Reaction

Prothrombin Time Prolonged reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,969 reports · 351 co-occurring drugs

As of the last recalculation, Prothrombin Time Prolonged appears in 5,969 FAERS reports alongside 351 co-occurring drug terms. The strongest observed disproportionality signal is WARFARIN SODIUM (PRR 34.4).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Warfarin Sodium	426	34.4	34.7
Warfarin	771	24.2	24.3
Phytonadione	37	15.3	15.4
Rifampicin	41	14.2	14.3
Digoxin	278	14.1	14.2
Enoxaparin Sodium	168	10.4	10.5
Torsemide	90	9.6	9.6
Dabigatran Etexilate	206	9.5	9.6
Dabigatran Etexilate Mesylate	187	9.2	9.3
Metolazone	29	9.0	9.1
Cefazolin Sodium	31	9.0	9.0
Quinine	22	9.0	9.0
Cefazolin	23	8.8	8.8
Derma Foam Excel Hand Sanitizer	20	8.7	8.8
Ethanol	20	8.7	8.7
Pyrazinamide	23	8.6	8.6
Norepinephrine Bitartrate	34	8.3	8.3
Amiodarone Hydrochloride	26	8.1	8.1
Isoniazid	37	8.0	8.0
Pegaspargase	26	7.4	7.4
Heparin Sodium	29	7.4	7.4
Piperacillin Sodium And Tazobactam Sodium	40	7.2	7.2
Enalapril Maleate	49	6.9	7.0
Cimetidine	19	6.9	6.9
Vancomycin Hydrochloride	127	6.8	6.9
Potassium Chloride, Dextrose Monohydrate	172	6.6	6.6
Potassium Chloride Oral	172	6.6	6.6
Potassium Chloride Extended-Release	172	6.6	6.6
Diltiazem Hydrochloride	65	6.6	6.6
Dalteparin Sodium	20	6.6	6.6
Fondaparinux Sodium	15	6.5	6.5
Rivaroxaban	366	6.5	6.5
Isosorbide Dinitrate	36	6.5	6.5
Potassium Chloride	204	6.4	6.4
Vancomycin	104	6.4	6.4
Eplerenone	23	6.3	6.3
Vincristine Sulfate	52	6.2	6.2
Spironolactone	241	6.2	6.2
Linezolid	50	5.9	5.9
Tolterodine Tartrate	15	5.8	5.8
Standardized Senna Concentrate	21	5.8	5.8
Clindamycin Phosphate	55	5.8	5.8
Clindamycin	46	5.7	5.7
Docusate Sodium - Sennosides	52	5.7	5.7
Thalidomide	59	5.6	5.7
Insulin	87	5.5	5.5
Furosemide	579	5.5	5.5
Promethazine Hydrochloride	29	5.5	5.5
Captopril	15	5.5	5.5
Nitroglycerin	82	5.4	5.4
Granisetron Hydrochloride	16	5.4	5.4
Gentamicin	20	5.3	5.4
Granisetron	16	5.3	5.3
Ipratropium Bromide	54	5.3	5.3
Gentamicin Sulfate	24	5.3	5.3
Dextrose	20	5.3	5.3
Bumetanide	40	5.3	5.3
Remdesivir	20	5.2	5.3
Dextrose Monohydrate	20	5.2	5.2
Magnesium Hydroxide	20	5.2	5.2
Meropenem	47	5.1	5.1
Dronedarone	15	5.1	5.1
Docusate Sodium	84	5.1	5.1
Docusate Sodium 100Mg	35	5.1	5.1
Cefepime	21	5.1	5.1
Fluconazole	100	5.0	5.0
Diphenhydramine Hcl	16	5.0	5.0
Sodium Bicarbonate	33	5.0	5.0
Sodium Bicarbonate Injection,	33	5.0	5.0
Lactulose	54	4.9	5.0
Glyburide	34	4.9	4.9
Mercaptopurine	24	4.8	4.8
Ezetimibe And Simvastatin	21	4.8	4.8
Acetylcysteine	13	4.8	4.8
Ascorbic Acid	32	4.8	4.8
Carisoprodol	26	4.8	4.8
Leucovorin Calcium	26	4.8	4.8
Tranexamic Acid	12	4.7	4.7
Phenytoin	28	4.7	4.7
Nystatin Ointment	35	4.7	4.7
