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Which drugs are most reported with Joint effusion?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 6,829 reports · 362 co-occurring drugs

As of the last recalculation, Joint Effusion appears in 6,829 FAERS reports alongside 362 co-occurring drug terms. The strongest observed disproportionality signal is METHYLPREDNISOLONE ACETATE (PRR 55.2).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Methylprednisolone Acetate	142	55.2	56.2
Adalimumab-Fkjp	299	20.5	20.7
Sulfasalazine	490	20.5	20.6
Adalimumab-Aaty	298	20.0	20.1
Hydroxychloroquine Sulfate	532	19.2	19.3
Leflunomide	589	18.7	18.8
Anakinra	99	18.4	18.5
Adalimumab-Adaz	303	18.3	18.4
Alendronate Sodium	512	16.6	16.7
Diphenhydramine Hydrochloride Capsule, Liquid Filled	109	15.8	15.9
Risedronate Sodium	144	14.4	14.5
Naproxen Sodium Tablet, Coated	62	14.1	14.1
Naproxen Sodium, Coated Tablets	62	14.1	14.1
Naproxen Sodium 220Mg	62	14.1	14.1
Trimethoprim	53	13.8	13.9
Diclofenac Potassium, Film Coated	35	12.7	12.8
Diclofenac Potassium Tablets	35	12.7	12.8
Tocilizumab	446	12.7	12.7
Hydroxychloroquine	298	12.7	12.7
Indomethacin	54	12.5	12.6
Naproxen	303	12.3	12.3
Cortisone Acetate	48	11.9	12.0
Methotrexate Sodium	1,491	11.7	11.7
Methotrexate	1,318	11.6	11.6
Tofacitinib Citrate	49	11.5	11.5
Amitriptyline Hydrochloride	65	11.4	11.4
Tofacitinib	579	10.4	10.4
Esomeprazole Magnesium Capsule, Delayed Release	49	10.4	10.4
Esomeprazole Magnesium Delayed Release Capsules	49	10.4	10.4
Esomeprazole Magnesium Dihydrate	49	10.3	10.3
Folic Acid	736	10.0	10.0
Diclofenac Potassium	35	9.9	9.9
Celecoxib	396	9.7	9.7
Abatacept	404	9.4	9.4
Adalimumab	1,650	9.1	9.1
Calcium Gluconate	35	8.9	8.9
Meloxicam	163	8.7	8.8
Triamcinolone Acetonide Ointment Usp, 0.05%	66	8.7	8.7
Desoximetasone	52	8.4	8.4
Epoetin Alfa	32	8.3	8.3
Amiodarone Hydrochloride	30	8.2	8.2
Human Immunoglobulin G	53	7.9	7.9
Naproxen Sodium	352	7.9	7.9
Etanercept	1,278	7.8	7.8
Chlorhexidine Gluconate	23	7.7	7.7
Canakinumab	26	7.3	7.4
Pantoprazole Sodium In 0.9% Sodium Chloride	146	7.3	7.3
Pantoprazole Sodium Injection	146	7.3	7.3
Doxepin Hydrochloride	30	7.3	7.3
Infliximab	469	7.0	7.0
Golimumab	189	6.9	6.9
Triamcinolone Acetonide	68	6.8	6.8
Methylprednisolone	291	6.7	6.7
Prednisone	954	6.6	6.6
Hydrocortisone Sodium Succinate	20	6.5	6.5
Methylprednisolone Sodium Succinate	95	6.3	6.3
