Reaction

Which drugs are most reported with Aphthous ulcer?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 7,573 reports · 410 co-occurring drugs

As of the last recalculation, Aphthous Ulcer appears in 7,573 FAERS reports alongside 410 co-occurring drug terms. The strongest observed disproportionality signal is INFLIXIMAB-DYYB (PRR 78.5).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Infliximab-Dyyb	753	78.5	80.6
Everolimus	294	16.5	16.6
Dimenhydrinate	56	14.5	14.6
Everolimus Tablets	79	13.1	13.1
Infliximab	770	10.7	10.7
Hydrocortisone Sodium Succinate	36	10.6	10.6
Azathioprine	318	10.3	10.3
Diphenhydramine Hydrochloride Capsule, Liquid Filled	78	10.1	10.2
Exemestane	74	9.6	9.6
Diphenhydramine	206	9.2	9.2
Alpelisib	29	9.2	9.2
Mesalamine	181	9.1	9.1
Ribociclib	101	8.9	8.9
Anti-Itch	210	8.8	8.9
Anti-Pruritic	210	8.8	8.9
Antipruritic (Anti-Itch)	210	8.8	8.9
Cool Relief Gel With Aloe	210	8.8	8.9
Drs. Hydrocortisone	210	8.8	8.9
Hydrocortisone Continuous Spray	210	8.8	8.9
Hydrocortisone Spray	210	8.8	8.9
Anti-Itch Cream	210	8.8	8.9
Hydrocortisone Lotion	210	8.8	8.8
Hydrocortisone Cream 1%	210	8.8	8.8
Hydrocortisone Cream 1/2%	210	8.8	8.8
Hydrocortisone 1%	210	8.8	8.8
Hydrocortisone Cream	210	8.8	8.8
Hydrocortisone	269	8.6	8.6
Hydrocortisone Acetate	214	8.3	8.3
Sirolimus	39	8.0	8.0
Panitumumab	44	7.8	7.8
Mometasone	51	7.7	7.7
Adalimumab-Adaz	145	7.7	7.7
Cholestyramine	32	7.3	7.3
Dicyclomine Hydrochloride	37	7.2	7.2
Pantoprazole Sodium In 0.9% Sodium Chloride	156	7.0	7.1
Pantoprazole Sodium Injection	156	7.0	7.1
Adalimumab-Fkjp	116	7.0	7.0
Fulvestrant	78	6.5	6.6
Vedolizumab	194	6.3	6.3
Rabeprazole	50	6.2	6.2
Diphenhydramine Hydrochloride	360	6.2	6.2
Sarilumab	59	6.2	6.2
Adalimumab-Aaty	104	6.1	6.1
Instalax Polyethylene Glycol 3350	27	6.0	6.0
Colchicine	56	5.9	5.9
Polyethylene Glycol 400	27	5.9	5.9
Dronabinol	17	5.8	5.8
Nystatin Ointment	55	5.8	5.8
Nystatin Cream	55	5.8	5.8
Nystatin	56	5.7	5.7
Budesonide	118	5.6	5.6
Ado-Trastuzumab Emtansine	17	5.6	5.6
Letrozole	121	5.5	5.5
Prednisone	902	5.5	5.5
Sucralfate Oral	28	5.4	5.4
Letrozole Tablets	94	5.4	5.4
Methotrexate Sodium	868	5.4	5.4
Sucralfate Oral Suspension	28	5.4	5.4
Fosaprepitant Dimeglumine	27	5.4	5.4
Tocilizumab	212	5.2	5.2
Metronidazole Topical	89	5.2	5.2
Daspone	18	5.1	5.1
Dapsone Gel, 5%	18	5.1	5.1
Brinzolamide	16	5.1	5.1
Desoximetasone	35	5.1	5.1
Cefuroxime	21	5.1	5.1
Metronidazole	116	5.1	5.1
Methotrexate	714	5.0	5.1
Ciprofloxacin Hydrochloride And Hydrocortisone	38	5.0	5.0