Nystatin Cream	35	4.7	4.7
Gefitinib	12	4.6	4.6
Calcium Gluconate	16	4.6	4.6
Cytarabine	79	4.6	4.6
Chlorhexidine Gluconate	12	4.6	4.6
Cefuroxime	15	4.6	4.6
Norepinephrine	14	4.6	4.6
Cefepime Hydrochloride	21	4.6	4.6
Morphine	96	4.5	4.5
Metronidazole	82	4.5	4.5
Deferasirox	34	4.5	4.5
Nystatin	35	4.5	4.5
Febuxostat Tablets 40 Mg	13	4.5	4.5
Febuxostat Tablets 80 Mg	13	4.5	4.5
Metoroprolol Tartrate	83	4.4	4.4
Ceftriaxone Sodium	48	4.4	4.4
Sorafenib	26	4.4	4.4
Valsartan And Hydrochlorothiazide	17	4.4	4.4
Enalapril	69	4.4	4.4
Acetaminophen 500Mg	305	4.3	4.3
Acetaminophen Tablet Extended Release	304	4.3	4.3
Pain Reliever	304	4.3	4.3
Ceftriaxone	40	4.3	4.3
Colchicine	32	4.3	4.3
Ciprofloxacin Hydrochloride And Hydrocortisone	25	4.2	4.2
Extended Phenytoin Sodium	20	4.2	4.2
Allopurinol	182	4.2	4.2
Voriconazole	36	4.2	4.2
Ado-Trastuzumab Emtansine	10	4.1	4.1
Acetaminophen	497	4.1	4.1
Amoxicillin And Clavulanate Potassium	32	4.1	4.1
Tolvaptan	17	4.1	4.1
Metronidazole Topical	55	4.1	4.1
Bisacodyl Suppositories	15	4.0	4.1
Magnesium Oxide	48	4.0	4.0
Blinatumomab	12	4.0	4.0
Biscodyl	15	4.0	4.0
Vitamin E	36	4.0	4.0
Atenolol	150	4.0	4.0
Alcohol	44	4.0	4.0
Pantoprazole Sodium	165	4.0	4.0
Theophylline	13	4.0	4.0
Ciprofloxacin	102	3.9	3.9
Niacin	13	3.9	3.9
Dronabinol	9	3.9	3.9
Ciprofolxacin	78	3.8	3.8
Ciprofloxacin Tablets	78	3.8	3.8
Epoetin Alfa	13	3.8	3.8
Ciprofloxacin Hydrochloride	105	3.8	3.8
Temazepam	41	3.8	3.8
Metoclopramide Hydrochloride	83	3.8	3.8
Meperidine Hydrochloride	10	3.8	3.8
Sotalol Hydrochloride	18	3.8	3.8
Tobramycin Solution	13	3.8	3.8
Erythropoietin	22	3.7	3.7
Isopropyl Alcohol	36	3.7	3.7
Bisacodyl	15	3.7	3.7
Micafungin Sodium	9	3.7	3.7
Pantoprazole Sodium In 0.9% Sodium Chloride	65	3.7	3.7
Pantoprazole Sodium Injection	65	3.7	3.7
Carvedilol	140	3.7	3.7
Tobramycin Sulfate	13	3.7	3.7
Theophylline Anhydrous	13	3.7	3.7
Bosentan	52	3.6	3.6
Alemtuzumab	20	3.6	3.6
Metoprolol Succinate Er Tablets	64	3.6	3.6
Miconazole Nitrate	9	3.6	3.6
Imatinib	18	3.6	3.6
Atropine Sulfate	11	3.6	3.6
Propofol	37	3.5	3.5
Ursodiol	22	3.5	3.5
Ritonavir 100 Mg	15	3.5	3.5
Metformin Hcl	55	3.5	3.5
Piperacillin Sodium,Tazobactam Sodium	26	3.4	3.4
Azithromycin Dihydrate	57	3.4	3.4
Amlodipine Besylate And Benazepril Hydrochloride	9	3.4	3.4
Lamivudine	30	3.4	3.4
Diltiazem Hydrochloride Extended-Release Tablets	11	3.4	3.4
Felodipine Extended-Release Tablets	11	3.4	3.4
Felodipine	11	3.4	3.4
Isosorbide Mononitrate	20	3.4	3.4
Atropine	8	3.4	3.4
Rifampin	14	3.3	3.4
Lopinavir And Ritonavir	13	3.3	3.4
Sennosides 8.6 Mg Tablets	20	3.3	3.3
Febuxostat	16	3.3	3.3
Senna	20	3.3	3.3
Etonogestrel And Ethinyl Estradiol	21	3.3	3.3
Sodium Chloride Tablet	69	3.3	3.3
Sodium Chloride Tablets	69	3.3	3.3
