Reaction

Blood Pressure Diastolic Decreased reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 7,319 reports · 453 co-occurring drugs

As of the last recalculation, Blood Pressure Diastolic Decreased appears in 7,319 FAERS reports alongside 453 co-occurring drug terms. The strongest observed disproportionality signal is OCTREOTIDE ACETATE (PRR 93.0).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Octreotide Acetate	882	93.0	95.7
Diphenhydramine Hydrochloride Capsule, Liquid Filled	494	70.4	72.1
Infliximab-Dyyb	557	58.6	59.7
Methylprednisolone Sodium Succinate	536	35.4	35.8
Diphenhydramine Hydrochloride	1,442	30.6	30.8
Risedronate Sodium	304	29.0	29.3
Dimenhydrinate	93	25.1	25.3
Methylprednisolone	1,010	23.9	24.1
Diphenhydramine	469	22.5	22.6
Tocilizumab	805	22.4	22.6
Riociguat	235	21.1	21.3
Rabeprazole	152	19.9	20.0
Diphenhydramine Hcl	77	19.9	20.0
Desoximetasone	121	18.3	18.5
Ado-Trastuzumab Emtansine	53	18.0	18.1
Acetaminophen Tablet Extended Release	1,296	17.3	17.4
Pain Reliever	1,296	17.3	17.4
Acetaminophen 500Mg	1,296	17.3	17.4
Rosuvastatin Calcium	160	16.5	16.6
Rituximab	1,043	16.2	16.3
Esomeprazole Magnesium Capsule, Delayed Release	75	14.8	14.9
Esomeprazole Magnesium Delayed Release Capsules	75	14.8	14.9
Esomeprazole Magnesium Dihydrate	75	14.8	14.8
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	744	14.6	14.7
Acetaminophen	1,704	13.8	13.9
Hydrocortisone Sodium Succinate	44	13.4	13.4
Telmisartan	80	12.9	12.9
Ciclesonide	60	12.6	12.7
Hydrocortisone	354	11.8	11.8
Cannabidiol	92	11.3	11.4
Anti-Itch	257	11.3	11.3
Anti-Pruritic	257	11.3	11.3
Antipruritic (Anti-Itch)	257	11.3	11.3
Cool Relief Gel With Aloe	257	11.3	11.3
Drs. Hydrocortisone	257	11.3	11.3
Hydrocortisone Continuous Spray	257	11.3	11.3
Hydrocortisone Spray	257	11.3	11.3
Anti-Itch Cream	257	11.3	11.3
Hydrocortisone Lotion	257	11.3	11.3
Hydrocortisone Cream 1%	257	11.3	11.3
Hydrocortisone Cream 1/2%	257	11.3	11.3
Hydrocortisone 1%	257	11.2	11.3
Hydrocortisone Cream	257	11.2	11.2
Cetirizine Hydrochloride Allergy	116	11.1	11.1
Cetirizine Hydrochloride Tablets	116	11.1	11.1
Folic Acid	862	11.0	11.0
Prednisone	1,567	11.0	11.0
Hydrocortisone Acetate	267	10.8	10.8
Calcium	521	10.7	10.7
Pantoprazole Sodium In 0.9% Sodium Chloride	224	10.6	10.6
Pantoprazole Sodium Injection	224	10.6	10.6
Quinapril Hydrochloride	29	10.5	10.5
