Reaction

Lipase Increased reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 7,527 reports · 369 co-occurring drugs

As of the last recalculation, Lipase Increased appears in 7,527 FAERS reports alongside 369 co-occurring drug terms. The strongest observed disproportionality signal is NILOTINIB (PRR 25.0).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Nilotinib	258	25.0	25.2
Pegaspargase	105	24.0	24.2
Sorafenib	141	19.1	19.2
Quinine	57	18.5	18.6
Liraglutide	282	16.4	16.4
Ipilimumab	218	14.4	14.4
Zidovudine	59	12.3	12.3
Sitagliptin And Metformin Hydrochloride	91	11.8	11.8
Teduglutide	52	10.7	10.8
Sitagliptin	251	9.9	10.0
Encorafenib	35	9.8	9.8
Nivolumab	270	8.0	8.0
Nevirapine	25	7.7	7.7
Vemurafenib	33	7.6	7.6
Trametinib	66	7.6	7.6
Mercaptopurine	46	7.4	7.4
Brentuximab Vedotin	26	7.0	7.1
Vincristine Sulfate	73	6.9	7.0
Exenatide	129	6.9	6.9
Bosutinib	22	6.8	6.8
Entecavir	28	6.7	6.7
Lopinavir And Ritonavir	32	6.6	6.6
Dulaglutide	195	6.2	6.2
Lamivudine	64	5.8	5.8
Dabrafenib	43	5.7	5.7
Imatinib	36	5.7	5.7
Dasatinib	75	5.6	5.6
Cytarabine	120	5.6	5.6
Atezolizumab	76	5.5	5.5
Regorafenib	22	5.3	5.3
Rifampicin	19	5.2	5.2
Tirzepatide	281	5.0	5.0
Ritonavir	52	4.9	5.0
Oral Semaglutide	129	4.9	4.9
Metronidazole	111	4.9	4.9
Fosaprepitant Dimeglumine	24	4.8	4.8
Pazopanib Hydrochloride	46	4.7	4.7
Linagliptin	31	4.7	4.7
Indapamide	30	4.6	4.6
Lenvatinib	54	4.6	4.6
Sulfamethoxazole And Trimethoprim	134	4.5	4.5
Lamivudine Oral	40	4.4	4.4
Aprepitant	29	4.4	4.4
Glimepiride	60	4.3	4.3
Pancrelipase	59	4.3	4.3
Amlodipine Besylate And Benazepril Hydrochloride	14	4.2	4.2
Sunitinib Malate	59	4.2	4.2
Crizotinib	19	4.1	4.1
Ritonavir 100 Mg	22	4.1	4.1
Diphenoxylate Hydrochloride And Atropine Sulfate	20	4.0	4.0
Captopril	14	4.0	4.0
Metformin Hcl	80	4.0	4.0
Enalapril Maleate	36	4.0	4.0
Torsemide	48	4.0	4.0
Cimetidine	14	4.0	4.0
Mesalamine	81	4.0	4.0
Everolimus Tablets	24	4.0	4.0
Phytonadione	12	3.9	3.9
Candesartan	50	3.9	3.9
Febuxostat Tablets 40 Mg	14	3.8	3.8
Febuxostat Tablets 80 Mg	14	3.8	3.8
Candesartan Cilexetil	36	3.8	3.8
Cabozantinib	65	3.8	3.8
Standardized Senna Concentrate	17	3.7	3.7
Abacavir Sulfate	13	3.7	3.7
Durvalumab	27	3.7	3.7
Felodipine Extended-Release Tablets	15	3.6	3.7
Felodipine	15	3.6	3.7
Esomeprazole Magnesium Capsule, Delayed Release	19	3.6	3.6
Esomeprazole Magnesium Delayed Release Capsules	19	3.6	3.6
Esomeprazole Magnesium Dihydrate	19	3.6	3.6
Gentamicin	17	3.6	3.6
Promethazine Hydrochloride	24	3.6	3.6
Glyburide	31	3.6	3.6
Fluconazole	89	3.5	3.5
Pyrazinamide	12	3.5	3.5
Fenofibrate	45	3.5	3.5
Raltegravir	21	3.5	3.5
Doxorubicin Hydrochloride	41	3.5	3.5
Valsartan Oral	68	3.5	3.5
Atazanavir	18	3.5	3.5
Gemfibrozil	19	3.5	3.5
Piperacillin Sodium,Tazobactam Sodium	33	3.5	3.5
Dronabinol	10	3.4	3.4