Cyanocobalamin	60	5.0	5.0
Anastrozole Tablets	38	4.9	4.9
Loperamide Hydrochloride Oral	18	4.9	4.9
Valganciclovir Hydrochloride Powder,	21	4.7	4.7
Ciprofloxacin Hydrochloride	164	4.7	4.7
Methylprednisolone Sodium Succinate	78	4.7	4.7
Dapsone	18	4.6	4.6
Methylprednisolone	227	4.6	4.6
Calcium	243	4.6	4.6
Psyllium Husk	16	4.5	4.5
Ciprofloxacin	146	4.4	4.4
Pantoprazole	392	4.4	4.4
Palbociclib	151	4.4	4.4
Ciprofolxacin	113	4.4	4.4
Ciprofloxacin Tablets	113	4.4	4.4
Standardized Senna Concentrate	20	4.4	4.4
Sunitinib Malate	62	4.4	4.4
Acetaminophen Tablet Extended Release	387	4.3	4.3
Pain Reliever	387	4.3	4.3
Acetaminophen 500Mg	387	4.3	4.3
Aprepitant	29	4.3	4.3
Risedronate Sodium	48	4.3	4.3
Valganciclovir	29	4.2	4.2
Valganciclovir Hydrochloride	29	4.2	4.2
Iron	102	4.2	4.2
Meperidine Hydrochloride	14	4.2	4.2
Folic Acid	364	4.2	4.2
Leflunomide	155	4.1	4.1
Secukinumab	237	4.1	4.1
Ursosiol	29	4.1	4.1
Baricitinib	14	4.0	4.0
Esomeprazole Magnesium Capsule, Delayed Release	21	4.0	4.0
Esomeprazole Magnesium Delayed Release Capsules	21	4.0	4.0
Esomeprazole Magnesium Dihydrate	21	4.0	4.0
Polatuzumab Vedotin	14	3.9	4.0
Phytonadione	12	3.9	3.9
Cannabidiol	33	3.9	3.9
Cabozantinib	67	3.9	3.9
Loperamide Hcl	18	3.9	3.9
Desloratadine	15	3.8	3.9
Fam-Trastuzumab Deruxtecan-Nxki	14	3.8	3.8
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	217	3.8	3.8
Sucralfate	33	3.8	3.8
Ketoprofen	18	3.8	3.8
Valacyclovir	57	3.8	3.8
Ursodiol	29	3.7	3.7
Fenofibrate	47	3.7	3.7
Mercaptopurine	23	3.7	3.7
Venlafaxine	93	3.6	3.6
Midazolam Hydrochloride	35	3.6	3.6
Drs. Clotrimazole	15	3.6	3.6
Family Wellness Clotrimazole	15	3.6	3.6
Clotrimazole Topical	15	3.6	3.6
Valacyclovir Hydrochloride	90	3.5	3.5
Acetaminophen	540	3.5	3.5
Pertuzumab	34	3.4	3.5
Mycophenolate Mofetil Hydrochloride	168	3.4	3.5
Trametinib	30	3.4	3.4
Candesartan	44	3.4	3.4
Sulfasalazine	95	3.4	3.4
Clotrimazole	15	3.4	3.4
Niraparib	27	3.4	3.4
Amoxicillin And Clavulanate Potassium	33	3.3	3.4
Esomeprazole	75	3.3	3.3
Abatacept	166	3.3	3.3
Lisdexamfetamine Dimesylate	40	3.3	3.3
Chlorhexidine Gluconate	11	3.3	3.3
Canakinumab	13	3.3	3.3
Mycophenolate Mofetil	160	3.3	3.3
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	36	3.3	3.3
Loperamide Hydrochloride	53	3.3	3.3
Pemetrexed Disodium	45	3.3	3.3
Rizatriptan Benzoate	12	3.2	3.2
Rifampin	17	3.2	3.2
Lapatinib	18	3.2	3.2
Pantoprazole Sodium	169	3.2	3.2
Midazolam	29	3.2	3.2
Filgrastim	43	3.2	3.2
Zinc	28	3.1	3.1
Zinc Chloride	28	3.1	3.1
Terbinafine Hydrochloride	10	3.1	3.1
Upadacitinib	91	3.1	3.1