Colchicine	52	6.1	6.1
Cetirizine Hydrochloride Allergy	58	5.9	5.9
Cetirizine Hydrochloride Tablets	58	5.9	5.9
Alendronate Sodium Tablet	35	5.8	5.8
Rosuvastatin Calcium	53	5.8	5.8
Doxepin	19	5.7	5.7
Cimetidine	18	5.7	5.7
Azathioprine	160	5.6	5.7
Diclofenac	155	5.6	5.6
Cephalexin	39	5.5	5.5
Magnesium Hydroxide	24	5.4	5.5
Diclofenac Sodium 1%	63	5.4	5.4
Diclofenac Sodium Topical	63	5.4	5.4
Diclofenac Sodium Topical Gel, 1%	63	5.4	5.4
Rituximab	358	5.4	5.4
Vitamin E	55	5.4	5.4
Certolizumab Pegol	201	5.4	5.4
Quinine	15	5.3	5.3
Hyoscyamine Sulfate	16	5.3	5.3
Ascorbic Acid	38	5.0	5.0
Emicizumab	20	4.9	5.0
Felodipine Extended-Release Tablets	18	4.8	4.8
Felodipine	18	4.8	4.8
Tizanidine Hydrochloride	28	4.7	4.7
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	240	4.7	4.7
Dexlansoprazole	63	4.6	4.6
Upadacitinib	121	4.6	4.6
Esomeprazole	92	4.6	4.6
Moxifloxacin	21	4.6	4.6
Losartan Potassium And Hydrochlorothiazide	17	4.5	4.5
Pseudoephedrine Hydrochloride	15	4.5	4.5
Misoprostol	14	4.4	4.4
Diclofenac Sodium	211	4.4	4.4
Sulfamethoxazole And Trimethoprim	119	4.4	4.4
Zoledronic Acid	57	4.4	4.4
Pantoprazole Sodium	205	4.3	4.3
Acetaminophen Tablet Extended Release	342	4.2	4.3
Pain Reliever	342	4.2	4.3
Acetaminophen 500Mg	342	4.2	4.2
Pseudoephedrine Hcl	15	4.2	4.2
Fondaparinux Sodium	11	4.1	4.2
Ibuprofen Capsule	262	4.1	4.1
Ibuprofen Tablet, Film Coated	262	4.1	4.1
Ibupfrofen	262	4.1	4.1
Ibuprofen Tablets Usp, 200Mg	262	4.1	4.1
Ibuprofen Oral	262	4.1	4.1
Ibuprofen Capsules 200 Mg	262	4.1	4.1
Ibuprofen 200 Mg	262	4.1	4.1
Ibuprofen 200Mg	262	4.1	4.1
Pantoprazole	328	4.1	4.1
Amoxicillin	101	4.1	4.1
Diphenhydramine Hydrochloride	213	4.0	4.0
Cyanocobalamin	43	4.0	4.0
Hydrocortisone	115	4.0	4.0
Rifampicin	13	3.9	3.9
Clindamycin Phosphate	42	3.9	3.9
Secukinumab	196	3.8	3.8
Clindamycin	35	3.8	3.8
Gentamicin	16	3.7	3.7
Calcium	178	3.7	3.7
Lidocaine Hydrochloride	73	3.7	3.7
Docusate Sodium 100Mg	29	3.7	3.7
Carisoprodol	23	3.7	3.7
Lidocaine Hydrochloride And Epinephrine Bitartrate	64	3.7	3.7
Thalidomide	44	3.7	3.7
Meperidine Hydrochloride	11	3.6	3.6
Acetaminophen	504	3.6	3.6
Moxifloxacin Hydrochloride	24	3.6	3.6
Promethazine Hydrochloride	22	3.6	3.6
Doxyclycline Hyclate	20	3.6	3.6
Ibuprofen	309	3.6	3.6
Temazepam	44	3.6	3.6
Cyclobenzaprine	58	3.6	3.6
Infliximab-Dyyb	34	3.6	3.6
Clobetasol Propionate Ointment Usp, 0.05%	12	3.6	3.6