Hydroxychloroquine Sulfate	315	10.2	10.3
Tolterodine Tartrate	32	10.2	10.2
Loperamide Hydrochloride And Dimethicone	109	9.8	9.8
Irbesartan	151	9.8	9.8
Esomeprazole	195	9.2	9.2
Dexlansoprazole	131	9.1	9.1
Methylprednisolone Acetate	25	8.9	8.9
Methotrexate	1,132	8.9	8.9
Standardized Senna Concentrate	39	8.9	8.9
Sulfasalazine	234	8.8	8.8
Azathioprine	259	8.6	8.7
Pertuzumab	81	8.6	8.6
Hydrochlorothiazide	415	8.6	8.6
Naproxen	227	8.4	8.5
Dalteparin Sodium	31	8.4	8.4
Methotrexate Sodium	1,204	8.2	8.3
Pantoprazole	666	8.1	8.2
Cyclobenzaprine Hydrochloride	25	7.9	8.0
Loperamide Hydrochloride	121	7.8	7.8
Ramipril	319	7.6	7.6
Valsartan Oral	142	7.6	7.6
Infliximab	541	7.5	7.5
Nifedipine	122	7.5	7.5
Valsartan	266	7.4	7.4
Losartan Potassium And Hydrochlorothiazide	30	7.4	7.4
Iron	166	7.2	7.2
Mesalamine	137	7.1	7.1
Tramadol Hydrochloride	90	6.9	6.9
Glyburide	57	6.7	6.8
Amlodipine Besylate And Valsartan	26	6.7	6.7
Dutasteride	19	6.7	6.7
Leflunomide	233	6.5	6.5
Cholestyramine	27	6.4	6.4
Valsartan And Hydrochlorothiazide	30	6.3	6.3
Colchicine	57	6.2	6.2
Alendronate Sodium Tablet	40	6.2	6.2
Pramipexole	33	6.1	6.2
Oxazepam	46	6.1	6.1
Levothyroxine Sodium	618	6.0	6.0
Candesartan Cilexetil	55	6.0	6.0
Theophylline	24	6.0	6.0
Diltiazem Hydrochloride	71	5.9	5.9
Bisoprolol Fumarate	272	5.9	5.9
Candesartan	73	5.9	5.9
Omalizumab	172	5.9	5.9
Enalapril Maleate	50	5.8	5.8
Theophylline Anhydrous	25	5.8	5.8
Indapamide	36	5.7	5.7
Celecoxib	254	5.6	5.7
Atenolol	255	5.6	5.6
Atorvastatin Calcium, Film Coated	135	5.6	5.6
Morphine	142	5.5	5.5
Ciprofloxacin Hydrochloride And Hydrocortisone	40	5.5	5.5
Vitamin E	60	5.5	5.5
Rabeprazole Sodium	52	5.5	5.5
Mometasone	35	5.4	5.5
Digoxin	135	5.4	5.4
Dicyclomine Hydrochloride	27	5.4	5.4
Cetirizine	143	5.3	5.3
Linagliptin	34	5.3	5.3
Clindamycin Phosphate	62	5.3	5.3
Clindamycin	52	5.2	5.2
Psyllium Husk	18	5.2	5.2
Naproxen Sodium	253	5.2	5.2
Amlodipine	461	5.1	5.1
Alendronate Sodium	178	5.1	5.1
Everolimus	89	5.0	5.0
Magnesium	141	5.0	5.0
Pantoprazole Sodium	250	4.9	4.9
Fluticasone Propionate And Salmeterol Xinafoate	102	4.9	4.9
Hydroxychloroquine	126	4.9	4.9
Human Immunoglobulin G	35	4.8	4.8
Sucralfate Oral	24	4.8	4.8
Sucralfate Oral Suspension	24	4.8	4.8
Insulin	92	4.7	4.7
Fluticasone Furoate	20	4.7	4.7
Metformin Er 500 Mg	469	4.7	4.7
Metformin Er 750 Mg	469	4.7	4.7
Antacid	77	4.6	4.7
Metformin	546	4.6	4.6
