.5
Tofacitinib Citrate	6	1.5	1.5
Glecaprevir And Pibrentasvir	5	1.5	1.5
Risankizumab-Rzaa	37	1.5	1.5
Oseltamivir Phosphate	11	1.5	1.5
Brimonidine Tartrate	8	1.5	1.5
Nicotine Polacrilex	17	1.5	1.5
Morphine Sulfate	53	1.5	1.5
Paliperidone	10	1.4	1.4
Lifitegrast	7	1.4	1.4
Interferon Beta-1B	8	1.4	1.4
Buprenorphine	37	1.3	1.3
Prasugrel Hydrochloride	4	1.3	1.3
Dofetilide	4	1.3	1.3
Exenatide	20	1.3	1.3
Levonorgestrel	75	1.2	1.2
Patiromer	5	1.2	1.2
Fremanezumab-Vfrm	4	1.2	1.2
Ranitidine	69	1.2	1.2
Erenumab-Aooe	13	0.8	0.8
Hydrocodone Bitartrate	10	0.8	0.8
Etonogestrel	10	0.7	0.7
Abaloparatide	6	0.7	0.7
Galcanezumab-Gnlm	6	0.6	0.6
Dulaglutide	16	0.6	0.6
Nirmatrelvir And Ritonavir	9	0.6	0.6
Copper	5	0.4	0.4
Salicylic Acid	3	0.2	0.2
Adapalene	7	0.1	0.1

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.