Reaction

Post-Traumatic Stress Disorder reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 6,628 reports · 395 co-occurring drugs

As of the last recalculation, Post-Traumatic Stress Disorder appears in 6,628 FAERS reports alongside 395 co-occurring drug terms. The strongest observed disproportionality signal is HYDROCODONE BITARTRATE AND ACETAMINOPHEN (PRR 31.2).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Hydrocodone Bitartrate And Acetaminophen	517	31.2	31.4
Oxycodone And Acetaminophen Tablets	80	21.3	21.5
Calcium, Magnesium, Potassium, And Sodium Oxybates	54	19.8	20.0
Oxycodone And Acetaminophen	143	19.7	19.8
Diphenhydramine Hydrochloride Capsule, Liquid Filled	108	16.1	16.2
Tramadol Hydrochloride	184	15.8	15.8
Buspirone Hydrochloride	51	14.6	14.7
Sodium Oxybate	292	14.5	14.6
Buprenorphine Hydrochloride, Naloxone Hydrochloride	107	14.1	14.2
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	155	14.1	14.1
Hydromorphone Hydrochloride	384	13.9	13.9
Cetirizine Hydrochloride Allergy	126	13.3	13.4
Cetirizine Hydrochloride Tablets	126	13.3	13.3
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	171	13.3	13.3
Dimenhydrinate	42	12.4	12.5
Oxycodone Hydrochloride	733	11.8	11.8
Carisoprodol	70	11.6	11.7
Acetaminophen And Codeine	43	11.1	11.2
Esomeprazole Magnesium Capsule, Delayed Release	50	10.9	10.9
Esomeprazole Magnesium Delayed Release Capsules	50	10.9	10.9
Esomeprazole Magnesium Dihydrate	50	10.8	10.9
Morphine Sulfate	366	10.0	10.0
Armodafinil	66	9.9	9.9
Methylprednisolone Acetate	25	9.8	9.9
Modafinil	98	9.7	9.7
Vilazodone Hydrochloride	28	9.6	9.6
Oxycodone Hydrochloride And Acetaminophen	287	9.5	9.5
Desvenlafaxine Succinate	80	9.4	9.4
Lurasidone Hydrochloride	62	9.4	9.4
Copper	125	9.3	9.3
Etonogestrel And Ethinyl Estradiol	63	9.0	9.0
Butalbital, Acetaminophen, And Caffeine	30	8.9	8.9
Ziprasidone Mesylate	40	8.9	8.9
Vitamin E	87	8.8	8.8
Tizanidine Hydrochloride	50	8.7	8.8
Clonazepam	421	8.7	8.8
Oxymorphone Hydrochloride	31	8.4	8.4
Hyoscyamine Sulfate	24	8.2	8.3
Methadone	110	8.2	8.2
Esketamine Hydrochloride	46	8.2	8.2
Sumatriptan Succinate	64	8.0	8.0
Ziprasidone	43	7.7	7.7
Duloxetine	166	7.6	7.7
Mometasone	44	7.6	7.6
Lithium	59	7.4	7.4
Lithium Bromatum	59	7.4	7.4
Methadone Hydrochloride	25	7.3	7.3
Methocarbamol	51	7.1	7.1
Sertraline Hydrochloride	259	7.1	7.1
Testosterone Cypionate	20	7.0	7.1
Cetirizine	169	7.0	7.0
Bupropion Hydrochloride	213	7.0	7.0
Ciclesonide	30	6.9	7.0
Lisdexamfetamine Dimesylate	72	6.9	6.9
Duloxetine Hydrochloride	392	6.9	6.9
Senna Leaf	50	6.9	6.9
Cariprazine	20	6.8	6.8
Quetiapine	392	6.7	6.7