Cholestyramine	15	3.4	3.4
Metformin Er 500 Mg	361	3.4	3.4
Metformin Er 750 Mg	361	3.4	3.4
Hydroxyurea	26	3.4	3.4
Bisoprolol Fumarate	164	3.4	3.4
Metronidazole Topical	58	3.4	3.4
Metformin	413	3.3	3.3
Pembrolizumab	125	3.3	3.3
Amphotericin B	15	3.3	3.3
Dicyclomine Hydrochloride	17	3.3	3.3
Enoxaparin Sodium	68	3.3	3.3
Dexamethasone Sodium Phosphate	12	3.3	3.3
Hydrocortisone Sodium Succinate	11	3.2	3.2
Pantoprazole Sodium In 0.9% Sodium Chloride	72	3.2	3.2
Pantoprazole Sodium Injection	72	3.2	3.2
Efavirenz	13	3.2	3.2
Hydrocortisone Cream	78	3.2	3.2
Loperamide Hydrochloride And Dimethicone	37	3.2	3.2
Anti-Itch	77	3.2	3.2
Anti-Pruritic	77	3.2	3.2
Antipruritic (Anti-Itch)	77	3.2	3.2
Cool Relief Gel With Aloe	77	3.2	3.2
Drs. Hydrocortisone	77	3.2	3.2
Hydrocortisone Continuous Spray	77	3.2	3.2
Hydrocortisone Spray	77	3.2	3.2
Anti-Itch Cream	77	3.2	3.2
Hydrocortisone Lotion	77	3.2	3.2
Hydrocortisone Cream 1%	77	3.2	3.2
Hydrocortisone Cream 1/2%	77	3.2	3.2
Hydrocortisone 1%	77	3.2	3.2
Blinatumomab	12	3.2	3.2
Gentamicin Sulfate	18	3.2	3.2
Hydrocortisone	100	3.1	3.1
Daspone	11	3.1	3.1
Dapsone Gel, 5%	11	3.1	3.1
Sucralfate Oral	16	3.1	3.1
Lactulose	43	3.1	3.1
Sucralfate Oral Suspension	16	3.1	3.1
Azathioprine	98	3.1	3.1
Desloratadine	12	3.1	3.1
Imatinib Mesylate	31	3.1	3.1
Polyethylene Glycol	12	3.1	3.1
Valsartan And Hydrochlorothiazide	15	3.1	3.1
Olanzapine Pamoate	45	3.1	3.1
Pantoprazole	271	3.0	3.0
Hydrocortisone Acetate	79	3.0	3.0
Prochlorperazine Maleate	10	3.0	3.0
Bisacodyl Suppositories	14	3.0	3.0
Magnesium Oxide	45	3.0	3.0
Vancomycin	62	3.0	3.0
Empagliflozin	72	3.0	3.0
Biscodyl	14	3.0	3.0
Amoxicillin And Clavulanate Potassium	29	3.0	3.0
Ketoprofen	14	3.0	3.0
Allopurinol	163	2.9	2.9
Loperamide Hydrochloride	47	2.9	2.9
Ezetimibe And Simvastatin	16	2.9	2.9
Atenolol	138	2.9	2.9
Gemcitabine	41	2.9	2.9
Niacin	12	2.9	2.9
Dapsone	11	2.9	2.9
Enalapril	57	2.8	2.9
Vancomycin Hydrochloride	67	2.8	2.8
Basiliximab	12	2.8	2.8
Esomeprazole	63	2.8	2.8
Teriflunomide	46	2.8	2.8
Magnesium Sulfate In Water For	13	2.8	2.8
Methylprednisolone Sodium Succinate	47	2.8	2.8
Febuxostat	17	2.8	2.8
Quinapril Hydrochloride	8	2.8	2.8
Sucralfate	24	2.8	2.8
Gemcitabine Hydrochloride	53	2.8	2.8
Posaconazole Delayed-Release	11	2.8	2.8
Magnesium Sulfate Heptahydrate	13	2.8	2.8
Magnesium Sulfate	13	2.8	2.8
Bisacodyl	14	2.8	2.8
Cetuximab	31	2.7	2.7
Propofol	36	2.7	2.7
Posaconazole	16	2.7	2.7
Dronedarone	10	2.7	2.7
Ramipril	120	2.7	2.7
Antacid	46	2.7	2.7
Irbesartan	43	2.7	2.7
Ursodiol	21	2.7	2.7
Docusate Sodium - Sennosides	31	2.7	2.7
Mometasone Furoate	40	2.7	2.7
Granisetron Hydrochloride	10	2.6	2.7
Sennosides 8.6 Mg Tablets	20	2.6	2.6
Senna Leaf	22	2.6	2.6
Senna	20	2.6	2.6
Valsartan	99	2.6	2.6
Divalproex Sodium	44	2.6	2.6
Deferasirox	25	2.6	2.6
