Reaction

Which drugs are most reported with Hyperthermia?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 7,464 reports · 354 co-occurring drugs

As of the last recalculation, Hyperthermia appears in 7,464 FAERS reports alongside 354 co-occurring drug terms. The strongest observed disproportionality signal is SEVOFLURANE (PRR 31.2).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Sevoflurane	92	31.2	31.6
Atropine	77	26.2	26.4
Atropine Sulfate	87	22.7	22.9
Haloperidol	156	18.3	18.4
Haloperidol Lactate	157	18.0	18.2
Oxazepam	112	14.7	14.8
Midazolam	120	13.5	13.5
Midazolam Hydrochloride	126	13.3	13.3
Brentuximab Vedotin	44	12.0	12.1
Amphetamine	29	9.8	9.8
Valproate Sodium	70	9.5	9.6
Propofol	121	9.4	9.4
Amoxicillin And Clavulanate Potassium	90	9.3	9.4
Norepinephrine	34	8.9	8.9
Rifampicin	32	8.9	8.9
Rasagiline Mesylate	35	8.8	8.8
Olanzapine	319	8.6	8.6
Lithium	76	8.5	8.5
Lithium Bromatum	76	8.5	8.5
Dabrafenib	63	8.4	8.4
Aprepitant	55	8.4	8.4
Piperacillin Sodium,Tazobactam Sodium	78	8.3	8.3
Fosaprepitant Dimeglumine	38	7.7	7.8
Norepinephrine Bitartrate	39	7.6	7.6
Methylprednisolone Sodium Succinate	124	7.6	7.6
Paroxetine Hydrochloride Hemihydrate	88	7.4	7.5
Paroxetine	88	7.3	7.3
Fondaparinux Sodium	21	7.3	7.3
Trametinib	60	7.0	7.0
Valproic Acid	78	7.0	7.0
Lithium Carbonate	42	6.9	6.9
Oxaliplatin	174	6.7	6.7
Rocuronium Bromide	28	6.6	6.7
Cefepime	34	6.6	6.7
Phenobarbital	33	6.4	6.4
Risperidone	293	6.4	6.4
Cefepime Hydrochloride	36	6.3	6.3
Escitslopram	127	6.2	6.2
Ceftriaxone Sodium	83	6.1	6.1
Bendamustine Hydrochloride	26	6.1	6.1
Iohexol	18	6.1	6.1
Gentamicin Sulfate	34	6.0	6.0
Quetiapine	396	6.0	6.0
Quetiapine Fumarate	63	6.0	6.0
Amitriptyline Hydrochloride	37	5.9	5.9
Piperacillin And Tazobactam	27	5.9	5.9
Lamotrigine	269	5.9	5.9
Iron Sucrose	20	5.9	5.9
Vancomycin Hydrochloride	136	5.8	5.9
Levodopa	25	5.8	5.8
Gentamicin	27	5.8	5.8
Vancomycin	118	5.8	5.8
Sulfamethoxazole And Trimethoprim	171	5.8	5.8
Aripiprazole Oral	84	5.7	5.7
Aripiprazole Orally Disintegrating	84	5.7	5.7
Escitalopram Oxalate	146	5.7	5.7
Cefazolin Sodium	24	5.6	5.6
Olanzapine Pamoate	80	5.5	5.5
Diazepam Oral Solution (Concentrate)	172	5.5	5.5
Diazepam Oral	172	5.5	5.5
Amantadine	30	5.4	5.4
Lamotirigine	137	5.4	5.4
Lamotrigine Extended-Release	137	5.4	5.4
Lamotrigine Chewable Dispersible	137	5.4	5.4
Anti-Thymocyte Globulin (Rabbit)	15	5.2	5.2
Meropenem	59	5.2	5.2
Venlafaxine	129	5.1	5.1
Diazepam	213	5.0	5.0
Piperacillin Sodium And Tazobactam Sodium	35	5.0	5.0
Phenytoin	37	5.0	5.0
Ceftriaxone	58	5.0	5.0
Carbamazepine	117	4.9	4.9
Amikacin	30	4.9	4.9
Enoxaparin Sodium	98	4.8	4.8
Hydrocortisone Sodium Succinate	16	4.8	4.8