Divalproex Sodium	97	6.6	6.6
Cyclobenzaprine	103	6.6	6.6
Rizatriptan Benzoate	21	6.5	6.5
Diazepam	244	6.5	6.5
Topiramate	184	6.3	6.4
Doxepin Hydrochloride	25	6.2	6.2
Varenicline Tartrate	155	6.2	6.2
Olanzapine Pamoate	80	6.2	6.2
Fentanyl Citrate	35	6.2	6.2
Meperidine Hydrochloride	18	6.1	6.2
Meclizine Hcl 12.5Mg	26	6.0	6.0
Meclizine Hcl 25Mg	26	6.0	6.0
Meclizine Hcl 12.5 Mg	26	6.0	6.0
Meclizine Hcl 25 Mg	26	6.0	6.0
Aripiprazole	227	6.0	6.0
Dicyclomine Hydrochloride	27	6.0	6.0
Thyroid, Porcine	20	5.9	5.9
Doxepin	19	5.9	5.9
Sennosides 8.6 Mg Tablets	39	5.9	5.9
Senna	39	5.8	5.8
Venlafaxine Hydrochloride	236	5.8	5.8
Amitriptyline Hydrochloride	32	5.8	5.8
Alprazolam	359	5.7	5.7
Methylphenidate Hydrochloride	106	5.7	5.7
Methocarbamol Tablets	30	5.6	5.7
Buprenorphine	160	5.5	5.5
Hydroxyzine	83	5.5	5.5
Sumatriptan	66	5.5	5.5
Nicotine Polacrilex Mini	26	5.5	5.5
Nicotine Polarilex	26	5.5	5.5
Trazodone Hydrochloride	27	5.4	5.4
Naproxen	133	5.4	5.4
Meclizine	28	5.4	5.4
Ibuprofen And Diphenhydramine Citrate	39	5.3	5.3
Hydroxyzine Hydrochloride	22	5.3	5.3
Hydroxyzine Hydrochloride Oral	22	5.3	5.3
Cimetidine	16	5.2	5.2
Guanfacine	13	5.2	5.2
Lithium Carbonate	28	5.2	5.2
Meclizine Hydrochloride	32	5.2	5.2
Aripiprazole Oral	67	5.1	5.1
Aripiprazole Orally Disintegrating	67	5.1	5.1
Oxycodone	294	5.1	5.1
Drospirenone And Ethinyl Estradiol	71	5.1	5.1
Escitalopram	221	5.1	5.1
Paroxetine Hydrochloride	143	5.0	5.0
Sennosides	47	5.0	5.0
Temazepam	59	4.9	5.0
Mometasone Furoate	65	4.9	4.9
Tizanidine	37	4.9	4.9
Fluoxetine Hydrochloride	192	4.8	4.8
Cetirizine Hydrochloride	246	4.8	4.8
Diazepam Oral Solution (Concentrate)	134	4.8	4.8
Diazepam Oral	134	4.8	4.8
Diphenhydramine Hydrochloride	245	4.8	4.8
Mirtazapine	136	4.7	4.7
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Alafenamide	15	4.7	4.7
Oxcarbazepine	48	4.7	4.7
Cetiirizine	62	4.6	4.6
Citalopram	196	4.6	4.6
Hydrocodone Bitartrate	63	4.6	4.6
Promethazine Hydrochloride	27	4.6	4.6
Brexpiprazole	24	4.6	4.6
Cyclobenzaprine Hydrochloride	13	4.5	4.6
Elexacaftor, Tezacaftor, And Ivacaftor	18	4.5	4.5
Dolutegravir Sodium	13	4.5	4.5
Cetirizine Hcl	13	4.5	4.5
Sertraline	163	4.4	4.5
Emtricitabine And Tenofovir Alafenamide	16	4.4	4.4
Montelukast Sodium	167	4.4	4.4
Lorazepam	242	4.3	4.4
Liothyronine Sodium	12	4.3	4.3
Esomeprazole	84	4.3	4.3
Ethyl Alcohol	37	4.3	4.3
Zolpidem Tartrate	180	4.3	4.3
Atenolol	177	4.3	4.3
Epinephrine	87	4.2	4.2
Ursosiol	26	4.2	4.2
Eszopiclone	34	4.2	4.2
Fentanyl	130	4.2	4.2
Methylprednisolone	181	4.2	4.2
Propranolol Hydrochloride	95	4.2	4.2
Albuterol	154	4.1	4.1
Loratadine Tablet	68	4.0	4.0