Clobetasol Propionate	12	3.5	3.5
Anastrozole	42	3.5	3.5
Hydrochlorothiazide	164	3.5	3.5
Methocarbamol	26	3.5	3.5
Pregabalin	298	3.4	3.4
Cyclobenzaprine Hydrochloride	10	3.4	3.4
Oxycodone And Acetaminophen Tablets	13	3.3	3.3
Busulfan	17	3.3	3.3
Docusate Sodium	62	3.3	3.3
Magnesium	88	3.3	3.3
Nystatin Ointment	28	3.3	3.3
Nystatin Cream	28	3.3	3.3
Ketoprofen	14	3.3	3.3
Fulvestrant	35	3.2	3.2
Acetylcysteine	10	3.2	3.2
Phytonadione	9	3.2	3.2
Docusate Sodium - Sennosides	34	3.2	3.2
Lidocaine, Menthol	52	3.2	3.2
Ketoconazole	18	3.2	3.2
Ciprofloxacin Hydrochloride	100	3.2	3.2
Alemtuzumab	20	3.2	3.2
Raloxifene Hydrochloride	15	3.1	3.1
Lidicaine	50	3.1	3.1
Burn Relief	50	3.1	3.1
Nystatin	28	3.1	3.1
Cetirizine	79	3.1	3.1
Lidocaine Hydrochloride And Epinephrine	50	3.1	3.1
Vancomycin Hydrochloride	67	3.1	3.1
Methocarbamol Tablets	17	3.1	3.1
Ketoconazole Foam	15	3.1	3.1
Antacid	48	3.1	3.1
Gentamicin Sulfate	16	3.1	3.1
Ketoconazole Cream, 2%	15	3.1	3.1
Duloxetine	70	3.1	3.1
Enalapril Maleate	25	3.1	3.1
Bisacodyl Suppositories	13	3.1	3.1
Biscodyl	13	3.0	3.0
Rabeprazole Sodium	27	3.0	3.0
Diphenhydramine Hcl	11	3.0	3.0
Ergocalciferol	365	3.0	3.0
Exemestane	21	3.0	3.0
Piperacillin Sodium And Tazobactam Sodium	19	3.0	3.0
Oxycodone Hydrochloride And Acetaminophen	95	3.0	3.0
Prednisolone Acetate	10	2.9	3.0
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	48	2.9	2.9
Ramipril	118	2.9	2.9
Sotalol Hydrochloride	16	2.9	2.9
Estrogens, Conjugated	56	2.9	2.9
Allopurinol	146	2.9	2.9
Lidocaine 4%	51	2.9	2.9
Vancomycin	54	2.9	2.9
Nitroglycerin	50	2.9	2.9
Duloxetine Hydrochloride	173	2.9	2.9
Anastrozole Tablets	20	2.8	2.8
Bisacodyl	13	2.8	2.8
Ciprofloxacin Hydrochloride And Hydrocortisone	19	2.8	2.8
Conjugated Estrogens	53	2.8	2.8
Tramadol Hydrochloride	34	2.8	2.8
Oxycodone And Acetaminophen	21	2.8	2.8
Calcium Carbonate	60	2.7	2.7
Lidocaine	52	2.7	2.7
Indapamide	16	2.7	2.7
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	27	2.7	2.7
Methimazole	7	2.7	2.7
Vitamin C	81	2.7	2.7
Quinapril Hydrochloride	7	2.7	2.7
Ranitidine Hydrochloride	48	2.7	2.7
Esomeprazole Magnesium	201	2.7	2.7
Piperacillin Sodium,Tazobactam Sodium	23	2.6	2.6
Doxycycline Hyclate	58	2.6	2.6
Lurasidone Hydrochloride	18	2.6	2.6
Piperacillin And Tazobactam	11	2.6	2.6
Ferrous Sulfate	43	2.6	2.6
Fish Oil	77	2.6	2.6
Doxycycline	58	2.6	2.6
Letrozole	52	2.6	2.6
