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Which drugs are most reported with Oropharyngeal discomfort?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 8,819 reports · 417 co-occurring drugs

As of the last recalculation, Oropharyngeal Discomfort appears in 8,819 FAERS reports alongside 417 co-occurring drug terms. The strongest observed disproportionality signal is CICLESONIDE (PRR 13.6).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Ciclesonide	78	13.6	13.7
Budesonide, Glycopyrrolate, And Formoterol Fumarate	57	13.0	13.0
Levodopa	55	10.8	10.8
Cholestyramine	49	9.6	9.6
Salmeterol Xinafoate	33	9.1	9.1
Iohexol	31	8.9	8.9
Amikacin	61	8.5	8.5
Dimenhydrinate	35	7.8	7.8
Thiamine Hydrochloride	38	7.2	7.3
Ribociclib	92	6.9	7.0
0Xygen	139	6.8	6.8
Oxygen	139	6.8	6.8
Phytonadione	22	6.1	6.1
Infliximab-Dyyb	75	6.1	6.1
Calcium, Magnesium, Potassium, And Sodium Oxybates	22	6.0	6.1
Nicotine Polacrilex	94	5.8	5.9
Omalizumab	205	5.8	5.8
Benralizumab	47	5.6	5.6
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate	96	5.5	5.5
Sevoflurane	19	5.4	5.4
Human Immunoglobulin G	46	5.3	5.3
Hydrocortisone Sodium Succinate	21	5.3	5.3
Aprepitant	41	5.3	5.3
Rosuvastatin Calcium	62	5.2	5.2
Nintedanib	67	5.1	5.1
Diphenhydramine	134	5.1	5.1
Treprostinil	255	4.9	4.9
Budesonide And Formoterol Fumarate Dihydrate	192	4.7	4.8
Diphenhydramine Hydrochloride Capsule, Liquid Filled	42	4.7	4.7
Fluticasone Propionate Nasal	59	4.6	4.6
Methylprednisolone Sodium Succinate	90	4.6	4.6
Theophylline Anhydrous	24	4.6	4.6
Cetirizine Hydrochloride Allergy	58	4.5	4.6
Cetirizine Hydrochloride Tablets	58	4.5	4.5
Ipratropium Bromide	68	4.5	4.5
Azelastine	34	4.5	4.5
Cyanocobalamin	61	4.4	4.4
Umeclidinium Bromide And Vilanterol Trifenatate	31	4.4	4.4
Fexofenadine Hcl	17	4.3	4.4
Fluticasone Propionate And Salmeterol Xinafoate	109	4.3	4.3
Psyllium Husk	18	4.3	4.3
Fluticasone Furoate	22	4.3	4.3
Umeclidinium	16	4.2	4.2
Desloratadine	19	4.2	4.2
Fluticasone Furoate And Vilanterol Trifenatate	63	4.2	4.2
Eptinezumab-Jjmr	16	4.2	4.2
Valproate Sodium	36	4.1	4.1
Theophylline	20	4.1	4.1
Selexipag	44	4.0	4.0
Nicotine Polacrilex Mini	25	3.9	3.9
Nicotine Polarilex	25	3.9	3.9
Mometasone Furoate	69	3.9	3.9
Lifitegrast	27	3.9	3.9
Diphenhydramine Hydrochloride	268	3.9	3.9
Adrenalinum	68	3.9	3.9
Mometasone	30	3.9	3.9
Inclisiran	13	3.8	3.8
Montelukast Sodium	190	3.7	3.7
Budesonide	92	3.7	3.7
Nicotine	63	3.7	3.7
Zinc Chloride	37	3.5	3.5
Niraparib	33	3.5	3.5
Fulvestrant	49	3.5	3.5
Cetirizine	113	3.5	3.5
Montelukast	122	3.5	3.5
Ascorbic Acid	34	3.5	3.5
Zinc	36	3.5	3.5
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	30	3.5	3.5
