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Which drugs are most reported with Hyperaesthesia?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 8,163 reports · 369 co-occurring drugs

As of the last recalculation, Hyperaesthesia appears in 8,163 FAERS reports alongside 369 co-occurring drug terms. The strongest observed disproportionality signal is BUPIVACAINE (PRR 21.8).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Bupivacaine	79	21.8	21.9
Ketoprofen	73	14.3	14.4
Ado-Trastuzumab Emtansine	44	13.4	13.4
Methadone	188	11.4	11.5
Morphine	320	11.3	11.4
Brinzolamide	35	10.3	10.4
Fentanyl	358	9.6	9.7
Standardized Senna Concentrate	45	9.2	9.2
Dimenhydrinate	37	8.9	8.9
Sunitinib Malate	133	8.8	8.8
Sevoflurane	27	8.3	8.3
Regorafenib	35	7.7	7.7
Mometasone	53	7.4	7.4
Fentanyl Citrate	50	7.2	7.2
Sorafenib	55	6.8	6.8
Midazolam Hydrochloride	66	6.3	6.3
Midazolam	57	5.8	5.8
Clonidine	115	5.8	5.8
Oxycodone	389	5.5	5.5
Tranexamic Acid	19	5.5	5.5
Capecitabine	192	5.5	5.5
Axitinib	41	5.4	5.4
Tretinoin	17	5.3	5.4
Tramadol Hydrochloride	76	5.2	5.2
Morphine Sulfate	231	5.0	5.0
Pertuzumab	51	4.8	4.8
Tapentadol Hydrochloride	59	4.5	4.5
Hydromorphone Hydrochloride	160	4.5	4.5
Pregabalin	459	4.5	4.5
Cyclobenzaprine	85	4.4	4.4
Buprenorphine	156	4.4	4.4
Cefuroxime	19	4.2	4.3
Alemtuzumab	32	4.2	4.2
Lapatinib	25	4.1	4.1
Lidocaine Hydrochloride	96	4.1	4.1
Trastuzumab	108	4.1	4.1
Lidocaine, Menthol	76	3.9	3.9
Amitriptyline Hydrochloride	27	3.9	3.9
Duloxetine Hydrochloride	279	3.9	3.9
Bicalutamide	23	3.9	3.9
Methylprednisolone Acetate	12	3.8	3.8
Vemurafenib	18	3.8	3.8
Baclofen	126	3.8	3.8
Lidocaine Hydrochloride And Epinephrine Bitartrate	78	3.8	3.8
Abiraterone	20	3.8	3.8
Lidicaine	71	3.7	3.7
Burn Relief	71	3.7	3.7
Lidocaine Hydrochloride And Epinephrine	71	3.7	3.7
Methocarbamol Tablets	24	3.7	3.7
Carisoprodol	27	3.6	3.6
Hyoscyamine Sulfate	13	3.6	3.6
Clindamycin	40	3.6	3.6
Hydrocodone Bitartrate And Acetaminophen	79	3.6	3.6
Heparin Sodium	19	3.5	3.5
Methylprednisolone Sodium Succinate	63	3.5	3.5
Human Immunoglobulin G	28	3.5	3.5
Duloxetine	94	3.5	3.5
Lidocaine 4%	73	3.4	3.4
Trazodone Hydrochloride	21	3.4	3.4
Oxycodone And Acetaminophen Tablets	16	3.4	3.4
Granisetron Hydrochloride	14	3.4	3.4
Zinc	33	3.4	3.4
Interferon Beta-1A	253	3.4	3.4
Colchicine	35	3.4	3.4