Fenofibrate	57	4.6	4.6
Amlodipine Besylate	231	4.6	4.6
Diltiazem Hydrochloride Extended-Release Tablets	18	4.5	4.5
Terazosin Hydrochloride	14	4.5	4.5
Rosuvastatin	310	4.5	4.5
Quetiapine Fumarate	46	4.5	4.5
Eplerenone	20	4.5	4.5
Docusate Sodium 100Mg	37	4.4	4.4
Ibuprofen Tablets, Coated	65	4.4	4.4
0Xygen	75	4.4	4.4
Oxygen	75	4.4	4.4
Ibuprofen Sodium	65	4.3	4.3
Metformin Hydrochloride Tablets	86	4.3	4.3
Metformin Hydrochloride Extended-Release Tablets	86	4.3	4.3
Metformin Hydrochloride Tablet	86	4.3	4.3
Felodipine Extended-Release Tablets	17	4.3	4.3
Felodipine	17	4.3	4.3
Vitamin C	135	4.2	4.2
Moxifloxacin Hydrochloride	30	4.2	4.2
Metformin Hydrochloride	87	4.2	4.2
Ciprofloxacin	134	4.2	4.2
Acetaminophen And Codeine	18	4.2	4.2
Spironolactone	202	4.2	4.2
Cyclobenzaprine	72	4.1	4.1
Isosorbide Mononitrate	30	4.1	4.1
Doxazosin Mesylate	52	4.1	4.1
Canagliflozin	43	4.1	4.1
Aspirin 325 Mg	684	4.1	4.1
Aspirin 81 Mg	684	4.1	4.1
Warfarin	179	4.1	4.1
Venlafaxine	101	4.1	4.1
Moxifloxacin	20	4.0	4.1
Ciprofloxacin Hydrochloride	136	4.0	4.0
Atorvastatin Calcium	335	4.0	4.0
Furosemide	528	4.0	4.0
Metoprolol Tartrate Injection	256	3.9	3.9
Ciprofolxacin	98	3.9	3.9
Ciprofloxacin Tablets	98	3.9	3.9
Clopidogrel Bisulfate	139	3.9	3.9
Cetiirizine	58	3.9	3.9
Metoprolol	338	3.9	3.9
Aspirin	687	3.9	3.9
Nitroglycerin	73	3.9	3.9
Anti-Thymocyte Globulin (Rabbit)	11	3.9	3.9
Docusate Sodium	78	3.9	3.9
Indomethacin	18	3.9	3.9
Selexipag	35	3.9	3.9
Metoprolol Tartrate	358	3.9	3.9
Bisacodyl Suppositories	17	3.7	3.7
Heparin Sodium	18	3.7	3.7
Docusate Sodium - Sennosides	42	3.7	3.7
Biscodyl	17	3.7	3.7
Enalapril	72	3.7	3.7
Valacyclovir	54	3.7	3.7
Cortisone Acetate	16	3.7	3.7
Ketoprofen	17	3.7	3.7
Chlorthalidone	15	3.7	3.7
Epinephrine	84	3.7	3.7
Calcium Carbonate	85	3.6	3.6
Metoroprolol Tartrate	83	3.6	3.6
Dorzolamide Hydrochloride And Timolol Maleate	10	3.6	3.6
Liothyronine Sodium	11	3.6	3.6
Cephalexin	27	3.6	3.6
Cyanocobalamin	41	3.6	3.6
Atovaquone	10	3.5	3.5
Ezetimibe	92	3.5	3.5
Apixaban	82	3.5	3.5
Ergocalciferol	454	3.5	3.5
Trastuzumab	84	3.5	3.5
Daspone	12	3.5	3.5
Sulfamethoxazole And Trimethoprim	103	3.5	3.5
Dapsone Gel, 5%	12	3.5	3.5
Tamsulosin Hydrochloride	25	3.5	3.5
Lorazepam	214	3.5	3.5
Bisacodyl	17	3.4	3.4
Ascorbic Acid	28	3.4	3.4
Valacyclovir Hydrochloride	84	3.4	3.4
Lansoprazole	207	3.4	3.4
Hydromorphone Hydrochloride	107	3.3	3.3