Escitslopram	49	2.6	2.6
Sarilumab	22	2.5	2.5
Crisaborole	8	2.5	2.5
Ciprofloxacin	76	2.5	2.5
Mycophenolate Mofetil Hydrochloride	112	2.5	2.5
Prednisolone	148	2.5	2.5
Prednisolone Oral	148	2.5	2.5
Prednisolone Oral Solution	148	2.5	2.5
Cholestyramine	10	2.5	2.5
Cyclosporine	91	2.5	2.5
Mycophenolate Mofetil	110	2.5	2.5
Amoxicillin And Clavulanate Potassium	22	2.5	2.5
Nifedipine	38	2.5	2.5
Potassium Chloride	91	2.5	2.5
Liothyronine Sodium	7	2.5	2.5
Diphenoxylate Hydrochloride And Atropine Sulfate	11	2.4	2.5
Metolazone	9	2.4	2.4
Ciprofolxacin	57	2.4	2.4
Ciprofloxacin Tablets	57	2.4	2.4
Ezetimibe And Simvastatin	12	2.4	2.4
Quetiapine Fumarate	23	2.4	2.4
Febuxostat	13	2.4	2.4
Ibuprofen And Diphenhydramine Citrate	18	2.4	2.4
Granisetron Hydrochloride	8	2.3	2.3
Iron	51	2.3	2.3
Irbesartan	34	2.3	2.3
Zolpidem Tartrate	102	2.3	2.3
Empagliflozin	51	2.3	2.3
Potassium Chloride, Dextrose Monohydrate	70	2.3	2.3
Potassium Chloride Oral	70	2.3	2.3
Potassium Chloride Extended-Release	70	2.3	2.3
Melphalan Hydrochloride	19	2.3	2.3
Amlodipine Besylate And Benazepril Hydrochloride	7	2.3	2.3
Valsartan Oral	41	2.3	2.3
Tizanidine	18	2.3	2.3
Enoxaparin Sodium	43	2.3	2.3
Levofloxacin	45	2.3	2.3
Levofloxacin In 5% Dextrose	45	2.3	2.3
Melphalan	17	2.3	2.3
Escitalopram	104	2.3	2.3
Losartan Potassium	58	2.3	2.3
Insulin Glargine-Yfgn	16	2.2	2.2
Ibuprofen Tablets, Coated	31	2.2	2.2
Escitalopram Oxalate	53	2.2	2.2
Levothyroxine Sodium	225	2.2	2.2
Nitrofurantoin	12	2.2	2.2
Heparin Sodium	10	2.2	2.2
Ibuprofen Sodium	31	2.2	2.2
Bicalutamide	11	2.2	2.2
Nitrofurantoin (Monohydrate/Macrocrystals)	12	2.2	2.2
Doxazosin	20	2.2	2.2
Cetirizine Hydrochloride	116	2.2	2.2
Oxycodone	131	2.2	2.2
Eplerenone	9	2.1	2.1
Omeprazole Magnesium	306	2.1	2.1
Metoroprolol Tartrate	46	2.1	2.1
Naproxen Sodium Tablet	37	2.1	2.1
Ezetimibe	52	2.1	2.1
Loratadine Oral	34	2.1	2.1
Warfarin Sodium	32	2.1	2.1
Niacin	8	2.1	2.1
Febuxostat Tablets 40 Mg	7	2.1	2.1
Febuxostat Tablets 80 Mg	7	2.1	2.1
Prochlorperazine	19	2.1	2.1
Furosemide	268	2.1	2.1
Valsartan	71	2.1	2.1
Simvastatin	167	2.1	2.1
Terazosin Hydrochloride	6	2.1	2.1
Metoprolol Succinate	58	2.0	2.0
Sitagliptin	48	2.0	2.0
Mupirocin	9	2.0	2.0
Lopinavir And Ritonavir	9	2.0	2.0
Omeprazole	225	2.0	2.0
Valsartan And Hydrochlorothiazide	9	2.0	2.0
Gabapentin	236	2.0	2.0
Hydromorphone Hydrochloride	60	2.0	2.0