Naproxen Sodium, Pseudoephedrine Hydrochloride	30	3.4	3.5
Loratadine Oral	71	3.4	3.4
Buspirone Hydrochloride	16	3.4	3.4
Epinephrine	94	3.4	3.4
Tiotropium Bromide Inhalation Spray	16	3.4	3.4
Fluticasone Propionate And Salmeterol	59	3.4	3.4
Ofatumumab	47	3.4	3.4
Zinc Gluconate	37	3.3	3.4
Cetirizine Hcl	13	3.3	3.4
Mepolizumab	70	3.3	3.3
Alpelisib	12	3.3	3.3
Sodium Chloride	107	3.2	3.2
Sodium Chloride Tablet	99	3.2	3.2
Sodium Chloride Tablets	99	3.2	3.2
Biotin	42	3.2	3.2
Guaifenesin	40	3.1	3.1
Anastrozole Tablets	28	3.1	3.1
Albuterol Sulfate	375	3.1	3.1
Nirmatrelvir And Ritonavir	70	3.1	3.1
Fluticasone Propionate	166	3.1	3.1
Ferrous Sulfate	64	3.0	3.0
Cimetidine	12	2.9	2.9
Fexofenadine Hydrochloride	27	2.9	2.9
Cyclobenzaprine Hydrochloride	11	2.9	2.9
Mometasone Furoate And Formoterol Fumarate Dihydrate	19	2.9	2.9
Acetaminophen Tablet Extended Release	301	2.8	2.9
Pain Reliever	301	2.8	2.8
Acetaminophen 500Mg	301	2.8	2.8
Loratadine	128	2.8	2.8
Ravulizumab	16	2.8	2.8
Metoprolol Succinate Er Tablets	73	2.8	2.8
Esomeprazole Magnesium Capsule, Delayed Release	17	2.8	2.8
Esomeprazole Magnesium Delayed Release Capsules	17	2.8	2.8
Esomeprazole Magnesium Dihydrate	17	2.8	2.8
Fosaprepitant Dimeglumine	16	2.7	2.8
Sildenafil	67	2.7	2.7
Cetirizine Hydrochloride	189	2.7	2.7
Famotidine	135	2.7	2.7
Hydroxyzine Hydrochloride	15	2.7	2.7
Hydroxyzine Hydrochloride Oral	15	2.7	2.7
Riociguat	37	2.7	2.7
Fremanezumab-Vfrm	13	2.7	2.7
Ondansetron Hydrochloride	137	2.7	2.7
Botulinum Toxin Type A	14	2.7	2.7
Butalbital, Acetaminophen, And Caffeine	12	2.7	2.7
Levocetirizine Dihydrochloride	27	2.7	2.7
Doxyclycline Hyclate	19	2.6	2.6
Desvenlafaxine Succinate	30	2.6	2.6
Nystatin Ointment	29	2.6	2.6
Nystatin Cream	29	2.6	2.6
Desoximetasone	21	2.6	2.6
Esomeprazole	68	2.6	2.6
Nystatin	30	2.6	2.6
Ondansetron	118	2.6	2.6
Ondansetron Tablets	118	2.6	2.6
Prochlorperazine Maleate	10	2.6	2.6
Clarithromycin	37	2.5	2.6
Alirocumab	27	2.5	2.5
Loperamide Hydrochloride Oral	11	2.5	2.5
Antacid	51	2.5	2.5
Pitavastatin Calcium	11	2.5	2.5
Acetaminophen	465	2.5	2.5
Oxaliplatin	79	2.5	2.5
Methylprednisolone	146	2.5	2.5
Telmisartan	19	2.5	2.5
Cabozantinib	51	2.5	2.5
Hydrocortisone	94	2.5	2.5
Secukinumab	169	2.5	2.5
Macitentan	72	2.5	2.5
Cetiirizine	44	2.5	2.5
Anastrozole	38	2.4	2.5
Liothyronine Sodium	9	2.4	2.4
Calcium Carbonate	69	2.4	2.4
Tamsulosin Hydrochloride	21	2.4	2.4
Fexofenadine	17	2.4	2.4
Rimegepant Sulfate	13	2.4	2.4
Albuterol	122	2.4	2.4
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	51	2.4	2.4
Ceftriaxone Sodium	39	2.4	2.4
Trimethoprim	12	2.4	2.4
Fesoterodine Fumarate	11	2.4	2.4