Sodium Chloride	74	3.3	3.3
Valsartan	98	3.3	3.3
Aspirin 325 Mg	456	3.3	3.3
Bisoprolol Fumarate	126	3.3	3.3
Magnesium Sulfate In Water For	12	3.3	3.3
Aspirin 81 Mg	456	3.3	3.3
Piperacillin And Tazobactam	12	3.3	3.3
Moxifloxacin Hydrochloride	19	3.3	3.3
Imatinib Mesylate	26	3.3	3.3
Loperamide Hcl	12	3.3	3.3
Alteplase	14	3.3	3.3
Metoprolol Succinate	80	3.2	3.2
Salmeterol Xinafoate	8	3.2	3.2
Aspirin	470	3.2	3.2
Ramipril	113	3.2	3.2
Magnesium Sulfate Heptahydrate	12	3.2	3.2
Magnesium Sulfate	12	3.2	3.2
Bicalutamide	14	3.2	3.2
Clopidogrel Bisulfate	93	3.2	3.2
Sucralfate Oral	13	3.2	3.2
Sucralfate Oral Suspension	13	3.2	3.2
Indomethacin	12	3.2	3.2
Simvastatin	220	3.1	3.1
Metoprolol Tartrate	238	3.1	3.1
Lisinopril And Hydrochlorothiazide Tablets	7	3.1	3.1
Valproic Acid	28	3.1	3.1
Quinapril Hydrochloride	7	3.1	3.1
Ethyl Alcohol	24	3.1	3.1
Levofloxacin	53	3.1	3.1
Levofloxacin In 5% Dextrose	53	3.1	3.1
Lisinopril And Hydrochlorothiazide	9	3.1	3.1
Amlodipine Besylate	127	3.1	3.1
Sucralfate	21	3.1	3.1
Levothyroxine Sodium Anhydrous	87	3.1	3.1
Sulfamethoxazole And Trimethoprim	73	3.0	3.0
Lamivudine Oral	22	3.0	3.0
Zolpidem Tartrate	116	3.0	3.0
Senna Leaf	20	3.0	3.0
Lovastatin	22	3.0	3.0
Gemfibrozil	13	3.0	3.0
Valsartan Oral	46	3.0	3.0
Clarithromycin	29	3.0	3.0
Candesartan	30	2.9	2.9
Clopidogrel	162	2.9	2.9
Voriconazole Injection	18	2.9	2.9
Carbamazepine	55	2.9	2.9
Albuterol	98	2.9	2.9
Lorazepam	146	2.9	2.9
Valproate Sodium	17	2.9	2.9
Amikacin	14	2.9	2.9
Abacavir Sulfate	8	2.9	2.9
Nebivolol	13	2.8	2.9
Ketoconazole	14	2.8	2.8
Glipizide	49	2.8	2.8
Famotidine	92	2.8	2.8
Guaifenesin	24	2.8	2.8
Crizotinib	10	2.7	2.7
Lansoprazole	138	2.7	2.7
Fentanyl Citrate	14	2.7	2.7
Darbepoetin Alfa	42	2.7	2.7
Moxifloxacin	11	2.7	2.7
Ferrous Sulfate	39	2.7	2.7
Insulin Glargine-Yfgn	17	2.7	2.7
Losartan Potassium And Hydrochlorothiazide	9	2.7	2.7
0Xygen	38	2.7	2.7
Oxygen	38	2.7	2.7
Capecitabine	70	2.7	2.7
Fludarabine Phosphate	30	2.7	2.7
Metoprolol	190	2.7	2.7
Temozolomide	16	2.7	2.7
Melphalan Hydrochloride	19	2.6	2.6
Metoclopramide	41	2.6	2.6
Tobramycin	18	2.6	2.6
Azithromycin	30	2.6	2.6
Anti-Thymocyte Globulin (Rabbit)	6	2.6	2.6
Ibuprofen Capsule	146	2.6	2.6
Ibuprofen Tablet, Film Coated	146	2.6	2.6
Ibupfrofen	146	2.6	2.6
Ibuprofen Tablets Usp, 200Mg	146	2.6	2.6
Ibuprofen Oral	146	2.6	2.6
Ibuprofen Capsules 200 Mg	146	2.6	2.6
Ibuprofen 200 Mg	146	2.6	2.6
Ibuprofen 200Mg	146	2.6	2.6
Oxcarbazepine	24	2.6	2.6
Hydrochlorothiazide	106	2.6	2.6
Rabeprazole Sodium	20	2.6	2.6
Nicotine Polacrilex Mini	11	2.6	2.6
Nicotine Polarilex	11	2.6	2.6
Doxazosin Mesylate	26	2.5	2.5
Ritonavir	21	2.5	2.5
Hydroxyurea	15	2.5	2.5
Insulin Human	28	2.5	2.5
Sennosides	21	2.5	2.5
Nifedipine	33	2.4	2.4