Dalteparin Sodium	18	4.8	4.8
Tranexamic Acid	15	4.7	4.7
Fluorouracil Cream, 0.5%	126	4.7	4.7
Topiramate	153	4.7	4.7
Vemurafenib	20	4.7	4.7
Fluorouracil	126	4.6	4.6
Cefazolin	15	4.6	4.6
Bupropion	71	4.5	4.5
Dutasteride	13	4.5	4.5
Esomeprazole Magnesium Capsule, Delayed Release	23	4.4	4.4
Esomeprazole Magnesium Delayed Release Capsules	23	4.4	4.4
Esomeprazole Magnesium Dihydrate	23	4.4	4.4
Ampicillin	13	4.4	4.4
Ampicillin Sodium	13	4.4	4.4
Ketoprofen	20	4.3	4.3
Leucovorin Calcium	29	4.2	4.2
Cetuximab	47	4.2	4.2
Paroxetine Hydrochloride	135	4.2	4.2
Fentanyl	144	4.1	4.1
Thiotepa	14	4.1	4.1
Regorafenib	17	4.1	4.1
Valacyclovir	60	4.0	4.0
Misoprostol	14	4.0	4.0
Pramipexole	22	4.0	4.0
Daptomycin	13	3.9	3.9
Temazepam	52	3.9	3.9
Primidone	14	3.8	3.8
Hydroxyzine	65	3.8	3.8
Bendamustine Hcl	21	3.8	3.8
Aripiprazole	161	3.7	3.7
Cetiirizine	56	3.7	3.7
Alemtuzumab	25	3.6	3.6
Polyethylene Glycol	14	3.6	3.6
Fentanyl Citrate	23	3.6	3.6
Entecavir	15	3.6	3.6
Clozapine	159	3.6	3.6
Bupivacaine	12	3.6	3.6
Quinine	11	3.6	3.6
Fludarabine Phosphate	50	3.6	3.6
Salmeterol Xinafoate	11	3.6	3.6
Methimazole	10	3.6	3.6
Mirtazapine	115	3.5	3.5
Morphine	93	3.5	3.5
Levetiracetam In Sodium Chloride	96	3.5	3.5
Levetiracetam Oral	96	3.5	3.5
Levetiracetam Injection	96	3.5	3.5
Atovaquone	10	3.5	3.5
Acetaminophen Tablet Extended Release	307	3.5	3.5
Pain Reliever	307	3.5	3.5
Palivizumab	19	3.5	3.5
Acetaminophen 500Mg	307	3.5	3.5
Citalopram Hydrobromide	131	3.5	3.5
Esomeprazole	76	3.4	3.4
Posaconazole	20	3.4	3.4
Carboplatin	154	3.4	3.4
Metronidazole	78	3.4	3.4
Lorazepam	216	3.4	3.4
Venlafaxine Hydrochloride	159	3.4	3.4
Linezolid	36	3.4	3.4
Mesna Injection	10	3.4	3.4
Divalproex Sodium	56	3.4	3.4
Clonazepam	188	3.3	3.3
Sertraline	138	3.3	3.3
Mesna	10	3.3	3.3
Duloxetine	82	3.3	3.3
Micafungin Sodium	10	3.3	3.3
Paclitaxel (Aibumin-Bound)	96	3.3	3.3
Magnesium Sulfate In Water For	15	3.3	3.3
Eplerenone	15	3.3	3.3
Clarithromycin	40	3.3	3.3
Magnesium Sulfate Heptahydrate	15	3.2	3.2
Trazodone Hydrochloride	18	3.2	3.2
Magnesium Sulfate	15	3.2	3.2
Panitumumab	18	3.2	3.2
Zonisamide	17	3.2	3.2
Busulfan	18	3.2	3.2
Pertuzumab	31	3.2	3.2
Baclofen	97	3.2	3.2
Fluoxetine	75	3.2	3.2
Tramadol Hydrochloride	42	3.1	3.1
Axicabtagene Ciloleucel	11	3.1	3.1
Basiliximab	13	3.1	3.1
Escitalopram	153	3.1	3.1
Clobazam	26	3.0	3.0
Diphenhydramine	66	2.9	2.9
Levetiracetam	138	2.9	2.9
Thiamine Hydrochloride	13	2.9	2.9
Trastuzumab	71	2.9	2.9
Filgrastim	39	2.9	2.9
Paclitaxel	101	2.9	2.9
Pemetrexed Disodium	39	2.9	2.9
Desloratadine	11	2.9	2.9
Valacyclovir Hydrochloride	71	2.8	2.8
Desoximetasone	19	2.8	2.8
Citalopram	135	2.8	2.8
Ethyl Alcohol	27	2.8	2.8
Hydroxyzine Hydrochloride	13	2.8	2.8