Magnesium Hydroxide	17	4.0	4.0
Clonidine	64	4.0	4.0
Gemfibrozil	19	3.9	3.9
Pramipexole	19	3.9	3.9
Baclofen	105	3.9	3.9
Meloxicam	71	3.9	3.9
Lamotrigine	159	3.9	3.9
Progesterone	28	3.9	3.9
Olanzapine	130	3.9	3.9
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Disoproxil Fumarate	11	3.8	3.8
Cyanocobalamin	40	3.8	3.8
Paroxetine Hydrochloride Hemihydrate	40	3.8	3.8
Cephalexin	26	3.8	3.8
Lansoprazole	209	3.8	3.8
Tapentadol Hydrochloride	40	3.8	3.8
Ursodiol	26	3.8	3.8
Escitalopram Oxalate	86	3.7	3.7
Quetiapine Fumarate	35	3.7	3.7
Paroxetine	40	3.7	3.7
Methylphenidate	34	3.7	3.7
Escitslopram	68	3.7	3.7
Acetylcysteine	11	3.7	3.7
Loratadine Oral	57	3.7	3.7
Asenapine Maleate	10	3.6	3.6
Naproxen Sodium	162	3.6	3.6
Citalopram Hydrobromide	122	3.6	3.6
Melatonin	62	3.6	3.6
Loratadine	121	3.6	3.6
Misoprostol	11	3.6	3.6
Isopropyl Alcohol	38	3.5	3.5
Human Insulin	14	3.5	3.5
Azithromycin Dihydrate	65	3.5	3.5
Mupirocin	15	3.5	3.5
Gabapentin	383	3.4	3.4
Mupirocin Calcium	15	3.4	3.4
Benzonatate	18	3.4	3.4
Extended Phenytoin Sodium	18	3.4	3.4
Venlafaxine	76	3.4	3.4
Diphenhydramine	67	3.4	3.4
Pregabalin	281	3.3	3.3
Acetaminophen, Aspirin (Nsaid) And Caffeine	18	3.3	3.3
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	32	3.3	3.3
Fluticasone Propionate Nasal	32	3.3	3.3
Sucralfate Oral	15	3.3	3.3
Sucralfate Oral Suspension	15	3.3	3.3
Famotidine	122	3.3	3.3
Ciprofloxacin	95	3.3	3.3
Estradiol Gel 0.1%	47	3.3	3.3
Estradiol Transdermal	47	3.3	3.3
Amoxicillin	79	3.3	3.3
Ciprofolxacin	74	3.3	3.3
Ciprofloxacin Tablets	74	3.3	3.3
Niacin	12	3.2	3.3
Ciprofloxacin Hydrochloride	99	3.2	3.2
Clindamycin	29	3.2	3.2
Clindamycin Phosphate	34	3.2	3.2
Azithromycin Monohydrate	42	3.2	3.2
Lamotirigine	72	3.2	3.2
Lamotrigine Extended-Release	72	3.2	3.2
Lamotrigine Chewable Dispersible	72	3.2	3.2
Ciprofloxacin Hydrochloride And Hydrocortisone	21	3.2	3.2
Azithromycin	40	3.1	3.1
Dronabinol	8	3.1	3.1
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	18	3.1	3.1
Darunavir	15	3.1	3.1
Esomeprazole Magnesium	227	3.1	3.1
Guaifenesin	30	3.1	3.1
Tretinoin	8	3.1	3.1
Chlorhexidine Gluconate	9	3.1	3.1
Albuterol Sulfate	284	3.1	3.1
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	49	3.1	3.1
Alcohol	38	3.1	3.1
Ibuprofen Capsule	192	3.1	3.1
Ibuprofen Tablet, Film Coated	192	3.1	3.1
Ibupfrofen	192	3.1	3.1
Ibuprofen Tablets Usp, 200Mg	192	3.1	3.1
Ibuprofen Oral	192	3.1	3.1
Ibuprofen Capsules 200 Mg	192	3.1	3.1
Ibuprofen 200 Mg	192	3.1	3.1
Ibuprofen 200Mg	192	3.1	3.1
Naltrexone	30	3.1	3.1
Nicotine	39	3.0	3.0
Amphetamine	8	3.0	3.0
Ibuprofen	256	3.0	3.0
Lidicaine	47	3.0	3.0