Magnesium	83	2.4	2.4
Letrozole	62	2.4	2.4
Hydrocortisone Acetate	73	2.4	2.4
Atorvastatin Calcium, Film Coated	70	2.4	2.4
Amlodipine Besylate And Valsartan	11	2.3	2.3
Avapritinib	12	2.3	2.3
Sumatriptan Succinate	25	2.3	2.3
Anti-Itch	66	2.3	2.3
Anti-Pruritic	66	2.3	2.3
Antipruritic (Anti-Itch)	66	2.3	2.3
Cool Relief Gel With Aloe	66	2.3	2.3
Drs. Hydrocortisone	66	2.3	2.3
Hydrocortisone Continuous Spray	66	2.3	2.3
Hydrocortisone Spray	66	2.3	2.3
Anti-Itch Cream	66	2.3	2.3
Hydrocortisone Lotion	66	2.3	2.3
Hydrocortisone Cream 1%	66	2.3	2.3
Hydrocortisone Cream 1/2%	66	2.3	2.3
Hydrocortisone 1%	66	2.3	2.3
Calcium	145	2.3	2.3
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	156	2.3	2.3
Hydrocortisone Cream	66	2.3	2.3
Dicyclomine Hydrochloride	14	2.3	2.3
Primidone	10	2.3	2.3
Sacubitril And Valsartan	113	2.3	2.3
Pegvaliase-Pqpz	8	2.3	2.3
Irbesartan	43	2.3	2.3
Acetylcysteine	9	2.3	2.3
Metoprolol Succinate	82	2.2	2.2
Iron Sucrose	9	2.2	2.2
Oral Semaglutide	69	2.2	2.2
Icosapent Ethyl	8	2.2	2.2
Melatonin	51	2.2	2.2
Cladribine	9	2.2	2.2
Loratadine Tablet	50	2.2	2.2
Amoxicillin	71	2.2	2.2
Tiotropium Bromide	126	2.2	2.2
Moxifloxacin	13	2.2	2.2
Oxycodone And Acetaminophen Tablets	11	2.2	2.2
Lidocaine Hydrochloride And Epinephrine Bitartrate	49	2.2	2.2
Letrozole Tablets	44	2.2	2.2
Ketoprofen	12	2.2	2.2
Losartan	158	2.2	2.2
Carbidopa And Levodopa	43	2.1	2.1
Tadalafil	90	2.1	2.1
Rabeprazole	20	2.1	2.1
Tofacitinib	165	2.1	2.1
Lidicaine	44	2.1	2.1
Burn Relief	44	2.1	2.1
Lidocaine Hydrochloride And Epinephrine	44	2.1	2.1
Calcitriol Capsules 0.25 Mcg	18	2.1	2.1
Calcitriol Capsules 0.5 Mcg	18	2.1	2.1
Tolvaptan	13	2.1	2.1
Lidocaine	52	2.1	2.1
Relugolix	21	2.1	2.1
Lidocaine, Menthol	44	2.1	2.1
Ibuprofen Sodium	38	2.1	2.1
Calcitriol	18	2.1	2.1
Ceftriaxone	29	2.1	2.1
Potassium Chloride, Dextrose Monohydrate	81	2.1	2.1
Potassium Chloride Oral	81	2.1	2.1
Potassium Chloride Extended-Release	81	2.1	2.1
Propofol	32	2.1	2.1
Dupilumab	412	2.1	2.1
Mesalamine	49	2.1	2.1
Clobetasol Propionate Ointment Usp, 0.05%	9	2.1	2.1
Vibegron	7	2.1	2.1
Ibuprofen Tablets, Coated	37	2.1	2.1
Clobetasol Propionate	9	2.1	2.1
Vitamin C	79	2.0	2.0
Diclofenac	74	2.0	2.0
Chlorthalidone	10	2.0	2.0
Pravastatin Sodium	17	2.0	2.0
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	26	2.0	2.0
Irinotecan Hydrochloride	11	2.0	2.0
Loperamide Hcl	11	2.0	2.0
Daratumumab	34	2.0	2.0
Lidocaine Hydrochloride	51	2.0	2.0
Levofloxacin	51	2.0	2.0
Levofloxacin In 5% Dextrose	51	2.0	2.0
Ticagrelor	27	2.0	2.0
Benzonatate	14	2.0	2.0
Sucralfate Oral	12	2.0	2.0
Sucralfate Oral Suspension	12	2.0	2.0
Sumatriptan	32	2.0	2.0