Meloxicam	65	3.1	3.1
Anastrozole	41	3.1	3.1
Magnesium	91	3.1	3.1
Zinc Gluconate	29	3.1	3.1
Basiliximab	13	3.0	3.0
Hydroxyurea	23	3.0	3.0
Trazodone Hydrochloride	17	3.0	3.0
Vitamin C	99	3.0	3.0
Ocrelizumab	67	3.0	3.0
Vemurafenib	13	3.0	3.0
Bimekizumab	23	3.0	3.0
Triamcinolone Acetonide Ointment Usp, 0.05%	25	2.9	2.9
Rosuvastatin Calcium	30	2.9	2.9
Telmisartan	19	2.9	2.9
Loperamide Hydrochloride And Dimethicone	34	2.9	2.9
Ixekizumab	39	2.9	2.9
Prednisolone	187	2.9	2.9
Prednisolone Oral	187	2.9	2.9
Prednisolone Oral Solution	187	2.9	2.9
Quinine	9	2.9	2.9
Dabrafenib	22	2.9	2.9
Rituximab	217	2.9	2.9
Duloxetine	72	2.9	2.9
Valsartan Oral	56	2.8	2.8
Hydroxychloroquine	76	2.8	2.8
Azithromycin	41	2.8	2.8
Irbesartan	45	2.8	2.8
Methylprednisolone Acetate	8	2.7	2.7
Celecoxib	130	2.7	2.7
Leucovorin Calcium	19	2.7	2.7
Atovaquone	8	2.7	2.7
Cetirizine Hydrochloride Allergy	30	2.7	2.7
Cetirizine Hydrochloride Tablets	30	2.7	2.7
Rasagiline Mesylate	11	2.7	2.7
Azithromycin Monohydrate	41	2.7	2.7
Alemtuzumab	19	2.7	2.7
Octreotide Acetate	30	2.7	2.7
Obinutuzumab	16	2.7	2.7
Memantine	13	2.6	2.6
Memantine Hydrochloride	13	2.6	2.6
Regorafenib	11	2.6	2.6
Ibrutinib	76	2.6	2.6
Lidicaine	46	2.6	2.6
Burn Relief	46	2.6	2.6
Lidocaine Hydrochloride And Epinephrine	46	2.6	2.6
Trastuzumab	64	2.6	2.6
Lidocaine, Menthol	46	2.6	2.6
Venlafaxine Hydrochloride	121	2.5	2.5
Lidocaine Hydrochloride And Epinephrine Bitartrate	49	2.5	2.5
Clindamycin	26	2.5	2.5
Lidocaine Hydrochloride	55	2.5	2.5
Ergocalciferol	341	2.5	2.5
Naproxen	71	2.5	2.5
Melatonin	49	2.5	2.5
Morphine	67	2.5	2.5
Paroxetine Hydrochloride Hemihydrate	30	2.5	2.5
Clindamycin Phosphate	30	2.5	2.5
Biotin	28	2.5	2.5
Escitslopram	52	2.5	2.5
Ustekinumab	91	2.5	2.5
Methimazole	7	2.5	2.5
Naproxen Sodium Tablet, Coated	12	2.4	2.4
Naproxen Sodium, Coated Tablets	12	2.4	2.4
Naproxen Sodium 220Mg	12	2.4	2.4
Paroxetine	30	2.4	2.4
Clobetasol Propionate Ointment Usp, 0.05%	9	2.4	2.4
Clobetasol Propionate	9	2.4	2.4
Hydrochlorothiazide	125	2.4	2.4
Escitalopram Oxalate	63	2.4	2.4
Citalopram Hydrobromide	92	2.4	2.4
Alendronate Sodium Tablet	16	2.4	2.4
Lidocaine	50	2.4	2.4
Ceftriaxone	28	2.4	2.4
Duloxetine Hydrochloride	158	2.3	2.3
Hydroxychloroquine Sulfate	77	2.3	2.3
Trimethoprim	10	2.3	2.3
Lidocaine 4%	46	2.3	2.3
Fluorouracil	65	2.3	2.3
Triamcinolone Acetonide	26	2.3	2.3
Amantadine	13	2.3	2.3
Pemetrexed	18	2.3	2.3
Oxaliplatin	62	2.3	2.3
Hydroxyzine Hydrochloride	11	2.3	2.3
Hydroxyzine Hydrochloride Oral	11	2.3	2.3
Progesterone	19	2.3	2.3