Zinc Chloride	33	3.4	3.4
Adrenalinum	55	3.4	3.4
Tocilizumab	149	3.4	3.4
Clindamycin Phosphate	44	3.4	3.4
Psyllium Husk	13	3.4	3.4
Desoximetasone	25	3.4	3.4
Methadone Hydrochloride	14	3.3	3.3
Methocarbamol	29	3.3	3.3
Gabapentin	449	3.3	3.3
Zinc Gluconate	33	3.2	3.2
Lidocaine	73	3.2	3.2
Oxycodone And Acetaminophen	29	3.2	3.2
Esomeprazole Magnesium Capsule, Delayed Release	18	3.2	3.2
Esomeprazole Magnesium Delayed Release Capsules	18	3.2	3.2
Granisetron	13	3.2	3.2
Esomeprazole Magnesium Dihydrate	18	3.2	3.2
Fondaparinux Sodium	10	3.2	3.2
Peginterferon Alfa-2A	66	3.1	3.1
Diazepam	146	3.1	3.1
Magnesium	99	3.1	3.1
Diclofenac	102	3.0	3.0
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	36	3.0	3.0
Trimethoprim	14	3.0	3.0
Rifampicin	12	3.0	3.0
Oxycodone Hydrochloride	251	3.0	3.0
Diazepam Oral Solution (Concentrate)	104	3.0	3.0
Diazepam Oral	104	3.0	3.0
Tizanidine Hydrochloride	21	3.0	3.0
Acetaminophen Tablet Extended Release	286	2.9	2.9
Pain Reliever	286	2.9	2.9
Acetaminophen 500Mg	286	2.9	2.9
Ciprofloxacin	103	2.9	2.9
Ciprofolxacin	80	2.9	2.9
Ciprofloxacin Tablets	80	2.9	2.9
Ciprofloxacin Hydrochloride	108	2.9	2.9
Ciprofloxacin Hydrochloride And Hydrocortisone	23	2.8	2.8
Sertraline	127	2.8	2.8
Naproxen	85	2.8	2.8
Vitamin E	34	2.8	2.8
Magnesium Sulfate	14	2.7	2.7
Infliximab-Dyyb	31	2.7	2.7
Epinephrine	68	2.7	2.7
Ibuprofen Capsule	204	2.6	2.7
Ibuprofen Tablet, Film Coated	204	2.6	2.7
Ibupfrofen	204	2.6	2.7
Ibuprofen Tablets Usp, 200Mg	204	2.6	2.7
Ibuprofen Oral	204	2.6	2.6
Ibuprofen Capsules 200 Mg	204	2.6	2.6
Ibuprofen 200 Mg	204	2.6	2.6
Ibuprofen 200Mg	204	2.6	2.6
Pazopanib Hydrochloride	28	2.6	2.6
Liothyronine Sodium	9	2.6	2.6
Calcium	151	2.6	2.6
Rocuronium Bromide	12	2.6	2.6
Magnesium Sulfate In Water For	13	2.6	2.6
Epoetin Alfa	12	2.6	2.6
Multivitamin	50	2.6	2.6
Sumatriptan	38	2.5	2.6
Doxyclycline Hyclate	17	2.5	2.6
Magnesium Sulfate Heptahydrate	13	2.5	2.5
Dronabinol	8	2.5	2.5
Letrozole	61	2.5	2.5
Peginterferon Beta-1A	13	2.5	2.5
Ezetimibe And Simvastatin	15	2.5	2.5
Dexlansoprazole	41	2.5	2.5
Acetaminophen And Codeine	12	2.5	2.5
Diphenhydramine Hydrochloride	161	2.5	2.5
Octreotide Acetate	30	2.5	2.5
Prochlorperazine Maleate	9	2.5	2.5
Iron	65	2.5	2.5
Cortisone Acetate	12	2.5	2.5
Ribavirin	62	2.5	2.5
Acetaminophen	415	2.4	2.4
Estradiol Gel 0.1%	43	2.4	2.4
