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Which drugs are most reported with Major depression?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 7,230 reports · 399 co-occurring drugs

As of the last recalculation, Major Depression appears in 7,230 FAERS reports alongside 399 co-occurring drug terms. The strongest observed disproportionality signal is TOFACITINIB CITRATE (PRR 37.7).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Tofacitinib Citrate	168	37.7	38.2
Venlafaxine	504	21.7	21.8
Tramadol Hydrochloride	264	20.9	21.1
Esomeprazole Magnesium Capsule, Delayed Release	101	20.3	20.4
Esomeprazole Magnesium Delayed Release Capsules	101	20.3	20.4
Esomeprazole Magnesium Dihydrate	101	20.2	20.4
Esketamine Hydrochloride	120	19.7	19.8
Calcium, Magnesium, Potassium, And Sodium Oxybates	58	19.5	19.7
Escitalopram Oxalate	434	18.2	18.3
Venlafaxine Hydrochloride	745	18.0	18.1
Esomeprazole	313	15.1	15.2
Valsartan Oral	267	14.7	14.7
Fluoxetine Hydrochloride	584	14.2	14.3
Escitalopram	630	14.1	14.1
Escitslopram	245	12.5	12.6
Lithium	96	11.1	11.1
Lithium Bromatum	96	11.1	11.1
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	133	11.0	11.1
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	140	9.9	9.9
Doxepin Hydrochloride	43	9.9	9.9
Doxepin	34	9.7	9.7
Modafinil	106	9.6	9.6
Lithium Carbonate	56	9.6	9.6
Mirtazapine	290	9.5	9.5
Hydrocodone Bitartrate And Acetaminophen	180	9.4	9.4
Vortioxetine	54	9.2	9.2
Olanzapine Pamoate	124	8.9	8.9
Fluoxetine	200	8.9	8.9
Sodium Oxybate	197	8.8	8.8
Quetiapine	534	8.5	8.6
Carisoprodol	56	8.5	8.5
Bupropion Hydrochloride	276	8.3	8.3
Olanzapine	299	8.3	8.3
Valsartan	288	8.2	8.2
Meperidine Hydrochloride	26	8.1	8.2
Desvenlafaxine Succinate	75	8.1	8.1
Bupropion	123	8.1	8.1
Varenicline Tartrate	214	7.9	7.9
Lurasidone Hydrochloride	57	7.9	7.9
Cariprazine	25	7.8	7.8
Sertraline Hydrochloride	306	7.7	7.7
Ziprasidone Mesylate	38	7.7	7.7
Finasteride	154	7.5	7.5
Buspirone Hydrochloride	28	7.3	7.3
Sumatriptan Succinate	63	7.2	7.2
Temazepam	93	7.2	7.2
Methylphenidate Hydrochloride	142	7.0	7.0
Ziprasidone	42	6.9	6.9
Trazodone Hydrochloride	37	6.8	6.9
Paroxetine Hydrochloride	209	6.8	6.8
Aripiprazole Oral	96	6.8	6.8
Aripiprazole Orally Disintegrating	96	6.8	6.8
Clonazepam	355	6.7	6.7
Lorazepam	395	6.6	6.6
Promethazine Hydrochloride	42	6.5	6.6
Aripiprazole	269	6.5	6.5
Buprenorphine Hydrochloride, Naloxone Hydrochloride	54	6.5	6.5
Sertraline	254	6.4	6.4
Liothyronine Sodium	19	6.3	6.3
Quetiapine Fumarate	64	6.3	6.3
Etonogestrel And Ethinyl Estradiol	48	6.3	6.3
Tizanidine Hydrochloride	39	6.2	6.3
Butalbital, Acetaminophen, And Caffeine	23	6.2	6.2