Losartan Potassium	66	2.0	2.0
Colchicine	22	2.0	2.0
Lidocaine 4%	45	2.0	2.0
Iron	55	1.9	1.9
Rifampin	12	1.9	1.9
Palbociclib	78	1.9	1.9
Naltrexone Hydrochloride And Bupropion Hydrochloride	7	1.9	1.9
Potassium Chloride	93	1.9	1.9
Hydroxyzine	39	1.9	1.9
Paliperidone	19	1.9	1.9
Ergocalciferol	308	1.9	1.9
Metformin Hydrochloride Tablets	46	1.9	1.9
Metformin Hydrochloride Extended-Release Tablets	46	1.9	1.9
Metformin Hydrochloride Tablet	46	1.9	1.9
Cyclobenzaprine	40	1.9	1.9
Azithromycin	32	1.9	1.9
Naproxen Sodium Tablet	42	1.9	1.9
Moxifloxacin Hydrochloride	16	1.9	1.9
Siponimod	7	1.9	1.9
Fentanyl Citrate	14	1.9	1.9
Testosterone Cypionate	7	1.9	1.9
Diclofenac Sodium	117	1.8	1.8
Metformin Hydrochloride	46	1.8	1.8
Levothyroxine Sodium	241	1.8	1.8
Regorafenib	9	1.8	1.8
Tizanidine Hydrochloride	14	1.8	1.8
Sorafenib	16	1.8	1.8
Azithromycin Monohydrate	32	1.8	1.8
Meclizine Hydrochloride	15	1.8	1.8
Methimazole	6	1.8	1.8
Omeprazole	260	1.8	1.8
Dextrose	10	1.8	1.8
Meloxicam	44	1.8	1.8
Belimumab	24	1.8	1.8
Rosuvastatin	154	1.8	1.8
Agalsidase Beta	7	1.8	1.8
Linaclotide	20	1.8	1.8
Dextrose Monohydrate	10	1.8	1.8
Nilotinib	22	1.8	1.8
Ketoconazole Foam	11	1.8	1.8
Zonisamide	11	1.8	1.8
Ibuprofen	200	1.8	1.8
Ocrelizumab	46	1.8	1.8
Fish Oil	67	1.8	1.8
Sildenafil Citrate	94	1.8	1.8
Mupirocin	10	1.8	1.8
Ketoconazole Cream, 2%	11	1.7	1.8
Esomeprazole Magnesium	171	1.7	1.7
Duloxetine	51	1.7	1.7
Mupirocin Calcium	10	1.7	1.7
Empagliflozin	48	1.7	1.7
Omeprazole Magnesium	314	1.7	1.7
Ibuprofen Capsule	141	1.7	1.7
Ibuprofen Tablet, Film Coated	141	1.7	1.7
Ibupfrofen	141	1.7	1.7
Ibuprofen Tablets Usp, 200Mg	141	1.7	1.7
Ibuprofen Oral	141	1.7	1.7
Ibuprofen Capsules 200 Mg	141	1.7	1.7
Ibuprofen 200 Mg	141	1.7	1.7
Ibuprofen 200Mg	141	1.7	1.7
Bisoprolol Fumarate	95	1.7	1.7
Asfotase Alfa	7	1.6	1.7
Febuxostat Tablets 40 Mg	7	1.6	1.6
Febuxostat Tablets 80 Mg	7	1.6	1.6
Rizatriptan Benzoate	7	1.6	1.6
Prochlorperazine	19	1.6	1.6
Aripiprazole Oral	28	1.6	1.6
Aripiprazole Orally Disintegrating	28	1.6	1.6
Naproxen Sodium	96	1.6	1.6
Loperamide Hydrochloride	30	1.6	1.6
Sotalol Hydrochloride	11	1.6	1.6
Exemestane	14	1.5	1.5
Paclitaxel (Aibumin-Bound)	53	1.5	1.5
Fentanyl	63	1.5	1.5
Carboxymethylcellulose Sodium	6	1.5	1.5
Dorzolamide Hydrochloride And Timolol Maleate	5	1.5	1.5
Loratadine And Pseudoephedrine Sulfate	5	1.5	1.5
Leucovorin Calcium	12	1.5	1.5
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	22	1.5	1.5
Lovastatin	16	1.5	1.5
Atovaquone	5	1.5	1.5
Cabotegravir	5	1.5	1.5
Infliximab	134	1.5	1.5
Vedolizumab	53	1.5	1.5
Axitinib	12	1.5	1.5
Misoprostol	6	1.5	1.5
Triamcinolone Acetonide	19	1.5	1.5