Burn Relief	47	3.0	3.0
Lidocaine Hydrochloride And Epinephrine	47	3.0	3.0
Sucralfate	23	3.0	3.0
Fluticasone Propionate And Salmeterol Xinafoate	57	3.0	3.0
Lidocaine, Menthol	47	3.0	3.0
Bupropion	42	3.0	3.0
Ibuprofen Tablets, Coated	40	3.0	3.0
Testosterone	22	3.0	3.0
Ibuprofen Sodium	40	2.9	2.9
Montelukast	78	2.9	2.9
Risperidone	123	2.9	2.9
Trimethoprim	11	2.9	2.9
Diroximel Fumarate	11	2.9	2.9
Docusate Sodium 100Mg	22	2.9	2.9
Fluticasone Propionate	118	2.9	2.9
Conjugated Estrogens	53	2.9	2.9
Psyllium Husk	9	2.9	2.9
Fluticasone Furoate	11	2.9	2.9
Indomethacin	12	2.8	2.8
Acetaminophen Tablet Extended Release	226	2.8	2.8
Pain Reliever	226	2.8	2.8
Acetaminophen 500Mg	226	2.8	2.8
Morphine	67	2.8	2.8
Lidocaine Hydrochloride And Epinephrine Bitartrate	48	2.8	2.8
Acetaminophen, Aspirin, And Caffeine	19	2.8	2.8
Labetalol	12	2.8	2.8
Haloperidol Lactate	22	2.8	2.8
Brivaracetam	8	2.8	2.8
Naproxen Sodium Tablet, Coated	12	2.8	2.8
Naproxen Sodium, Coated Tablets	12	2.8	2.8
Naproxen Sodium 220Mg	12	2.8	2.8
Atomoxetine Hydrochloride	21	2.8	2.8
Vortioxetine	15	2.8	2.8
Ketoconazole Foam	13	2.8	2.8
Estrogens, Conjugated	52	2.8	2.8
Ketoconazole Cream, 2%	13	2.8	2.8
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	18	2.8	2.8
Naproxen Sodium, Pseudoephedrine Hydrochloride	18	2.8	2.8
Ketoconazole	15	2.7	2.7
Lidocaine 4%	47	2.7	2.7
Haloperidol	21	2.7	2.7
Fluoxetine	57	2.7	2.7
Minocycline	10	2.7	2.7
Emtricitabine And Tenofovir Disoproxil Fumarate	39	2.7	2.7
Lidocaine Hydrochloride	51	2.7	2.7
Amoxicillin And Clavulanate Potassium	23	2.7	2.7
Acetaminophen	366	2.7	2.7
Azelastine	15	2.6	2.6
Estradiol	71	2.6	2.6
Lidocaine	48	2.6	2.6
Linaclotide	22	2.6	2.6
Doxyclycline Hyclate	14	2.6	2.6
Dexlansoprazole	34	2.6	2.6
Erythromycin	15	2.5	2.5
Oxazepam	17	2.5	2.5
Fish Oil	71	2.5	2.5
Nitrofurantoin	13	2.5	2.5
Ropinirole	12	2.5	2.5
Nitrofurantoin (Monohydrate/Macrocrystals)	13	2.4	2.4
Losartan Potassium And Hydrochlorothiazide	9	2.4	2.4
Docetaxel Anhydrous	51	2.4	2.4
Docetaxel	51	2.4	2.4
Nicotine Polacrilex	29	2.4	2.4
Vitamin C	69	2.4	2.4
Doxycycline	51	2.4	2.4
Ondansetron Hydrochloride	90	2.3	2.3
Biotin	23	2.3	2.3
Doxycycline Hyclate	49	2.3	2.3
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	115	2.3	2.3
Glipizide	44	2.3	2.3
Propofol	26	2.2	2.2
Timolol Maleate	7	2.2	2.2
Atazanavir	10	2.2	2.2
Ocrelizumab	43	2.2	2.2
Ondansetron	75	2.2	2.2
Ondansetron Tablets	75	2.2	2.2
Isotretinoin	34	2.2	2.2
Oxybutynin Chloride	6	2.2	2.2
Clobetasol Propionate Ointment Usp, 0.05%	7	2.1	2.1
Clobetasol Propionate	7	2.1	2.1
Adrenalinum	28	2.1	2.1
Tobramycin Solution	8	2.1	2.1