Sumatriptan	79	6.0	6.0
Montelukast Sodium	245	6.0	6.0
Vilazodone Hydrochloride	19	5.9	6.0
Duloxetine Hydrochloride	371	5.9	5.9
Divalproex Sodium	94	5.9	5.9
Isotretinoin	99	5.8	5.8
Topiramate	183	5.8	5.8
Armodafinil	42	5.8	5.8
Paroxetine Hydrochloride Hemihydrate	66	5.7	5.8
Esomeprazole Magnesium	443	5.7	5.7
Gemfibrozil	30	5.7	5.7
Citalopram	263	5.7	5.7
Paroxetine	66	5.6	5.6
Atomoxetine Hydrochloride	46	5.6	5.6
Risperidone	249	5.5	5.6
Amitriptyline Hydrochloride	33	5.4	5.4
Zolpidem Tartrate	244	5.3	5.4
Meclizine Hcl 12.5Mg	25	5.3	5.3
Meclizine Hcl 25Mg	25	5.3	5.3
Meclizine Hcl 12.5 Mg	25	5.3	5.3
Meclizine Hcl 25 Mg	25	5.3	5.3
Duloxetine	126	5.3	5.3
Methocarbamol	41	5.2	5.2
Acetaminophen Tablet Extended Release	440	5.2	5.2
Pain Reliever	440	5.2	5.2
Brexpiprazole	30	5.2	5.2
Acetaminophen 500Mg	440	5.2	5.2
Lamotrigine	231	5.2	5.2
Alprazolam	354	5.1	5.2
Eszopiclone	45	5.1	5.1
Oxazepam	38	5.1	5.1
Rizatriptan Benzoate	18	5.1	5.1
Primidone	18	5.1	5.1
Lamotirigine	124	5.1	5.1
Lamotrigine Extended-Release	124	5.1	5.1
Lamotrigine Chewable Dispersible	124	5.1	5.1
Meclizine Hydrochloride	34	5.0	5.0
Ethyl Alcohol	47	5.0	5.0
Nicotine Polacrilex Mini	26	5.0	5.0
Nicotine Polarilex	26	5.0	5.0
Meclizine	28	5.0	5.0
Oxycodone Hydrochloride	358	4.9	4.9
Haloperidol Lactate	41	4.8	4.8
Haloperidol	40	4.8	4.8
Ibuprofen And Diphenhydramine Citrate	38	4.7	4.7
Magnesium Hydroxide	22	4.7	4.7
Amlodipine Besylate And Benazepril Hydrochloride	15	4.7	4.7
Thyroid, Porcine	17	4.6	4.6
Diazepam	190	4.6	4.6
Citalopram Hydrobromide	167	4.6	4.6
Valproate Sodium	32	4.5	4.5
Hydromorphone Hydrochloride	140	4.4	4.5
Hydroxyzine Hydrochloride	20	4.4	4.4
Hydroxyzine Hydrochloride Oral	20	4.4	4.4
Alendronate Sodium	151	4.4	4.4
Asenapine Maleate	13	4.3	4.3
Dronabinol	12	4.3	4.3
Lisdexamfetamine Dimesylate	49	4.3	4.3
Isopropyl Alcohol	50	4.3	4.3
Methadone	62	4.2	4.2
Methylphenidate	42	4.2	4.2
Cimetidine	14	4.2	4.2
Abacavir Sulfate	14	4.1	4.1
Docusate Sodium - Sennosides	46	4.1	4.1
Cyclobenzaprine	70	4.1	4.1
Mupirocin	19	4.1	4.1
Phenytoin	29	4.0	4.0
Mupirocin Calcium	19	4.0	4.0
Carbamazepine	89	3.9	3.9
Psyllium Husk	13	3.8	3.8
Methocarbamol Tablets	22	3.8	3.8
Hyoscyamine Sulfate	12	3.8	3.8
Pramipexole	20	3.8	3.8
Desloratadine	14	3.8	3.8
Valproic Acid	41	3.8	3.8
Acetaminophen	550	3.7	3.7
Baclofen	109	3.7	3.7
Lubiprostone	12	3.7	3.7
Sucralfate Oral	18	3.7	3.7
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	63	3.6	3.7
Sucralfate Oral Suspension	18	3.6	3.6
Extended Phenytoin Sodium	21	3.6	3.6
Levetiracetam In Sodium Chloride	96	3.6	3.6
Levetiracetam Oral	96	3.6	3.6
Levetiracetam Injection	96	3.6	3.6