Bimekizumab	13	1.4	1.4
Apalutamide	7	1.4	1.4
Timolol	7	1.4	1.4
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	24	1.4	1.4
Paclitaxel	57	1.4	1.4
Dexlansoprazole	24	1.4	1.4
Conjugated Estrogens	33	1.3	1.3
Estrogens, Conjugated	33	1.3	1.3
Canakinumab	6	1.3	1.3
Dolutegravir Sodium	5	1.3	1.3
Dulaglutide	49	1.3	1.3
Teriflunomide	25	1.3	1.3
Sitagliptin	39	1.3	1.3
Tobramycin	13	1.3	1.3
Dapagliflozin	17	1.3	1.3
Galcanezumab-Gnlm	17	1.3	1.3
Sarilumab	14	1.3	1.3
Tirzepatide	85	1.2	1.2
Mirabegron	20	1.2	1.2
Aripiprazole	63	1.2	1.2
Pertuzumab	14	1.2	1.2
Polyethylene Glycol 3350	49	1.2	1.2
Panitumumab	8	1.2	1.2
Lanreotide Acetate	4	1.2	1.2
Guanfacine	4	1.2	1.2
Diroximel Fumarate	6	1.2	1.2
Abemaciclib	10	1.2	1.2
Evolocumab	81	1.2	1.2
Dexamethasone	143	1.1	1.1
Elexacaftor, Tezacaftor, And Ivacaftor	6	1.1	1.1
Carboplatin	61	1.1	1.1
Onabotulinumtoxina	37	1.1	1.1
Dexamethasone 1.5 Mg	140	1.1	1.1
Armodafinil	10	1.1	1.1
Oxycodone And Acetaminophen	11	1.1	1.1
Crizotinib	6	1.1	1.1
Suvorexant	6	1.1	1.1
Travoprost	4	1.1	1.1
Voclosporin	4	1.1	1.1
Brinzolamide	4	1.1	1.1
Ixekizumab	17	1.1	1.1
Brimonidine Tartrate	8	1.1	1.1
Ambrisentan	55	1.0	1.0
Vilazodone Hydrochloride	4	1.0	1.0
Olaparib	9	1.0	1.0
Cariprazine	4	1.0	1.0
Lenvatinib	14	1.0	1.0
Obinutuzumab	7	1.0	1.0
Tafamidis	5	1.0	1.0
Naltrexone	13	1.0	1.0
Etoposide	31	1.0	1.0
Glatiramer Acetate	25	1.0	1.0
Teriparatide	47	1.0	1.0
Cenegermin-Bkbj	5	1.0	1.0
Acalabrutinib	5	1.0	1.0
Vortioxetine	7	1.0	1.0
Fingolimod Hcl	35	1.0	1.0
Encorafenib	4	1.0	1.0
Docetaxel Anhydrous	27	0.9	0.9
Docetaxel	27	0.9	0.9
Etonogestrel	19	0.9	0.9
Prasugrel Hydrochloride	4	0.9	0.9
Abatacept	54	0.9	0.9
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	7	0.9	0.9
Erenumab-Aooe	21	0.9	0.9
Ivacaftor	3	0.9	0.9
Romosozumab-Aqqg	5	0.9	0.9
Sodium Oxybate	24	0.9	0.9
Ruxolitinib	26	0.9	0.9
Cenobamate	3	0.8	0.8
Voxelotor	8	0.8	0.8
Asenapine Maleate	3	0.8	0.8
Rucaparib	3	0.8	0.8
Abaloparatide	10	0.8	0.8
Ranitidine	67	0.8	0.8
Canagliflozin	10	0.8	0.8
Dimethyl Fumarate	41	0.8	0.8
Acetaminophen, Aspirin, And Caffeine	7	0.8	0.8
Denosumab	65	0.8	0.8
Cetuximab	10	0.8	0.8
Varenicline Tartrate	25	0.7	0.7
Axicabtagene Ciloleucel	3	0.7	0.7
Eltrombopag Olamine	7	0.7	0.7
Abiraterone	4	0.7	0.7
Enzalutamide	16	0.6	0.6
Pirfenidone	11	0.6	0.6
Dornase Alfa	5	0.6	0.6
Osimertinib	8	0.6	0.6
Durvalumab	5	0.6	0.6
Ranitidine Hydrochloride	13	0.6	0.6
Pimavanserin Tartrate	12	0.5	0.5
Valbenazine	5	0.5	0.5
Esketamine Hydrochloride	3	0.4	0.4
Apremilast	23	0.4	0.4
Levonorgestrel	31	0.4	0.4
Salicylic Acid	3	0.1	0.1

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.