Estradiol Transdermal	43	2.4	2.4
Clonazepam	151	2.4	2.4
Hydroxyzine	45	2.4	2.4
Diclofenac Sodium 1%	33	2.4	2.4
Diclofenac Sodium Topical	33	2.4	2.4
Diclofenac Sodium Topical Gel, 1%	33	2.4	2.4
Valproate Sodium	19	2.3	2.3
Ergocalciferol	345	2.3	2.3
Doxycycline	62	2.3	2.3
Celecoxib	119	2.3	2.3
Cholestyramine	11	2.3	2.3
Teriflunomide	41	2.3	2.3
Doxycycline Hyclate	61	2.3	2.3
Ibuprofen	241	2.3	2.3
Fish Oil	81	2.3	2.3
Folic Acid	221	2.3	2.3
Venlafaxine	64	2.3	2.3
Escitslopram	52	2.3	2.3
Latanoprost	45	2.3	2.3
Testosterone Cypionate	8	2.3	2.3
Mometasone Furoate	37	2.3	2.3
Doxepin	9	2.3	2.3
Botulinum Toxin Type A	11	2.3	2.3
Rizatriptan Benzoate	9	2.3	2.3
Ciclesonide	12	2.2	2.2
Escitalopram Oxalate	64	2.2	2.2
Docusate Sodium 100Mg	21	2.2	2.2
Diclofenac Sodium	131	2.2	2.2
Lorazepam	156	2.2	2.2
Letrozole Tablets	42	2.2	2.2
Trametinib	21	2.2	2.2
Modafinil	28	2.2	2.2
Niacin	10	2.2	2.2
Estradiol	74	2.2	2.2
Cannabidiol	20	2.2	2.2
Dabrafenib	18	2.2	2.2
Levothyroxine Sodium	264	2.2	2.2
Venlafaxine Hydrochloride	112	2.2	2.2
Lubiprostone	8	2.2	2.2
Alprazolam	172	2.2	2.2
Vitamin C	77	2.1	2.1
Exemestane	18	2.1	2.1
Iron Sucrose	8	2.1	2.1
Tizanidine	20	2.1	2.1
Dextrose	11	2.1	2.1
Crisaborole	8	2.1	2.1
Sertraline Hydrochloride	98	2.1	2.1
Sumatriptan Succinate	21	2.1	2.1
Erlotinib	8	2.1	2.1
Oxycodone Hydrochloride And Acetaminophen	81	2.1	2.1
Dextrose Monohydrate	11	2.1	2.1
Propofol	30	2.1	2.1
Abacavir Sulfate	8	2.1	2.1
Bupropion Hydrochloride	80	2.1	2.1
Loperamide Hydrochloride And Dimethicone	26	2.1	2.1
Lactulose	31	2.1	2.1
Diphenoxylate Hydrochloride And Atropine Sulfate	11	2.0	2.0
Lenvatinib	26	2.0	2.0
Hydroxychloroquine Sulfate	72	2.0	2.0
Carbamazepine	53	2.0	2.0
Gemfibrozil	12	2.0	2.0
Nitrofurantoin	13	2.0	2.0
Fulvestrant	26	2.0	2.0
Progesterone	18	2.0	2.0
Fremanezumab-Vfrm	9	2.0	2.0
Lisinopril And Hydrochlorothiazide	8	2.0	2.0
Nitrofurantoin (Monohydrate/Macrocrystals)	13	2.0	2.0
Minocycline	9	2.0	2.0
Natalizumab	139	2.0	2.0
Phenytoin	16	2.0	2.0
Panitumumab	12	2.0	2.0
Anastrozole	28	1.9	1.9
Paroxetine Hydrochloride	69	1.9	1.9
Ocrelizumab	47	1.9	1.9
Minoxidil	34	1.9	1.9
Dimethyl Fumarate	92	1.9	1.9
Trifluridine And Tipiracil	8	1.9	1.9
Diphenhydramine	47	1.9	1.9
Oxazepam	16	1.9	1.9
Fesoterodine Fumarate	8	1.9	1.9
Glatiramer Acetate	44	1.9	1.9
Sennosides	22	1.9	1.9