Buprenorphine Hydrochloride, Naloxone Hydrochloride	20	2.3	2.3
Fluorouracil Cream, 0.5%	63	2.3	2.3
Ibuprofen Tablets, Coated	35	2.3	2.3
Vortioxetine	14	2.3	2.3
Ibuprofen Sodium	35	2.3	2.3
Sodium Bicarbonate	19	2.2	2.2
Sodium Bicarbonate Injection,	19	2.2	2.2
Capecitabine	74	2.2	2.2
Bupropion	36	2.2	2.2
Levothyroxine Sodium	249	2.2	2.2
Valsartan	84	2.2	2.2
Azithromycin Dihydrate	47	2.2	2.2
Lorazepam	143	2.2	2.2
Abemaciclib	16	2.2	2.2
Amitriptyline Hydrochloride	14	2.2	2.2
Cyclosporine	87	2.2	2.2
Sulfamethoxazole And Trimethoprim	66	2.2	2.2
Indapamide	14	2.1	2.1
Lisinopril And Hydrochlorothiazide Tablets	6	2.1	2.1
Cetirizine	59	2.1	2.1
Armodafinil	16	2.1	2.1
Citalopram	103	2.1	2.1
Ceftriaxone Sodium	29	2.1	2.1
Nebivolol	12	2.1	2.1
Bendamustine Hydrochloride	9	2.1	2.1
Mycophenolic Acid	24	2.1	2.1
Osimertinib	24	2.1	2.1
Isotretinoin	37	2.1	2.1
Goserelin	10	2.0	2.0
Sertraline	86	2.0	2.0
Iron Sucrose	7	2.0	2.0
Bisoprolol Fumarate	99	2.0	2.0
Tacrolimus	114	2.0	2.0
Mupirocin Calcium	10	2.0	2.0
Dexlansoprazole	30	2.0	2.0
Doxycycline	49	2.0	2.0
Apixaban	48	2.0	2.0
Diphenhydramine Hcl	8	2.0	2.0
Nebivolol Hydrochloride	24	2.0	2.0
Diclofenac	61	2.0	2.0
Cetiirizine	30	2.0	2.0
Cetuximab	22	1.9	1.9
Amlodipine	187	1.9	1.9
Doxycycline Hyclate	47	1.9	1.9
Naproxen Sodium	99	1.9	1.9
Amoxicillin	53	1.9	1.9
Primidone	7	1.9	1.9
Vigabatrin	10	1.9	1.9
Lisinopril And Hydrochlorothiazide	7	1.9	1.9
Adalimumab	470	1.9	1.9
Nicotine Polacrilex	26	1.9	1.9
Ketoconazole Foam	10	1.9	1.9
Sorafenib	14	1.9	1.9
Ketoconazole Cream, 2%	10	1.9	1.9
Zoledronic Acid	27	1.9	1.9
Mupirocin	9	1.8	1.8
Nevirapine	6	1.8	1.8
Ondansetron Hydrochloride	81	1.8	1.8
Ofatumumab	22	1.8	1.8
Bupropion Hydrochloride	64	1.8	1.8
Tacrolimus Ointment 0.1%	80	1.8	1.8
Tacrolimus Extended-Release Capsules	80	1.8	1.8
Ezetimibe	48	1.8	1.8
Clarithromycin	22	1.8	1.8
Lenvatinib	21	1.8	1.8
Paclitaxel	63	1.8	1.8
Paclitaxel (Aibumin-Bound)	52	1.7	1.7
Rimegepant Sulfate	8	1.7	1.7
Levofloxacin	38	1.7	1.7
Levofloxacin In 5% Dextrose	38	1.7	1.7
Fingolimod Hcl	54	1.7	1.7
Nicotine	25	1.7	1.7
Eltrombopag Olamine	14	1.7	1.7
Minocycline	7	1.7	1.7
Omalizumab	51	1.6	1.6
Hydromorphone Hydrochloride	55	1.6	1.6
Tofacitinib	108	1.6	1.6
Risankizumab-Rzaa	48	1.6	1.6
Pregabalin	158	1.6	1.6
Oxcarbazepine	19	1.6	1.6
Rivastigmine	11	1.6	1.6
Levocetirizine Dihydrochloride	14	1.6	1.6
Denosumab	117	1.6	1.6
Prednisolone Acetate	6	1.6	1.6
Tenofovir Disoproxil Fumarate Tablets	5	1.6	1.6
Peginterferon Alfa-2A	31	1.6	1.6
Ruxolitinib	41	1.6	1.6
Melphalan	13	1.6	1.6