Loperamide Hcl	15	3.3	3.3
Esomeprazole Magnesium	266	3.3	3.3
Metolazone	13	3.3	3.3
Iron Sucrose	11	3.3	3.3
Oxybutynin Chloride	10	3.2	3.3
Albuterol Sulfate	327	3.2	3.2
Budesonide And Formoterol Fumarate Dihydrate	109	3.2	3.2
Sucralfate	27	3.2	3.2
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	34	3.2	3.2
Dapsone	12	3.2	3.2
Niacin	13	3.2	3.2
Olmesartan Medoxomil	40	3.2	3.2
Mycophenolate Mofetil	149	3.2	3.2
Tiotropium Bromide	150	3.2	3.2
Mycophenolate Mofetil Hydrochloride	149	3.2	3.2
Estradiol	95	3.2	3.2
Nitrofurantoin (Monohydrate/Macrocrystals)	18	3.1	3.1
Loperamide Hydrochloride Oral	11	3.1	3.1
Morphine Sulfate	129	3.1	3.1
Ipratropium Bromide	38	3.0	3.0
Citalopram Hydrobromide	113	3.0	3.0
Carboxymethylcellulose Sodium	10	3.0	3.0
Clonazepam	168	3.0	3.0
Torsemide	35	3.0	3.0
Isoniazid	17	3.0	3.0
Diclofenac	89	3.0	3.0
Ferrous Sulfate	52	3.0	3.0
Nitrofurantoin	17	2.9	2.9
Empagliflozin	69	2.9	2.9
Isosorbide Dinitrate	20	2.9	2.9
Budesonide	60	2.9	2.9
Methimazole	8	2.9	2.9
Citalopram	137	2.9	2.9
Mirabegron	39	2.9	2.9
Warfarin Sodium	46	2.8	2.8
Metronidazole	63	2.8	2.8
Cefazolin	9	2.8	2.8
Insulin Glulisine	10	2.8	2.8
Deferasirox	26	2.8	2.8
Metformin Hcl	54	2.8	2.8
Ropinirole	15	2.8	2.8
Cetirizine Hydrochloride	159	2.8	2.8
Meperidine Hydrochloride	9	2.8	2.8
Levothyroxine Sodium Anhydrous	97	2.8	2.8
Amoxicillin	74	2.8	2.8
Venlafaxine Hydrochloride	127	2.8	2.8
Bupivacaine	9	2.7	2.7
Sotalol Hydrochloride	16	2.7	2.7
Mometasone Furoate	40	2.7	2.7
Sitagliptin	69	2.7	2.7
Ranolazine	10	2.7	2.7
Diphenoxylate Hydrochloride And Atropine Sulfate	13	2.7	2.7
Sacubitril And Valsartan	109	2.7	2.7
Azithromycin	38	2.7	2.7
Albuterol	112	2.7	2.7
Prochlorperazine	26	2.7	2.7
Sodium Chloride Tablet	68	2.6	2.6
Sodium Chloride Tablets	68	2.6	2.6
Duloxetine	64	2.6	2.6
Clonidine	47	2.6	2.6
Montelukast Sodium	111	2.6	2.6
Azithromycin Monohydrate	38	2.6	2.6
Dextrose	12	2.6	2.6
Timolol Maleate	9	2.6	2.6
Ibuprofen And Diphenhydramine Citrate	21	2.6	2.6
Macitentan	62	2.6	2.6
Dextrose Monohydrate	12	2.6	2.6
Umeclidinium	8	2.5	2.5
Amiodarone Hydrochloride	10	2.5	2.5
Fluticasone Furoate And Vilanterol Trifenatate	32	2.5	2.5
Sodium Chloride	70	2.5	2.5
Leucovorin Calcium	17	2.5	2.5
Magnesium Oxide	37	2.5	2.5
Medroxyprogesterone Acetate	44	2.5	2.5
Temazepam	33	2.5	2.5
Sertraline Hydrochloride	103	2.5	2.5
Clopidogrel	170	2.5	2.5
Diclofenac Sodium	129	2.5	2.5