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	117	1.9	1.9
Mirtazapine	67	1.9	1.9
Nicotine Polacrilex Mini	11	1.9	1.9
Nicotine Polarilex	11	1.9	1.9
Brimonidine Tartrate	13	1.9	1.9
Escitalopram	101	1.8	1.8
Paroxetine Hydrochloride Hemihydrate	24	1.8	1.8
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	36	1.8	1.8
Naproxen Sodium	102	1.8	1.8
Ropinirole	11	1.8	1.8
Oxaliplatin	53	1.8	1.8
Oxcarbazepine	23	1.8	1.8
Paroxetine	24	1.8	1.8
Anastrozole Tablets	15	1.8	1.8
Methylphenidate Hydrochloride	41	1.8	1.8
Prasugrel Hydrochloride	7	1.8	1.8
Epoprostenol	9	1.8	1.8
Atenolol	91	1.7	1.7
Pitavastatin Calcium	7	1.7	1.7
Metoroprolol Tartrate	45	1.7	1.7
Palbociclib	65	1.7	1.7
Interferon Beta-1B	13	1.7	1.7
Terbinafine Hydrochloride	6	1.7	1.7
Loperamide Hydrochloride	30	1.7	1.7
Diroximel Fumarate	8	1.7	1.7
Bosutinib	6	1.7	1.7
Dolutegravir Sodium	6	1.7	1.7
Finasteride	40	1.7	1.7
Sofosbuvir	13	1.7	1.7
Thyroid, Porcine	7	1.7	1.7
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	23	1.7	1.7
Prochlorperazine	18	1.7	1.7
Erlotinib Hydrochloride	8	1.6	1.6
Lisinopril And Hydrochlorothiazide Tablets	5	1.6	1.6
Ibuprofen Tablets, Coated	27	1.6	1.6
Omalizumab	54	1.6	1.6
Ibuprofen Sodium	27	1.6	1.6
Oral Semaglutide	46	1.6	1.6
Rosuvastatin	127	1.6	1.6
Onabotulinumtoxina	48	1.6	1.6
Armodafinil	13	1.6	1.6
Fingolimod Hcl	53	1.6	1.6
Doxazosin Mesylate	22	1.6	1.6
Benzonatate	10	1.5	1.5
Sotalol Hydrochloride	10	1.5	1.5
Conjugated Estrogens	35	1.5	1.5
Estrogens, Conjugated	35	1.5	1.5
Pirfenidone	24	1.5	1.5
Eszopiclone	15	1.5	1.5
Amantadine	9	1.5	1.5
Denosumab	117	1.5	1.5
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	24	1.5	1.5
Loratadine Tablet	31	1.5	1.5
Oxybutynin	16	1.4	1.4
Lisdexamfetamine Dimesylate	18	1.4	1.4
Ofatumumab	18	1.4	1.4
Buprenorphine Hydrochloride, Naloxone Hydrochloride	13	1.4	1.4
Ribociclib	17	1.4	1.4
Ritonavir 100 Mg	8	1.4	1.4
Docetaxel Anhydrous	36	1.4	1.4
Docetaxel	36	1.4	1.4
Carboxymethylcellulose Sodium	5	1.4	1.4
Dexamethasone 1.5 Mg	155	1.4	1.4
Dexamethasone	155	1.3	1.3
Desvenlafaxine Succinate	14	1.3	1.3
Leuprolide Acetate	40	1.3	1.3
Oxymorphone Hydrochloride	6	1.3	1.3
Abiraterone Acetate	21	1.3	1.3
Imatinib Mesylate	14	1.3	1.3
Paclitaxel (Aibumin-Bound)	41	1.3	1.3
Asfotase Alfa	5	1.3	1.3
Niraparib	11	1.3	1.3
Avapritinib	6	1.3	1.3
Adalimumab	347	1.3	1.3