Clobazam	23	2.6	2.6
Tenofovir Disoproxil Fumarate	31	2.6	2.6
Ezetimibe	70	2.6	2.6
Metoclopramide Hydrochloride	72	2.6	2.6
Eplerenone	12	2.6	2.6
Meropenem	30	2.6	2.6
Alemtuzumab	18	2.6	2.6
Ondansetron	101	2.6	2.6
Ondansetron Tablets	101	2.6	2.6
Mometasone	17	2.6	2.6
Rosuvastatin	186	2.6	2.6
Alpelisib	8	2.5	2.5
Ondansetron Hydrochloride	111	2.5	2.5
Metformin Hydrochloride Tablets	52	2.5	2.5
Metformin Hydrochloride Extended-Release Tablets	52	2.5	2.5
Metformin Hydrochloride Tablet	52	2.5	2.5
Linezolid	27	2.5	2.5
Canagliflozin	27	2.5	2.5
Metformin Hydrochloride	53	2.5	2.5
Ceftriaxone	29	2.4	2.5
Insulin Glulisine	9	2.4	2.5
Olanzapine	94	2.4	2.4
Nebivolol	14	2.4	2.4
Metoclopramide	48	2.4	2.4
Colchicine	23	2.4	2.4
Etoposide	64	2.4	2.4
Inclisiran	7	2.4	2.4
Sennosides	26	2.4	2.4
Isoniazid	14	2.4	2.4
Pantoprazole Sodium	127	2.4	2.4
Sofosbuvir	17	2.4	2.4
Ceftriaxone Sodium	33	2.4	2.4
Losartan Potassium And Hydrochlorothiazide	10	2.4	2.4
Granisetron	9	2.4	2.4
Pioglitazone	37	2.4	2.4
Loperamide Hcl	11	2.4	2.4
Levothyroxine Sodium Anhydrous	85	2.4	2.4
Acetylcysteine	8	2.3	2.4
Calcitriol Capsules 0.25 Mcg	17	2.3	2.3
Calcitriol Capsules 0.5 Mcg	17	2.3	2.3
Atropine	7	2.3	2.3
Simvastatin	207	2.3	2.3
Calcitriol	17	2.3	2.3
Cefepime	12	2.3	2.3
Prochlorperazine	23	2.3	2.3
Erlotinib	8	2.3	2.3
Micafungin Sodium	7	2.3	2.3
Axitinib	16	2.3	2.3
Oxaliplatin	60	2.2	2.2
Abiraterone	11	2.2	2.2
Everolimus	41	2.2	2.2
Erlotinib Hydrochloride	10	2.2	2.2
Escitalopram Oxalate	58	2.2	2.2
Valproic Acid	25	2.2	2.2
Vismodegib	7	2.2	2.2
Pitavastatin Calcium	8	2.2	2.2
Spironolactone	109	2.2	2.2
Aripiprazole	95	2.2	2.2
Hydroxyzine	37	2.2	2.2
Escitslopram	45	2.1	2.1
Valproate Sodium	16	2.1	2.1
Atorvastatin Calcium, Film Coated	54	2.1	2.1
Ribociclib	24	2.1	2.1
Dextrose	10	2.1	2.1
Pravastatin Sodium	15	2.1	2.1
Bumetanide	20	2.1	2.1
Fexofenadine Hcl	7	2.1	2.1
Tolvaptan	11	2.1	2.1
Dextrose Monohydrate	10	2.1	2.1
Atovaquone	6	2.1	2.1
Ifosfamide	16	2.1	2.1
Cefepime Hydrochloride	12	2.1	2.1
Tramadol Hydrochloride	28	2.1	2.1
Carboxymethylcellulose Sodium	7	2.1	2.1
Oxazepam	16	2.1	2.1
Midazolam Hydrochloride	20	2.1	2.1
Doxycycline Hyclate	50	2.1	2.1
Nebivolol Hydrochloride	25	2.1	2.1
Atorvastatin Calcium	181	2.0	2.0
Carboplatin	93	2.0	2.0
Tamsulosin Hydrochloride	15	2.0	2.0
Doxycycline	50	2.0	2.0
Omeprazole	248	2.0	2.0
Insulin Human	29	2.0	2.0
Obinutuzumab	12	2.0	2.0
Darunavir	11	2.0	2.0
Glipizide	44	2.0	2.0
Amlodipine Besylate And Valsartan	8	2.0	2.0
Doxorubicin	64	2.0	2.0
Insulin	40	2.0	2.0
Filgrastim	27	2.0	2.0
Polatuzumab Vedotin	7	2.0	2.0
Ado-Trastuzumab Emtansine	6	2.0	2.0
Donepezil Hydrochloride	26	2.0	2.0
Omeprazole Magnesium	310	2.0	2.0
Lithium Carbonate	12	2.0	2.0
Bevacizumab	87	2.0	2.0
Aripiprazole Oral	29	1.9	1.9
Aripiprazole Orally Disintegrating	29	1.9	1.9