Oxybutynin Chloride	5	1.6	1.6
Metformin Er 500 Mg	170	1.6	1.6
Metformin Er 750 Mg	170	1.6	1.6
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	20	1.6	1.6
Rucaparib	5	1.6	1.6
Thyroid, Porcine	6	1.5	1.5
Azelastine	10	1.5	1.5
Acyclovir	62	1.5	1.5
Brexpiprazole	9	1.5	1.5
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	22	1.5	1.5
Fremanezumab-Vfrm	6	1.4	1.4
Carboplatin	66	1.4	1.4
Cladribine	5	1.4	1.4
Pazopanib Hydrochloride	14	1.4	1.4
Axitinib	10	1.4	1.4
Dupilumab	244	1.4	1.4
Lanreotide Acetate	4	1.4	1.4
Teriflunomide	23	1.4	1.4
Dorzolamide Hydrochloride And Timolol Maleate	4	1.4	1.4
Prochlorperazine	14	1.4	1.4
Dexamethasone 1.5 Mg	147	1.4	1.4
Dexamethasone	147	1.4	1.4
Cabotegravir	4	1.4	1.4
Azacitidine For	9	1.4	1.4
Ozanimod Hydrochloride	4	1.3	1.3
Umeclidinium Bromide And Vilanterol Trifenatate	8	1.3	1.3
Golimumab	41	1.3	1.3
Budesonide, Glycopyrrolate, And Formoterol Fumarate	5	1.3	1.3
Bevacizumab	59	1.3	1.3
Doxorubicin	42	1.3	1.3
Thalidomide	17	1.3	1.3
Diclofenac Potassium	5	1.3	1.3
Docetaxel Anhydrous	31	1.3	1.3
Docetaxel	31	1.3	1.3
Umeclidinium	4	1.2	1.2
Azacitidine	13	1.2	1.2
Naproxen Sodium Tablet	23	1.2	1.2
Olaparib	9	1.2	1.2
Glycerin, Lidocaine	6	1.2	1.2
Oral Semaglutide	31	1.2	1.2
Ixazomib	12	1.1	1.1
Deferasirox	11	1.1	1.1
Timolol	5	1.1	1.1
Mirabegron	16	1.1	1.1
Docosanol	6	1.1	1.1
Cortisone Acetate	5	1.1	1.1
Nivolumab	39	1.1	1.1
Certolizumab Pegol	47	1.1	1.1
Sodium Oxybate	26	1.1	1.1
Irinotecan Hydrochloride	5	1.1	1.1
Amphetamine	3	1.0	1.0
Methoxy Polyethylene Glycol-Epoetin Beta	4	1.0	1.0
Ranitidine	72	1.0	1.0
Cenobamate	3	1.0	1.0
Alirocumab	9	1.0	1.0
Diclofenac Potassium, Film Coated	3	1.0	1.0
Diclofenac Potassium Tablets	3	1.0	1.0
Nintedanib	11	1.0	1.0
Voclosporin	3	0.9	0.9
Vismodegib	3	0.9	0.9
Siponimod	3	0.9	0.9
Venetoclax	20	0.9	0.9
Naltrexone	10	0.9	0.9
Erlotinib	3	0.9	0.9
Suvorexant	4	0.8	0.8
Benralizumab	6	0.8	0.8
Ravulizumab	4	0.8	0.8
Romosozumab-Aqqg	4	0.8	0.8
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate	12	0.8	0.8
Blinatumomab	3	0.8	0.8
Abaloparatide	8	0.7	0.7
Orlistat	7	0.7	0.7
Ledipasvir And Sofosbuvir	5	0.7	0.7
Nirmatrelvir And Ritonavir	14	0.7	0.7
Galcanezumab-Gnlm	8	0.7	0.7
Pegfilgrastim	25	0.7	0.7
Diroximel Fumarate	3	0.7	0.7
Lifitegrast	4	0.7	0.7
Elexacaftor, Tezacaftor, And Ivacaftor	3	0.7	0.7
Erenumab-Aooe	11	0.5	0.5
Apremilast	27	0.5	0.5
Pomalidomide	18	0.5	0.5
Guselkumab	6	0.5	0.5
Evolocumab	23	0.4	0.4
Minoxidil	6	0.4	0.4
Levonorgestrel	27	0.4	0.4

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.