Oseltamivir Phosphate	12	1.3	1.3
Teriparatide	54	1.2	1.2
Cabozantinib	23	1.2	1.2
Belimumab	15	1.2	1.2
Etanercept	282	1.2	1.2
Acetaminophen, Aspirin (Nsaid) And Caffeine	8	1.2	1.2
Linezolid	14	1.2	1.2
Nicotine	19	1.2	1.2
Tadalafil	46	1.2	1.2
Rucaparib	4	1.2	1.2
Vismodegib	4	1.1	1.1
Isopropyl Alcohol	15	1.1	1.1
Golimumab	38	1.1	1.1
Secukinumab	71	1.1	1.1
Certolizumab Pegol	51	1.1	1.1
Cariprazine	4	1.1	1.1
Acetaminophen, Aspirin, And Caffeine	9	1.1	1.1
Paclitaxel	41	1.1	1.1
Gemcitabine	16	1.0	1.0
Liraglutide	20	1.0	1.0
Emtricitabine And Tenofovir Disoproxil Fumarate	18	1.0	1.0
Esketamine Hydrochloride	7	1.0	1.0
Dronedarone	4	1.0	1.0
Hydrocodone Bitartrate	17	1.0	1.0
Naltrexone	12	1.0	1.0
Conjugated Estrogens And Medroxyprogesterone Acetate	9	1.0	1.0
Ustekinumab	39	1.0	1.0
Methylphenidate	11	1.0	1.0
Tirzepatide	61	1.0	1.0
Loratadine And Pseudoephedrine Sulfate	3	1.0	1.0
Cabotegravir	3	0.9	0.9
Canakinumab	4	0.9	0.9
Ledipasvir And Sofosbuvir	7	0.9	0.9
Varenicline Tartrate	29	0.9	0.9
Alirocumab	9	0.9	0.9
Gemcitabine Hydrochloride	19	0.9	0.9
Glycerin, Lidocaine	5	0.9	0.9
Pegfilgrastim	35	0.9	0.9
Dalfampridine	25	0.9	0.9
Docosanol	5	0.9	0.9
Enzalutamide	20	0.9	0.9
Tafamidis	4	0.9	0.9
Drospirenone And Ethinyl Estradiol	15	0.9	0.9
Siponimod	3	0.9	0.9
Brivaracetam	3	0.9	0.9
Nirmatrelvir And Ritonavir	18	0.8	0.8
Ethyl Alcohol	9	0.8	0.8
Eptinezumab-Jjmr	3	0.8	0.8
Osimertinib	10	0.8	0.8
Daratumumab	12	0.8	0.8
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Alafenamide	3	0.8	0.8
Paricalcitol	4	0.7	0.7
Glecaprevir And Pibrentasvir	3	0.7	0.7
Etonogestrel	13	0.7	0.7
Medroxyprogesterone Acetate	13	0.7	0.7
Abemaciclib	5	0.6	0.6
Elexacaftor, Tezacaftor, And Ivacaftor	3	0.6	0.6
Rimegepant Sulfate	3	0.6	0.6
Erenumab-Aooe	13	0.6	0.6
Velpatasvir And Sofosbuvir	3	0.6	0.6
Romosozumab-Aqqg	3	0.6	0.6
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	4	0.6	0.6
Paliperidone Palmitate	7	0.6	0.6
Abaloparatide	6	0.5	0.5
Palivizumab	3	0.5	0.5
Galcanezumab-Gnlm	6	0.5	0.5
Lifitegrast	3	0.5	0.5
Evolocumab	29	0.5	0.5
Apremilast	25	0.4	0.4
Relugolix	4	0.4	0.4
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	5	0.4	0.4
Minoxidil Foam 5% (Womens)	5	0.4	0.4
Levonorgestrel	27	0.3	0.3
Dupilumab	62	0.3	0.3
Copper	5	0.3	0.3

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.