Carvedilol	116	2.5	2.5
Lidocaine Hydrochloride And Epinephrine Bitartrate	46	2.5	2.5
Fluconazole	60	2.4	2.4
Duloxetine Hydrochloride	159	2.4	2.4
Allopurinol	132	2.4	2.4
Gabapentin	303	2.4	2.4
Potassium Chloride, Dextrose Monohydrate	78	2.4	2.4
Potassium Chloride Oral	78	2.4	2.4
Potassium Chloride Extended-Release	78	2.4	2.4
Abatacept	116	2.4	2.4
Sunitinib Malate	33	2.4	2.4
Lidicaine	41	2.4	2.4
Burn Relief	41	2.4	2.4
Lidocaine Hydrochloride And Epinephrine	41	2.4	2.4
Diclofenac Potassium, Film Coated	7	2.4	2.4
Famotidine	97	2.4	2.4
Diclofenac Potassium Tablets	7	2.4	2.4
Baricitinib	8	2.4	2.4
Lidocaine, Menthol	41	2.4	2.4
Zoledronic Acid	33	2.3	2.3
Fentanyl	80	2.3	2.3
Lidocaine Hydrochloride	49	2.3	2.3
Melatonin	44	2.3	2.3
Pregabalin	217	2.3	2.3
Azithromycin Dihydrate	47	2.3	2.3
Simvastatin	198	2.3	2.3
Aripiprazole Oral	33	2.3	2.3
Aripiprazole Orally Disintegrating	33	2.3	2.3
Letrozole Tablets	38	2.3	2.3
Gemfibrozil	12	2.3	2.3
Pioglitazone	34	2.2	2.2
Progesterone	18	2.2	2.2
Primidone	8	2.2	2.2
Letrozole	48	2.2	2.2
Brivaracetam	7	2.2	2.2
Tapentadol Hydrochloride	26	2.2	2.2
Lidocaine 4%	42	2.2	2.2
Tofacitinib Citrate	10	2.2	2.2
Prochlorperazine Maleate	7	2.2	2.2
Meloxicam	44	2.2	2.2
Cyclosporine	84	2.2	2.2
Capecitabine	69	2.2	2.2
Hydroxyurea	16	2.2	2.2
Tizanidine	18	2.1	2.1
Montelukast	63	2.1	2.1
Ticagrelor	24	2.1	2.1
Cefazolin Sodium	9	2.1	2.1
Dronabinol	6	2.1	2.1
Diclofenac Potassium	8	2.1	2.1
Lidocaine	43	2.1	2.1
Metronidazole Topical	35	2.1	2.1
Potassium Chloride	83	2.1	2.1
Lactulose	28	2.1	2.1
Botulinum Toxin Type A	9	2.1	2.1
Bumetanide	19	2.0	2.0
Ibuprofen	193	2.0	2.0
Doxycycline Hyclate	48	2.0	2.0
Pravastatin Sodium	14	2.0	2.0
Escitslopram	41	2.0	2.0
Doxycycline	48	2.0	2.0
Ribociclib	22	2.0	2.0
Fulvestrant	23	2.0	2.0
Salmeterol Xinafoate	6	2.0	2.0
Travoprost	6	2.0	2.0
Mercaptopurine	12	2.0	2.0
Rivaroxaban	142	2.0	2.0
Lisinopril And Hydrochlorothiazide	7	1.9	1.9
Etonogestrel And Ethinyl Estradiol	15	1.9	1.9
Prednisolone Acetate	7	1.9	1.9
Escitalopram Oxalate	49	1.9	1.9
Atomoxetine Hydrochloride	16	1.9	1.9
Budesonide, Glycopyrrolate, And Formoterol Fumarate	7	1.9	1.9
Dofetilide	7	1.9	1.9
Tobramycin Solution	8	1.9	1.9
Naproxen Sodium Tablet, Coated	9	1.9	1.9
Naproxen Sodium, Coated Tablets	9	1.9	1.9
Naproxen Sodium 220Mg	9	1.9	1.9
Paclitaxel (Aibumin-Bound)	54	1.9	1.9
Vancomycin	38	1.9	1.9