Atorvastatin Calcium	160	2.0	2.0
Lansoprazole	114	2.0	2.0
Metoprolol Tartrate	174	2.0	2.0
Bupivacaine	6	2.0	2.0
Posaconazole Delayed-Release	7	1.9	1.9
Mercaptopurine	11	1.9	1.9
Metoprolol	158	1.9	1.9
Lovastatin	16	1.9	1.9
Rosuvastatin	126	1.9	1.9
Doxazosin Mesylate	22	1.9	1.9
Warfarin	77	1.9	1.9
Pravastatin Sodium	12	1.8	1.8
Ranitidine	119	1.8	1.8
Risankizumab-Rzaa	49	1.8	1.8
Metoprolol Tartrate Injection	113	1.8	1.8
Asfotase Alfa	6	1.8	1.8
Methadone	25	1.8	1.8
Erythropoietin	12	1.8	1.8
Loratadine	62	1.8	1.8
Acetaminophen And Codeine	7	1.8	1.8
Atorvastatin Calcium, Film Coated	40	1.7	1.7
Ribociclib	18	1.7	1.7
Sitagliptin And Metformin Hydrochloride	12	1.7	1.7
Methadone Hydrochloride	6	1.7	1.7
Posaconazole	9	1.7	1.7
Teriparatide	61	1.7	1.7
Vilazodone Hydrochloride	5	1.7	1.7
Daptomycin	5	1.7	1.7
Aprepitant	10	1.7	1.7
Loratadine Tablet	29	1.7	1.7
Fludarabine Phosphate	21	1.6	1.6
Sevelamer Carbonate	6	1.6	1.6
Eltrombopag Olamine	12	1.6	1.6
Multivitamin	26	1.6	1.6
Sildenafil	30	1.6	1.6
Oxycodone Hydrochloride	112	1.6	1.6
Eszopiclone	13	1.6	1.6
Dorzolamide Hydrochloride And Timolol Maleate	4	1.5	1.5
Mepolizumab	25	1.5	1.5
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Alafenamide	5	1.5	1.5
Etonogestrel And Ethinyl Estradiol	11	1.5	1.5
Denosumab	100	1.5	1.5
Sildenafil Citrate	61	1.5	1.5
Deferasirox	12	1.4	1.4
Brimonidine Tartrate	8	1.4	1.4
Insulin Lispro	60	1.3	1.3
Imatinib Mesylate	12	1.3	1.3
Armodafinil	9	1.3	1.3
Ibrutinib	34	1.3	1.3
Crizotinib	5	1.2	1.2
Bortezomib	35	1.2	1.2
Loratadine And Pseudoephedrine Sulfate	3	1.1	1.1
Inclisiran	3	1.1	1.1
Apremilast	54	1.1	1.1
Obinutuzumab	6	1.1	1.1
Ipilimumab	15	1.1	1.1
Ustekinumab	35	1.0	1.0
Tafamidis	4	1.0	1.0
Conjugated Estrogens And Medroxyprogesterone Acetate	8	1.0	1.0
Canagliflozin	10	1.0	1.0
Bosutinib	3	1.0	1.0
Vemurafenib	4	1.0	1.0
Tapentadol Hydrochloride	11	1.0	1.0
Hydrocodone Bitartrate	14	1.0	1.0
Ruxolitinib	23	1.0	1.0
Guselkumab	11	0.9	0.9
Emtricitabine And Tenofovir Disoproxil Fumarate	14	0.9	0.9
Romosozumab-Aqqg	4	0.9	0.9
Venetoclax	18	0.9	0.9
Hydrocodone Bitartrate And Acetaminophen	15	0.8	0.8
Ledipasvir And Sofosbuvir	5	0.8	0.8
Relugolix	6	0.8	0.8
Diroximel Fumarate	3	0.8	0.8
Palivizumab	3	0.6	0.6
Ixekizumab	7	0.6	0.6
Lenalidomide	80	0.6	0.6
Lifitegrast	3	0.6	0.6
Abaloparatide	5	0.5	0.5
Evolocumab	21	0.4	0.4

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.