Hydroxyzine	59	3.6	3.6
Montelukast	103	3.6	3.6
Cabotegravir	10	3.6	3.6
Terbinafine Hydrochloride	11	3.6	3.6
Doxyclycline Hyclate	21	3.6	3.6
Oxcarbazepine	40	3.6	3.6
Cyclobenzaprine Hydrochloride	11	3.5	3.5
Zonisamide	18	3.5	3.5
Alcohol	47	3.5	3.5
Amphetamine	10	3.5	3.5
Levetiracetam	159	3.5	3.5
Ascorbic Acid	28	3.5	3.5
Dicyclomine Hydrochloride	17	3.4	3.4
Darunavir	18	3.4	3.4
Propranolol Hydrochloride	85	3.4	3.4
Ezetimibe And Simvastatin	18	3.4	3.4
Ropinirole	18	3.4	3.4
Naproxen	90	3.3	3.3
Methimazole	9	3.3	3.3
Indomethacin	15	3.3	3.3
Docusate Sodium	65	3.3	3.3
Thiamine Hydrochloride	14	3.2	3.2
Tolterodine Tartrate	10	3.2	3.2
Gabapentin	391	3.2	3.2
Tretinoin	9	3.2	3.2
Ketoconazole	19	3.2	3.2
Candesartan	39	3.2	3.2
Chlorhexidine Gluconate	10	3.2	3.2
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Alafenamide	11	3.2	3.2
Morphine Sulfate	131	3.1	3.2
Bisacodyl Suppositories	14	3.1	3.1
Ursosiol	21	3.1	3.1
Amlodipine	284	3.1	3.1
Diphenhydramine Hcl	12	3.1	3.1
Biscodyl	14	3.1	3.1
Cyanocobalamin	35	3.1	3.1
Ritonavir	31	3.1	3.1
Tizanidine	25	3.0	3.0
Sucralfate	25	3.0	3.0
Salmeterol Xinafoate	9	3.0	3.0
Losartan Potassium And Hydrochlorothiazide	12	3.0	3.0
Nystatin Ointment	27	3.0	3.0
Nystatin Cream	27	3.0	3.0
Minocycline	12	3.0	3.0
Albuterol	122	3.0	3.0
Nystatin	28	3.0	3.0
Loratadine Oral	50	2.9	2.9
Cephalexin	22	2.9	2.9
Quinapril Hydrochloride	8	2.9	2.9
Ursodiol	22	2.9	2.9
Nitroglycerin	54	2.9	2.9
Brivaracetam	9	2.9	2.9
Nevirapine	9	2.9	2.9
Bisacodyl	14	2.9	2.9
Pregabalin	264	2.9	2.9
Nicotine	40	2.9	2.9
Rasagiline Mesylate	11	2.8	2.8
Guaifenesin	30	2.8	2.8
Dutasteride	8	2.8	2.8
Fluticasone Propionate	126	2.8	2.8
Diazepam Oral Solution (Concentrate)	86	2.8	2.8
Diazepam Oral	86	2.8	2.8
Meloxicam	56	2.8	2.8
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	29	2.8	2.8
Theophylline	11	2.8	2.8
Doxycycline Hyclate	64	2.7	2.7
Tofacitinib	173	2.7	2.7
Dabrafenib	20	2.7	2.7
Diphenoxylate Hydrochloride And Atropine Sulfate	13	2.7	2.7
Ketoconazole Foam	14	2.7	2.7
Paliperidone	22	2.7	2.7
Ketoconazole Cream, 2%	14	2.7	2.7
Doxycycline	64	2.7	2.7
Melatonin	51	2.7	2.7
Ritonavir 100 Mg	14	2.7	2.7
Quinine	8	2.7	2.7
Fluticasone Propionate Nasal	28	2.7	2.7
Oxybutynin Chloride	8	2.6	2.6
Benzonatate	15	2.6	2.6
Oxycodone And Acetaminophen	21	2.6	2.6
Hydrocodone Bitartrate	39	2.6	2.6
Clindamycin Phosphate	30	2.6	2.6
Testosterone	21	2.6	2.6
Phenobarbital	13	2.6	2.6
Ibuprofen	239	2.6	2.6
Testosterone Cypionate	8	2.6	2.6
Vitamin E	28	2.6	2.6
Guanfacine	7	2.6	2.6
Amlodipine Besylate	129	2.6	2.6
Theophylline Anhydrous	11	2.6	2.6
Botulinum Toxin Type A	11	2.6	2.6