Hydroxyzine Hydrochloride Oral	13	2.8	2.8
Dextrose	13	2.8	2.8
Indomethacin	13	2.7	2.7
Dextrose Monohydrate	13	2.7	2.7
Insulin	54	2.7	2.7
Propranolol Hydrochloride	69	2.7	2.7
Clonidine	49	2.7	2.7
Lopinavir And Ritonavir	13	2.7	2.7
Fluoxetine Hydrochloride	121	2.7	2.7
Theophylline	11	2.7	2.7
Oxcarbazepine	31	2.7	2.7
Cetirizine	73	2.6	2.6
Heparin Sodium	13	2.6	2.6
Phytonadione	8	2.6	2.6
Nebivolol	15	2.6	2.6
Cytarabine	56	2.6	2.6
Alprazolam	188	2.6	2.6
Obinutuzumab	15	2.5	2.5
Zolpidem Tartrate	121	2.5	2.5
Rabeprazole	20	2.5	2.5
Ondansetron	98	2.5	2.5
Ondansetron Tablets	98	2.5	2.5
Anti-Itch	60	2.5	2.5
Anti-Pruritic	60	2.5	2.5
Antipruritic (Anti-Itch)	60	2.5	2.5
Cool Relief Gel With Aloe	60	2.5	2.5
Drs. Hydrocortisone	60	2.5	2.5
Hydrocortisone Continuous Spray	60	2.5	2.5
Hydrocortisone Spray	60	2.5	2.5
Anti-Itch Cream	60	2.5	2.5
Hydrocortisone Lotion	60	2.5	2.5
Hydrocortisone Cream 1%	60	2.5	2.5
Hydrocortisone Cream 1/2%	60	2.5	2.5
Diphenhydramine Hcl	10	2.5	2.5
Hydrocortisone 1%	60	2.5	2.5
Hydrocortisone Cream	60	2.5	2.5
Teduglutide	12	2.5	2.5
Theophylline Anhydrous	11	2.5	2.5
Prednisolone	158	2.5	2.5
Prednisolone Oral	158	2.5	2.5
Prednisolone Oral Solution	158	2.5	2.5
Ondansetron Hydrochloride	106	2.4	2.4
Lidocaine Hydrochloride And Epinephrine Bitartrate	46	2.4	2.4
Nivolumab	83	2.4	2.4
Methylphenidate Hydrochloride	51	2.4	2.4
Pembrolizumab	90	2.4	2.4
Voriconazole	26	2.4	2.4
Enalapril	47	2.4	2.4
Sucralfate Oral	12	2.4	2.4
Methadone	36	2.4	2.4
Sucralfate Oral Suspension	12	2.3	2.3
Lidicaine	41	2.3	2.3
Burn Relief	41	2.3	2.3
Lidocaine Hydrochloride And Epinephrine	41	2.3	2.3
Atazanavir	12	2.3	2.3
Allopurinol	129	2.3	2.3
Bisoprolol Fumarate	112	2.3	2.3
Lidocaine, Menthol	41	2.3	2.3
Posaconazole Delayed-Release	9	2.3	2.3
Cyclobenzaprine	40	2.2	2.2
Alpelisib	7	2.2	2.2
Amoxicillin	61	2.2	2.2
Alcohol	31	2.2	2.2
Isopropyl Alcohol	27	2.2	2.2
Levofloxacin	48	2.2	2.2
Levofloxacin In 5% Dextrose	48	2.2	2.2
Tizanidine	19	2.2	2.2
Methylphenidate	23	2.2	2.2
Nitrofurantoin	13	2.2	2.2
Ritonavir	23	2.2	2.2
Terbinafine Hydrochloride	7	2.2	2.2
Infliximab-Dyyb	23	2.2	2.2
Insulin Glulisine	8	2.2	2.2
Ropinirole	12	2.2	2.2
Indapamide	14	2.2	2.2
Acetaminophen	341	2.2	2.2
Nitrofurantoin (Monohydrate/Macrocrystals)	13	2.2	2.2
Everolimus Tablets	13	2.2	2.2
Lapatinib	12	2.2	2.2
Granisetron	8	2.1	2.1
Irbesartan	34	2.1	2.1
Lidocaine 4%	41	2.1	2.1
Metoclopramide	41	2.1	2.1
Pyrazinamide	7	2.1	2.1
Valganciclovir Hydrochloride Powder,	9	2.1	2.1
Gemcitabine	29	2.1	2.1
Gemcitabine Hydrochloride	39	2.1	2.1
Melatonin	40	2.1	2.1
Paliperidone	17	2.0	2.0
Instalax Polyethylene Glycol 3350	9	2.0	2.0
Sitagliptin	52	2.0	2.0