Lopinavir And Ritonavir	9	2.1	2.1
Metoclopramide Hydrochloride	51	2.1	2.1
Ritonavir	19	2.0	2.0
Tobramycin Sulfate	8	2.0	2.0
Lisinopril	194	2.0	2.0
Oral Semaglutide	47	2.0	2.0
Omeprazole Magnesium	281	2.0	2.0
Fluticasone Furoate And Vilanterol Trifenatate	23	2.0	2.0
Pseudoephedrine Hcl	7	2.0	2.0
Midazolam	16	2.0	2.0
Finasteride	38	2.0	2.0
Iron Sucrose	6	2.0	2.0
Loratadine And Pseudoephedrine Sulfate	5	2.0	2.0
Loperamide Hcl	8	2.0	2.0
Multivitamin	31	1.9	1.9
Diclofenac Sodium 1%	22	1.9	1.9
Diclofenac Sodium Topical	22	1.9	1.9
Diclofenac Sodium Topical Gel, 1%	22	1.9	1.9
Raltegravir	10	1.9	1.9
Tenofovir Disoproxil Fumarate	20	1.9	1.9
Fexofenadine	10	1.9	1.9
Mepolizumab	30	1.9	1.9
Metoclopramide	33	1.9	1.9
Asfotase Alfa	6	1.9	1.9
Paliperidone Palmitate	19	1.9	1.9
Loperamide Hydrochloride Oral	6	1.8	1.8
Tiotropium Bromide	80	1.8	1.8
Budesonide And Formoterol Fumarate Dihydrate	56	1.8	1.8
Ticagrelor	18	1.8	1.8
Paliperidone	13	1.8	1.8
Sildenafil Citrate	70	1.7	1.7
Galcanezumab-Gnlm	17	1.7	1.7
Suvorexant	7	1.7	1.7
Tiotropium Bromide Inhalation Spray	6	1.7	1.7
Insulin Aspart	35	1.7	1.7
Fluticasone Propionate And Salmeterol	22	1.7	1.7
Fremanezumab-Vfrm	6	1.6	1.6
Teduglutide	7	1.6	1.6
Mirabegron	20	1.6	1.6
Pegvaliase-Pqpz	4	1.5	1.5
Medroxyprogesterone Acetate	24	1.5	1.5
Fexofenadine Hydrochloride	10	1.4	1.4
Omalizumab	39	1.4	1.4
Miconazole Nitrate	4	1.4	1.4
Natalizumab	82	1.4	1.4
Ofatumumab	15	1.4	1.4
Clobazam	11	1.4	1.4
Mometasone Furoate And Formoterol Fumarate Dihydrate	7	1.4	1.4
Eptinezumab-Jjmr	4	1.4	1.4
Interferon Beta-1A	84	1.4	1.4
Onabotulinumtoxina	33	1.3	1.3
Cannabidiol	10	1.3	1.3
Teriflunomide	19	1.3	1.3
Tobramycin	10	1.3	1.3
Insulin Lispro	57	1.3	1.3
Avapritinib	5	1.3	1.3
Belimumab	13	1.3	1.3
Dulaglutide	36	1.3	1.3
Lacosamide	15	1.3	1.3
Benralizumab	8	1.3	1.3
Rimegepant Sulfate	5	1.2	1.2
Inclisiran	3	1.2	1.2
Ravulizumab	5	1.2	1.2
Liraglutide	18	1.1	1.1
Dimethyl Fumarate	44	1.1	1.1
Erenumab-Aooe	19	1.1	1.1
Risankizumab-Rzaa	28	1.1	1.1
Conjugated Estrogens And Medroxyprogesterone Acetate	8	1.1	1.1
Etonogestrel	16	1.1	1.1
Glatiramer Acetate	20	1.1	1.1
Peginterferon Alfa-2A	18	1.0	1.0
Dalfampridine	23	1.0	1.0
Clozapine	40	1.0	1.0
Lifitegrast	5	1.0	1.0
Ranitidine	60	0.9	0.9
Sacubitril And Valsartan	34	0.9	0.9
Pseudoephedrine Hydrochloride	3	0.9	0.9
Dornase Alfa	5	0.8	0.8
Levonorgestrel	50	0.8	0.8
Valbenazine	6	0.7	0.7
Pimavanserin Tartrate	12	0.7	0.7
Nirmatrelvir And Ritonavir	10	0.6	0.6
Tirzepatide	28	0.5	0.5
Apremilast	21	0.4	0.4
Salicylic Acid	3	0.2	0.2
Adapalene	4	0.1	0.1

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.