Ibuprofen Capsule	174	2.5	2.5
Ibuprofen Tablet, Film Coated	174	2.5	2.5
Ibupfrofen	174	2.5	2.5
Ibuprofen Tablets Usp, 200Mg	174	2.5	2.5
Ibuprofen Oral	174	2.5	2.5
Ibuprofen Capsules 200 Mg	174	2.5	2.5
Ibuprofen 200 Mg	174	2.5	2.5
Ibuprofen 200Mg	174	2.5	2.5
Clonidine	45	2.5	2.5
Conjugated Estrogens	51	2.5	2.5
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	18	2.5	2.5
Naproxen Sodium, Pseudoephedrine Hydrochloride	18	2.5	2.5
Prednisolone Acetate	9	2.5	2.5
Estrogens, Conjugated	51	2.5	2.5
Niacin	10	2.5	2.5
Loratadine	92	2.5	2.5
Lovastatin	22	2.5	2.5
Fentanyl	83	2.4	2.4
Paliperidone Palmitate	27	2.4	2.4
Lidicaine	41	2.4	2.4
Burn Relief	41	2.4	2.4
Peginterferon Beta-1A	11	2.4	2.4
Lidocaine Hydrochloride And Epinephrine	41	2.4	2.4
Ferrous Sulfate	42	2.4	2.4
Azithromycin Dihydrate	49	2.4	2.4
Nicotine Polacrilex	32	2.4	2.4
Pantoprazole Sodium	123	2.4	2.4
Azelastine	15	2.4	2.4
Lidocaine, Menthol	41	2.4	2.4
Trametinib	20	2.4	2.4
Dimethyl Fumarate	101	2.4	2.4
Posaconazole Delayed-Release	9	2.4	2.4
Naproxen Sodium	116	2.4	2.4
Mometasone Furoate	34	2.4	2.4
Lidocaine Hydrochloride	49	2.3	2.4
Lidocaine Hydrochloride And Epinephrine Bitartrate	43	2.3	2.3
Albuterol Sulfate	235	2.3	2.3
Docusate Sodium 100Mg	19	2.3	2.3
Loratadine Tablet	42	2.3	2.3
Oxycodone Hydrochloride And Acetaminophen	77	2.3	2.3
Celecoxib	102	2.2	2.2
Clobetasol Propionate Ointment Usp, 0.05%	8	2.2	2.2
Amantadine	12	2.2	2.2
Clobetasol Propionate	8	2.2	2.2
Famotidine	90	2.2	2.2
Ciprofloxacin Hydrochloride And Hydrocortisone	16	2.2	2.2
Oxycodone And Acetaminophen Tablets	9	2.2	2.2
Lidocaine 4%	41	2.2	2.2
Levodopa	9	2.1	2.1
Glyburide	18	2.1	2.1
Glipizide	45	2.1	2.1
Thiotepa	7	2.1	2.1
Metoclopramide Hydrochloride	56	2.1	2.1
Elexacaftor, Tezacaftor, And Ivacaftor	9	2.1	2.1
Human Insulin	9	2.1	2.1
Efavirenz	8	2.1	2.1
Atenolol	95	2.1	2.1
Lamivudine Oral	18	2.1	2.1
Rimegepant Sulfate	9	2.0	2.0
Donepezil Hydrochloride	26	2.0	2.0
Metformin Hcl	39	2.0	2.0
Ibuprofen Sodium	30	2.0	2.0
Clozapine	87	2.0	2.0
Cetirizine Hydrochloride	113	2.0	2.0
Lisinopril	208	2.0	2.0
Lisinopril And Hydrochlorothiazide	7	2.0	2.0
Valacyclovir Hydrochloride	48	2.0	2.0
Naltrexone	21	2.0	2.0
Raltegravir	11	1.9	1.9
Dolutegravir Sodium	6	1.9	1.9
Ibuprofen Tablets, Coated	28	1.9	1.9
Drospirenone And Ethinyl Estradiol	29	1.9	1.9
Acetaminophen And Codeine	8	1.9	1.9
Cetirizine Hcl	6	1.9	1.9
Exemestane	14	1.9	1.9
Estradiol	56	1.9	1.9
Methadone Hydrochloride	7	1.9	1.9
Medroxyprogesterone Acetate	32	1.9	1.9
Estradiol Gel 0.1%	29	1.9	1.9
Estradiol Transdermal	29	1.8	1.9
Oxycodone	119	1.8	1.8
Carboxymethylcellulose Sodium	6	1.8	1.8
Atorvastatin Calcium	156	1.8	1.8