Zoledronic Acid	29	2.0	2.0
Mycophenolic Acid	23	2.0	2.0
Amphotericin B	9	2.0	2.0
Ado-Trastuzumab Emtansine	6	2.0	2.0
Polyethylene Glycol 400	9	2.0	2.0
Carfilzomib	20	2.0	2.0
Daratumumab	28	2.0	2.0
Irinotecan Hydrochloride	9	2.0	2.0
Rivastigmine	13	1.9	1.9
Bevacizumab	85	1.9	1.9
Dexamethasone Sodium Phosphate	7	1.9	1.9
Metoclopramide Hydrochloride	53	1.9	1.9
Bleomycin Sulfate	7	1.9	1.9
Granisetron Hydrochloride	7	1.9	1.9
Duloxetine Hydrochloride	125	1.9	1.9
Buprenorphine Hydrochloride, Naloxone Hydrochloride	16	1.9	1.9
Darunavir	10	1.8	1.8
Pregabalin	177	1.8	1.8
Pegaspargase	8	1.8	1.8
Bortezomib	58	1.8	1.8
Prochlorperazine	18	1.8	1.8
Agalsidase Beta	6	1.8	1.8
Methadone Hydrochloride	7	1.8	1.8
Metformin Hydrochloride Tablets	37	1.8	1.8
Metformin Hydrochloride Extended-Release Tablets	37	1.8	1.8
Metformin Hydrochloride Tablet	37	1.8	1.8
Etoposide	47	1.8	1.8
Melphalan Hydrochloride	16	1.8	1.8
Buspirone Hydrochloride	7	1.8	1.8
Esomeprazole Magnesium	144	1.7	1.7
Hydroxyurea	13	1.7	1.7
Azacitidine	18	1.7	1.7
Atezolizumab	23	1.7	1.7
Cisplatin	46	1.6	1.6
Vortioxetine	10	1.6	1.6
Vincristine Sulfate	17	1.6	1.6
Docetaxel Anhydrous	39	1.6	1.6
Docetaxel	39	1.6	1.6
Asenapine Maleate	5	1.6	1.6
Blinatumomab	6	1.6	1.6
Melphalan	13	1.6	1.6
Everolimus	29	1.6	1.6
Ziprasidone	10	1.6	1.6
Cyclophosphamide Injection, Solution	100	1.6	1.6
Cyclophosphamide	100	1.6	1.6
Cyclophosphamide For Injection	100	1.6	1.6
Deferasirox	15	1.6	1.6
Capecitabine	51	1.6	1.6
Dolutegravir Sodium	5	1.5	1.5
Gefitinib	5	1.5	1.5
Rotigotine	8	1.5	1.5
Donepezil Hydrochloride	20	1.5	1.5
Cariprazine	5	1.5	1.5
Dexamethasone 1.5 Mg	156	1.5	1.5
Dexamethasone	156	1.5	1.5
Omalizumab	45	1.5	1.5
Derma Foam Excel Hand Sanitizer	4	1.4	1.4
Ethanol	4	1.4	1.4
Azacitidine For	9	1.4	1.4
Ixazomib	14	1.4	1.4
Lurasidone Hydrochloride	10	1.3	1.3
Venetoclax	29	1.3	1.3
Interferon Beta-1B	9	1.3	1.3
Alteplase	7	1.3	1.3
Ifosfamide	10	1.3	1.3
Carbidopa And Levodopa	22	1.3	1.3
Canakinumab	5	1.3	1.3
Brinzolamide	4	1.3	1.3
Doxorubicin Hydrochloride	15	1.3	1.3
Oseltamivir Phosphate	11	1.3	1.3
Doxorubicin	40	1.3	1.3
Temozolomide	9	1.2	1.2
Peginterferon Alfa-2A	22	1.1	1.1
Sofosbuvir	8	1.1	1.1
Ipilimumab	17	1.1	1.1
Pegfilgrastim	38	1.1	1.1
Paliperidone Palmitate	12	1.0	1.0
Buprenorphine	34	1.0	1.0
Aflibercept	11	1.0	1.0
Brivaracetam	3	0.9	0.9
Suvorexant	4	0.9	0.9
Emtricitabine And Tenofovir Disoproxil Fumarate	14	0.9	0.9
Encorafenib	3	0.8	0.8
Tapentadol Hydrochloride	10	0.8	0.8
Ofatumumab	9	0.8	0.8
Durvalumab	5	0.7	0.7
Olaparib	5	0.7	0.7
Lenalidomide	97	0.6	0.6
Vigabatrin	3	0.6	0.6
Droxidopa	4	0.5	0.5
Somatropin	13	0.5	0.5

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.