Everolimus Tablets	11	1.9	1.9
Vancomycin Hydrochloride	43	1.9	1.9
Baclofen	56	1.9	1.9
Levofloxacin	39	1.8	1.8
Levofloxacin In 5% Dextrose	39	1.8	1.8
Tobramycin Sulfate	8	1.8	1.8
Biotin	20	1.8	1.8
Dapagliflozin	20	1.8	1.8
Lisinopril And Hydrochlorothiazide Tablets	5	1.8	1.8
Methadone	27	1.8	1.8
Lovastatin	16	1.8	1.8
Denosumab	125	1.8	1.8
Fentanyl Citrate	11	1.8	1.8
Epoprostenol	8	1.7	1.7
Treprostinil	76	1.7	1.7
Tadalafil	60	1.7	1.7
Bicalutamide	9	1.7	1.7
Diclofenac Sodium 1%	21	1.7	1.7
Diclofenac Sodium Topical	21	1.7	1.7
Dronedarone	6	1.7	1.7
Paclitaxel	58	1.7	1.7
Diclofenac Sodium Topical Gel, 1%	21	1.7	1.7
Erythropoietin	12	1.7	1.7
Clobetasol Propionate Ointment Usp, 0.05%	6	1.7	1.7
Clobetasol Propionate	6	1.7	1.7
Timolol	7	1.6	1.6
Loratadine Tablet	31	1.6	1.6
Latanoprost	29	1.6	1.6
Brinzolamide	5	1.6	1.6
Propofol	21	1.6	1.6
Insulin Glargine	140	1.6	1.6
Temozolomide	12	1.6	1.6
Brimonidine Tartrate	10	1.6	1.6
Cefepime	8	1.6	1.6
Sildenafil	32	1.6	1.6
Conjugated Estrogens	32	1.6	1.6
Oxycodone	102	1.6	1.6
Oxybutynin	16	1.6	1.6
Donepezil Hydrochloride	20	1.6	1.6
Methoxy Polyethylene Glycol-Epoetin Beta	6	1.5	1.5
Estrogens, Conjugated	32	1.5	1.5
Tiotropium Bromide Inhalation Spray	6	1.5	1.5
Ranitidine	105	1.5	1.5
Insulin Human	21	1.5	1.5
Golimumab	45	1.5	1.5
Nintedanib	16	1.5	1.5
Ambrisentan	62	1.4	1.4
Doxorubicin Hydrochloride	16	1.4	1.4
Vedolizumab	42	1.4	1.4
Sevoflurane	4	1.4	1.4
Carboplatin	59	1.3	1.3
Methadone Hydrochloride	5	1.3	1.3
Niraparib	10	1.3	1.3
Varenicline Tartrate	36	1.3	1.3
Gefitinib	4	1.3	1.3
Oxycodone And Acetaminophen	10	1.2	1.2
Droxidopa	9	1.2	1.2
Tobramycin	10	1.2	1.2
Bevacizumab	51	1.2	1.2
Insulin Lispro	55	1.1	1.1
Brentuximab Vedotin	4	1.1	1.1
Darbepoetin Alfa	21	1.1	1.1
Irinotecan Hydrochloride	5	1.1	1.1
Cetuximab	12	1.1	1.1
Guanfacine	3	1.1	1.1
Tofacitinib	70	1.1	1.1
Oxycodone Hydrochloride	81	1.1	1.1
Iohexol	3	1.0	1.0
Naproxen Sodium Tablet	19	1.0	1.0
Orlistat	9	1.0	1.0
Bimatoprost	10	1.0	1.0
Secukinumab	55	1.0	1.0
Siponimod	3	1.0	1.0
Agalsidase Beta	3	0.9	0.9
Buprenorphine	30	0.9	0.9
Crizotinib	4	0.9	0.9
Suvorexant	4	0.9	0.9
Pazopanib Hydrochloride	8	0.8	0.8
Palbociclib	25	0.7	0.7
Sevelamer Carbonate	3	0.7	0.7
Relugolix	6	0.7	0.7
Avapritinib	3	0.7	0.7
Abaloparatide	7	0.7	0.7
Pegfilgrastim	19	0.5	0.5
Nirmatrelvir And Ritonavir	9	0.5	0.5

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.