Valbenazine	16	1.8	1.8
Lisinopril And Hydrochlorothiazide Tablets	5	1.8	1.8
Pseudoephedrine Hcl	7	1.8	1.8
Atazanavir	9	1.8	1.8
Interferon Beta-1B	12	1.8	1.8
Dexlansoprazole	26	1.8	1.8
Valacyclovir	26	1.8	1.8
Posaconazole	10	1.8	1.8
Lamivudine	19	1.8	1.8
Clobazam	15	1.8	1.8
Triamcinolone Acetonide Ointment Usp, 0.05%	14	1.7	1.7
Buprenorphine	55	1.7	1.7
Natalizumab	106	1.7	1.7
Naltrexone Hydrochloride And Bupropion Hydrochloride	5	1.7	1.7
Memantine	8	1.7	1.7
Memantine Hydrochloride	8	1.7	1.7
Pseudoephedrine Hydrochloride	6	1.7	1.7
Pioglitazone	25	1.7	1.7
Rifaximin	12	1.7	1.7
Miconazole Nitrate	5	1.6	1.7
Dalfampridine	41	1.6	1.6
Lacosamide	21	1.6	1.6
Peginterferon Alfa-2A	29	1.5	1.5
Ribavirin	34	1.5	1.5
Oral Semaglutide	38	1.5	1.5
Triamcinolone Acetonide	16	1.5	1.5
Naproxen Sodium Tablet, Coated	7	1.5	1.5
Naproxen Sodium, Coated Tablets	7	1.5	1.5
Naproxen Sodium 220Mg	7	1.5	1.5
Diroximel Fumarate	6	1.4	1.4
Polyethylene Glycol 3350	48	1.4	1.4
Timolol	6	1.4	1.4
Prasugrel Hydrochloride	5	1.4	1.4
Emtricitabine And Tenofovir Disoproxil Fumarate	22	1.4	1.4
Budesonide, Glycopyrrolate, And Formoterol Fumarate	5	1.4	1.4
Docetaxel Anhydrous	32	1.4	1.4
Docetaxel	32	1.4	1.4
Conjugated Estrogens And Medroxyprogesterone Acetate	11	1.3	1.3
Carbidopa And Levodopa	22	1.3	1.3
Fesoterodine Fumarate	5	1.3	1.3
Fexofenadine Hydrochloride	10	1.3	1.3
Interferon Beta-1A	88	1.3	1.3
Mometasone Furoate And Formoterol Fumarate Dihydrate	7	1.3	1.3
Fremanezumab-Vfrm	5	1.3	1.3
Insulin Lispro	60	1.3	1.3
Tafamidis	5	1.2	1.2
Tadalafil	42	1.2	1.2
Glatiramer Acetate	25	1.2	1.2
Levonorgestrel	78	1.1	1.1
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	7	1.1	1.1
Acetaminophen, Aspirin, And Caffeine	8	1.1	1.1
Ivacaftor	3	1.1	1.1
Loratadine And Pseudoephedrine Sulfate	3	1.1	1.1
Etonogestrel	18	1.1	1.1
Naproxen Sodium Tablet	20	1.1	1.1
Copper	16	1.1	1.1
Ocrelizumab	23	1.1	1.1
Diclofenac Potassium	4	1.1	1.1
Pegvaliase-Pqpz	3	1.1	1.1
Umeclidinium Bromide And Vilanterol Trifenatate	6	1.0	1.0
Diclofenac Potassium, Film Coated	3	1.0	1.0
Diclofenac Potassium Tablets	3	1.0	1.0
Galcanezumab-Gnlm	11	1.0	1.0
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Disoproxil Fumarate	3	1.0	1.0
Bimekizumab	7	0.9	0.9
Ledipasvir And Sofosbuvir	6	0.9	0.9
Teriflunomide	14	0.9	0.9
Leuprolide Acetate	23	0.9	0.9
Tapentadol Hydrochloride	9	0.8	0.8
Emtricitabine And Tenofovir Alafenamide	3	0.8	0.8
Apremilast	36	0.7	0.7
Lifitegrast	4	0.7	0.7
Relugolix	5	0.6	0.6
Dornase Alfa	4	0.6	0.6
Erenumab-Aooe	11	0.6	0.6
Guselkumab	6	0.5	0.5
Tirzepatide	23	0.4	0.4

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.