Ibuprofen	186	2.4	2.4
Apixaban	46	2.4	2.4
Gemcitabine	27	2.4	2.4
Prochlorperazine	19	2.4	2.4
Loperamide Hydrochloride Oral	7	2.4	2.4
Olanzapine Pamoate	28	2.4	2.4
Testosterone	16	2.4	2.4
Fentanyl	67	2.4	2.4
Donepezil Hydrochloride	25	2.4	2.4
Atorvastatin Calcium	166	2.4	2.4
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	14	2.4	2.4
Naproxen Sodium, Pseudoephedrine Hydrochloride	14	2.4	2.4
Fenofibrate	24	2.4	2.4
Loperamide Hydrochloride	30	2.3	2.3
Ursosiol	13	2.3	2.3
Dofetilide	7	2.3	2.3
Melphalan	15	2.3	2.3
Loperamide Hydrochloride And Dimethicone	21	2.3	2.3
Letrozole	40	2.3	2.3
Diclofenac Sodium 1%	23	2.2	2.3
Diclofenac Sodium Topical	23	2.2	2.3
Doxorubicin Hydrochloride	21	2.2	2.2
Diclofenac Sodium Topical Gel, 1%	23	2.2	2.2
Erlotinib Hydrochloride	8	2.2	2.2
Irinotecan Hydrochloride	8	2.2	2.2
Oxycodone Hydrochloride And Acetaminophen	61	2.2	2.2
Fluorouracil Cream, 0.5%	47	2.2	2.2
Raloxifene Hydrochloride	9	2.2	2.2
Dutasteride	5	2.1	2.1
Etoposide	45	2.1	2.1
Fluorouracil	47	2.1	2.1
Pravastatin Sodium	12	2.1	2.1
Regorafenib	7	2.1	2.1
Sevoflurane	5	2.1	2.1
Nebivolol Hydrochloride	20	2.1	2.1
Cisplatin	46	2.1	2.1
Atomoxetine Hydrochloride	14	2.1	2.1
Filgrastim	22	2.0	2.0
Tenofovir Disoproxil Fumarate Tablets	5	2.0	2.0
Ribavirin	37	2.0	2.0
Oseltamivir Phosphate	14	2.0	2.0
Morphine Sulfate	69	2.0	2.0
Polyethylene Glycol 3350	54	2.0	2.0
Gemcitabine Hydrochloride	30	2.0	2.0
Multivitamin	28	2.0	2.0
Pioglitazone	24	1.9	1.9
Posaconazole	9	1.9	1.9
Rivastigmine	10	1.9	1.9
Bortezomib	47	1.8	1.8
Pemetrexed Disodium	20	1.8	1.8
Rifaximin	11	1.8	1.8
Naproxen Sodium Tablet, Coated	7	1.8	1.8
Naproxen Sodium, Coated Tablets	7	1.8	1.8
Naproxen Sodium 220Mg	7	1.8	1.8
Erlotinib	5	1.8	1.8
Dexamethasone 1.5 Mg	149	1.8	1.8
Entecavir	6	1.8	1.8
Dexamethasone	150	1.8	1.8
Cyclophosphamide Injection, Solution	89	1.8	1.8
Cyclophosphamide	89	1.8	1.8
Cyclophosphamide For Injection	89	1.8	1.8
Selexipag	13	1.8	1.8
Loratadine And Pseudoephedrine Sulfate	4	1.8	1.8
Oxaliplatin	35	1.6	1.6
Romiplostim	7	1.6	1.6
Levetiracetam In Sodium Chloride	35	1.6	1.6
Levetiracetam Oral	35	1.6	1.6
Levetiracetam Injection	35	1.6	1.6
Macitentan	31	1.6	1.6
Bevacizumab	55	1.6	1.6
Interferon Beta-1B	8	1.5	1.5
Paclitaxel (Aibumin-Bound)	34	1.4	1.4
Carboplatin	52	1.4	1.4
Dornase Alfa	8	1.4	1.4
Elexacaftor, Tezacaftor, And Ivacaftor	5	1.4	1.4
Paclitaxel	39	1.4	1.4
Suvorexant	5	1.3	1.3
Pemetrexed	8	1.3	1.3
Cetuximab	11	1.2	1.2
Lumacaftor And Ivacaftor	3	1.2	1.2
Exenatide	16	1.1	1.1
Eltrombopag Olamine	7	1.1	1.1
Romosozumab-Aqqg	4	1.0	1.0
Sacubitril And Valsartan	29	0.9	0.9
Emicizumab	3	0.8	0.8
Orlistat	6	0.8	0.8
Hydrocodone Bitartrate	9	0.7	0.7

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.