Salmeterol Xinafoate	6	1.9	1.9
Tenofovir Disoproxil Fumarate Tablets	6	1.9	1.9
Brinzolamide	6	1.9	1.9
Rivastigmine	13	1.9	1.9
Ribavirin	44	1.9	1.9
Lisinopril And Hydrochlorothiazide	7	1.9	1.9
Oxybutynin Chloride	6	1.9	1.9
Desoximetasone	13	1.9	1.9
Clopidogrel	133	1.9	1.9
Sildenafil Powder,	24	1.9	1.9
Terazosin Hydrochloride	6	1.9	1.9
Aspirin 325 Mg	338	1.9	1.9
Aspirin 81 Mg	338	1.9	1.9
Olmesartan Medoxomil	24	1.8	1.8
Furosemide	260	1.8	1.8
Sodium Chloride Tablet	48	1.8	1.8
Sodium Chloride Tablets	48	1.8	1.8
Aspirin	344	1.8	1.8
Lisinopril	196	1.8	1.8
Oxcarbazepine	21	1.8	1.8
Cisplatin	50	1.8	1.8
Insulin Glargine-Yfgn	14	1.8	1.8
Midazolam	16	1.8	1.8
Levetiracetam	84	1.7	1.7
Ziprasidone Mesylate	9	1.7	1.7
Cyclophosphamide Injection, Solution	111	1.7	1.7
Cyclophosphamide	111	1.7	1.7
Cyclophosphamide For Injection	111	1.7	1.7
Capecitabine	57	1.7	1.7
Fentanyl	61	1.7	1.7
Pemetrexed	13	1.7	1.7
Mesna Injection	5	1.7	1.7
Letrozole Tablets	29	1.7	1.7
Remdesivir	8	1.7	1.7
Mesna	5	1.6	1.6
Loperamide Hydrochloride Oral	6	1.6	1.6
Amikacin	10	1.6	1.6
Lovastatin	15	1.6	1.6
Oxybutynin	17	1.6	1.6
Lapatinib	9	1.6	1.6
Fluorouracil Cream, 0.5%	44	1.6	1.6
Pemetrexed Disodium	22	1.6	1.6
Oseltamivir Phosphate	14	1.6	1.6
Acyclovir	65	1.6	1.6
Fluorouracil	44	1.6	1.6
Temozolomide	12	1.6	1.6
Ziprasidone	10	1.6	1.6
Abiraterone Acetate	23	1.5	1.5
Dolutegravir Sodium	5	1.5	1.5
Dexamethasone 1.5 Mg	160	1.5	1.5
Emtricitabine And Tenofovir Disoproxil Fumarate	25	1.5	1.5
Irinotecan Hydrochloride	7	1.5	1.5
Dexamethasone	160	1.5	1.5
Dapagliflozin	17	1.5	1.5
Peginterferon Alfa-2A	29	1.5	1.5
Ticagrelor	17	1.5	1.5
Insulin Aspart	35	1.5	1.5
Insulin Glargine	130	1.5	1.5
Rivaroxaban	109	1.5	1.5
Thiotepa	5	1.4	1.4
Sevelamer Carbonate	6	1.4	1.4
Insulin Degludec	12	1.4	1.4
Dorzolamide Hydrochloride And Timolol Maleate	4	1.4	1.4
Oseltamivir	4	1.4	1.4
Orlistat	13	1.4	1.4
Derma Foam Excel Hand Sanitizer	4	1.4	1.4
Paclitaxel (Aibumin-Bound)	41	1.4	1.4
Ethanol	4	1.4	1.4
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	9	1.4	1.4
Paclitaxel	49	1.4	1.4
Vortioxetine	8	1.3	1.3
Ledipasvir And Sofosbuvir	9	1.3	1.3
Levetiracetam Injection	36	1.3	1.3
Hydromorphone Hydrochloride	42	1.3	1.3
Lacosamide	17	1.3	1.3
Levetiracetam In Sodium Chloride	35	1.3	1.3
Levetiracetam Oral	35	1.3	1.3
Brivaracetam	4	1.2	1.2
Bendamustine Hydrochloride	5	1.2	1.2
Bortezomib	36	1.1	1.1
Bosentan	20	1.1	1.1
Iohexol	3	1.0	1.0
Nirmatrelvir And Ritonavir	18	0.9	0.9
Naltrexone	10	0.9	0.9
Cariprazine	3	0.9	0.9
Carfilzomib	9	0.9	0.9
Velpatasvir And Sofosbuvir	4	0.9	0.9
Dornase Alfa	6	0.8	0.8
Alcohol	11	0.8	0.8
Elexacaftor, Tezacaftor, And Ivacaftor	3	0.7	0.7
Olaparib	5	0.7	0.7
Osimertinib	7	0.6	0.6
Guselkumab	6	0.5	0.5

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.